diff --git a/clang/lib/Basic/Targets/AMDGPU.h b/clang/lib/Basic/Targets/AMDGPU.h
index db7a095ba2a4f..ea4189cdea47d 100644
--- a/clang/lib/Basic/Targets/AMDGPU.h
+++ b/clang/lib/Basic/Targets/AMDGPU.h
@@ -120,7 +120,8 @@ class LLVM_LIBRARY_VISIBILITY AMDGPUTargetInfo final : public TargetInfo {
               toTargetAddressSpace(A) == llvm::AMDGPUAS::FLAT_ADDRESS)) &&
             isTargetAddressSpace(B) &&
             toTargetAddressSpace(B) >= llvm::AMDGPUAS::FLAT_ADDRESS &&
-            toTargetAddressSpace(B) <= llvm::AMDGPUAS::PRIVATE_ADDRESS);
+            toTargetAddressSpace(B) <= llvm::AMDGPUAS::PRIVATE_ADDRESS &&
+            toTargetAddressSpace(B) != llvm::AMDGPUAS::REGION_ADDRESS);
   }
 
   uint64_t getMaxPointerWidth() const override {
diff --git a/clang/test/Sema/amdgcn-address-spaces.c b/clang/test/Sema/amdgcn-address-spaces.c
index 50c12993ac69b..70545db920c80 100644
--- a/clang/test/Sema/amdgcn-address-spaces.c
+++ b/clang/test/Sema/amdgcn-address-spaces.c
@@ -9,7 +9,7 @@
 #define _AS999 __attribute__((address_space(999)))
 
 void *p1(void _AS1 *p) { return p; }
-void *p2(void _AS2 *p) { return p; }
+void *p2(void _AS2 *p) { return p; } // expected-error {{returning '_AS2 void *' from a function with result type 'void *' changes address space of pointer}}
 void *p3(void _AS3 *p) { return p; }
 void *p4(void _AS4 *p) { return p; }
 void *p5(void _AS5 *p) { return p; }