Episode 46

Author: kescobo

episodes/episode046.md

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+using Dates
+title = "Walk farther and farther to the left"
+season = 2
+episode = 46
+date = DateTime(2025, 09, 19, 13, 0, 0)
+tags = ["RAG", "VDJ", "T-cells", "B-cells", "history", "adaptive immunity"]
+rss_descr = """
+Matt and Kevin take a humbling look back a classic 1989 immunology paper
+from the lab of David Baltimore (RIP)
+in which the gene encoding RAG-1,
+one of two genes that is responsible for
+the VDJ recombination -
+a mechanism for the generation of diversity
+in the adaptive immune system.
+"""
+rss_title = title
+rss_pubdate = date
+rss_enclosure = "https://archive.org/download/audiommunity_episode046/audiommunity_episode046.mp3"
+episode_length = "72629211"
+itunes_duration = "3520"
+youtube = "https://youtu.be/xup3wX4Fzgc"
++++
+
+Matt and Kevin take a humbling look back a classic 1989 immunology paper
+from the lab of David Baltimore (RIP)
+in which the gene encoding RAG-1,
+one of two genes that is responsible for
+the VDJ recombination -
+a mechanism for the generation of diversity
+in the adaptive immune system.
+
+But most of this conversation is about
+the wildly complicated molecular biology
+they had to use in 1989.
+
+
+## Links
+
+- The Paper: [The V(D)J recombinase activating gene, RAG-1](https://doi.org/10.1016/0092-8674(89)90760-5)
+- Previous audiommunity episode on VDJ recombination: 
+  [Antibodies and Infantry](https://audiommunity.org/episodes/episode002/)
+- [TWiV Episode 100](https://www.microbe.tv/twiv/twiv-special-david-baltimore/) - podcast interviewing Baltimore
+  about his life and career
+- David Baltimore [Nobel Lecture](https://www.nobelprize.org/uploads/2018/06/baltimore-lecture.pdf)
+