diff --git a/lldb/bindings/python/python-typemaps.swig b/lldb/bindings/python/python-typemaps.swig
index 3baeaa7770e6c..f73ab768b4c42 100644
--- a/lldb/bindings/python/python-typemaps.swig
+++ b/lldb/bindings/python/python-typemaps.swig
@@ -220,9 +220,9 @@ AND call SWIG_fail at the same time, because it will result in a double free.
 }
 
 // Disable default type checking for this method to avoid SWIG dispatch issues.
-// 
+//
 // Problem: SBThread::GetStopDescription has two overloads:
-//   1. GetStopDescription(char* dst_or_null, size_t dst_len) 
+//   1. GetStopDescription(char* dst_or_null, size_t dst_len)
 //   2. GetStopDescription(lldb::SBStream& stream)
 //
 // SWIG generates a dispatch function to select the correct overload based on argument types.
@@ -230,9 +230,9 @@ AND call SWIG_fail at the same time, because it will result in a double free.
 // However, this dispatcher doesn't consider typemaps that transform function signatures.
 //
 // In Python, our typemap converts GetStopDescription(char*, size_t) to GetStopDescription(int).
-// The dispatcher still checks against the original (char*, size_t) signature instead of 
+// The dispatcher still checks against the original (char*, size_t) signature instead of
 // the transformed (int) signature, causing type matching to fail.
-// This only affects SBThread::GetStopDescription since the type check also matches 
+// This only affects SBThread::GetStopDescription since the type check also matches
 // the argument name, which is unique to this function.
 %typemap(typecheck, precedence=SWIG_TYPECHECK_POINTER) (char *dst_or_null, size_t dst_len) ""
 
@@ -628,12 +628,11 @@ template <> bool SetNumberFromPyObject<double>(double &number, PyObject *obj) {
   }
 }
 
-// These two pybuffer macros are copied out of swig/Lib/python/pybuffer.i,
-// and fixed so they will not crash if PyObject_GetBuffer fails.
-// https://github.com/swig/swig/issues/1640
-//
-// I've also moved the call to PyBuffer_Release to the end of the SWIG wrapper,
-// doing it right away is not legal according to the python buffer protocol.
+// These two pybuffer macros are copied out of swig/Lib/python/pybuffer.i.
+// - Avoids crash if PyObject_GetBuffer fails and delays calling
+//   PyBuffer_Release (https://github.com/swig/swig/issues/1640)
+// - Avoids using deprecated "old buffer protocol" APIs when targeting the
+//   Stable C API.
 %inline %{
 struct Py_buffer_RAII {
   Py_buffer buffer = {};
diff --git a/lldb/bindings/python/python-wrapper.swig b/lldb/bindings/python/python-wrapper.swig
index 3a0995e84f643..9b9245eac14ce 100644
--- a/lldb/bindings/python/python-wrapper.swig
+++ b/lldb/bindings/python/python-wrapper.swig
@@ -128,8 +128,11 @@ bool lldb_private::python::SWIGBridge::LLDBSwigPythonCallTypeScript(
 
   PyObject *pfunc_impl = nullptr;
 
-  if (pyfunct_wrapper && *pyfunct_wrapper &&
-      PyFunction_Check(*pyfunct_wrapper)) {
+  if (pyfunct_wrapper && *pyfunct_wrapper 
+#ifndef Py_LIMITED_API
+      && PyFunction_Check(*pyfunct_wrapper)
+#endif
+      ) {
     pfunc_impl = (PyObject *)(*pyfunct_wrapper);
     if (pfunc_impl->ob_refcnt == 1) {
       Py_XDECREF(pfunc_impl);
diff --git a/lldb/bindings/python/python.swig b/lldb/bindings/python/python.swig
index 4a5a39dc4b06d..b2823f98acac8 100644
--- a/lldb/bindings/python/python.swig
+++ b/lldb/bindings/python/python.swig
@@ -59,6 +59,11 @@ except ImportError:
 // Parameter types will be used in the autodoc string.
 %feature("autodoc", "1");
 
+// Include lldb-python first as it sets Py_LIMITED_API.
+%begin %{
+#include "../source/Plugins/ScriptInterpreter/Python/lldb-python.h"
+%}
+
 %pythoncode%{
 import uuid
 import re
diff --git a/lldb/cmake/modules/LLDBConfig.cmake b/lldb/cmake/modules/LLDBConfig.cmake
index 4b568d27c4709..4621642890066 100644
--- a/lldb/cmake/modules/LLDBConfig.cmake
+++ b/lldb/cmake/modules/LLDBConfig.cmake
@@ -180,13 +180,29 @@ if (LLDB_ENABLE_PYTHON)
       "Path to use as PYTHONHOME in lldb. If a relative path is specified, it will be resolved at runtime relative to liblldb directory.")
   endif()
 
-  if (SWIG_VERSION VERSION_GREATER_EQUAL "4.2" AND NOT LLDB_EMBED_PYTHON_HOME)
+  set(python_limited_api_swig_version "4.2")
+  set(python_limited_api_python_version "3.11")
+
+  if (SWIG_VERSION VERSION_GREATER_EQUAL python_limited_api_swig_version
+      AND Python3_VERSION VERSION_GREATER_EQUAL python_limited_api_python_version
+      AND NOT LLDB_EMBED_PYTHON_HOME)
     set(default_enable_python_limited_api ON)
   else()
     set(default_enable_python_limited_api OFF)
   endif()
-  option(LLDB_ENABLE_PYTHON_LIMITED_API "Force LLDB to only use the Python Limited API (requires SWIG 4.2 or later)"
+  option(LLDB_ENABLE_PYTHON_LIMITED_API "Only use the Python Limited API (requires at least Python 3.11 and SWIG 4.2)"
     ${default_enable_python_limited_api})
+
+  # Diagnose unsupported configurations.
+  if (LLDB_ENABLE_PYTHON_LIMITED_API AND LLDB_EMBED_PYTHON_HOME)
+    message(SEND_ERROR "LLDB_ENABLE_PYTHON_LIMITED_API is not compatible with LLDB_EMBED_PYTHON_HOME")
+  endif()
+  if (LLDB_ENABLE_PYTHON_LIMITED_API AND Python3_VERSION VERSION_LESS python_limited_api_python_version)
+    message(SEND_ERROR "LLDB_ENABLE_PYTHON_LIMITED_API is not compatible with Python ${Python3_VERSION} (requires Python ${python_limited_api_python_version})")
+  endif()
+  if (LLDB_ENABLE_PYTHON_LIMITED_API AND SWIG_VERSION VERSION_LESS python_limited_api_swig_version)
+    message(SEND_ERROR "LLDB_ENABLE_PYTHON_LIMITED_API is not compatible with SWIG ${SWIG_VERSION} (requires SWIG ${python_limited_api_swig_version})")
+  endif()
 else()
   # Even if Python scripting is disabled, we still need a Python interpreter to
   # build, for example to generate SBLanguages.h.
diff --git a/lldb/source/Plugins/ScriptInterpreter/Python/lldb-python.h b/lldb/source/Plugins/ScriptInterpreter/Python/lldb-python.h
index 0c281793613a5..98941f504e44c 100644
--- a/lldb/source/Plugins/ScriptInterpreter/Python/lldb-python.h
+++ b/lldb/source/Plugins/ScriptInterpreter/Python/lldb-python.h
@@ -45,12 +45,13 @@ static llvm::Expected<bool> *g_fcxx_modules_workaround [[maybe_unused]];
 #include <locale>
 #endif
 
-#define LLDB_MINIMUM_PYTHON_VERSION 0x03080000
-
-#if LLDB_ENABLE_PYTHON_LIMITED_API
 // If defined, LLDB will be ABI-compatible with all Python 3 releases from the
 // specified one onward, and can use Limited API introduced up to that version.
+#if LLDB_ENABLE_PYTHON_LIMITED_API
+#define LLDB_MINIMUM_PYTHON_VERSION 0x030b0000
 #define Py_LIMITED_API LLDB_MINIMUM_PYTHON_VERSION
+#else
+#define LLDB_MINIMUM_PYTHON_VERSION 0x03080000
 #endif
 
 // Include python for non windows machines