diff --git a/CHANGELOG.md b/CHANGELOG.md
index 8cd80f5dac..ab2db27c85 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -46,6 +46,12 @@ Increment the:
   [#3320](https://github.com/open-telemetry/opentelemetry-cpp/pull/3220)
   [#3368](https://github.com/open-telemetry/opentelemetry-cpp/pull/3368)
 
+* [BUILD] Upgrade opentelemetry-proto to 1.6.0
+  [#3407](https://github.com/open-telemetry/opentelemetry-cpp/pull/3407)
+
+* [BUILD] Upgrade nlohmann_json to 3.12.0
+  [#3406](https://github.com/open-telemetry/opentelemetry-cpp/pull/3406)
+
 ## [1.20 2025-04-01]
 
 * [BUILD] Update opentelemetry-proto version
diff --git a/MODULE.bazel b/MODULE.bazel
index 4cc1a41bee..e01fcbaf17 100644
--- a/MODULE.bazel
+++ b/MODULE.bazel
@@ -12,8 +12,8 @@ bazel_dep(name = "abseil-cpp", version = "20240116.1", repo_name = "com_google_a
 bazel_dep(name = "bazel_skylib", version = "1.5.0")
 bazel_dep(name = "curl", version = "8.8.0")
 bazel_dep(name = "grpc", version = "1.63.1.bcr.1", repo_name = "com_github_grpc_grpc")
-bazel_dep(name = "nlohmann_json", version = "3.11.3", repo_name = "github_nlohmann_json")
-bazel_dep(name = "opentelemetry-proto", version = "1.5.0", repo_name = "com_github_opentelemetry_proto")
+bazel_dep(name = "nlohmann_json", version = "3.12.0", repo_name = "github_nlohmann_json")
+bazel_dep(name = "opentelemetry-proto", version = "1.6.0", repo_name = "com_github_opentelemetry_proto")
 bazel_dep(name = "opentracing-cpp", version = "1.6.0", repo_name = "com_github_opentracing")
 bazel_dep(name = "platforms", version = "0.0.8")
 bazel_dep(name = "prometheus-cpp", version = "1.3.0", repo_name = "com_github_jupp0r_prometheus_cpp")
diff --git a/bazel/repository.bzl b/bazel/repository.bzl
index 423db01fd1..0656331708 100644
--- a/bazel/repository.bzl
+++ b/bazel/repository.bzl
@@ -88,10 +88,10 @@ def opentelemetry_cpp_deps():
         http_archive,
         name = "com_github_opentelemetry_proto",
         build_file = "@io_opentelemetry_cpp//bazel:opentelemetry_proto.BUILD",
-        sha256 = "08f40636adbc5f33d2084bd8e7b64e491dd0239d1a95021dbffbdf1ca8cea454",
-        strip_prefix = "opentelemetry-proto-1.5.0",
+        sha256 = "92682778affe8d00cd36f68308b49295db34fce379bef0a781c50837eccbc3c0",
+        strip_prefix = "opentelemetry-proto-1.6.0",
         urls = [
-            "https://github.com/open-telemetry/opentelemetry-proto/archive/v1.5.0.tar.gz",
+            "https://github.com/open-telemetry/opentelemetry-proto/archive/v1.6.0.tar.gz",
         ],
     )
 
@@ -100,9 +100,9 @@ def opentelemetry_cpp_deps():
         http_archive,
         name = "github_nlohmann_json",
         build_file = "@io_opentelemetry_cpp//bazel:nlohmann_json.BUILD",
-        sha256 = "a22461d13119ac5c78f205d3df1db13403e58ce1bb1794edc9313677313f4a9d",
+        sha256 = "b8cb0ef2dd7f57f18933997c9934bb1fa962594f701cd5a8d3c2c80541559372",
         urls = [
-            "https://github.com/nlohmann/json/releases/download/v3.11.3/include.zip",
+            "https://github.com/nlohmann/json/releases/download/v3.12.0/include.zip",
         ],
     )
 
diff --git a/cmake/opentelemetry-proto.cmake b/cmake/opentelemetry-proto.cmake
index 67e54149d7..246a41e5d5 100644
--- a/cmake/opentelemetry-proto.cmake
+++ b/cmake/opentelemetry-proto.cmake
@@ -49,7 +49,7 @@ else()
          "opentelemetry-proto=[ \\t]*([A-Za-z0-9_\\.\\-]+)")
         set(opentelemetry-proto "${CMAKE_MATCH_1}")
       else()
-        set(opentelemetry-proto "v1.5.0")
+        set(opentelemetry-proto "v1.6.0")
       endif()
       unset(OTELCPP_THIRD_PARTY_RELEASE_CONTENT)
     endif()
diff --git a/install/conan/conanfile_latest.txt b/install/conan/conanfile_latest.txt
index 9f2da4aab8..6db1d7b130 100644
--- a/install/conan/conanfile_latest.txt
+++ b/install/conan/conanfile_latest.txt
@@ -7,7 +7,7 @@ libcurl/8.12.1
 abseil/20240116.2
 protobuf/5.27.0
 grpc/1.67.1
-nlohmann_json/3.11.3
+nlohmann_json/3.12.0
 prometheus-cpp/1.3.0
 opentracing-cpp/1.6.0
 
@@ -37,4 +37,4 @@ CMakeToolchain
 CMakeDeps
 
 [layout]
-cmake_layout
\ No newline at end of file
+cmake_layout
diff --git a/third_party/nlohmann-json b/third_party/nlohmann-json
index 9cca280a4d..55f93686c0 160000
--- a/third_party/nlohmann-json
+++ b/third_party/nlohmann-json
@@ -1 +1 @@
-Subproject commit 9cca280a4d0ccf0c08f47a99aa71d1b0e52f8d03
+Subproject commit 55f93686c01528224f448c19128836e7df245f72
diff --git a/third_party/opentelemetry-proto b/third_party/opentelemetry-proto
index 2bd940b2b7..be5d584704 160000
--- a/third_party/opentelemetry-proto
+++ b/third_party/opentelemetry-proto
@@ -1 +1 @@
-Subproject commit 2bd940b2b77c1ab57c27166af21384906da7bb2b
+Subproject commit be5d58470429d0255ffdd49491f0815a3a63d6ef
diff --git a/third_party_release b/third_party_release
index 37d6feb9f3..8761dc9338 100644
--- a/third_party_release
+++ b/third_party_release
@@ -18,8 +18,8 @@ abseil=20240116.1
 benchmark=v1.8.3
 googletest=1.14.0
 ms-gsl=v3.1.0-67-g6f45293
-nlohmann-json=v3.11.3
-opentelemetry-proto=v1.5.0
+nlohmann-json=v3.12.0
+opentelemetry-proto=v1.6.0
 opentracing-cpp=v1.6.0
 prometheus-cpp=v1.3.0
 vcpkg=2024.02.14