diff --git a/lldb/packages/Python/lldbsuite/test/builders/builder.py b/lldb/packages/Python/lldbsuite/test/builders/builder.py
index 96c7b3987d8a1..024c9f1c7e435 100644
--- a/lldb/packages/Python/lldbsuite/test/builders/builder.py
+++ b/lldb/packages/Python/lldbsuite/test/builders/builder.py
@@ -258,6 +258,7 @@ def _getDebugInfoArgs(self, debug_info):
             "gmodules": {"MAKE_DSYM": "NO", "MAKE_GMODULES": "YES"},
             "debug_names": {"MAKE_DEBUG_NAMES": "YES"},
             "dwp": {"MAKE_DSYM": "NO", "MAKE_DWP": "YES"},
+            "pdb": {"MAKE_PDB": "YES"},
         }
 
         # Collect all flags, with later options overriding earlier ones
diff --git a/lldb/packages/Python/lldbsuite/test/lldbtest.py b/lldb/packages/Python/lldbsuite/test/lldbtest.py
index b92de941c4124..8c1eea97620e2 100644
--- a/lldb/packages/Python/lldbsuite/test/lldbtest.py
+++ b/lldb/packages/Python/lldbsuite/test/lldbtest.py
@@ -1791,6 +1791,11 @@ def no_reason(_):
                         if can_replicate
                     ]
 
+                    # PDB is off by default, because it has a lot of failures right now.
+                    # See llvm.org/pr149498
+                    if original_testcase.TEST_WITH_PDB_DEBUG_INFO:
+                        dbginfo_categories.append("pdb")
+
                 xfail_for_debug_info_cat_fn = getattr(
                     attrvalue, "__xfail_for_debug_info_cat_fn__", no_reason
                 )
@@ -1878,6 +1883,13 @@ class TestBase(Base, metaclass=LLDBTestCaseFactory):
     # test multiple times with various debug info types.
     NO_DEBUG_INFO_TESTCASE = False
 
+    TEST_WITH_PDB_DEBUG_INFO = False
+    """
+    Subclasses can set this to True to test with PDB in addition to the other debug info
+    types. This id off by default because many tests will fail due to missing functionality in PDB.
+    See llvm.org/pr149498.
+    """
+
     def generateSource(self, source):
         template = source + ".template"
         temp = os.path.join(self.getSourceDir(), template)
diff --git a/lldb/packages/Python/lldbsuite/test/make/Makefile.rules b/lldb/packages/Python/lldbsuite/test/make/Makefile.rules
index 09939e29e5b75..94c926402b733 100644
--- a/lldb/packages/Python/lldbsuite/test/make/Makefile.rules
+++ b/lldb/packages/Python/lldbsuite/test/make/Makefile.rules
@@ -249,6 +249,10 @@ ifeq ($(CC_TYPE), clang)
    MODULE_DEBUG_INFO_FLAGS += -gmodules
 endif
 
+ifeq "$(MAKE_PDB)" "YES"
+	DEBUG_INFO_FLAG ?= -g -gcodeview
+endif
+
 # If the OS is Windows, we need to pass -gdwarf to clang, otherwise it will build
 # with codeview by default but all the tests rely on dwarf.
 ifeq "$(OS)" "Windows_NT"
diff --git a/lldb/packages/Python/lldbsuite/test/test_categories.py b/lldb/packages/Python/lldbsuite/test/test_categories.py
index 1f6e8a78e0c0d..b8a764fb3349a 100644
--- a/lldb/packages/Python/lldbsuite/test/test_categories.py
+++ b/lldb/packages/Python/lldbsuite/test/test_categories.py
@@ -12,7 +12,13 @@
 
 # Key: Category name
 # Value: should be used in lldbtest's debug-info replication
-debug_info_categories = {"dwarf": True, "dwo": True, "dsym": True, "gmodules": False}
+debug_info_categories = {
+    "dwarf": True,
+    "dwo": True,
+    "dsym": True,
+    "pdb": False,
+    "gmodules": False,
+}
 
 all_categories = {
     "basic_process": "Basic process execution sniff tests.",
@@ -34,6 +40,7 @@
     "lldb-dap": "Tests for the Debug Adapter Protocol with lldb-dap",
     "llgs": "Tests for the gdb-server functionality of lldb-server",
     "msvcstl": "Test for MSVC STL data formatters",
+    "pdb": "Tests that can be run with PDB debug information",
     "pexpect": "Tests requiring the pexpect library to be available",
     "objc": "Tests related to the Objective-C programming language support",
     "pyapi": "Tests related to the Python API",
@@ -65,6 +72,8 @@ def is_supported_on_platform(category, platform, compiler_path):
         if platform not in ["darwin", "macosx", "ios", "watchos", "tvos", "bridgeos"]:
             return False
         return gmodules.is_compiler_clang_with_gmodules(compiler_path)
+    elif category == "pdb":
+        return platform == "windows"
     return True
 
 
diff --git a/lldb/test/API/test_utils/pdb/Makefile b/lldb/test/API/test_utils/pdb/Makefile
new file mode 100644
index 0000000000000..99998b20bcb05
--- /dev/null
+++ b/lldb/test/API/test_utils/pdb/Makefile
@@ -0,0 +1,3 @@
+CXX_SOURCES := main.cpp
+
+include Makefile.rules
diff --git a/lldb/test/API/test_utils/pdb/TestPdb.py b/lldb/test/API/test_utils/pdb/TestPdb.py
new file mode 100644
index 0000000000000..bd3a9d0c34ab3
--- /dev/null
+++ b/lldb/test/API/test_utils/pdb/TestPdb.py
@@ -0,0 +1,18 @@
+"""
+Test PDB enabled tests
+"""
+
+from lldbsuite.test.decorators import *
+from lldbsuite.test.lldbtest import *
+
+
+class TestBuildMethod(TestBase):
+    TEST_WITH_PDB_DEBUG_INFO = True
+
+    def test(self):
+        self.build()
+        self.assertTrue(self.dbg.CreateTarget(self.getBuildArtifact()))
+        if self.getDebugInfo() == "pdb":
+            self.expect(
+                "target modules dump symfile", patterns=["SymbolFile (native-)?pdb"]
+            )
diff --git a/lldb/test/API/test_utils/pdb/main.cpp b/lldb/test/API/test_utils/pdb/main.cpp
new file mode 100644
index 0000000000000..76e8197013aab
--- /dev/null
+++ b/lldb/test/API/test_utils/pdb/main.cpp
@@ -0,0 +1 @@
+int main() { return 0; }