diff --git a/.github/workflows/test_and_deploy.yml b/.github/workflows/test_and_deploy.yml
index bd43879..eac6db3 100644
--- a/.github/workflows/test_and_deploy.yml
+++ b/.github/workflows/test_and_deploy.yml
@@ -64,7 +64,7 @@ jobs:
       - name: Install dependencies
         run: |
           python -m pip install --upgrade pip
-          python -m pip install tox tox-gh-actions
+          python -m pip install tox tox-gh tox-uv
 
       # this runs the platform-specific tests declared in tox.ini
       - name: Test with tox
diff --git a/pyproject.toml b/pyproject.toml
index f76831a..6b54e14 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -2,9 +2,81 @@
 requires = ["setuptools", "setuptools_scm"]
 build-backend = "setuptools.build_meta"
 
+[project]
+name = "napari-matplotlib"
+description = "A plugin to use Matplotlib with napari"
+readme = "README.md"
+requires-python = ">=3.11"
+license = { text = "BSD-3-Clause" }
+authors = [
+    { name = "David Stansby", email = "d.stansby@ucl.ac.uk" },
+]
+classifiers = [
+    "Development Status :: 5 - Production/Stable",
+    "Framework :: napari",
+    "Intended Audience :: Developers",
+    "License :: OSI Approved :: BSD License",
+    "Operating System :: OS Independent",
+    "Programming Language :: Python",
+    "Programming Language :: Python :: 3",
+    "Programming Language :: Python :: 3 :: Only",
+    "Topic :: Software Development :: Testing",
+]
+dependencies = [
+    "matplotlib",
+    "napari>=0.5",
+    "numpy>=1.23",
+    "tinycss2",
+]
+dynamic = ["version"]
+
+[project.urls]
+"Bug Tracker" = "https://github.com/matplotlib/napari-matplotlib/issues"
+Documentation = "https://napari-matplotlib.github.io"
+"Source Code" = "https://github.com/matplotlib/napari-matplotlib"
+"User Support" = "https://github.com/matplotlib/napari-matplotlib/issues"
+
+[project.entry-points."napari.manifest"]
+"napari-matplotlib" = "napari_matplotlib:napari.yaml"
+
+[project.optional-dependencies]
+docs = [
+    "napari[all]",
+    "numpydoc",
+    "pydantic<2",
+    "pydata-sphinx-theme",
+    "sphinx",
+    "sphinx-automodapi",
+    "sphinx-gallery",
+]
+testing = [
+    "napari[pyqt6_experimental]>=0.4.18",
+    "pooch",
+    "pyqt6",
+    "pytest",
+    "pytest-cov",
+    "pytest-mock",
+    "pytest-mpl",
+    "pytest-qt",
+    "tox",
+    "pytest-xvfb; sys_platform == 'linux'",
+]
+
 [tool.setuptools_scm]
 write_to = "src/napari_matplotlib/_version.py"
 
+[tool.setuptools]
+include-package-data = true
+
+[tool.setuptools.packages.find]
+where = ["src"]
+
+[tool.setuptools.package-dir]
+"" = "src"
+
+[tool.setuptools.package-data]
+"*" = ["*.yaml"]
+
 [tool.pytest.ini_options]
 filterwarnings = [
     "error",
@@ -74,3 +146,70 @@ enable_error_code = ["ignore-without-code", "redundant-expr", "truthy-bool"]
 [[tool.mypy.overrides]]
 module = ["napari_matplotlib/tests/*"]
 disallow_untyped_defs = false
+
+[dependency-groups]
+docs = [
+    "napari[all]",
+    "numpydoc",
+    "pydantic<2",
+    "pydata-sphinx-theme",
+    "sphinx",
+    "sphinx-automodapi",
+    "sphinx-gallery",
+]
+test = [
+    "napari[pyqt6_experimental]>=0.4.18",
+    "pooch",
+    "pyqt6",
+    "pytest",
+    "pytest-cov",
+    "pytest-mock",
+    "pytest-mpl",
+    "pytest-qt",
+    "tox",
+    "pytest-xvfb; sys_platform == 'linux'",
+]
+dev = [
+    "napari[all]",
+    "numpydoc",
+    "pydantic<2",
+    "pydata-sphinx-theme",
+    "sphinx",
+    "sphinx-automodapi",
+    "sphinx-gallery",
+    "napari[pyqt6_experimental]>=0.4.18",
+    "pooch",
+    "pyqt6",
+    "pytest",
+    "pytest-cov",
+    "pytest-mock",
+    "pytest-mpl",
+    "pytest-qt",
+    "tox",
+    "pytest-xvfb; sys_platform == 'linux'",
+]
+
+[tool.tox]
+requires = ["tox>=4.19"]
+env_list = ["py311", "py312", "py313"]
+isolate_build = true
+
+[tool.tox.gh.python]
+py311 = ["3.11"]
+pt312 = ["3.12"]
+py313 = ["3.13"]
+
+[tool.tox.env.test]
+extras = ["testing"]
+commands = [[
+        "python",
+        "-m",
+        "pytest",
+        "--mpl",
+        "--mpl-generate-summary=html",
+        "--mpl-results-path=./reports",
+        "-v",
+        "--color=yes",
+        "--cov=napari_matplotlib",
+        "--cov-report=xml"
+]]
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index 5ccef5c..0000000
--- a/setup.cfg
+++ /dev/null
@@ -1,70 +0,0 @@
-[metadata]
-name = napari-matplotlib
-description = A plugin to use Matplotlib with napari
-long_description = file: README.md
-long_description_content_type = text/markdown
-url = https://github.com/matplotlib/napari-matplotlib
-author = David Stansby
-author_email = d.stansby@ucl.ac.uk
-license = BSD-3-Clause
-license_files = LICENSE
-classifiers =
-    Development Status :: 5 - Production/Stable
-    Framework :: napari
-    Intended Audience :: Developers
-    License :: OSI Approved :: BSD License
-    Operating System :: OS Independent
-    Programming Language :: Python
-    Programming Language :: Python :: 3
-    Programming Language :: Python :: 3 :: Only
-    Topic :: Software Development :: Testing
-project_urls =
-    Bug Tracker = https://github.com/matplotlib/napari-matplotlib/issues
-    Documentation = https://napari-matplotlib.github.io
-    Source Code = https://github.com/matplotlib/napari-matplotlib
-    User Support = https://github.com/matplotlib/napari-matplotlib/issues
-
-[options]
-packages = find:
-install_requires =
-    matplotlib
-    napari>=0.5
-    numpy>=1.23
-    tinycss2
-python_requires = >=3.11
-include_package_data = True
-package_dir =
-    =src
-setup_requires =
-    setuptools-scm
-
-[options.packages.find]
-where = src
-
-[options.entry_points]
-napari.manifest =
-    napari-matplotlib = napari_matplotlib:napari.yaml
-
-[options.extras_require]
-docs =
-    napari[all]
-    numpydoc
-    pydantic<2
-    pydata-sphinx-theme
-    sphinx
-    sphinx-automodapi
-    sphinx-gallery
-testing =
-    napari[pyqt6_experimental]>=0.4.18
-    pooch
-    pyqt6
-    pytest
-    pytest-cov
-    pytest-mock
-    pytest-mpl
-    pytest-qt
-    tox
-    pytest-xvfb;sys_platform == 'linux'
-
-[options.package_data]
-* = *.yaml
diff --git a/tox.ini b/tox.ini
deleted file mode 100644
index 1ad69a4..0000000
--- a/tox.ini
+++ /dev/null
@@ -1,14 +0,0 @@
-[tox]
-envlist = py{310,311,312}
-isolated_build = true
-
-[gh-actions]
-python =
-    3.11: py311
-    3.12: py312
-    3.13: py313
-
-[testenv]
-extras = testing
-commands =
-    python -m pytest --mpl --mpl-generate-summary=html --mpl-results-path={toxinidir}/reports -v --color=yes --cov=napari_matplotlib --cov-report=xml