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‎index.html‎

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<!DOCTYPE html>
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<html lang="en">
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</body>
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>>>>>>> parent of ebd0787 (Update index.html)
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=======
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<!DOCTYPE html>
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<html lang="en">
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<head>
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<meta charset="utf-8">
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<meta name="viewport" content="width=device-width, initial-scale=1">
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<title>Manish Datt</title>
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<link rel="stylesheet" href="https://cdn.jsdelivr.net/npm/bulma@0.9.4/css/bulma.min.css">
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<link rel="preconnect" href="https://fonts.googleapis.com">
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<link rel="preconnect" href="https://fonts.gstatic.com" crossorigin>
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<link href="https://fonts.googleapis.com/css2?family=Geo&family=Lato&family=Bungee+Shade&display=swap" rel="stylesheet">
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<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome-animation/0.3.0/font-awesome-animation.min.css">
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<script src="https://kit.fontawesome.com/c6d49cdb5e.js" crossorigin="anonymous"></script>
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</head>
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<body>
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<section class="has-background-grey-dark">
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<!-- <p class="is-size-6 has-text-right has-text-white pr-4">
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Research &nbsp; Contact</p>
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--> <br>
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</section>
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<section class="section pt-5 px-6 pb-0 has-background-grey-dark">
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<div class="columns is-centered" style="min-height: 30vh;">
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<div class="column is-three-fifths title is-size-3 is-size-4-mobile has-text-weight-normal">
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<span lang="hi" class="has-text-white ">
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कर्मण्येवाधिकारस्ते मा फलेषु कदाचन। <br>
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मा कर्मफलहेतुर्भूर्मा ते सङ्गोऽस्त्वकर्मणि॥
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<p class="subtitle is-size-6 has-text-right mt-2 has-text-white pr-6">
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भगवद गीता २-४७</p>
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</span>
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<p class="is-size-6 mt-1 has-text-grey-light translation" style="margin-left: -1em;"><u>Translate</u></p>
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<div class="column is-hidden" id="trans_eng" style="margin-left: -1em; margin-top: -0.25em;">
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<span class="is-size-6 has-text-light">
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<p>You have the right to work only but never to its fruits.</p>
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<p>Let not the fruits of action be your motive,
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nor let your attachment be to inaction.</p>
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<p class="has-text-right pr-5"><small>Bhagwad Gita, Chapter 2, Verse 47</small></p>
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</span>
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</div>
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</div>
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</div>
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</section>
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<section class="section py-5">
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<div class="column is-four-fifths is-offset-1 is-full-mobile">
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<div class="tabs is-boxed is-medium is-small-mobile is-centered">
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<ul>
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<li class="is-active" data-target="Welcome">
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<a>
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<span class="icon"><i class="fa-solid fa-hands-praying" aria-hidden="true"></i></span>
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<span>Welcome</span>
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</a>
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</li>
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<li data-target="Education">
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<a>
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<span class="icon"><i class="fas fa-building-columns" aria-hidden="true"></i></span>
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<span>Education</span>
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</a>
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</li>
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<li data-target="Experience">
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<a>
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<span class="icon"><i class="fas fa-user-tie" aria-hidden="true"></i></span>
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<span>Experience</span>
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</a>
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</li>
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<li data-target="Fellowships">
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<a>
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<span class="icon"><i class="fas fa-graduation-cap" aria-hidden="true"></i></span>
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<span>Fellowships</span>
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</a>
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</li>
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</ul>
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</div>
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<div class="px-1" id="tab-content" style="min-height: 250px;">
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<div class="columns" id="Welcome">
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<div class="column is-one-third has-text-centered">
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<figure class="is-inline-block">
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<img src="images/MD_headshot_grey.jpg" alt="Manish Datt"
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style="object-fit: cover; border-radius: 50%; width: 200px; height: 200px;
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box-shadow: 0px 10px 20px grey;">
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</figure>
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</div>
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<div class="column is-full">
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<p class="title is-size-5 mb-6 pt-2">
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Three things you should know about me
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</p>
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<div class="subtitle mb-4" style="list-style-type: none;">
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<p class="mb-4"><span class="is-size-4" style="font-family: Bungee Shade; font-weight: bold;">1&nbsp;</span>
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I enjoy data science and its application in biology.</p>
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<p class="mb-4"><span class="is-size-4" style="font-family: Bungee Shade; font-weight: bold;">2&nbsp;</span>
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I am intrigued by structure and dynamics of biomolecules.</p>
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<p class="mb-6"><span class="is-size-4" style="font-family: Bungee Shade; font-weight: bold;">3&nbsp;</span>
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I strive to foster knowledge-sharing; which keeps me motivated.</p>
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</div>
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</div>
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</div>
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<div id="Education" class="columns is-hidden">
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<div class="column is-one-third has-text-centered">
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<figure class="is-inline-block">
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<img src="images/MD_headshot_grey.jpg" alt="Manish Datt"
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style="object-fit: cover; border-radius: 50%; width: 200px; height: 200px;
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box-shadow: 0px 10px 20px grey;">
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</figure>
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</div>
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<div class="column is-full">
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<p class="title is-size-5">
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PhD &ndash; Bioinformatics &ndash; 2004-2010
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</p>
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<p class="subtitle mb-6">
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CSIR-Institute of Microbial Technology, Chandigarh, India.
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</p>
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<p class="title is-size-5">
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MSc &ndash; Biotechnology &ndash; 2002-2004
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</p>
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<p class="subtitle mb-6">
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Panjab University, Chandigarh, India.
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</p>
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<p class="title is-size-5">
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BSc &ndash; Biochemistry &ndash; 1998-2001
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</p>
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<p class="subtitle mb-4">
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University of Delhi, New Delhi, India.
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</p>
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</div>
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</div>
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<div id="Experience" class="columns is-hidden">
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<div class="column is-one-third has-text-centered">
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<figure class="is-inline-block">
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<img src="images/MD_headshot_grey.jpg" alt="Manish Datt"
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style="object-fit: cover; border-radius: 50%; width: 200px; height: 200px;
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box-shadow: 0px 10px 20px grey;">
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</figure>
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</div>
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<div class="column is-four-fifths">
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<p class="title is-size-5 mb-4">
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Associate Professor &ndash; 2022-2023
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</p>
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<p class="subtitle is-size-6 mb-5">
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MIT World Peace University, Maharashtra, India.
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</p>
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<p class="title is-size-5 mb-4 mt-1">
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Assistant Professor &ndash; 2015-2021
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</p>
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<p class="subtitle is-size-6 mb-5">
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Ahmdedabad University, Gujarat, India.
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</p>
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<p class="title is-size-5 mb-4 mt-1">
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Research Scientist &ndash; 2012-2015
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</p>
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<p class="subtitle is-size-6 mb-5">
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International Center for Genetic Engineering and Biotechnology, New Delhi, India.
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</p>
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<p class="title is-size-5 mb-4">
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Post-doctoral Scholar &ndash; 2010-2012
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</p>
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<p class="subtitle is-size-6 mb-1">
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Case Western Reserve University, OH, USA.
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</p>
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</div>
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</div>
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<div id="Fellowships" class="columns is-hidden">
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<div class="column is-one-third has-text-centered">
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<figure class="is-inline-block">
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<img src="images/MD_headshot_grey.jpg" alt="Manish Datt"
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style="object-fit: cover; border-radius: 50%; width: 200px; height: 200px;
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box-shadow: 0px 10px 20px grey;">
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</figure>
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</div>
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<div class="column is-full">
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<p class="title is-size-5">
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The Argosy Fellow &ndash; 2017
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</p>
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<p class="subtitle mb-6">
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Olin College of Engineering, MA, USA.
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</p>
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<p class="title is-size-5">
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Senior Research Fellow &ndash; 2006-2009
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</p>
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<p class="subtitle mb-6">
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Council of Scientific and Industrial Research, India.
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</p>
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<p class="title is-size-5">
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Junior Research Fellow &ndash; 2004-2006
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</p>
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<p class="subtitle mb-6">
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Council of Scientific and Industrial Research, India.
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</p>
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</div>
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</div>
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</div>
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</div>
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</section>
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<div class="column is-four-fifths is-offset-1 is-full-mobile mb-5"
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style="margin-top: -4em;">
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<p class="subtitle is-size-5 box">I am the founder of <a href="https://bioinfo.guru"><span style="font-family: Geo; color: #9c51e0; font-size: 125%;">bioinfo.guru</span></a> &mdash; a digital-first learning
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platform that aims to empower biologists by helping them apply
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computational methods in their research.
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</p>
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<p class="subtitle is-size-5 box">I blog at <a href="https://my.bioinfo.guru">
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<span style="font-family: Geo; color: #9c51e0; font-size: 125%;">my.bioinfo.guru</span></a>
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about coding, biology, and everything in-between. <br>
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My book on Python is available <a href="https://bioinfo.guru/pythonbook">here</a>.
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</p>
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</div>
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<link rel="stylesheet" href="https://cdn.jsdelivr.net/npm/bulma-carousel@4.0.3/dist/css/bulma-carousel.min.css">
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<section class="column is-four-fifths is-offset-1 is-full-mobile">
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<p class="title is-size-5">Research highlights
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(<a href="https://pubmed.ncbi.nlm.nih.gov/?term=manish+datt%5BAuthor%5D&sort=" target="_blank">PubMed</a>)</p>
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<div class="container" style="overflow: hidden;">
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<!-- Start Carousel -->
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<div id="carousel-demo" class="carousel">
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<div class="item-1">
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<div class="card">
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<div class="card-image">
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<figure class="image is-3by1 is-covered">
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<img
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src="images/Fig_FEL.png"
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alt="Free energy landscape" style="object-fit: scale-down;"
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/>
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</figure>
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</div>
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<div class="card-content">
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<p>Aminoacyl-tRNA synthetases are an indispensable component
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of ribosomal protein translational machinery and have been
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validated as potential drug target for malaria. The dynamic
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conformational landscape of <i>Plasmodium</i> tyrosyl-tRNA
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synthetase has been analyzed in the presence and absence
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of bound ligand. All-atom simulations with a cumulative time
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scale of microseconds show quantitative differences in the
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conformational diversity of this enzyme.</p>
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<p><b>Datt M*</b></p>
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<p>Interplay of substrate polymorphism and conformational plasticity of <i>Plasmodium</i> tyrosyl-tRNA synthetase.
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Computational Biology and Chemistry, Vol. 95, Dec 2021.</p>
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</div>
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</div>
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</div>
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<div class="item-2">
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<div class="card">
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<div class="card-image">
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<figure class="image is-3by1 is-covered">
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<img
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src="images/3Biotech_docking.jpg"
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alt="Free energy landscape" style="object-fit: scale-down;"
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/>
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</figure>
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</div>
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<div class="card-content">
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<p>We have explored the prospects of repositioning the
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repertoire of approved drugs and natural products for
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potentially inhibiting malarial protein translation
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machinery. Molecular docking of a diverse set of small
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molecules with lysyl-, prolyl-, and tyrosyl- synthetases
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from <i>Plasmodium</i> and human helped us identify promising
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lead molecules. Overall, this study provides an exciting
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foundation for the development of specific antimalarials.
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</p>
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<p>Doshi K, Pandya N, <b>Datt M*</b>.</p>
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<p>In silico assessment of natural products and approved drugs as potential inhibitory scaffolds targeting aminoacyl-tRNA synthetases from <i>Plasmodium</i>.
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3 Biotech. 2020 Nov;10(11):470.
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</p>
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</div>
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</div>
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</div>
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<div class="item-3">
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<div class="card">
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<div class="card-image">
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<figure class="image is-3by1 is-covered">
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<img
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src="images/Geometric_analysis.jpg"
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alt="Convex hull" style="object-fit: scale-down;"
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/>
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</figure>
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</div>
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<div class="card-content">
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<p>Understanding a protein structure is indispensable to decipher
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the molecular underpinning of its physiological functions. Protein
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structure is a collection of Cartesian coordinates of atoms
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within the covalently connected amino-acids.
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Iterative calculation of convex hull layers in the
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structures have provided interesting insights into the
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packing of atoms in the proteins. The figure shows
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coordinates of C-alpha atoms of a protein structure (left)
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and the right image shows the same set of coordinates colored
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according to different convex hull layers.
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<p><b>Datt M*</b></p>
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<p>Geometric analysis of the conformational features of protein structures (BIOMAT 2015)</p>
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</div>
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</div>
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</div>
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<div class="item-4">
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<div class="card">
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<div class="card-image">
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<figure class="image is-3by1 is-covered">
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<img
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src="images/NP_violin.png"
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alt="Natural products" style="object-fit: scale-down;"
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/>
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</figure>
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</div>
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<div class="card-content">
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<p>Natural Products (NPs) are chemical compounds that exist
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within the living systems. These molecules are suitable
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candidates for lead discovery. Molecular descriptor
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based evaluation of chemical space for NPs has provided
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interesting insights into their drug-likeliness. A
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detailed comparison of NPs from two different databases
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and FDA-approved drugs highlight the potential for NPs
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as lead molecules. The figure shows the distribution of
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molecules based on quantitative estimation of
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drug-likeness (QED) in two NP databases and their
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comparison with approved drugs.
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</p>
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<p><b>Datt M*</b> and Shah H</p>
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<p>Molecular Descriptor Based Evaluation of Drug-Likeliness
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and Chemical Space of Natural Products.</p>
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</div>
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</div>
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</div>
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</div>
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<!-- End Carousel -->
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</div>
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</section>
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<script src="https://cdn.jsdelivr.net/npm/bulma-carousel@4.0.4/dist/js/bulma-carousel.min.js"></script>
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<script>
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bulmaCarousel.attach('#carousel-demo', {
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slidesToScroll: 1,
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slidesToShow: 1,
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pagination: false,
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infinite: true,
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});
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</script>
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<div class="footer has-background-grey-dark has-text-light has-text-centered">
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<span class="icon is-size-5">
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<a class="has-text-link-light" href="https://in.linkedin.com/in/manishdatt">
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<i class="fa-brands fa-linkedin-in"></i></a>
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&nbsp;&nbsp;
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<a class="has-text-link-light" href="https://twitter.com/dr_manishdatt">
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<i class="fa-brands fa-twitter"></i></a>
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</span>
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<p>bioinfo<span class="icon is-size-6 has-text-light"><i class="fas fa-at"></i></span>manishdatt.com</p>
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</div>
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<script src="index.js"></script>
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</body>
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</html>
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>>>>>>> parent of ebd0787 (Update index.html)

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