diff --git a/mesonpy/_rpath.py b/mesonpy/_rpath.py
index a7cbbb92..13aedb4f 100644
--- a/mesonpy/_rpath.py
+++ b/mesonpy/_rpath.py
@@ -74,7 +74,7 @@ def fix_rpath(filepath: Path, libs_relative_path: str) -> None:
 
     def _get_rpath(filepath: Path) -> List[str]:
         r = subprocess.run(['patchelf', '--print-rpath', os.fspath(filepath)], capture_output=True, text=True)
-        return r.stdout.strip().split(':')
+        return [x for x in r.stdout.strip().split(':') if x]
 
     def _set_rpath(filepath: Path, rpath: Iterable[str]) -> None:
         subprocess.run(['patchelf','--set-rpath', ':'.join(rpath), os.fspath(filepath)], check=True)
diff --git a/tests/packages/sharedlib-in-package/meson.build b/tests/packages/sharedlib-in-package/meson.build
index 71921cfe..d311a58a 100644
--- a/tests/packages/sharedlib-in-package/meson.build
+++ b/tests/packages/sharedlib-in-package/meson.build
@@ -6,4 +6,7 @@ project('sharedlib-in-package', 'c', version: '1.0.0')
 
 py = import('python').find_installation(pure: false)
 
+origin = build_machine.system() == 'darwin' ? '@loader_path' : '$ORIGIN'
+
+subdir('src')
 subdir('mypkg')
diff --git a/tests/packages/sharedlib-in-package/mypkg/__init__.py b/tests/packages/sharedlib-in-package/mypkg/__init__.py
index 857d2e90..e4fbc2a9 100644
--- a/tests/packages/sharedlib-in-package/mypkg/__init__.py
+++ b/tests/packages/sharedlib-in-package/mypkg/__init__.py
@@ -45,7 +45,7 @@ def _append_to_sharedlib_load_path():
 # end-literalinclude
 
 
-from ._example import example_prod, example_sum  #noqa: E402
+from ._example import prodsum  # noqa: E402
 
 
-__all__ = ['example_prod', 'example_sum']
+__all__ = ['prodsum']
diff --git a/tests/packages/sharedlib-in-package/mypkg/_examplemod.c b/tests/packages/sharedlib-in-package/mypkg/_examplemod.c
index 080e03c1..b4cc3f0c 100644
--- a/tests/packages/sharedlib-in-package/mypkg/_examplemod.c
+++ b/tests/packages/sharedlib-in-package/mypkg/_examplemod.c
@@ -4,36 +4,23 @@
 
 #include <Python.h>
 
-#include "examplelib.h"
-#include "examplelib2.h"
+#include "lib.h"
 
-static PyObject* example_sum(PyObject* self, PyObject *args)
+static PyObject* example_prodsum(PyObject* self, PyObject *args)
 {
-    int a, b;
-    if (!PyArg_ParseTuple(args, "ii", &a, &b)) {
-        return NULL;
-    }
+    int a, b, x;
 
-    long result = sum(a, b);
-
-    return PyLong_FromLong(result);
-}
-
-static PyObject* example_prod(PyObject* self, PyObject *args)
-{
-    int a, b;
-    if (!PyArg_ParseTuple(args, "ii", &a, &b)) {
+    if (!PyArg_ParseTuple(args, "iii", &a, &b, &x)) {
         return NULL;
     }
 
-    long result = prod(a, b);
+    long result = prodsum(a, b, x);
 
     return PyLong_FromLong(result);
 }
 
 static PyMethodDef methods[] = {
-    {"example_prod", (PyCFunction)example_prod, METH_VARARGS, NULL},
-    {"example_sum", (PyCFunction)example_sum, METH_VARARGS, NULL},
+    {"prodsum", (PyCFunction)example_prodsum, METH_VARARGS, NULL},
     {NULL, NULL, 0, NULL},
 };
 
diff --git a/tests/packages/sharedlib-in-package/mypkg/examplelib.c b/tests/packages/sharedlib-in-package/mypkg/examplelib.c
deleted file mode 100644
index f486bd7f..00000000
--- a/tests/packages/sharedlib-in-package/mypkg/examplelib.c
+++ /dev/null
@@ -1,9 +0,0 @@
-// SPDX-FileCopyrightText: 2022 The meson-python developers
-//
-// SPDX-License-Identifier: MIT
-
-#include "sub/mypkg_dll.h"
-
-MYPKG_DLL int sum(int a, int b) {
-    return a + b;
-}
diff --git a/tests/packages/sharedlib-in-package/mypkg/examplelib.h b/tests/packages/sharedlib-in-package/mypkg/examplelib.h
deleted file mode 100644
index c09f4f78..00000000
--- a/tests/packages/sharedlib-in-package/mypkg/examplelib.h
+++ /dev/null
@@ -1,7 +0,0 @@
-// SPDX-FileCopyrightText: 2022 The meson-python developers
-//
-// SPDX-License-Identifier: MIT
-
-#include "sub/mypkg_dll.h"
-
-MYPKG_DLL int sum(int a, int b);
diff --git a/tests/packages/sharedlib-in-package/mypkg/meson.build b/tests/packages/sharedlib-in-package/mypkg/meson.build
index 75904bed..cebf2d52 100644
--- a/tests/packages/sharedlib-in-package/mypkg/meson.build
+++ b/tests/packages/sharedlib-in-package/mypkg/meson.build
@@ -2,37 +2,17 @@
 #
 # SPDX-License-Identifier: MIT
 
-if meson.get_compiler('c').get_id() in ['msvc', 'clang-cl', 'intel-cl']
-    export_dll_args = ['-DMYPKG_DLL_EXPORTS']
-    import_dll_args = ['-DMYPKG_DLL_IMPORTS']
-else
-    export_dll_args = []
-    import_dll_args = []
-endif
-
-example_lib = shared_library(
-    'examplelib',
-    'examplelib.c',
-    c_args: export_dll_args,
-    install: true,
-    install_dir: py.get_install_dir() / 'mypkg',
-)
-
-example_lib_dep = declare_dependency(
-    compile_args: import_dll_args,
-    link_with: example_lib,
-)
-
-subdir('sub')
-
 py.extension_module(
     '_example',
     '_examplemod.c',
-    dependencies: [example_lib_dep, example_lib2_dep],
-    include_directories: 'sub',
+    dependencies: lib_dep,
     install: true,
     subdir: 'mypkg',
-    install_rpath: '$ORIGIN',
+    # install_rpath is not exposed in the Meson introspection data in Meson
+    # versions prior to 1.6.0 and thus cannot be set by meson-python when
+    # building the Python wheel. Use link_args to set the RPATH.
+    # install_rpath: f'@origin@',
+    link_args: f'-Wl,-rpath,@origin@',
 )
 
 py.install_sources(
diff --git a/tests/packages/sharedlib-in-package/mypkg/sub/examplelib2.h b/tests/packages/sharedlib-in-package/mypkg/sub/examplelib2.h
deleted file mode 100644
index 64b6a907..00000000
--- a/tests/packages/sharedlib-in-package/mypkg/sub/examplelib2.h
+++ /dev/null
@@ -1,7 +0,0 @@
-// SPDX-FileCopyrightText: 2022 The meson-python developers
-//
-// SPDX-License-Identifier: MIT
-
-#include "mypkg_dll.h"
-
-MYPKG_DLL int prod(int a, int b);
diff --git a/tests/packages/sharedlib-in-package/src/lib.c b/tests/packages/sharedlib-in-package/src/lib.c
new file mode 100644
index 00000000..e4fe1478
--- /dev/null
+++ b/tests/packages/sharedlib-in-package/src/lib.c
@@ -0,0 +1,10 @@
+// SPDX-FileCopyrightText: 2022 The meson-python developers
+//
+// SPDX-License-Identifier: MIT
+
+#include "lib.h"
+#include "sublib.h"
+
+int prodsum(int a, int b, int x) {
+    return prod(a,  x) + b;
+}
diff --git a/tests/packages/sharedlib-in-package/src/lib.h b/tests/packages/sharedlib-in-package/src/lib.h
new file mode 100644
index 00000000..fb6a02d8
--- /dev/null
+++ b/tests/packages/sharedlib-in-package/src/lib.h
@@ -0,0 +1,13 @@
+// SPDX-FileCopyrightText: 2022 The meson-python developers
+//
+// SPDX-License-Identifier: MIT
+
+#if defined(MYPKG_DLL_EXPORTS)
+    #define EXPORT __declspec(dllexport)
+#elif defined(MYPKG_DLL_IMPORTS)
+    #define EXPORT __declspec(dllimport)
+#else
+    #define EXPORT
+#endif
+
+EXPORT int prodsum(int a, int b, int x);
diff --git a/tests/packages/sharedlib-in-package/src/meson.build b/tests/packages/sharedlib-in-package/src/meson.build
new file mode 100644
index 00000000..b673ef29
--- /dev/null
+++ b/tests/packages/sharedlib-in-package/src/meson.build
@@ -0,0 +1,44 @@
+# SPDX-FileCopyrightText: 2022 The meson-python developers
+#
+# SPDX-License-Identifier: MIT
+
+if meson.get_compiler('c').get_id() in ['msvc', 'clang-cl', 'intel-cl']
+    export_dll_args = ['-DMYPKG_DLL_EXPORTS']
+    import_dll_args = ['-DMYPKG_DLL_IMPORTS']
+else
+    export_dll_args = []
+    import_dll_args = []
+endif
+
+sublib = shared_library(
+    'sublib',
+    'sublib.c',
+    c_args: export_dll_args,
+    install: true,
+    install_dir: py.get_install_dir() / 'mypkg/sub',
+)
+
+sublib_dep = declare_dependency(
+    compile_args: import_dll_args,
+    link_with: sublib,
+)
+
+lib = shared_library(
+    'lib',
+    'lib.c',
+    dependencies: sublib_dep,
+    c_args: export_dll_args,
+    install: true,
+    install_dir: py.get_install_dir() / 'mypkg',
+    # install_rpath is not exposed in the Meson introspection data in Meson
+    # versions prior to 1.6.0 and thus cannot be set by meson-python when
+    # building the Python wheel. Use link_args to set the RPATH.
+    # install_rpath: f'@origin@/sub',
+    link_args: f'-Wl,-rpath,@origin@/sub',
+)
+
+lib_dep = declare_dependency(
+    compile_args: import_dll_args,
+    link_with: lib,
+    include_directories: include_directories('.'),
+)
diff --git a/tests/packages/sharedlib-in-package/mypkg/sub/examplelib2.c b/tests/packages/sharedlib-in-package/src/sublib.c
similarity index 66%
rename from tests/packages/sharedlib-in-package/mypkg/sub/examplelib2.c
rename to tests/packages/sharedlib-in-package/src/sublib.c
index 12f5b87a..facfdf2e 100644
--- a/tests/packages/sharedlib-in-package/mypkg/sub/examplelib2.c
+++ b/tests/packages/sharedlib-in-package/src/sublib.c
@@ -2,8 +2,8 @@
 //
 // SPDX-License-Identifier: MIT
 
-#include "mypkg_dll.h"
+#include "sublib.h"
 
-MYPKG_DLL int prod(int a, int b) {
+int prod(int a, int b) {
     return a * b;
 }
diff --git a/tests/packages/sharedlib-in-package/src/sublib.h b/tests/packages/sharedlib-in-package/src/sublib.h
new file mode 100644
index 00000000..9fc7ae51
--- /dev/null
+++ b/tests/packages/sharedlib-in-package/src/sublib.h
@@ -0,0 +1,13 @@
+// SPDX-FileCopyrightText: 2022 The meson-python developers
+//
+// SPDX-License-Identifier: MIT
+
+#if defined(MYPKG_DLL_EXPORTS)
+    #define EXPORT __declspec(dllexport)
+#elif defined(MYPKG_DLL_IMPORTS)
+    #define EXPORT __declspec(dllimport)
+#else
+    #define EXPORT
+#endif
+
+EXPORT int prod(int a, int b);
diff --git a/tests/test_wheel.py b/tests/test_wheel.py
index b6f64cee..d118a4e0 100644
--- a/tests/test_wheel.py
+++ b/tests/test_wheel.py
@@ -178,15 +178,50 @@ def test_local_lib(venv, wheel_link_against_local_lib):
     assert int(output) == 3
 
 
+@pytest.mark.skipif(sys.platform in {'win32', 'cygwin'}, reason='requires RPATH support')
+def test_sharedlib_in_package_rpath(wheel_sharedlib_in_package, tmp_path):
+    artifact = wheel.wheelfile.WheelFile(wheel_sharedlib_in_package)
+    artifact.extractall(tmp_path)
+
+    origin = '@loader_path' if sys.platform == 'darwin' else '$ORIGIN'
+
+    rpath = set(mesonpy._rpath._get_rpath(tmp_path / 'mypkg' / f'_example{EXT_SUFFIX}'))
+    # This RPATH entry should be removed by meson-python but it is not.
+    build_rpath = {f'{origin}/../src'}
+    assert rpath == {origin, *build_rpath}
+
+    rpath = set(mesonpy._rpath._get_rpath(tmp_path / 'mypkg' / f'liblib{LIB_SUFFIX}'))
+    # This RPATH entry should be removed by meson-python but it is not.
+    build_rpath = {f'{origin}/'}
+    assert rpath == {f'{origin}/sub', *build_rpath}
+
+    rpath = set(mesonpy._rpath._get_rpath(tmp_path / 'mypkg' / 'sub' / f'libsublib{LIB_SUFFIX}'))
+    assert rpath == set()
+
+
+@pytest.mark.skipif(sys.platform in {'win32', 'cygwin'}, reason='requires RPATH support')
+def test_sharedlib_in_package_rpath_ldflags(package_sharedlib_in_package, tmp_path, monkeypatch):
+    origin = '@loader_path' if sys.platform == 'darwin' else '$ORIGIN'
+    extra_rpath = {f'{origin}/test-ldflags', '/usr/lib/test-ldflags'}
+    ldflags = ' '.join(f'-Wl,-rpath,{p}' for p in extra_rpath)
+    monkeypatch.setenv('LDFLAGS', ldflags)
+
+    filename = mesonpy.build_wheel(tmp_path)
+    artifact = wheel.wheelfile.WheelFile(tmp_path / filename)
+    artifact.extractall(tmp_path)
+
+    for path in f'_example{EXT_SUFFIX}', f'liblib{LIB_SUFFIX}', f'sub/libsublib{LIB_SUFFIX}':
+        rpath = set(mesonpy._rpath._get_rpath(tmp_path / 'mypkg' / path))
+        assert extra_rpath <= rpath
+
+
 def test_sharedlib_in_package(venv, wheel_sharedlib_in_package):
     venv.pip('install', wheel_sharedlib_in_package)
-    output = venv.python('-c', 'import mypkg; print(mypkg.example_sum(2, 5))')
-    assert int(output) == 7
-    output = venv.python('-c', 'import mypkg; print(mypkg.example_prod(6, 7))')
-    assert int(output) == 42
+    output = venv.python('-c', 'import mypkg; print(mypkg.prodsum(2, 3, 4))')
+    assert int(output) == 11
 
 
-@pytest.mark.skipif(MESON_VERSION < (1, 3, 0), reason='Meson version too old')
+@pytest.mark.skipif(MESON_VERSION < (1, 3, 0), reason='meson too old')
 def test_link_library_in_subproject(venv, wheel_link_library_in_subproject):
     venv.pip('install', wheel_link_library_in_subproject)
     output = venv.python('-c', 'import foo; print(foo.example_sum(3, 6))')
@@ -194,7 +229,7 @@ def test_link_library_in_subproject(venv, wheel_link_library_in_subproject):
 
 
 @pytest.mark.skipif(sys.platform in {'win32', 'cygwin'}, reason='requires RPATH support')
-def test_rpath(wheel_link_against_local_lib, tmp_path):
+def test_link_against_local_lib_rpath(wheel_link_against_local_lib, tmp_path):
     artifact = wheel.wheelfile.WheelFile(wheel_link_against_local_lib)
     artifact.extractall(tmp_path)
 
@@ -202,9 +237,26 @@ def test_rpath(wheel_link_against_local_lib, tmp_path):
     expected = {f'{origin}/../.link_against_local_lib.mesonpy.libs', 'custom-rpath',}
 
     rpath = set(mesonpy._rpath._get_rpath(tmp_path / 'example' / f'_example{EXT_SUFFIX}'))
-    # Verify that rpath is a superset of the expected one: linking to
-    # the Python runtime may require additional rpath entries.
-    assert rpath >= expected
+    assert rpath == expected
+
+
+@pytest.mark.skipif(sys.platform in {'win32', 'cygwin'}, reason='requires RPATH support')
+def test_link_against_local_lib_rpath_ldflags(package_link_against_local_lib, tmp_path, monkeypatch):
+    origin = '@loader_path' if sys.platform == 'darwin' else '$ORIGIN'
+    extra_rpath = {f'{origin}/test-ldflags', '/usr/lib/test-ldflags'}
+    ldflags = ' '.join(f'-Wl,-rpath,{p}' for p in extra_rpath)
+    monkeypatch.setenv('LDFLAGS', ldflags)
+
+    filename = mesonpy.build_wheel(tmp_path)
+    artifact = wheel.wheelfile.WheelFile(tmp_path / filename)
+    artifact.extractall(tmp_path)
+
+    # The RPATH entry relative to $ORIGIN added via $LDFLAGS is
+    # erroneusly stripped by meson-python.
+    extra_rpath = {'/usr/lib/test-ldflags',}
+
+    rpath = set(mesonpy._rpath._get_rpath(tmp_path / 'example' / f'_example{EXT_SUFFIX}'))
+    assert extra_rpath <= rpath
 
 
 @pytest.mark.skipif(sys.platform in {'win32', 'cygwin'}, reason='requires RPATH support')