diff --git a/libcxx/include/CMakeLists.txt b/libcxx/include/CMakeLists.txt
index 43cefd5600646..52611e43968bc 100644
--- a/libcxx/include/CMakeLists.txt
+++ b/libcxx/include/CMakeLists.txt
@@ -1706,6 +1706,11 @@ add_dependencies(cxx-headers generate-cxx-headers)
 target_include_directories(cxx-headers INTERFACE ${LIBCXX_GENERATED_INCLUDE_TARGET_DIR}
                                                  ${LIBCXX_GENERATED_INCLUDE_DIR})
 
+# Make sure to map the generated include directory back to libc++'s actual source directory when generating
+# debug information. Otherwise, the debug information will refer to generated headers which are created during
+# the build and generally not persistent.
+target_add_compile_flags_if_supported(cxx-headers INTERFACE "-fdebug-prefix-map=${LIBCXX_GENERATED_INCLUDE_DIR}=${LIBCXX_SOURCE_DIR}/include")
+
 if (LIBCXX_INSTALL_HEADERS)
   foreach(file ${files})
     get_filename_component(dir ${file} DIRECTORY)