diff --git a/src/lmstudio/_kv_config.py b/src/lmstudio/_kv_config.py
index e558531..589d1f5 100644
--- a/src/lmstudio/_kv_config.py
+++ b/src/lmstudio/_kv_config.py
@@ -77,21 +77,39 @@ def _gpu_offload_fields(
     offload_settings: DictObject,
 ) -> Sequence[KvConfigFieldDict]:
     fields: list[KvConfigFieldDict] = []
-    gpu_keys = (
-        ("ratio", f"{endpoint}.load.llama.acceleration.offloadRatio"),
-        ("mainGpu", "llama.load.mainGpu"),
-        ("splitStrategy", "llama.load.splitStrategy"),
-    )
-    for key, mapped_key in gpu_keys:
+    remaining_keys = set(offload_settings.keys())
+    simple_gpu_keys = (("ratio", f"{endpoint}.load.llama.acceleration.offloadRatio"),)
+    for key, mapped_key in simple_gpu_keys:
         if key in offload_settings:
+            remaining_keys.remove(key)
             fields.append({"key": mapped_key, "value": offload_settings[key]})
+    split_config_keys = ("mainGpu", "splitStrategy", "disabledGpus")
+    split_config_settings: dict[str, Any] = {}
+    for key in split_config_keys:
+        if key in offload_settings:
+            remaining_keys.remove(key)
+            split_config_settings[key] = offload_settings[key]
+    if split_config_settings:
+        fields.append({"key": "load.gpuSplitConfig", "value": split_config_settings})
+    if remaining_keys:
+        raise LMStudioValueError(
+            f"Unknown GPU offload settings: {sorted(remaining_keys)}"
+        )
     return fields
 
 
 # Some fields have different names in the client and server configs
+# (this map has also been used to avoid adding new key categories for new setting scopes)
 _CLIENT_TO_SERVER_KEYMAP = {
     "maxTokens": "maxPredictedTokens",
     "rawTools": "tools",
+    # "reasoning" scope
+    "reasoningParsing": "reasoning.parsing",
+    # "speculativeDecoding" scope
+    "draftModel": "speculativeDecoding.draftModel",
+    "speculativeDecodingNumDraftTokensExact": "speculativeDecoding.numDraftTokensExact",
+    "speculativeDecodingMinDraftLengthToConsider": "speculativeDecoding.minDraftLengthToConsider",
+    "speculativeDecodingMinContinueDraftingProbability": "speculativeDecoding.minContinueDraftingProbability",
 }
 
 
@@ -99,6 +117,9 @@ def _to_server_key(key: str) -> str:
     return _CLIENT_TO_SERVER_KEYMAP.get(key, key)
 
 
+_NOT_YET_SUPPORTED_KEYS: set[str] = set()
+
+
 def _to_kv_config_stack_base(
     config: DictObject,
     namespace: str,
@@ -114,9 +135,12 @@ def _to_kv_config_stack_base(
     # TODO: Define a JSON or TOML data file for mapping prediction config
     #       fields to config stack entries (preferably JSON exported by
     #       lmstudio-js rather than something maintained in the Python SDK)
+    #       https://github.com/lmstudio-ai/lmstudio-js/issues/253
+    remaining_keys = set(config.keys() - _NOT_YET_SUPPORTED_KEYS)
 
     for client_key in checkbox_keys:
         if client_key in config:
+            remaining_keys.remove(client_key)
             server_key = _to_server_key(client_key)
             fields.append(
                 _to_checkbox_kv(
@@ -125,12 +149,14 @@ def _to_kv_config_stack_base(
             )
     for client_key in simple_keys:
         if client_key in config:
+            remaining_keys.remove(client_key)
             server_key = _to_server_key(client_key)
             fields.append(
                 _to_simple_kv(f"{namespace}.{request}", server_key, config[client_key])
             )
     for client_key in llama_keys:
         if client_key in config:
+            remaining_keys.remove(client_key)
             server_key = _to_server_key(client_key)
             fields.append(
                 _to_simple_kv(
@@ -139,6 +165,7 @@ def _to_kv_config_stack_base(
             )
     for client_key in llama_checkbox_keys:
         if client_key in config:
+            remaining_keys.remove(client_key)
             server_key = _to_server_key(client_key)
             fields.append(
                 _to_checkbox_kv(
@@ -149,8 +176,12 @@ def _to_kv_config_stack_base(
             )
     for gpu_offload_key in gpu_offload_keys:
         if gpu_offload_key in config:
+            remaining_keys.remove(gpu_offload_key)
             fields.extend(_gpu_offload_fields(namespace, config[gpu_offload_key]))
 
+    if remaining_keys:
+        raise LMStudioValueError(f"Unknown config settings: {sorted(remaining_keys)}")
+
     return fields
 
 
@@ -180,6 +211,7 @@ def _to_kv_config_stack_base(
     ],
 }
 
+
 _EMBEDDING_LOAD_CONFIG_KEYS = {
     "checkbox_keys": [],
     "simple_keys": [
@@ -253,6 +285,11 @@ def load_config_to_kv_config_stack(
         "topKSampling",
         "toolCallStopStrings",
         "rawTools",
+        "reasoningParsing",
+        "draftModel",
+        "speculativeDecodingNumDraftTokensExact",
+        "speculativeDecodingMinDraftLengthToConsider",
+        "speculativeDecodingMinContinueDraftingProbability",
     ],
     "llama_keys": [
         "cpuThreads",
diff --git a/tests/test_kv_config.py b/tests/test_kv_config.py
index f9f2a30..3198cdb 100644
--- a/tests/test_kv_config.py
+++ b/tests/test_kv_config.py
@@ -247,15 +247,7 @@ def test_snake_case_conversion(
         config_type._from_api_dict(input_dict)
 
 
-_NOT_YET_SUPPORTED_KEYS = {
-    "disabledGpus",
-    "reasoningParsing",
-    # "speculativeDecoding" scope
-    "draftModel",
-    "speculativeDecodingNumDraftTokensExact",
-    "speculativeDecodingMinDraftLengthToConsider",
-    "speculativeDecodingMinContinueDraftingProbability",
-}
+_NOT_YET_SUPPORTED_KEYS: set[str] = set()
 
 
 @pytest.mark.parametrize("keymap_dict,config_type", zip(KEYMAP_DICTS, KEYMAP_TYPES))
@@ -292,8 +284,14 @@ def test_kv_stack_field_coverage(
                         "key": "embedding.load.llama.acceleration.offloadRatio",
                         "value": 0.5,
                     },
-                    {"key": "llama.load.mainGpu", "value": 0},
-                    {"key": "llama.load.splitStrategy", "value": "evenly"},
+                    {
+                        "key": "load.gpuSplitConfig",
+                        "value": {
+                            "mainGpu": 0,
+                            "splitStrategy": "evenly",
+                            "disabledGpus": [1, 2],
+                        },
+                    },
                 ],
             },
             "layerName": "apiOverride",
@@ -332,8 +330,14 @@ def test_kv_stack_field_coverage(
                         "value": {"checked": True, "value": "f32"},
                     },
                     {"key": "llm.load.llama.acceleration.offloadRatio", "value": 0.5},
-                    {"key": "llama.load.mainGpu", "value": 0},
-                    {"key": "llama.load.splitStrategy", "value": "evenly"},
+                    {
+                        "key": "load.gpuSplitConfig",
+                        "value": {
+                            "mainGpu": 0,
+                            "splitStrategy": "evenly",
+                            "disabledGpus": [1, 2],
+                        },
+                    },
                 ]
             },
         }
@@ -392,7 +396,27 @@ def test_kv_stack_field_coverage(
                         "value": ["yellow"],
                     },
                     {"key": "llm.prediction.tools", "value": {"type": "none"}},
-                    {"key": "llm.prediction.llama.cpuThreads", "value": 7.0},
+                    {
+                        "key": "llm.prediction.reasoning.parsing",
+                        "value": {"enabled": False, "startString": "", "endString": ""},
+                    },
+                    {
+                        "key": "llm.prediction.speculativeDecoding.draftModel",
+                        "value": "some-model-key",
+                    },
+                    {
+                        "key": "llm.prediction.speculativeDecoding.numDraftTokensExact",
+                        "value": 2,
+                    },
+                    {
+                        "key": "llm.prediction.speculativeDecoding.minDraftLengthToConsider",
+                        "value": 5,
+                    },
+                    {
+                        "key": "llm.prediction.speculativeDecoding.minContinueDraftingProbability",
+                        "value": 0.1,
+                    },
+                    {"key": "llm.prediction.llama.cpuThreads", "value": 7},
                 ],
             },
             "layerName": "apiOverride",