diff --git a/clang/bindings/python/tests/CMakeLists.txt b/clang/bindings/python/tests/CMakeLists.txt
index 2543cf739463d..a0ddabc21bb41 100644
--- a/clang/bindings/python/tests/CMakeLists.txt
+++ b/clang/bindings/python/tests/CMakeLists.txt
@@ -47,6 +47,19 @@ if(${LLVM_NATIVE_ARCH} MATCHES "^(AArch64|Hexagon|Sparc|SystemZ)$")
   set(RUN_PYTHON_TESTS FALSE)
 endif()
 
+# Tests will fail if cross-compiling for a different target, as tests will try
+# to use the host Python3_EXECUTABLE and make FFI calls to functions in target
+# libraries.
+if(CMAKE_CROSSCOMPILING)
+  # FIXME: Consider a solution that allows better control over these tests in
+  # a crosscompiling scenario. e.g. registering them with lit to allow them to
+  # be explicitly skipped via appropriate LIT_ARGS, or adding a mechanism to
+  # allow specifying a python interpreter compiled for the target that could
+  # be executed using qemu-user.
+  message(WARNING "check-clang-python not added to check-all as these tests fail in a cross-build setup")
+  set(RUN_PYTHON_TESTS FALSE)
+endif()
+
 if(RUN_PYTHON_TESTS)
     set_property(GLOBAL APPEND PROPERTY
                  LLVM_ALL_ADDITIONAL_TEST_TARGETS check-clang-python)