diff --git a/lldb/test/API/CMakeLists.txt b/lldb/test/API/CMakeLists.txt
index da51f2252d023..b1ace6296f46a 100644
--- a/lldb/test/API/CMakeLists.txt
+++ b/lldb/test/API/CMakeLists.txt
@@ -139,6 +139,12 @@ if(CMAKE_HOST_APPLE)
   endif()
 endif()
 
+if(WIN32 AND CMAKE_BUILD_TYPE STREQUAL Debug)
+  set(LLDB_PYTHON_API_TEST_EXECUTABLE "${Python3_EXECUTABLE_DEBUG}")
+else()
+  set(LLDB_PYTHON_API_TEST_EXECUTABLE "${Python3_EXECUTABLE}")
+endif()
+
 set(dotest_args_replacement ${LLVM_BUILD_MODE})
 
 if(LLDB_BUILT_STANDALONE)
diff --git a/lldb/test/API/lit.site.cfg.py.in b/lldb/test/API/lit.site.cfg.py.in
index ecebc44774859..54807de8819d2 100644
--- a/lldb/test/API/lit.site.cfg.py.in
+++ b/lldb/test/API/lit.site.cfg.py.in
@@ -19,7 +19,7 @@ config.shared_libs = @LLVM_ENABLE_SHARED_LIBS@
 config.llvm_use_sanitizer = "@LLVM_USE_SANITIZER@"
 config.target_triple = "@LLVM_TARGET_TRIPLE@"
 config.lldb_build_directory = "@LLDB_TEST_BUILD_DIRECTORY@"
-config.python_executable = "@Python3_EXECUTABLE@"
+config.python_executable = "@LLDB_PYTHON_API_TEST_EXECUTABLE@"
 config.lua_executable = "@LUA_EXECUTABLE@"
 config.lldb_lua_cpath = "@LLDB_LUA_CPATH@"
 config.lua_test_entry = "TestLuaAPI.py"