diff --git a/llvm/lib/Target/WebAssembly/WebAssemblyISelLowering.cpp b/llvm/lib/Target/WebAssembly/WebAssemblyISelLowering.cpp
index cd434f7a331e4..61ef2f0c2fde0 100644
--- a/llvm/lib/Target/WebAssembly/WebAssemblyISelLowering.cpp
+++ b/llvm/lib/Target/WebAssembly/WebAssemblyISelLowering.cpp
@@ -3383,8 +3383,55 @@ static SDValue TryMatchTrue(SDNode *N, EVT VecVT, SelectionDAG &DAG) {
   return DAG.getZExtOrTrunc(Ret, DL, N->getValueType(0));
 }
 
+/// Try to convert a i128 comparison to a v16i8 comparison before type
+/// legalization splits it up into chunks
+static SDValue
+combineVectorSizedSetCCEquality(SDNode *N, TargetLowering::DAGCombinerInfo &DCI,
+                                const WebAssemblySubtarget *Subtarget) {
+
+  SDLoc DL(N);
+  SDValue X = N->getOperand(0);
+  SDValue Y = N->getOperand(1);
+  EVT VT = N->getValueType(0);
+  EVT OpVT = X.getValueType();
+
+  SelectionDAG &DAG = DCI.DAG;
+  if (DCI.DAG.getMachineFunction().getFunction().hasFnAttribute(
+          Attribute::NoImplicitFloat))
+    return SDValue();
+
+  ISD::CondCode CC = cast<CondCodeSDNode>(N->getOperand(2))->get();
+  // We're looking for an oversized integer equality comparison with SIMD
+  if (!OpVT.isScalarInteger() || !OpVT.isByteSized() || OpVT != MVT::i128 ||
+      !Subtarget->hasSIMD128() || !isIntEqualitySetCC(CC))
+    return SDValue();
+
+  // Don't perform this combine if constructing the vector will be expensive.
+  auto IsVectorBitCastCheap = [](SDValue X) {
+    X = peekThroughBitcasts(X);
+    return isa<ConstantSDNode>(X) || X.getOpcode() == ISD::LOAD;
+  };
+
+  if (!IsVectorBitCastCheap(X) || !IsVectorBitCastCheap(Y))
+    return SDValue();
+
+  SDValue VecX = DAG.getBitcast(MVT::v16i8, X);
+  SDValue VecY = DAG.getBitcast(MVT::v16i8, Y);
+  SDValue Cmp = DAG.getSetCC(DL, MVT::v16i8, VecX, VecY, CC);
+
+  SDValue Intr =
+      DAG.getNode(ISD::INTRINSIC_WO_CHAIN, DL, MVT::i32,
+                  {DAG.getConstant(CC == ISD::SETEQ ? Intrinsic::wasm_alltrue
+                                                    : Intrinsic::wasm_anytrue,
+                                   DL, MVT::i32),
+                   Cmp});
+
+  return DAG.getSetCC(DL, VT, Intr, DAG.getConstant(0, DL, MVT::i32), CC);
+}
+
 static SDValue performSETCCCombine(SDNode *N,
-                                   TargetLowering::DAGCombinerInfo &DCI) {
+                                   TargetLowering::DAGCombinerInfo &DCI,
+                                   const WebAssemblySubtarget *Subtarget) {
   if (!DCI.isBeforeLegalize())
     return SDValue();
 
@@ -3392,6 +3439,9 @@ static SDValue performSETCCCombine(SDNode *N,
   if (!VT.isScalarInteger())
     return SDValue();
 
+  if (SDValue V = combineVectorSizedSetCCEquality(N, DCI, Subtarget))
+    return V;
+
   SDValue LHS = N->getOperand(0);
   if (LHS->getOpcode() != ISD::BITCAST)
     return SDValue();
@@ -3532,7 +3582,7 @@ WebAssemblyTargetLowering::PerformDAGCombine(SDNode *N,
   case ISD::BITCAST:
     return performBitcastCombine(N, DCI);
   case ISD::SETCC:
-    return performSETCCCombine(N, DCI);
+    return performSETCCCombine(N, DCI, Subtarget);
   case ISD::VECTOR_SHUFFLE:
     return performVECTOR_SHUFFLECombine(N, DCI);
   case ISD::SIGN_EXTEND:
diff --git a/llvm/lib/Target/WebAssembly/WebAssemblyTargetTransformInfo.cpp b/llvm/lib/Target/WebAssembly/WebAssemblyTargetTransformInfo.cpp
index 52e706514226b..08fb7586d215e 100644
--- a/llvm/lib/Target/WebAssembly/WebAssemblyTargetTransformInfo.cpp
+++ b/llvm/lib/Target/WebAssembly/WebAssemblyTargetTransformInfo.cpp
@@ -147,7 +147,8 @@ WebAssemblyTTIImpl::enableMemCmpExpansion(bool OptSize, bool IsZeroCmp) const {
 
   Options.AllowOverlappingLoads = true;
 
-  // TODO: Teach WebAssembly backend about load v128.
+  if (ST->hasSIMD128())
+    Options.LoadSizes.push_back(16);
 
   Options.LoadSizes.append({8, 4, 2, 1});
   Options.MaxNumLoads = TLI->getMaxExpandSizeMemcmp(OptSize);
diff --git a/llvm/test/CodeGen/WebAssembly/memcmp-expand.ll b/llvm/test/CodeGen/WebAssembly/memcmp-expand.ll
index 8030438645f82..9c520ff9a4db7 100644
--- a/llvm/test/CodeGen/WebAssembly/memcmp-expand.ll
+++ b/llvm/test/CodeGen/WebAssembly/memcmp-expand.ll
@@ -1,5 +1,5 @@
 ; NOTE: Assertions have been autogenerated by utils/update_llc_test_checks.py UTC_ARGS: --version 5
-; RUN: llc < %s  -disable-wasm-fallthrough-return-opt -wasm-disable-explicit-locals -wasm-keep-registers | FileCheck %s
+; RUN: llc < %s  -disable-wasm-fallthrough-return-opt -wasm-disable-explicit-locals -wasm-keep-registers -mattr=+simd128 | FileCheck %s
 
 target triple = "wasm32-unknown-unknown"
 
@@ -127,24 +127,16 @@ define i1 @memcmp_expand_8(ptr %a, ptr %b) {
   ret i1 %res
 }
 
-; TODO: Should be using a single load i64x2 or equivalent in bitsizes
 define i1 @memcmp_expand_16(ptr %a, ptr %b) {
 ; CHECK-LABEL: memcmp_expand_16:
 ; CHECK:         .functype memcmp_expand_16 (i32, i32) -> (i32)
 ; CHECK-NEXT:  # %bb.0:
-; CHECK-NEXT:    i64.load $push7=, 0($0):p2align=0
-; CHECK-NEXT:    i64.load $push6=, 0($1):p2align=0
-; CHECK-NEXT:    i64.xor $push8=, $pop7, $pop6
-; CHECK-NEXT:    i32.const $push0=, 8
-; CHECK-NEXT:    i32.add $push3=, $0, $pop0
-; CHECK-NEXT:    i64.load $push4=, 0($pop3):p2align=0
-; CHECK-NEXT:    i32.const $push11=, 8
-; CHECK-NEXT:    i32.add $push1=, $1, $pop11
-; CHECK-NEXT:    i64.load $push2=, 0($pop1):p2align=0
-; CHECK-NEXT:    i64.xor $push5=, $pop4, $pop2
-; CHECK-NEXT:    i64.or $push9=, $pop8, $pop5
-; CHECK-NEXT:    i64.eqz $push10=, $pop9
-; CHECK-NEXT:    return $pop10
+; CHECK-NEXT:    v128.load $push1=, 0($0):p2align=0
+; CHECK-NEXT:    v128.load $push0=, 0($1):p2align=0
+; CHECK-NEXT:    i8x16.eq $push2=, $pop1, $pop0
+; CHECK-NEXT:    i8x16.all_true $push3=, $pop2
+; CHECK-NEXT:    i32.eqz $push4=, $pop3
+; CHECK-NEXT:    return $pop4
   %cmp_16 = call i32 @memcmp(ptr %a, ptr %b, i32 16)
   %res = icmp eq i32 %cmp_16, 0
   ret i1 %res
diff --git a/llvm/test/CodeGen/WebAssembly/simd-setcc.ll b/llvm/test/CodeGen/WebAssembly/simd-setcc.ll
new file mode 100644
index 0000000000000..9efa63ab9bbbd
--- /dev/null
+++ b/llvm/test/CodeGen/WebAssembly/simd-setcc.ll
@@ -0,0 +1,89 @@
+; NOTE: Assertions have been autogenerated by utils/update_llc_test_checks.py UTC_ARGS: --version 5
+; RUN: llc < %s -disable-wasm-fallthrough-return-opt -wasm-disable-explicit-locals -wasm-keep-registers -mattr=+simd128 | FileCheck %s
+
+target triple = "wasm32-unknown-unknown"
+
+declare i32 @memcmp(ptr, ptr, i32)
+
+define i1 @setcc_load(ptr %a, ptr %b) {
+; CHECK-LABEL: setcc_load:
+; CHECK:         .functype setcc_load (i32, i32) -> (i32)
+; CHECK-NEXT:  # %bb.0:
+; CHECK-NEXT:    v128.load $push1=, 0($0):p2align=0
+; CHECK-NEXT:    v128.load $push0=, 0($1):p2align=0
+; CHECK-NEXT:    i8x16.eq $push2=, $pop1, $pop0
+; CHECK-NEXT:    i8x16.all_true $push3=, $pop2
+; CHECK-NEXT:    i32.eqz $push4=, $pop3
+; CHECK-NEXT:    return $pop4
+  %cmp_16 = call i32 @memcmp(ptr %a, ptr %b, i32 16)
+  %res = icmp eq i32 %cmp_16, 0
+  ret i1 %res
+}
+
+; INFO: Negative test: noimplicitfloat disables simd
+define i1 @setcc_load_should_not_vectorize(ptr %a, ptr %b) noimplicitfloat {
+; CHECK-LABEL: setcc_load_should_not_vectorize:
+; CHECK:         .functype setcc_load_should_not_vectorize (i32, i32) -> (i32)
+; CHECK-NEXT:  # %bb.0:
+; CHECK-NEXT:    i64.load $push4=, 0($0):p2align=0
+; CHECK-NEXT:    i64.load $push3=, 0($1):p2align=0
+; CHECK-NEXT:    i64.xor $push5=, $pop4, $pop3
+; CHECK-NEXT:    i64.load $push1=, 8($0):p2align=0
+; CHECK-NEXT:    i64.load $push0=, 8($1):p2align=0
+; CHECK-NEXT:    i64.xor $push2=, $pop1, $pop0
+; CHECK-NEXT:    i64.or $push6=, $pop5, $pop2
+; CHECK-NEXT:    i64.eqz $push7=, $pop6
+; CHECK-NEXT:    return $pop7
+  %cmp_16 = call i32 @memcmp(ptr %a, ptr %b, i32 16)
+  %res = icmp eq i32 %cmp_16, 0
+  ret i1 %res
+}
+
+define i1 @setcc_eq_const_i128(ptr %ptr) {
+; CHECK-LABEL: setcc_eq_const_i128:
+; CHECK:         .functype setcc_eq_const_i128 (i32) -> (i32)
+; CHECK-NEXT:  # %bb.0:
+; CHECK-NEXT:    v128.load $push0=, 0($0)
+; CHECK-NEXT:    v128.const $push1=, 6, 0
+; CHECK-NEXT:    i8x16.eq $push2=, $pop0, $pop1
+; CHECK-NEXT:    i8x16.all_true $push3=, $pop2
+; CHECK-NEXT:    i32.eqz $push4=, $pop3
+; CHECK-NEXT:    return $pop4
+  %l = load i128, ptr %ptr
+  %res = icmp eq i128 %l, 6
+  ret i1 %res
+}
+
+define i1 @setcc_ne_const_i128(ptr %ptr) {
+; CHECK-LABEL: setcc_ne_const_i128:
+; CHECK:         .functype setcc_ne_const_i128 (i32) -> (i32)
+; CHECK-NEXT:  # %bb.0:
+; CHECK-NEXT:    v128.load $push0=, 0($0)
+; CHECK-NEXT:    v128.const $push1=, 16, 0
+; CHECK-NEXT:    i8x16.ne $push2=, $pop0, $pop1
+; CHECK-NEXT:    v128.any_true $push3=, $pop2
+; CHECK-NEXT:    return $pop3
+  %l = load i128, ptr %ptr
+  %res = icmp ne i128 %l, 16
+  ret i1 %res
+}
+
+; INFO: Negative test: only eq and ne works
+define i1 @setcc_slt_const_i128(ptr %ptr) {
+; CHECK-LABEL: setcc_slt_const_i128:
+; CHECK:         .functype setcc_slt_const_i128 (i32) -> (i32)
+; CHECK-NEXT:  # %bb.0:
+; CHECK-NEXT:    i64.load $push2=, 0($0)
+; CHECK-NEXT:    i64.const $push3=, 25
+; CHECK-NEXT:    i64.lt_u $push4=, $pop2, $pop3
+; CHECK-NEXT:    i64.load $push8=, 8($0)
+; CHECK-NEXT:    local.tee $push7=, $1=, $pop8
+; CHECK-NEXT:    i64.const $push0=, 0
+; CHECK-NEXT:    i64.lt_s $push1=, $pop7, $pop0
+; CHECK-NEXT:    i64.eqz $push5=, $1
+; CHECK-NEXT:    i32.select $push6=, $pop4, $pop1, $pop5
+; CHECK-NEXT:    return $pop6
+  %l = load i128, ptr %ptr
+  %res = icmp slt i128 %l, 25
+  ret i1 %res
+}