diff --git a/.github/workflows/sycl-linux-precommit.yml b/.github/workflows/sycl-linux-precommit.yml
index ab2a5bca19b65..9caed376bd869 100644
--- a/.github/workflows/sycl-linux-precommit.yml
+++ b/.github/workflows/sycl-linux-precommit.yml
@@ -62,6 +62,42 @@ jobs:
       e2e_binaries_artifact: e2e_bin
       e2e_binaries_preview_artifact: e2e_bin_preview
 
+  # Build and run native cpu e2e tests separately as cannot currently
+  # build all the e2e tests
+  build_run_native_cpu_e2e_tests:
+    if: ${{ always() && !cancelled() && needs.build.outputs.build_conclusion == 'success' }}  
+    runs-on: [Linux, build]
+    needs: [build]
+    container:
+      image: ghcr.io/intel/llvm/sycl_ubuntu2404_nightly:latest
+      options: -u 1001:1001
+    steps:
+      - uses: actions/checkout@v4
+        with:
+          sparse-checkout: |
+            devops/
+
+      # download build artefact
+      - name: Download toolchain
+        uses: actions/download-artifact@v4
+        with:
+          name: sycl_linux_default
+      - name: Extract SYCL toolchain
+        shell: bash
+        run: |
+          mkdir toolchain
+          tar -xf llvm_sycl.tar.zst -C toolchain
+          rm llvm_sycl.tar.zst
+      - name: Build and run E2E tests
+        uses: ./devops/actions/run-tests/e2e
+        with:
+          ref: ${{ inputs.ref || github.sha }}
+          testing_mode: build-only
+          target_devices: native_cpu
+          sycl_compiler: $GITHUB_WORKSPACE/toolchain/bin/clang++
+          extra_lit_opts: --param sycl_build_targets="native_cpu"
+          extra_cmake_args: -DSYCL_TEST_E2E_TARGETS="native_cpu:cpu" -DSYCL_TEST_E2E_STANDALONE=ON
+
   # If a PR changes CUDA adapter, run the build on Ubuntu 22.04 as well.
   # Ubuntu 22.04 container has CUDA 12.1 installed while Ubuntu 24.0 image
   # has CUDA 12.6.1 installed.
diff --git a/sycl/test-e2e/Adapters/enqueue-arg-order-image.cpp b/sycl/test-e2e/Adapters/enqueue-arg-order-image.cpp
index 67de65c5e7473..67acce1d5d260 100644
--- a/sycl/test-e2e/Adapters/enqueue-arg-order-image.cpp
+++ b/sycl/test-e2e/Adapters/enqueue-arg-order-image.cpp
@@ -20,6 +20,8 @@
 // resolved and 2 is merged we will re-enable Image support.
 // UNSUPPORTED: spirv-backend && arch-intel_gpu_bmg_g21
 // UNSUPPORTED-TRACKER: https://github.com/KhronosGroup/SPIRV-Headers/issues/487
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 
 #include <iostream>
 
diff --git a/sycl/test-e2e/Adapters/level_zero/lit.local.cfg b/sycl/test-e2e/Adapters/level_zero/lit.local.cfg
new file mode 100644
index 0000000000000..3815719611810
--- /dev/null
+++ b/sycl/test-e2e/Adapters/level_zero/lit.local.cfg
@@ -0,0 +1,4 @@
+# Currently mark Native CPU as unsupported, does not compile and should be
+# investigated and tracked post team transfer
+# see https://github.com/intel/llvm/issues/20142
+config.unsupported_features += ['target-native_cpu']
diff --git a/sycl/test-e2e/Adapters/queue_submit_mode.cpp b/sycl/test-e2e/Adapters/queue_submit_mode.cpp
index d14472ab51bec..f6a66981a8dd3 100644
--- a/sycl/test-e2e/Adapters/queue_submit_mode.cpp
+++ b/sycl/test-e2e/Adapters/queue_submit_mode.cpp
@@ -5,6 +5,9 @@
 // RUN: env %{l0_leak_check} SYCL_PI_LEVEL_ZERO_USE_IMMEDIATE_COMMANDLISTS=0 %{run} %t.out 0 2>&1 | FileCheck %s --check-prefixes=CHECK-STD
 // RUN: env %{l0_leak_check} SYCL_PI_LEVEL_ZERO_USE_IMMEDIATE_COMMANDLISTS=1 %{run} %t.out 1 2>&1 | FileCheck %s --check-prefixes=CHECK-IMM
 //
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
+//
 // Check that queue submission mode is honored when creating queue.
 //
 #include <iostream>
diff --git a/sycl/test-e2e/AddressSanitizer/lit.local.cfg b/sycl/test-e2e/AddressSanitizer/lit.local.cfg
index c2bc429f1bb3f..2c460b824422d 100644
--- a/sycl/test-e2e/AddressSanitizer/lit.local.cfg
+++ b/sycl/test-e2e/AddressSanitizer/lit.local.cfg
@@ -21,6 +21,8 @@ config.unsupported_features += ['spirv-backend']
 # https://github.com/intel/llvm/issues/16920
 config.unsupported_features += ['arch-intel_gpu_bmg_g21']
 
+# https://github.com/intel/llvm/issues/20142
+config.unsupported_features += ['target-native_cpu']
 unsupported_san_flags = [
     # "-fsanitize=address",
     "-fsanitize=memory",
diff --git a/sycl/test-e2e/Assert/check_resource_leak.cpp b/sycl/test-e2e/Assert/check_resource_leak.cpp
index a037421f342c6..2f3c512bf5a9c 100644
--- a/sycl/test-e2e/Assert/check_resource_leak.cpp
+++ b/sycl/test-e2e/Assert/check_resource_leak.cpp
@@ -6,6 +6,9 @@
 
 // TODO: Fails at JIT compilation for some reason.
 // UNSUPPORTED: hip
+
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
 #define SYCL_FALLBACK_ASSERT 1
 
 #include <sycl/detail/core.hpp>
diff --git a/sycl/test-e2e/BFloat16/lit.local.cfg b/sycl/test-e2e/BFloat16/lit.local.cfg
new file mode 100644
index 0000000000000..9bee696fb8c17
--- /dev/null
+++ b/sycl/test-e2e/BFloat16/lit.local.cfg
@@ -0,0 +1,2 @@
+# https://github.com/intel/llvm/issues/20142
+config.unsupported_features += ['target-native_cpu']
diff --git a/sycl/test-e2e/Basic/built-ins/marray_math.cpp b/sycl/test-e2e/Basic/built-ins/marray_math.cpp
index 1cd838a328b08..a02af52e83a12 100644
--- a/sycl/test-e2e/Basic/built-ins/marray_math.cpp
+++ b/sycl/test-e2e/Basic/built-ins/marray_math.cpp
@@ -2,6 +2,9 @@
 
 // RUN: %{build} %{mathflags} -o %t.out
 // RUN: %{run} %t.out
+//
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
 
 #include <cmath>
 #include <sycl/detail/core.hpp>
diff --git a/sycl/test-e2e/Basic/image/lit.local.cfg b/sycl/test-e2e/Basic/image/lit.local.cfg
index dba254424f0a2..8ce73f3911718 100644
--- a/sycl/test-e2e/Basic/image/lit.local.cfg
+++ b/sycl/test-e2e/Basic/image/lit.local.cfg
@@ -6,3 +6,8 @@
 # Legacy images aren't supported on AMD and also don't compile, so mark them
 # unsupported here. Bindless images should be used instead.
 config.unsupported_features += ['spirv-backend', 'target-amd']
+
+# Legacy images aren't supported on Native CPU. Bindless images should be used
+# instead when they are working.
+# https://github.com/intel/llvm/issues/20142
+config.unsupported_features += ['target-native_cpu']
diff --git a/sycl/test-e2e/Basic/vector/load_store.cpp b/sycl/test-e2e/Basic/vector/load_store.cpp
index df4af3976a1ed..00ddf5a0a3402 100644
--- a/sycl/test-e2e/Basic/vector/load_store.cpp
+++ b/sycl/test-e2e/Basic/vector/load_store.cpp
@@ -4,6 +4,9 @@
 // RUN: %if preview-breaking-changes-supported %{ %{build} -fpreview-breaking-changes -o %t2.out %}
 // RUN: %if preview-breaking-changes-supported %{ %{run} %t2.out %}
 
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
+
 // Tests load and store on sycl::vec.
 
 #include <sycl/detail/core.hpp>
diff --git a/sycl/test-e2e/Complex/sycl_complex_math_test.cpp b/sycl/test-e2e/Complex/sycl_complex_math_test.cpp
index 899fb82667271..48a8399abc84d 100644
--- a/sycl/test-e2e/Complex/sycl_complex_math_test.cpp
+++ b/sycl/test-e2e/Complex/sycl_complex_math_test.cpp
@@ -2,6 +2,8 @@
 
 // RUN: %{build} -Wno-error=deprecated-declarations -fsycl-device-code-split=per_kernel %{mathflags} -o %t.out
 // RUN: %{run} %t.out
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
 
 #include "sycl_complex_helper.hpp"
 #include "sycl_complex_math_test_cases.hpp"
diff --git a/sycl/test-e2e/Complex/sycl_complex_operator_test.cpp b/sycl/test-e2e/Complex/sycl_complex_operator_test.cpp
index 23eefc323a0ef..c784888548571 100644
--- a/sycl/test-e2e/Complex/sycl_complex_operator_test.cpp
+++ b/sycl/test-e2e/Complex/sycl_complex_operator_test.cpp
@@ -1,5 +1,8 @@
 // RUN: %{build} -Wno-error=deprecated-declarations -fsycl-device-code-split=per_kernel -o %t.out
 // RUN: %{run} %t.out
+//
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
 
 #include "sycl_complex_helper.hpp"
 #include "sycl_complex_operator_test_cases.hpp"
diff --git a/sycl/test-e2e/Compression/no_zstd_warning.cpp b/sycl/test-e2e/Compression/no_zstd_warning.cpp
index 86eb7830a9c07..03bd82dcf950f 100644
--- a/sycl/test-e2e/Compression/no_zstd_warning.cpp
+++ b/sycl/test-e2e/Compression/no_zstd_warning.cpp
@@ -1,5 +1,7 @@
 // using --offload-compress without zstd should throw an error.
 // REQUIRES: !zstd
 // RUN: not %{build} %O0 -g --offload-compress %S/Inputs/single_kernel.cpp -o %t_compress.out 2>&1 | FileCheck %s
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
 // CHECK: error: '--offload-compress' is specified but the compiler is built without zstd support.
 // CHECK-NEXT: If you are using a custom DPC++ build, please refer to https://github.com/intel/llvm/blob/sycl/sycl/doc/GetStartedGuide.md#build-dpc-toolchain-with-device-image-compression-support for more information on how to build with zstd support.
diff --git a/sycl/test-e2e/DeviceGlobal/device_global_arrow.cpp b/sycl/test-e2e/DeviceGlobal/device_global_arrow.cpp
index 47b0360a0d1e5..da56869b357c6 100644
--- a/sycl/test-e2e/DeviceGlobal/device_global_arrow.cpp
+++ b/sycl/test-e2e/DeviceGlobal/device_global_arrow.cpp
@@ -3,6 +3,8 @@
 //
 // UNSUPPORTED: opencl && gpu
 // UNSUPPORTED-TRACKER: GSD-4287
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 //
 // Tests operator-> on device_global.
 
diff --git a/sycl/test-e2e/DeviceGlobal/device_global_arrow_dis.cpp b/sycl/test-e2e/DeviceGlobal/device_global_arrow_dis.cpp
index d1dff5a16fa72..bc0d77f06608a 100644
--- a/sycl/test-e2e/DeviceGlobal/device_global_arrow_dis.cpp
+++ b/sycl/test-e2e/DeviceGlobal/device_global_arrow_dis.cpp
@@ -3,6 +3,8 @@
 //
 // UNSUPPORTED: opencl && gpu
 // UNSUPPORTED-TRACKER: GSD-4287
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 //
 // Tests operator-> on device_global with device_image_scope.
 // NOTE: USE_DEVICE_IMAGE_SCOPE needs both kernels to be in the same image so
diff --git a/sycl/test-e2e/DeviceGlobal/device_global_copy.cpp b/sycl/test-e2e/DeviceGlobal/device_global_copy.cpp
index c15320b55d352..97d128e6d5dc1 100644
--- a/sycl/test-e2e/DeviceGlobal/device_global_copy.cpp
+++ b/sycl/test-e2e/DeviceGlobal/device_global_copy.cpp
@@ -5,6 +5,8 @@
 //
 // UNSUPPORTED: opencl && gpu
 // UNSUPPORTED-TRACKER: GSD-4287
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 //
 // Tests the copy ctor on device_global without device_image_scope.
 
diff --git a/sycl/test-e2e/DeviceGlobal/device_global_device_only.cpp b/sycl/test-e2e/DeviceGlobal/device_global_device_only.cpp
index 56351c8c6cc1d..5e5aa5422b5c0 100644
--- a/sycl/test-e2e/DeviceGlobal/device_global_device_only.cpp
+++ b/sycl/test-e2e/DeviceGlobal/device_global_device_only.cpp
@@ -3,6 +3,8 @@
 //
 // UNSUPPORTED: opencl && gpu
 // UNSUPPORTED-TRACKER: GSD-4287
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 //
 // Tests basic device_global access through device kernels.
 
diff --git a/sycl/test-e2e/DeviceGlobal/device_global_device_only_dis.cpp b/sycl/test-e2e/DeviceGlobal/device_global_device_only_dis.cpp
index b97b71d3a023b..2b68622625ff8 100644
--- a/sycl/test-e2e/DeviceGlobal/device_global_device_only_dis.cpp
+++ b/sycl/test-e2e/DeviceGlobal/device_global_device_only_dis.cpp
@@ -3,6 +3,8 @@
 //
 // UNSUPPORTED: opencl && gpu
 // UNSUPPORTED-TRACKER: GSD-4287
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 //
 // Tests basic device_global with device_image_scope access through device
 // kernels.
diff --git a/sycl/test-e2e/DeviceGlobal/device_global_operator_passthrough.cpp b/sycl/test-e2e/DeviceGlobal/device_global_operator_passthrough.cpp
index c518c98e1ebbc..04bfab5a3952a 100644
--- a/sycl/test-e2e/DeviceGlobal/device_global_operator_passthrough.cpp
+++ b/sycl/test-e2e/DeviceGlobal/device_global_operator_passthrough.cpp
@@ -3,6 +3,8 @@
 //
 // UNSUPPORTED: opencl && gpu
 // UNSUPPORTED-TRACKER: GSD-4287
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 //
 // Tests the passthrough of operators on device_global.
 
diff --git a/sycl/test-e2e/DeviceGlobal/device_global_operator_passthrough_dis.cpp b/sycl/test-e2e/DeviceGlobal/device_global_operator_passthrough_dis.cpp
index 3757f092b2604..fd26b9b19e891 100644
--- a/sycl/test-e2e/DeviceGlobal/device_global_operator_passthrough_dis.cpp
+++ b/sycl/test-e2e/DeviceGlobal/device_global_operator_passthrough_dis.cpp
@@ -3,6 +3,8 @@
 //
 // UNSUPPORTED: opencl && gpu
 // UNSUPPORTED-TRACKER: GSD-4287
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 //
 // Tests the passthrough of operators on device_global with device_image_scope.
 // NOTE: USE_DEVICE_IMAGE_SCOPE needs both kernels to be in the same image so
diff --git a/sycl/test-e2e/DeviceGlobal/device_global_subscript.cpp b/sycl/test-e2e/DeviceGlobal/device_global_subscript.cpp
index 61ea599477a58..0a2878720f8ba 100644
--- a/sycl/test-e2e/DeviceGlobal/device_global_subscript.cpp
+++ b/sycl/test-e2e/DeviceGlobal/device_global_subscript.cpp
@@ -3,6 +3,8 @@
 //
 // UNSUPPORTED: opencl && gpu
 // UNSUPPORTED-TRACKER: GSD-4287
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 //
 // Tests operator[] on device_global.
 
diff --git a/sycl/test-e2e/DeviceGlobal/device_global_subscript_dis.cpp b/sycl/test-e2e/DeviceGlobal/device_global_subscript_dis.cpp
index 99b3538c31693..e21e82a2aa3e3 100644
--- a/sycl/test-e2e/DeviceGlobal/device_global_subscript_dis.cpp
+++ b/sycl/test-e2e/DeviceGlobal/device_global_subscript_dis.cpp
@@ -3,6 +3,8 @@
 //
 // UNSUPPORTED: opencl && gpu
 // UNSUPPORTED-TRACKER: GSD-4287
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 //
 // Tests operator[] on device_global with device_image_scope.
 // NOTE: USE_DEVICE_IMAGE_SCOPE needs both kernels to be in the same image so
diff --git a/sycl/test-e2e/DeviceImageDependencies/NewOffloadDriver/objects.cpp b/sycl/test-e2e/DeviceImageDependencies/NewOffloadDriver/objects.cpp
index 887609f882ffb..2aa7ac1e6175a 100644
--- a/sycl/test-e2e/DeviceImageDependencies/NewOffloadDriver/objects.cpp
+++ b/sycl/test-e2e/DeviceImageDependencies/NewOffloadDriver/objects.cpp
@@ -7,6 +7,9 @@
 // RUN: %{build} --offload-new-driver -fsycl-allow-device-image-dependencies %t_a.o %t_b.o %t_c.o %t_d.o -I %S/Inputs -o %t.out
 // RUN: %{run} %t.out
 
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
+
 #include "a.hpp"
 #include <iostream>
 #include <sycl/detail/core.hpp>
diff --git a/sycl/test-e2e/DeviceImageDependencies/objects.cpp b/sycl/test-e2e/DeviceImageDependencies/objects.cpp
index 80e8a28f7818a..9e64bbda3ceb9 100644
--- a/sycl/test-e2e/DeviceImageDependencies/objects.cpp
+++ b/sycl/test-e2e/DeviceImageDependencies/objects.cpp
@@ -6,3 +6,6 @@
 // RUN: %clangxx -fsycl %S/Inputs/d.cpp -I %S/Inputs -c -o %t_d.o
 // RUN: %clangxx -fsycl %{sycl_target_opts} -fsycl-device-code-split=per_kernel -fsycl-allow-device-image-dependencies %t_a.o %t_b.o %t_c.o %t_d.o %S/Inputs/basic.cpp -o %t.out
 // RUN: %{run} %t.out
+
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
diff --git a/sycl/test-e2e/DeviceLib/bfloat16_conversion_dlopen_test.cpp b/sycl/test-e2e/DeviceLib/bfloat16_conversion_dlopen_test.cpp
index 8abf71f5c0d83..3fb5731bebe22 100644
--- a/sycl/test-e2e/DeviceLib/bfloat16_conversion_dlopen_test.cpp
+++ b/sycl/test-e2e/DeviceLib/bfloat16_conversion_dlopen_test.cpp
@@ -23,5 +23,7 @@
 
 // UNSUPPORTED: target-nvidia || target-amd
 // UNSUPPORTED-INTENDED: bfloat16 device library is not used on AMD and Nvidia.
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 
 #include "bfloat16_conversion_dlopen_test.hpp"
diff --git a/sycl/test-e2e/DeviceLib/bfloat16_conversion_test.cpp b/sycl/test-e2e/DeviceLib/bfloat16_conversion_test.cpp
index 34b5d873d545d..154abe72a74e7 100644
--- a/sycl/test-e2e/DeviceLib/bfloat16_conversion_test.cpp
+++ b/sycl/test-e2e/DeviceLib/bfloat16_conversion_test.cpp
@@ -13,5 +13,7 @@
 
 // UNSUPPORTED: target-nvidia || target-amd
 // UNSUPPORTED-INTENDED: bfloat16 device library is not used on AMD and Nvidia.
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 
 #include "bfloat16_conversion_test.hpp"
diff --git a/sycl/test-e2e/DeviceLib/imf/lit.local.cfg b/sycl/test-e2e/DeviceLib/imf/lit.local.cfg
index 442db188e39a9..e305846a5491f 100644
--- a/sycl/test-e2e/DeviceLib/imf/lit.local.cfg
+++ b/sycl/test-e2e/DeviceLib/imf/lit.local.cfg
@@ -1,2 +1,6 @@
 # IMF is not supported on Nvidia and AMD
 config.unsupported_features += ['target-nvidia', 'target-amd']
+
+# IMF is not supported on Native CPU
+# https://github.com/intel/llvm/issues/20142
+config.unsupported_features += ['target-native_cpu']
diff --git a/sycl/test-e2e/ESIMD/lit.local.cfg b/sycl/test-e2e/ESIMD/lit.local.cfg
index ea8fb35d52afd..c6a79eb197063 100644
--- a/sycl/test-e2e/ESIMD/lit.local.cfg
+++ b/sycl/test-e2e/ESIMD/lit.local.cfg
@@ -24,3 +24,6 @@ config.substitutions.insert(0,
 
 # At the moment SPIR-V Backend has no plans to support this feature.
 config.unsupported_features += ['spirv-backend']
+
+# https://github.com/intel/llvm/issues/20142
+config.unsupported_features += ['target-native_cpu']
diff --git a/sycl/test-e2e/Experimental/clock.cpp b/sycl/test-e2e/Experimental/clock.cpp
index 1b37e7c8d7cb0..7eff0689dba80 100644
--- a/sycl/test-e2e/Experimental/clock.cpp
+++ b/sycl/test-e2e/Experimental/clock.cpp
@@ -7,6 +7,8 @@
 
 // RUN: %{build} -o %t.out
 // RUN: %{run} %t.out
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 
 #include <sycl/detail/core.hpp>
 #include <sycl/ext/oneapi/experimental/clock.hpp>
diff --git a/sycl/test-e2e/GroupAlgorithm/SYCL2020/group_sort/group_and_joint_sort.cpp b/sycl/test-e2e/GroupAlgorithm/SYCL2020/group_sort/group_and_joint_sort.cpp
index ad024570a819e..058494d745284 100644
--- a/sycl/test-e2e/GroupAlgorithm/SYCL2020/group_sort/group_and_joint_sort.cpp
+++ b/sycl/test-e2e/GroupAlgorithm/SYCL2020/group_sort/group_and_joint_sort.cpp
@@ -1,9 +1,9 @@
 // REQUIRES: sg-8
 // UNSUPPORTED: target-nvidia || target-amd
 // UNSUPPORTED-INTENDED: subgroup size requirement implicitly make nvptx/amdgcn
+// not supported
 // XFAIL: linux && run-mode && (gpu-intel-gen12 || gpu-intel-dg2)
 // XFAIL-TRACKER: https://github.com/intel/llvm/issues/18577
-// not supported
 
 // RUN: %{build} -fsycl-device-code-split=per_kernel -o %t.out
 // RUN: %{run} %t.out
diff --git a/sycl/test-e2e/InvokeSimd/lit.local.cfg b/sycl/test-e2e/InvokeSimd/lit.local.cfg
index c068d13d59cac..4b680ed078baf 100644
--- a/sycl/test-e2e/InvokeSimd/lit.local.cfg
+++ b/sycl/test-e2e/InvokeSimd/lit.local.cfg
@@ -9,3 +9,6 @@ if platform.system() != "Linux":
 
 # At the moment SPIR-V Backend has no plans to support this feature.
 config.unsupported_features += ['spirv-backend']
+
+# https://github.com/intel/llvm/issues/20142.
+config.unsupported_features += ['target-native_cpu']
diff --git a/sycl/test-e2e/KernelAndProgram/build-log.cpp b/sycl/test-e2e/KernelAndProgram/build-log.cpp
index c73c10ab5db27..764c52376f892 100644
--- a/sycl/test-e2e/KernelAndProgram/build-log.cpp
+++ b/sycl/test-e2e/KernelAndProgram/build-log.cpp
@@ -4,6 +4,8 @@
 // from ptxas that crashes clang. The JIT part is not relevant, because the
 // flow is such that the AOT compilation still happens, it’s just that if we
 // request JIT, it will do the thing again at the run time.
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 //
 // TODO: rewrite this into a unit-test
 
diff --git a/sycl/test-e2e/KernelAndProgram/cache-build-result.cpp b/sycl/test-e2e/KernelAndProgram/cache-build-result.cpp
index 92d971fe96378..e5f468f6ba046 100644
--- a/sycl/test-e2e/KernelAndProgram/cache-build-result.cpp
+++ b/sycl/test-e2e/KernelAndProgram/cache-build-result.cpp
@@ -6,6 +6,9 @@
 // request JIT, it will do the thing again at the run time.
 //
 // UNSUPPORTED: ze_debug
+//
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 
 // RUN: %{build} -DSYCL_DISABLE_FALLBACK_ASSERT=1 -o %t.out
 // RUN: %{build} -DSYCL_DISABLE_FALLBACK_ASSERT=1 -DGPU -o %t_gpu.out
diff --git a/sycl/test-e2e/KernelAndProgram/undefined-symbol.cpp b/sycl/test-e2e/KernelAndProgram/undefined-symbol.cpp
index 01cfd7451816a..0b75c00639d16 100644
--- a/sycl/test-e2e/KernelAndProgram/undefined-symbol.cpp
+++ b/sycl/test-e2e/KernelAndProgram/undefined-symbol.cpp
@@ -4,6 +4,8 @@
 // from ptxas that crashes clang. The JIT part is not relevant, because the
 // flow is such that the AOT compilation still happens, it’s just that if we
 // request JIT, it will do the thing again at the run time.
+// UNSUPPORTED: target-native_cpu
+// UNSUPPORTED-TRACKER: https://github.com/intel/llvm/issues/20142
 //
 // RUN: %{build} -o %t.out
 // RUN: %{run} %t.out
diff --git a/sycl/test-e2e/MemorySanitizer/lit.local.cfg b/sycl/test-e2e/MemorySanitizer/lit.local.cfg
index 617db32b60624..8b643a2c4abbc 100644
--- a/sycl/test-e2e/MemorySanitizer/lit.local.cfg
+++ b/sycl/test-e2e/MemorySanitizer/lit.local.cfg
@@ -18,6 +18,9 @@ config.unsupported_features += ['gpu-intel-gen12', 'gpu-intel-dg2']
 # CMPLRLLVM-64052
 config.unsupported_features += ['spirv-backend']
 
+# https://github.com/intel/llvm/issues/20142
+config.unsupported_features += ['target-native_cpu']
+
 # https://github.com/intel/llvm/issues/16920
 config.unsupported_features += ['arch-intel_gpu_bmg_g21']
 
diff --git a/sycl/test-e2e/NewOffloadDriver/multisource.cpp b/sycl/test-e2e/NewOffloadDriver/multisource.cpp
index 910dc824b2dc2..43a2ee7d9423c 100644
--- a/sycl/test-e2e/NewOffloadDriver/multisource.cpp
+++ b/sycl/test-e2e/NewOffloadDriver/multisource.cpp
@@ -37,6 +37,9 @@
 // RUN: %clangxx -Wno-error=unused-command-line-argument -fsycl %{sycl_target_opts} --offload-new-driver %t.main.o %t.a -o %t4.fat
 // RUN: %{run} %t4.fat
 
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
+
 #include <sycl/detail/core.hpp>
 
 #include <iostream>
diff --git a/sycl/test-e2e/NonUniformGroups/chunk_algorithms.cpp b/sycl/test-e2e/NonUniformGroups/chunk_algorithms.cpp
index 3c29b07c18d48..2bc1c39e47d15 100644
--- a/sycl/test-e2e/NonUniformGroups/chunk_algorithms.cpp
+++ b/sycl/test-e2e/NonUniformGroups/chunk_algorithms.cpp
@@ -15,6 +15,9 @@
 // UNSUPPORTED-TRACKER: CMPLRLLVM-64702
 // The test is disabled for spirv-backend while we investigate the root cause.
 
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
+
 #include <sycl/detail/core.hpp>
 #include <sycl/ext/oneapi/experimental/chunk.hpp>
 #include <sycl/group_algorithm.hpp>
diff --git a/sycl/test-e2e/SYCLBIN/lit.local.cfg b/sycl/test-e2e/SYCLBIN/lit.local.cfg
index 7abdeb54dd7c7..e0d1711d44760 100644
--- a/sycl/test-e2e/SYCLBIN/lit.local.cfg
+++ b/sycl/test-e2e/SYCLBIN/lit.local.cfg
@@ -5,3 +5,6 @@ if 'target-spir' in config.available_features and 'ocloc' in config.available_fe
   # wildcard. See https://github.com/intel/llvm/issues/19373.
   syclbin_exec_opts = '-fsycl-targets=spir64,spir64_gen -Xsycl-target-backend=spir64_gen "-device pvc,dg2,bmg-g21"'
 config.substitutions.append(('%{syclbin_exec_opts}', format(syclbin_exec_opts)))
+
+# https://github.com/intel/llvm/issues/20142
+config.unsupported_features += ['target-native_cpu']
diff --git a/sycl/test-e2e/Sampler/lit.local.cfg b/sycl/test-e2e/Sampler/lit.local.cfg
index 7689ebb337b7a..d5363329efec4 100644
--- a/sycl/test-e2e/Sampler/lit.local.cfg
+++ b/sycl/test-e2e/Sampler/lit.local.cfg
@@ -9,3 +9,7 @@
 # Legacy images aren't supported on AMD and also don't compile, so mark them
 # unsupported here. Bindless images should be used instead.
 config.unsupported_features += ['spirv-backend', 'target-amd']
+
+# Legacy images aren't supported on Native CPU. Use bindless_images when working.
+# https://github.com/intel/llvm/issues/20142
+config.unsupported_features += ['target-native_cpu']
diff --git a/sycl/test-e2e/SubGroup/load_store.cpp b/sycl/test-e2e/SubGroup/load_store.cpp
index 6ce24e3c62984..21f58268af89f 100644
--- a/sycl/test-e2e/SubGroup/load_store.cpp
+++ b/sycl/test-e2e/SubGroup/load_store.cpp
@@ -1,6 +1,9 @@
 // RUN: %{build} -Wno-error=deprecated-declarations -fsycl-device-code-split=per_kernel -o %t.out
 // RUN: %{run} %t.out
 
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
+
 //
 //==----------- load_store.cpp - SYCL sub_group load/store test ------------==//
 //
diff --git a/sycl/test-e2e/SubGroupMask/Basic.cpp b/sycl/test-e2e/SubGroupMask/Basic.cpp
index 627db85c082d1..040403d2f4afd 100644
--- a/sycl/test-e2e/SubGroupMask/Basic.cpp
+++ b/sycl/test-e2e/SubGroupMask/Basic.cpp
@@ -1,5 +1,8 @@
 // RUN: %{build} -o %t.out
 
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
+
 // REQUIRES: gpu
 // REQUIRES: sg-32
 
diff --git a/sycl/test-e2e/SubGroupMask/GroupSize.cpp b/sycl/test-e2e/SubGroupMask/GroupSize.cpp
index ca5ad344fea5c..ff8f7e7fec634 100644
--- a/sycl/test-e2e/SubGroupMask/GroupSize.cpp
+++ b/sycl/test-e2e/SubGroupMask/GroupSize.cpp
@@ -1,5 +1,8 @@
 // RUN: %{build} -Wno-error=incorrect-sub-group-size -fsycl-device-code-split=per_kernel -o %t.out
 
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
+
 // REQUIRES: gpu
 
 // GroupNonUniformBallot capability is supported on Intel GPU only
diff --git a/sycl/test-e2e/ThreadSanitizer/lit.local.cfg b/sycl/test-e2e/ThreadSanitizer/lit.local.cfg
index aee25f0a5ba0f..f87387034bc0c 100644
--- a/sycl/test-e2e/ThreadSanitizer/lit.local.cfg
+++ b/sycl/test-e2e/ThreadSanitizer/lit.local.cfg
@@ -17,6 +17,9 @@ config.unsupported_features += ['spirv-backend']
 # https://github.com/intel/llvm/issues/16920
 config.unsupported_features += ['arch-intel_gpu_bmg_g21']
 
+# https://github.com/intel/llvm/issues/20142
+config.unsupported_features += ['target-native_cpu']
+
 config.substitutions.append(
     ("%device_tsan_flags", "-Xarch_device -fsanitize=thread")
 )
diff --git a/sycl/test-e2e/bindless_images/lit.local.cfg b/sycl/test-e2e/bindless_images/lit.local.cfg
index f9c19f619b1d5..a03e60ba97420 100644
--- a/sycl/test-e2e/bindless_images/lit.local.cfg
+++ b/sycl/test-e2e/bindless_images/lit.local.cfg
@@ -2,4 +2,7 @@
 # https://github.com/llvm/llvm-project/pull/127737 to be merged with intel/llvm.
 config.unsupported_features += ['spirv-backend']
 
+# https://github.com/intel/llvm/issues/20142
+config.unsupported_features += ['target-native_cpu']
+
 cl_options = 'cl_options' in config.available_features
diff --git a/sycl/test-e2e/syclcompat/launch/launch_policy.cpp b/sycl/test-e2e/syclcompat/launch/launch_policy.cpp
index e7433a4f69984..5879b6c9466dc 100644
--- a/sycl/test-e2e/syclcompat/launch/launch_policy.cpp
+++ b/sycl/test-e2e/syclcompat/launch/launch_policy.cpp
@@ -24,6 +24,9 @@
 // RUN: %{build} -fsycl-device-code-split=per_kernel -o %t.out
 // RUN: %{run} %t.out
 
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
+
 #include <sycl/ext/intel/experimental/kernel_execution_properties.hpp>
 #include <sycl/ext/oneapi/kernel_properties/properties.hpp>
 #include <syclcompat/device.hpp>
diff --git a/sycl/test-e2e/syclcompat/launch/launch_policy_lmem.cpp b/sycl/test-e2e/syclcompat/launch/launch_policy_lmem.cpp
index 2f2f1c28f1adb..78501a8d1a348 100644
--- a/sycl/test-e2e/syclcompat/launch/launch_policy_lmem.cpp
+++ b/sycl/test-e2e/syclcompat/launch/launch_policy_lmem.cpp
@@ -30,6 +30,9 @@
 // UNSUPPORTED: spirv-backend
 // UNSUPPORTED-TRACKER: CMPLRLLVM-64705
 
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
+
 #include <sycl/detail/core.hpp>
 #include <sycl/ext/oneapi/properties/properties.hpp>
 #include <sycl/group_barrier.hpp>
diff --git a/sycl/test-e2e/syclcompat/math/math_compare.cpp b/sycl/test-e2e/syclcompat/math/math_compare.cpp
index dfeeba6b74a73..d3a93279fe308 100644
--- a/sycl/test-e2e/syclcompat/math/math_compare.cpp
+++ b/sycl/test-e2e/syclcompat/math/math_compare.cpp
@@ -35,6 +35,9 @@
 // RUN: %{build} -o %t.out
 // RUN: %{run} %t.out
 
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
+
 #include <sycl/half_type.hpp>
 #include <syclcompat/math.hpp>
 
diff --git a/sycl/test-e2e/syclcompat/math/math_complex.cpp b/sycl/test-e2e/syclcompat/math/math_complex.cpp
index 27e2bf8af8f71..037792d55fd77 100644
--- a/sycl/test-e2e/syclcompat/math/math_complex.cpp
+++ b/sycl/test-e2e/syclcompat/math/math_complex.cpp
@@ -33,6 +33,9 @@
 // RUN: %{build} -o %t.out
 // RUN: %{run} %t.out
 
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
+
 #include <complex>
 #include <iostream>
 
diff --git a/sycl/test-e2e/syclcompat/math/math_ops.cpp b/sycl/test-e2e/syclcompat/math/math_ops.cpp
index 09a77046b48e4..81590c7710aa3 100644
--- a/sycl/test-e2e/syclcompat/math/math_ops.cpp
+++ b/sycl/test-e2e/syclcompat/math/math_ops.cpp
@@ -25,6 +25,9 @@
 // RUN: %{build} %{mathflags} -o %t.out
 // RUN: %{run} %t.out
 
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
+
 #include <syclcompat/dims.hpp>
 #include <syclcompat/math.hpp>
 
diff --git a/sycl/test-e2e/syclcompat/memory/usm_allocations.cpp b/sycl/test-e2e/syclcompat/memory/usm_allocations.cpp
index c460c5e1304fb..2129a9a01c006 100644
--- a/sycl/test-e2e/syclcompat/memory/usm_allocations.cpp
+++ b/sycl/test-e2e/syclcompat/memory/usm_allocations.cpp
@@ -23,6 +23,9 @@
 // RUN: %{build} -o %t.out
 // RUN: %{run} %t.out
 
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
+
 #include <cassert>
 #include <numeric>
 
diff --git a/sycl/test-e2e/syclcompat/memory/usm_shared_allocations.cpp b/sycl/test-e2e/syclcompat/memory/usm_shared_allocations.cpp
index b3918254f144e..7f1925bd65b1a 100644
--- a/sycl/test-e2e/syclcompat/memory/usm_shared_allocations.cpp
+++ b/sycl/test-e2e/syclcompat/memory/usm_shared_allocations.cpp
@@ -24,6 +24,9 @@
 // RUN: %{build} -o %t.out
 // RUN: %{run} %t.out
 
+// XFAIL: target-native_cpu
+// XFAIL-TRACKER: https://github.com/intel/llvm/issues/20142
+
 #include <cassert>
 #include <numeric>