diff --git a/libc/config/gpu/entrypoints.txt b/libc/config/gpu/entrypoints.txt
index 28317c656d4be..b008e0e6684fd 100644
--- a/libc/config/gpu/entrypoints.txt
+++ b/libc/config/gpu/entrypoints.txt
@@ -271,9 +271,6 @@ set(TARGET_LIBC_ENTRYPOINTS
     libc.src.locale.newlocale
     libc.src.locale.setlocale
     libc.src.locale.uselocale
-
-    # gpu/rpc.h entrypoints
-    libc.src.gpu.rpc_host_call
 )
 
 set(TARGET_LIBM_ENTRYPOINTS
diff --git a/libc/config/gpu/headers.txt b/libc/config/gpu/headers.txt
index adbd014fba6c1..fa8ad7c11ba8b 100644
--- a/libc/config/gpu/headers.txt
+++ b/libc/config/gpu/headers.txt
@@ -18,7 +18,4 @@ set(TARGET_PUBLIC_HEADERS
     libc.include.uchar
     libc.include.features
     libc.include.locale
-
-    # Header for RPC extensions
-    libc.include.gpu_rpc
 )
diff --git a/libc/hdrgen/yaml/gpu/rpc.yaml b/libc/hdrgen/yaml/gpu/rpc.yaml
deleted file mode 100644
index da4f6afb7856d..0000000000000
--- a/libc/hdrgen/yaml/gpu/rpc.yaml
+++ /dev/null
@@ -1,23 +0,0 @@
-header: gpu-rpc.h
-macros: []
-types: []
-enums: []
-objects: []
-functions:
-  - name: rpc_fprintf
-    standards:
-      - GPUExtensions
-    return_type: int
-    arguments:
-      - type: ::FILE *__restrict
-      - type: const char *__restrict
-      - type: void *
-      - type: size_t
-  - name: rpc_host_call
-    standards:
-      - GPUExtensions
-    return_type: unsigned long long
-    arguments:
-      - type: void *
-      - type: void *
-      - type: size_t
diff --git a/libc/include/CMakeLists.txt b/libc/include/CMakeLists.txt
index 18ce8e22d1a0a..3a05c01abba5a 100644
--- a/libc/include/CMakeLists.txt
+++ b/libc/include/CMakeLists.txt
@@ -750,19 +750,6 @@ add_header_macro(
     .llvm-libc-types.struct_lconv
 )
 
-if(LIBC_TARGET_OS_IS_GPU)
-  file(MAKE_DIRECTORY ${LIBC_INCLUDE_DIR}/gpu)
-
-  add_header_macro(
-    gpu_rpc
-    ../libc/hdrgen/yaml/gpu/rpc.yaml
-    gpu/rpc.h.def
-    gpu/rpc.h
-    DEPENDS
-      .llvm_libc_common_h
-  )
-endif()
-
 if(NOT LLVM_LIBC_FULL_BUILD)
   # We don't install headers in non-fullbuild mode.
   return()
diff --git a/libc/include/gpu/rpc.h.def b/libc/include/gpu/rpc.h.def
deleted file mode 100644
index 060650345e1fb..0000000000000
--- a/libc/include/gpu/rpc.h.def
+++ /dev/null
@@ -1,18 +0,0 @@
-//===-- GPU header rpc.h --------------------------------------------------===//
-//
-// Part of the LLVM Project, under the Apache License v2.0 with LLVM Exceptions.
-// See https://llvm.org/LICENSE.txt for license information.
-// SPDX-License-Identifier: Apache-2.0 WITH LLVM-exception
-//
-//===----------------------------------------------------------------------===//
-
-#ifndef LLVM_LIBC_GPU_RPC_H
-#define LLVM_LIBC_GPU_RPC_H
-
-#include "__llvm-libc-common.h"
-
-#include "../llvm-libc-types/rpc_opcodes_t.h"
-
-%%public_api()
-
-#endif // LLVM_LIBC_GPU_RPC_H
diff --git a/libc/src/__support/RPC/CMakeLists.txt b/libc/src/__support/RPC/CMakeLists.txt
index 0a7141fb60bf0..cac9c4e05e369 100644
--- a/libc/src/__support/RPC/CMakeLists.txt
+++ b/libc/src/__support/RPC/CMakeLists.txt
@@ -9,6 +9,5 @@ add_object_library(
   HDRS
     rpc_client.h
   DEPENDS
-    libc.include.gpu_rpc
     libc.src.__support.GPU.utils
 )