diff --git a/compiler-rt/lib/rtsan/rtsan_interceptors_posix.cpp b/compiler-rt/lib/rtsan/rtsan_interceptors_posix.cpp
index 227d077290af7..9f89ab6bf1fc7 100644
--- a/compiler-rt/lib/rtsan/rtsan_interceptors_posix.cpp
+++ b/compiler-rt/lib/rtsan/rtsan_interceptors_posix.cpp
@@ -325,37 +325,6 @@ INTERCEPTOR(FILE *, fmemopen, void *buf, size_t size, const char *mode) {
 #define RTSAN_MAYBE_INTERCEPT_FMEMOPEN
 #endif
 
-#if SANITIZER_INTERCEPT_SETVBUF
-INTERCEPTOR(void, setbuf, FILE *stream, char *buf) {
-  __rtsan_notify_intercepted_call("setbuf");
-  return REAL(setbuf)(stream, buf);
-}
-
-INTERCEPTOR(void, setbuffer, FILE *stream, char *buf, size_t size) {
-  __rtsan_notify_intercepted_call("setbuffer");
-  return REAL(setbuffer)(stream, buf, size);
-}
-
-INTERCEPTOR(void, setlinebuf, FILE *stream) {
-  __rtsan_notify_intercepted_call("setlinebuf");
-  return REAL(setlinebuf)(stream);
-}
-
-INTERCEPTOR(int, setvbuf, FILE *stream, char *buf, int mode, size_t size) {
-  __rtsan_notify_intercepted_call("setvbuf");
-  return REAL(setvbuf)(stream, buf, mode, size);
-}
-#define RTSAN_MAYBE_INTERCEPT_SETBUF INTERCEPT_FUNCTION(setbuf)
-#define RTSAN_MAYBE_INTERCEPT_SETBUFFER INTERCEPT_FUNCTION(setbuffer)
-#define RTSAN_MAYBE_INTERCEPT_SETLINEBUF INTERCEPT_FUNCTION(setlinebuf)
-#define RTSAN_MAYBE_INTERCEPT_SETVBUF INTERCEPT_FUNCTION(setvbuf)
-#else
-#define RTSAN_MAYBE_INTERCEPT_SETBUF
-#define RTSAN_MAYBE_INTERCEPT_SETBUFFER
-#define RTSAN_MAYBE_INTERCEPT_SETLINEBUF
-#define RTSAN_MAYBE_INTERCEPT_SETVBUF
-#endif
-
 INTERCEPTOR(int, puts, const char *s) {
   __rtsan_notify_intercepted_call("puts");
   return REAL(puts)(s);
@@ -1017,10 +986,6 @@ void __rtsan::InitializeInterceptors() {
   RTSAN_MAYBE_INTERCEPT_FOPENCOOKIE;
   RTSAN_MAYBE_INTERCEPT_OPEN_MEMSTREAM;
   RTSAN_MAYBE_INTERCEPT_FMEMOPEN;
-  RTSAN_MAYBE_INTERCEPT_SETBUF;
-  RTSAN_MAYBE_INTERCEPT_SETBUFFER;
-  RTSAN_MAYBE_INTERCEPT_SETLINEBUF;
-  RTSAN_MAYBE_INTERCEPT_SETVBUF;
   INTERCEPT_FUNCTION(lseek);
   RTSAN_MAYBE_INTERCEPT_LSEEK64;
   INTERCEPT_FUNCTION(dup);
diff --git a/compiler-rt/lib/rtsan/tests/rtsan_test_interceptors_posix.cpp b/compiler-rt/lib/rtsan/tests/rtsan_test_interceptors_posix.cpp
index 2947510b2cfde..5adbf0fb63de8 100644
--- a/compiler-rt/lib/rtsan/tests/rtsan_test_interceptors_posix.cpp
+++ b/compiler-rt/lib/rtsan/tests/rtsan_test_interceptors_posix.cpp
@@ -403,56 +403,6 @@ TEST_F(RtsanFileTest, FmemOpenDiesWhenRealtime) {
 }
 #endif
 
-#if SANITIZER_INTERCEPT_SETVBUF
-TEST_F(RtsanFileTest, SetbufDieWhenRealtime) {
-  char buffer[BUFSIZ];
-  FILE *f = fopen(GetTemporaryFilePath(), "w");
-  EXPECT_THAT(f, Ne(nullptr));
-
-  auto Func = [&f, &buffer]() { setbuf(f, buffer); };
-
-  ExpectRealtimeDeath(Func, "setbuf");
-  ExpectNonRealtimeSurvival(Func);
-}
-
-TEST_F(RtsanFileTest, SetbufferDieWhenRealtime) {
-  char buffer[1024];
-  size_t size = sizeof(buffer);
-  FILE *f = fopen(GetTemporaryFilePath(), "w");
-  EXPECT_THAT(f, Ne(nullptr));
-
-  auto Func = [&f, &buffer, &size]() { setbuffer(f, buffer, size); };
-
-  ExpectRealtimeDeath(Func, "setbuffer");
-  ExpectNonRealtimeSurvival(Func);
-}
-
-TEST_F(RtsanFileTest, SetvbufDieWhenRealtime) {
-  char buffer[1024];
-  size_t size = sizeof(buffer);
-  FILE *f = fopen(GetTemporaryFilePath(), "w");
-  EXPECT_THAT(f, Ne(nullptr));
-
-  auto Func = [&f, &buffer, &size]() {
-    int r = setvbuf(f, buffer, _IOFBF, size);
-    EXPECT_THAT(r, Eq(0));
-  };
-
-  ExpectRealtimeDeath(Func, "setvbuf");
-  ExpectNonRealtimeSurvival(Func);
-}
-
-TEST_F(RtsanFileTest, SetlinebufDieWhenRealtime) {
-  FILE *f = fopen(GetTemporaryFilePath(), "w");
-  EXPECT_THAT(f, Ne(nullptr));
-
-  auto Func = [&f]() { setlinebuf(f); };
-
-  ExpectRealtimeDeath(Func, "setlinebuf");
-  ExpectNonRealtimeSurvival(Func);
-}
-#endif
-
 class RtsanOpenedFileTest : public RtsanFileTest {
 protected:
   void SetUp() override {