diff --git a/clang/include/clang/Basic/DiagnosticSerializationKinds.td b/clang/include/clang/Basic/DiagnosticSerializationKinds.td
index 5fc5937b80d35..7965da593f218 100644
--- a/clang/include/clang/Basic/DiagnosticSerializationKinds.td
+++ b/clang/include/clang/Basic/DiagnosticSerializationKinds.td
@@ -139,6 +139,11 @@ def warn_decls_in_multiple_modules : Warning<
   InGroup<DiagGroup<"decls-in-multiple-modules">>,
   DefaultIgnore;
 
+def warn_module_file_mapping_mismatch
+    : Warning<"loaded module file '%0' conflicts with imported file '%1'">,
+      InGroup<DiagGroup<"module-file-mapping-mismatch">>,
+      DefaultIgnore;
+
 def err_failed_to_find_module_file : Error<
   "failed to find module file for module '%0'">;
 } // let CategoryName
diff --git a/clang/lib/Serialization/ASTReader.cpp b/clang/lib/Serialization/ASTReader.cpp
index 70b54b7296882..352558de79249 100644
--- a/clang/lib/Serialization/ASTReader.cpp
+++ b/clang/lib/Serialization/ASTReader.cpp
@@ -3286,6 +3286,8 @@ ASTReader::ReadControlBlock(ModuleFile &F,
       time_t StoredModTime = 0;
       ASTFileSignature StoredSignature;
       std::string ImportedFile;
+      std::string StoredFile;
+      bool IgnoreImportedByNote = false;
 
       // For prebuilt and explicit modules first consult the file map for
       // an override. Note that here we don't search prebuilt module
@@ -3311,11 +3313,26 @@ ASTReader::ReadControlBlock(ModuleFile &F,
                                                    SignatureBytes.end());
         Blob = Blob.substr(ASTFileSignature::size);
 
+        // Use BaseDirectoryAsWritten to ensure we use the same path in the
+        // ModuleCache as when writing.
+        StoredFile = ReadPathBlob(BaseDirectoryAsWritten, Record, Idx, Blob);
         if (ImportedFile.empty()) {
-          // Use BaseDirectoryAsWritten to ensure we use the same path in the
-          // ModuleCache as when writing.
-          ImportedFile =
-              ReadPathBlob(BaseDirectoryAsWritten, Record, Idx, Blob);
+          ImportedFile = StoredFile;
+        } else if (!getDiags().isIgnored(
+                       diag::warn_module_file_mapping_mismatch,
+                       CurrentImportLoc)) {
+          auto ImportedFileRef =
+              PP.getFileManager().getOptionalFileRef(ImportedFile);
+          auto StoredFileRef =
+              PP.getFileManager().getOptionalFileRef(StoredFile);
+          if ((ImportedFileRef && StoredFileRef) &&
+              (*ImportedFileRef != *StoredFileRef)) {
+            Diag(diag::warn_module_file_mapping_mismatch)
+                << ImportedFile << StoredFile;
+            Diag(diag::note_module_file_imported_by)
+                << F.FileName << !F.ModuleName.empty() << F.ModuleName;
+            IgnoreImportedByNote = true;
+          }
         }
       }
 
@@ -3349,7 +3366,8 @@ ASTReader::ReadControlBlock(ModuleFile &F,
                                       .getModuleCache()
                                       .getInMemoryModuleCache()
                                       .isPCMFinal(F.FileName);
-      if (isDiagnosedResult(Result, Capabilities) || recompilingFinalized)
+      if (!IgnoreImportedByNote &&
+          (isDiagnosedResult(Result, Capabilities) || recompilingFinalized))
         Diag(diag::note_module_file_imported_by)
             << F.FileName << !F.ModuleName.empty() << F.ModuleName;
 
diff --git a/clang/test/Modules/invalid-module-dep.c b/clang/test/Modules/invalid-module-dep.c
new file mode 100644
index 0000000000000..2bcda8be5f1b6
--- /dev/null
+++ b/clang/test/Modules/invalid-module-dep.c
@@ -0,0 +1,64 @@
+/// This tests the expected error case when there is a mismatch between the pcm dependencies passed in 
+/// the command line with `fmodule-file` and whats encoded in the pcm. 
+
+/// The steps are: 
+/// 1. Build the module A with no dependencies. The first variant to build is A-1.pcm.
+/// 2. Build the same module with files that resolve from different search paths. 
+///     This variant is named A-2.pcm.
+/// 3. Build module B that depends on the earlier module A-1.pcm.
+/// 4. Build client that directly depends on both modules (A & B), 
+///     but depends on a incompatible variant of A (A-2.pcm) for B to use.
+
+// RUN: rm -rf %t
+// RUN: split-file %s %t
+
+// RUN: %clang_cc1 -emit-module -x c -fmodules -fno-implicit-modules -isysroot %t/Sysroot \
+// RUN:     -I%t/Sysroot/usr/include \
+// RUN:     -fmodule-name=A %t/Sysroot/usr/include/A/module.modulemap -o %t/A-1.pcm
+
+// RUN: %clang_cc1 -emit-module -x c -fmodules -fno-implicit-modules -isysroot %t/Sysroot \
+// RUN:     -I%t/BuildDir \
+// RUN:     -fmodule-name=A %t/BuildDir/A/module.modulemap -o %t/A-2.pcm
+
+// RUN: %clang_cc1 -emit-module -x c -fmodules -fno-implicit-modules -isysroot %t/Sysroot \
+// RUN:     -I%t/Sysroot/usr/include \
+// RUN:     -fmodule-map-file=%t/Sysroot/usr/include/A/module.modulemap \
+// RUN:     -fmodule-file=A=%t/A-1.pcm \
+// RUN:     -fmodule-name=B %t/Sysroot/usr/include/B/module.modulemap -o %t/B-1.pcm
+
+// RUN: %clang_cc1 -x c -fmodules -fno-implicit-modules -isysroot %t/Sysroot \
+// RUN:     -I%t/BuildDir -I%t/Sysroot/usr/include \
+// RUN:     -fmodule-map-file=%t/BuildDir/A/module.modulemap \
+// RUN:     -fmodule-map-file=%t/Sysroot/usr/include/B/module.modulemap \
+// RUN:     -fmodule-file=A=%t/A-2.pcm -fmodule-file=B=%t/B-1.pcm \
+// RUN:     -Wmodule-file-mapping-mismatch -verify %s  
+
+
+#include <A/A.h>
+#include <B/B.h> // expected-warning {{conflicts with imported file}} \
+                 // expected-note {{imported by module 'B'}} \
+                 // expected-error {{out of date and needs to be rebuilt}}
+
+//--- Sysroot/usr/include/A/module.modulemap
+module A [system] {
+  umbrella header "A.h"
+}
+//--- Sysroot/usr/include/A/A.h
+typedef int A_t;
+
+//--- Sysroot/usr/include/B/module.modulemap
+module B [system] {
+  umbrella header "B.h"
+}
+
+//--- Sysroot/usr/include/B/B.h
+#include <A/A.h>
+typedef int B_t;
+
+//--- BuildDir/A/module.modulemap
+module A [system] {
+  umbrella header "A.h"
+}
+
+//--- BuildDir/A/A.h
+typedef int A_t;