diff --git a/clang/lib/Frontend/InitPreprocessor.cpp b/clang/lib/Frontend/InitPreprocessor.cpp
index 008a35d5265e1..5980806fba5e4 100644
--- a/clang/lib/Frontend/InitPreprocessor.cpp
+++ b/clang/lib/Frontend/InitPreprocessor.cpp
@@ -1519,6 +1519,13 @@ static void InitializePredefinedMacros(const TargetInfo &TI,
   if (TI.getTriple().isOSBinFormatELF())
     Builder.defineMacro("__ELF__");
 
+  if (LangOpts.Sanitize.has(SanitizerKind::Address))
+    Builder.defineMacro("__SANITIZE_ADDRESS__");
+  if (LangOpts.Sanitize.has(SanitizerKind::HWAddress))
+    Builder.defineMacro("__SANITIZE_HWADDRESS__");
+  if (LangOpts.Sanitize.has(SanitizerKind::Thread))
+    Builder.defineMacro("__SANITIZE_THREAD__");
+
   // Target OS macro definitions.
   if (PPOpts.DefineTargetOSMacros) {
     const llvm::Triple &Triple = TI.getTriple();
diff --git a/clang/test/Preprocessor/sanitizer-predefines.c b/clang/test/Preprocessor/sanitizer-predefines.c
new file mode 100644
index 0000000000000..9d2f6bf2517a2
--- /dev/null
+++ b/clang/test/Preprocessor/sanitizer-predefines.c
@@ -0,0 +1,8 @@
+// RUN: %clang_cc1 -E -dM -triple aarch64-unknown-linux -fsanitize=address %s | FileCheck %s --check-prefix=ASAN
+// ASAN: #define __SANITIZE_ADDRESS__ 1
+
+// RUN: %clang_cc1 -E -dM -triple aarch64-unknown-linux -fsanitize=hwaddress %s | FileCheck %s --check-prefix=HWASAN
+// HWASAN: #define __SANITIZE_HWADDRESS__ 1
+
+// RUN: %clang_cc1 -E -dM -triple aarch64-unknown-linux -fsanitize=thread %s | FileCheck %s --check-prefix=TSAN
+// TSAN: #define __SANITIZE_THREAD__ 1