Start Jamulus client and open Settings. On my Mac laptop the default options are In: built-in mic Out: built-in speakers. Then, I go to System Preferences and choose options other than these, close the System Preferences window and go back to Jamulus and open Settings. The new settings are not reflected in the dropdown list of options. They remain the same as before. Quit Jamulus client, leaving the settings in System Preferences what you have changed them to.
Open Jamulus client and Settings. The new options show up in the dropdown list of options.
If you don't understand what's happening, that Jamulus doesn't update changes to input/output but only fetches the status at launch, it really causes all sorts of confusion and difficulty. Please fix.