diff --git a/llvm/include/llvm/Transforms/Vectorize/SandboxVectorizer/DependencyGraph.h b/llvm/include/llvm/Transforms/Vectorize/SandboxVectorizer/DependencyGraph.h
index 765b65c4971be..68a2daca1403d 100644
--- a/llvm/include/llvm/Transforms/Vectorize/SandboxVectorizer/DependencyGraph.h
+++ b/llvm/include/llvm/Transforms/Vectorize/SandboxVectorizer/DependencyGraph.h
@@ -117,7 +117,7 @@ class DGNode {
     assert(!isMemDepNodeCandidate(I) && "Expected Non-Mem instruction, ");
   }
   DGNode(const DGNode &Other) = delete;
-  virtual ~DGNode() = default;
+  virtual ~DGNode();
   /// \Returns the number of unscheduled successors.
   unsigned getNumUnscheduledSuccs() const { return UnscheduledSuccs; }
   void decrUnscheduledSuccs() {
@@ -292,6 +292,7 @@ class DependencyGraph {
 
   Context *Ctx = nullptr;
   std::optional<Context::CallbackID> CreateInstrCB;
+  std::optional<Context::CallbackID> EraseInstrCB;
 
   std::unique_ptr<BatchAAResults> BatchAA;
 
@@ -334,6 +335,12 @@ class DependencyGraph {
     // TODO: Update the dependencies for the new node.
     // TODO: Update the MemDGNode chain to include the new node if needed.
   }
+  /// Called by the callbacks when instruction \p I is about to get deleted.
+  void notifyEraseInstr(Instruction *I) {
+    InstrToNodeMap.erase(I);
+    // TODO: Update the dependencies.
+    // TODO: Update the MemDGNode chain to remove the node if needed.
+  }
 
 public:
   /// This constructor also registers callbacks.
@@ -341,10 +348,14 @@ class DependencyGraph {
       : Ctx(&Ctx), BatchAA(std::make_unique<BatchAAResults>(AA)) {
     CreateInstrCB = Ctx.registerCreateInstrCallback(
         [this](Instruction *I) { notifyCreateInstr(I); });
+    EraseInstrCB = Ctx.registerEraseInstrCallback(
+        [this](Instruction *I) { notifyEraseInstr(I); });
   }
   ~DependencyGraph() {
     if (CreateInstrCB)
       Ctx->unregisterCreateInstrCallback(*CreateInstrCB);
+    if (EraseInstrCB)
+      Ctx->unregisterEraseInstrCallback(*EraseInstrCB);
   }
 
   DGNode *getNode(Instruction *I) const {
diff --git a/llvm/include/llvm/Transforms/Vectorize/SandboxVectorizer/Scheduler.h b/llvm/include/llvm/Transforms/Vectorize/SandboxVectorizer/Scheduler.h
index 022fd71df67dc..3959f84c601e0 100644
--- a/llvm/include/llvm/Transforms/Vectorize/SandboxVectorizer/Scheduler.h
+++ b/llvm/include/llvm/Transforms/Vectorize/SandboxVectorizer/Scheduler.h
@@ -69,6 +69,10 @@ class SchedBundle {
 private:
   ContainerTy Nodes;
 
+  /// Called by the DGNode destructor to avoid accessing freed memory.
+  void eraseFromBundle(DGNode *N) { Nodes.erase(find(Nodes, N)); }
+  friend DGNode::~DGNode(); // For eraseFromBundle().
+
 public:
   SchedBundle() = default;
   SchedBundle(ContainerTy &&Nodes) : Nodes(std::move(Nodes)) {
diff --git a/llvm/lib/Transforms/Vectorize/SandboxVectorizer/DependencyGraph.cpp b/llvm/lib/Transforms/Vectorize/SandboxVectorizer/DependencyGraph.cpp
index 6217c9fecf45d..4b0e12c28f07b 100644
--- a/llvm/lib/Transforms/Vectorize/SandboxVectorizer/DependencyGraph.cpp
+++ b/llvm/lib/Transforms/Vectorize/SandboxVectorizer/DependencyGraph.cpp
@@ -10,6 +10,7 @@
 #include "llvm/ADT/ArrayRef.h"
 #include "llvm/SandboxIR/Instruction.h"
 #include "llvm/SandboxIR/Utils.h"
+#include "llvm/Transforms/Vectorize/SandboxVectorizer/Scheduler.h"
 
 namespace llvm::sandboxir {
 
@@ -58,6 +59,12 @@ bool PredIterator::operator==(const PredIterator &Other) const {
   return OpIt == Other.OpIt && MemIt == Other.MemIt;
 }
 
+DGNode::~DGNode() {
+  if (SB == nullptr)
+    return;
+  SB->eraseFromBundle(this);
+}
+
 #ifndef NDEBUG
 void DGNode::print(raw_ostream &OS, bool PrintDeps) const {
   OS << *I << " USuccs:" << UnscheduledSuccs << " Sched:" << Scheduled << "\n";
diff --git a/llvm/unittests/Transforms/Vectorize/SandboxVectorizer/DependencyGraphTest.cpp b/llvm/unittests/Transforms/Vectorize/SandboxVectorizer/DependencyGraphTest.cpp
index 206f6c5b4c135..e6bb4b4684d26 100644
--- a/llvm/unittests/Transforms/Vectorize/SandboxVectorizer/DependencyGraphTest.cpp
+++ b/llvm/unittests/Transforms/Vectorize/SandboxVectorizer/DependencyGraphTest.cpp
@@ -830,3 +830,31 @@ define void @foo(ptr %ptr, i8 %v1, i8 %v2, i8 %v3, i8 %arg) {
   // TODO: Check the dependencies to/from NewSN after they land.
   // TODO: Check the MemDGNode chain.
 }
+
+TEST_F(DependencyGraphTest, EraseInstrCallback) {
+  parseIR(C, R"IR(
+define void @foo(ptr %ptr, i8 %v1, i8 %v2, i8 %v3, i8 %arg) {
+  store i8 %v1, ptr %ptr
+  store i8 %v2, ptr %ptr
+  store i8 %v3, ptr %ptr
+  ret void
+}
+)IR");
+  llvm::Function *LLVMF = &*M->getFunction("foo");
+  sandboxir::Context Ctx(C);
+  auto *F = Ctx.createFunction(LLVMF);
+  auto *BB = &*F->begin();
+  auto It = BB->begin();
+  auto *S1 = cast<sandboxir::StoreInst>(&*It++);
+  auto *S2 = cast<sandboxir::StoreInst>(&*It++);
+  auto *S3 = cast<sandboxir::StoreInst>(&*It++);
+
+  // Check erase instruction callback.
+  sandboxir::DependencyGraph DAG(getAA(*LLVMF), Ctx);
+  DAG.extend({S1, S3});
+  S2->eraseFromParent();
+  auto *DeletedN = DAG.getNodeOrNull(S2);
+  EXPECT_TRUE(DeletedN == nullptr);
+  // TODO: Check the dependencies to/from NewSN after they land.
+  // TODO: Check the MemDGNode chain.
+}