I run MacTeX2012 on a MacBook under MacOS X 10.7.4. I recently discovered that I couldn't use the system font "Hoefler Text" under lualatex (but things were fine under xelatex) and reported the issue to tex.stackexchange.com (see http://tex.stackexchange.com/q/71098/5001). It turns out that the file otfl-blacklist.cnf, kept in /usr/local/texlive/2012/texmf-dist/tex/luatex/luaotfload, still references lots of fonts with extension .ttc even though the problem that led to their blacklisting has long since been solved. Based on a suggestion by Khaled Hosny, I've come with the following "solution", which works at least for a current version of lua(la)tex: just comment out (deleting should work too, I suppose) all lines that refer to fonts in .ttc format from this file. This leaves the font LastResort.ttf as the sole blacklisted font (which doesn't seem to work properly...).
Sincerely, Mico