tree-config.ts

// Auto-generated tree configuration with metadata
export const treeConfig = {
  "name": "dfda-wiki",
  "type": "directory",
  "path": ".",
  "children": [
    {
      "name": "01-problem.md",
      "type": "file",
      "path": "01-problem.md",
      "children": [],
      "metadata": {
        "description": "You and Everyone You Love Will Suffer and Die.",
        "emoji": "💀",
        "title": "Problems We Can Solve with a Decentralized FDA",
        "number": "150k",
        "textFollowingNumber": "people die every day from possibly preventable degenerative diseases",
        "tags": "global-health, chronic-diseases, preventable-deaths, healthcare-spending",
        "published": true,
        "editor": "markdown",
        "date": "2025-02-11T13:38:21.578Z",
        "dateCreated": "2025-02-11T13:38:21.578Z"
      }
    },
    {
      "name": "02-solution.md",
      "type": "file",
      "path": "02-solution.md",
      "children": [],
      "metadata": {
        "description": "How we reduce suffering using a decentralized autonomous organization as a vehicle to use the oceans of real-world evidence to discover new cures.",
        "emoji": "🎯",
        "title": "Personalized Precision Medicine Framework",
        "tags": "precision-medicine, insilico-models, machine-learning, genomics, transcriptomics, proteomics, metabolomics, microbiomics, phenotype",
        "published": true,
        "editor": "markdown",
        "date": "2025-02-11T14:02:49.420Z",
        "dateCreated": "2025-02-11T14:02:49.420Z"
      }
    },
    {
      "name": "03-platform.md",
      "type": "file",
      "path": "03-platform.md",
      "children": [],
      "metadata": {
        "title": "🏭 Platform",
        "description": "A detailed description of the core open-source platform and plugin framework that will enable the transformation of data into clinical discoveries.",
        "published": true,
        "date": "2025-02-18T05:14:54.240Z",
        "tags": "clinical-trials, health-data, decentralization, digital-health, interoperability, ehr-systems",
        "editor": "markdown",
        "dateCreated": "2023-11-07T19:01:19.907Z"
      }
    },
    {
      "name": "SITEMAP.md",
      "type": "file",
      "path": "SITEMAP.md",
      "children": [],
      "metadata": {
        "title": "DFDA Wiki Sitemap",
        "description": "Comprehensive navigation structure for the DFDA Wiki",
        "lastUpdated": "2024-02-09",
        "status": "live"
      }
    },
    {
      "name": "benefits",
      "type": "directory",
      "path": "benefits",
      "children": [
        {
          "name": "cost-savings-from-decentralized-clinical-trials.md",
          "type": "file",
          "path": "benefits/cost-savings-from-decentralized-clinical-trials.md",
          "children": [],
          "metadata": {
            "description": "Decentralized Clinical Trials Can Achieve Net Financial Benefits of 5X to 14X, Due to Reduced Trial Timelines and Other Factors",
            "emoji": "🌍",
            "title": "Cost Savings from Decentralized Clinical Trials",
            "tags": "decentralized-clinical-trials, cost-savings, financial-benefits, trial-timelines",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-11T15:30:36.846Z",
            "dateCreated": "2025-02-11T15:30:36.847Z"
          }
        },
        {
          "name": "faster-progress.md",
          "type": "file",
          "path": "benefits/faster-progress.md",
          "children": [],
          "metadata": {
            "number": "20X",
            "textFollowingNumber": "the rate of treatment discovery",
            "title": "20X the Speed of Curing Diseases",
            "description": "By reducing the cost of clinical trials by 95%, we can run 20 times more trials with the same resources, dramatically accelerating the discovery of new treatments and cures.",
            "emoji": "🚀",
            "featuredImage": "cost-per-participant.jpg",
            "source": "https://dfda.earth#cost-savings",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-09T16:20:32.118Z",
            "dateCreated": "2025-02-09T16:20:32.118Z"
          }
        },
        {
          "name": "improving-treatment-affordability-and-accessibility.md",
          "type": "file",
          "path": "benefits/improving-treatment-affordability-and-accessibility.md",
          "children": [],
          "metadata": {
            "description": "How the proposed decentralized FDA system could dramatically improve affordability and accessibility of treatments for patients through cost reductions, price competition, and faster access",
            "emoji": "💰",
            "title": "Improving Treatment Affordability and Accessibility",
            "tags": "affordability, accessibility, drug-prices, cost-reduction, patient-benefits",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-15T14:30:00.236Z",
            "dateCreated": "2025-02-15T14:30:00.236Z"
          }
        },
        {
          "name": "lower-costs-of-validated-observational-research-for-efficacy.md",
          "type": "file",
          "path": "benefits/lower-costs-of-validated-observational-research-for-efficacy.md",
          "children": [],
          "metadata": {
            "description": "Observational real-world evidence-based studies have several advantages over randomized, controlled trials, including lower cost, increased speed of research, and a broader range of patients.",
            "emoji": "👀",
            "title": "Lower Costs of Validated Observational Research for Efficacy",
            "tags": "observational-research, cost-effectiveness, real-world-evidence, meta-analyses, clinical-studies",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-12T15:32:45.179Z",
            "dateCreated": "2025-02-12T15:32:45.179Z"
          }
        },
        {
          "name": "lower-costs.md",
          "type": "file",
          "path": "benefits/lower-costs.md",
          "children": [],
          "metadata": {
            "number": "95%",
            "textFollowingNumber": "lower costs of clinical trials and treatments",
            "title": "95% Lower Costs of Clinical Trials and Treatments",
            "description": "By automating clinical trials and treatments, we can reduce costs by 95%",
            "emoji": "📉",
            "featuredImage": "cost-per-participant.jpg",
            "source": "https://dfda.earth#cost-savings",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-09T16:20:32.127Z",
            "dateCreated": "2025-02-09T16:20:32.127Z"
          }
        },
        {
          "name": "lower-drug-prices.md",
          "type": "file",
          "path": "benefits/lower-drug-prices.md",
          "children": [],
          "metadata": {
            "title": "Lower Drug Prices",
            "description": "Below is a deeper quantitative analysis of how drastically cheaper trials and increased competition (including off-patent/unpatentable compounds) could push drug prices down.",
            "emoji": "🤑",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-09T16:20:32.129Z",
            "dateCreated": "2025-02-09T16:20:32.129Z"
          }
        },
        {
          "name": "more-cures-and-less-lifelong-attempts-at-masking-symptoms.md",
          "type": "file",
          "path": "benefits/more-cures-and-less-lifelong-attempts-at-masking-symptoms.md",
          "children": [],
          "metadata": {
            "description": "High Costs Punish Finding Cures Over Masking Symptoms Since Cures Are Far Less Profitable Than Lifetime Treatments",
            "emoji": "💰",
            "title": "Economic Incentives for Medical Cures vs Symptom Management",
            "tags": "medical-economics, drug-development, cures, symptom-management, R&D",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-12T15:33:40.236Z",
            "dateCreated": "2025-02-12T15:33:40.236Z"
          }
        },
        {
          "name": "overall-economic-benefits.md",
          "type": "file",
          "path": "benefits/overall-economic-benefits.md",
          "children": [],
          "metadata": {
            "title": "Overall Economic Benefits",
            "description": "Quantitative analysis of global economic benefits from decentralized clinical trials and automated FDA processes",
            "emoji": "📈",
            "toc": true,
            "published": true,
            "editor": "markdown",
            "date": "2025-02-09T16:20:32.132Z",
            "dateCreated": "2025-02-09T16:20:32.132Z"
          }
        },
        {
          "name": "patient-participation.md",
          "type": "file",
          "path": "benefits/patient-participation.md",
          "children": [],
          "metadata": {
            "number": "100%",
            "textFollowingNumber": "of patients can participate in trials",
            "title": "100% Patient Participation in Trials",
            "description": "By removing traditional barriers and using decentralized trials, we can include the 100% of patients typically excluded from clinical research",
            "emoji": "🌍",
            "featuredImage": "patient-participation.jpg",
            "source": "https://dfda.earth",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-09T16:20:32.136Z",
            "dateCreated": "2025-02-09T16:20:32.136Z"
          }
        },
        {
          "name": "time-to-treatment.md",
          "type": "file",
          "path": "benefits/time-to-treatment.md",
          "children": [],
          "metadata": {
            "number": "2 Years",
            "textFollowingNumber": "instead of 17 years to get new treatments to patients",
            "title": "17 years to 2 Year From Research to Treatment",
            "description": "By streamlining the clinical trial process through automation and decentralization, we can reduce the time from initial research to patient availability from 17 years to just 2 years",
            "emoji": "⚡",
            "featuredImage": "treatment-time.jpg",
            "source": "https://dfda.earth",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-09T16:20:32.141Z",
            "dateCreated": "2025-02-09T16:20:32.141Z"
          }
        }
      ]
    },
    {
      "name": "blueprint",
      "type": "directory",
      "path": "blueprint",
      "children": [
        {
          "name": "blueprint-gas.md",
          "type": "file",
          "path": "blueprint/blueprint-gas.md",
          "children": [],
          "metadata": {
            "description": "A system of incentivized actions to promote the adoption of a global blueprint, including rewards for optimizing the blueprint and generating public support.",
            "emoji": "🤝",
            "title": "Incentivized Actions for Global Blueprint Adoption",
            "tags": "global-blueprint, incentives, public-support, blueprint-optimization",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-12T16:46:56.763Z",
            "dateCreated": "2025-02-12T16:46:56.763Z"
          }
        },
        {
          "name": "blueprint-high-level.md",
          "type": "file",
          "path": "blueprint/blueprint-high-level.md",
          "children": [],
          "metadata": {
            "description": "A framework for envisioning and implementing a world without disease, including defining the ideal, creating a roadmap, seeking global consent, and enacting legal reforms.",
            "emoji": "🌍",
            "title": "Framework for a World Without Disease",
            "tags": "disease-eradication, global-health, policy, framework",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-12T16:47:32.477Z",
            "dateCreated": "2025-02-12T16:47:32.477Z"
          }
        },
        {
          "name": "blueprint-sitemap.md",
          "type": "file",
          "path": "blueprint/blueprint-sitemap.md",
          "children": [],
          "metadata": {
            "description": "A proposal to shift healthcare focus from treating diseases to preventing and curing them, with a plan involving global participation and legislative change.",
            "emoji": "🌍",
            "title": "Blueprint for a World Without Disease",
            "tags": "healthcare-reform, disease-prevention, global-initiatives, public-health",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-12T16:50:24.919Z",
            "dateCreated": "2025-02-12T16:50:24.919Z"
          }
        },
        {
          "name": "blueprint-strategy.md",
          "type": "file",
          "path": "blueprint/blueprint-strategy.md",
          "children": [],
          "metadata": {
            "description": "A strategy for reducing disease by collecting global health data, empowering patient choice, incentivizing cures, and involving all stakeholders.",
            "emoji": "🌍",
            "title": "Strategy for a World Without Disease",
            "tags": "global-health, data-collection, patient-empowerment, disease-prevention, healthcare-innovation",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-12T16:50:31.159Z",
            "dateCreated": "2025-02-12T16:50:31.159Z"
          }
        },
        {
          "name": "blueprint-summary.md",
          "type": "file",
          "path": "blueprint/blueprint-summary.md",
          "children": [],
          "metadata": {
            "description": "An overview of the unnecessary suffering caused by current healthcare and regulatory systems, highlighting specific examples of preventable pain and disease.",
            "emoji": "🚫",
            "title": "Creating a World Without Disease",
            "tags": "healthcare, regulatory-systems, disease-prevention, FDA",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-12T16:50:53.964Z",
            "dateCreated": "2025-02-12T16:50:53.964Z"
          }
        },
        {
          "name": "blueprint.md",
          "type": "file",
          "path": "blueprint/blueprint.md",
          "children": [],
          "metadata": {
            "description": "Analysis of the preventable suffering caused by systemic issues in healthcare and drug development",
            "emoji": "🩺",
            "title": "Creating a World Without Disease",
            "tags": "healthcare, drug-development, regulatory-system, disease-prevention",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-12T16:51:17.425Z",
            "dateCreated": "2025-02-12T16:51:17.425Z"
          }
        }
      ]
    },
    {
      "name": "clinical-trials",
      "type": "directory",
      "path": "clinical-trials",
      "children": [
        {
          "name": "decentralized-methods",
          "type": "directory",
          "path": "clinical-trials/decentralized-methods",
          "children": [
            {
              "name": "desci-ai-dao.md",
              "type": "file",
              "path": "clinical-trials/decentralized-methods/desci-ai-dao.md",
              "children": [],
              "metadata": {
                "title": "DeSci DAO AI Agent Framework",
                "description": "How to create a truly autonomous DAO that actually accelerates scientific progress",
                "published": true,
                "date": "2023-07-23T19:59:32.942Z",
                "tags": "dao, ai, automation, desci",
                "editor": "markdown",
                "dateCreated": "2023-07-22T20:42:01.243Z"
              }
            }
          ]
        },
        {
          "name": "methodologies",
          "type": "directory",
          "path": "clinical-trials/methodologies",
          "children": [
            {
              "name": "definitions.md",
              "type": "file",
              "path": "clinical-trials/methodologies/definitions.md",
              "children": [],
              "metadata": {
                "description": "Precise definitions of relevant terms used",
                "emoji": "📚",
                "title": "📖Key Definitions",
                "tags": "healthcare, interventions, efficacy, effectiveness, definitions",
                "published": true,
                "editor": "markdown",
                "date": "2022-07-26T02:40:33.718Z",
                "dateCreated": "2022-07-22T19:05:03.787Z"
              }
            }
          ]
        },
        {
          "name": "protocols",
          "type": "directory",
          "path": "clinical-trials/protocols",
          "children": [
            {
              "name": "crowdsourcing-longevity-research.md",
              "type": "file",
              "path": "clinical-trials/protocols/crowdsourcing-longevity-research.md",
              "children": [],
              "metadata": {
                "title": "Experimental Protocol for Crowdsourcing Longevity Research",
                "description": "An experimental protocol for crowdsourcing longevity research for a random intervention and collecting outcome data to characterize the participant's overall health status using affordable and valuable collection methods",
                "published": true,
                "date": "2023-06-21T04:49:22.560Z",
                "tags": "longevity, experimental protocols",
                "editor": "markdown",
                "dateCreated": "2023-06-21T04:49:22.560Z"
              }
            }
          ]
        }
      ]
    },
    {
      "name": "community",
      "type": "directory",
      "path": "community",
      "children": [
        {
          "name": "CONTRIBUTING.md",
          "type": "file",
          "path": "community/CONTRIBUTING.md",
          "children": [],
          "metadata": {
            "description": "Guidelines for contributing to the Community Directory, including steps for getting started and making contributions via pull requests.",
            "emoji": "🤝",
            "title": "Contributing to the Community Directory",
            "tags": "dFDA, community-directory, contributing, open-source",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-12T16:51:44.377Z",
            "dateCreated": "2025-02-12T16:51:44.377Z"
          }
        },
        {
          "name": "README.md",
          "type": "file",
          "path": "community/README.md",
          "children": [],
          "metadata": {
            "description": "A directory to facilitate collaboration among stakeholders in the project",
            "emoji": "👥",
            "title": "Community Directory",
            "tags": "dFDA, community, collaboration, decentralized-health, regulatory-processes",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-12T16:52:13.974Z",
            "dateCreated": "2025-02-12T16:52:13.974Z"
          }
        },
        {
          "name": "community_volunteers",
          "type": "directory",
          "path": "community/community_volunteers",
          "children": [
            {
              "name": "README.md",
              "type": "file",
              "path": "community/community_volunteers/README.md",
              "children": [],
              "metadata": {
                "description": "A directory for community volunteers contributing to the project, providing resources and guidance for involvement.",
                "emoji": "🤝",
                "title": "Community Volunteers Directory",
                "tags": "volunteers, community, contribution",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T16:51:40.444Z",
                "dateCreated": "2025-02-12T16:51:40.444Z"
              }
            }
          ]
        },
        {
          "name": "developers",
          "type": "directory",
          "path": "community/developers",
          "children": [
            {
              "name": "README.md",
              "type": "file",
              "path": "community/developers/README.md",
              "children": [],
              "metadata": {
                "description": "A directory for developers, data scientists, and AI experts contributing to the technical development of the project.",
                "emoji": "💻",
                "title": "Developers Directory",
                "tags": "developers, software, data-science, AI, community",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T16:51:47.494Z",
                "dateCreated": "2025-02-12T16:51:47.494Z"
              }
            }
          ]
        },
        {
          "name": "funding_sources",
          "type": "directory",
          "path": "community/funding_sources",
          "children": [
            {
              "name": "README.md",
              "type": "file",
              "path": "community/funding_sources/README.md",
              "children": [],
              "metadata": {
                "description": "A directory for funding sources interested in supporting initiatives within the project, providing information on funding opportunities and facilitating connections between funders and project teams.",
                "emoji": "💰",
                "title": "Funding Sources Directory",
                "tags": "funding, investors, philanthropy, grants",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T16:51:51.033Z",
                "dateCreated": "2025-02-12T16:51:51.033Z"
              }
            }
          ]
        },
        {
          "name": "governance",
          "type": "directory",
          "path": "community/governance",
          "children": [
            {
              "name": "dfda-collaboration-framework.md",
              "type": "file",
              "path": "community/governance/dfda-collaboration-framework.md",
              "children": [],
              "metadata": {
                "description": "A coordination framework for facilitating cooperation, communication, and collaborative actions among stakeholders in clinical discovery and health outcomes.",
                "emoji": "🤝",
                "title": "dFDA Collaboration Framework",
                "tags": "coordination-framework, clinical-discovery, stakeholder-collaboration, health-outcomes",
                "published": true,
                "editor": "markdown",
                "date": "2023-10-28T22:44:51.813Z",
                "dateCreated": "2023-10-28T22:42:49.138Z"
              }
            }
          ]
        },
        {
          "name": "healthcare_providers",
          "type": "directory",
          "path": "community/healthcare_providers",
          "children": [
            {
              "name": "README.md",
              "type": "file",
              "path": "community/healthcare_providers/README.md",
              "children": [],
              "metadata": {
                "description": "A directory for healthcare providers including hospitals, clinics, and health apps involved in the project",
                "emoji": "🏥",
                "title": "Healthcare Providers Directory",
                "tags": "healthcare-providers, community-directory, collaboration",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T16:51:55.194Z",
                "dateCreated": "2025-02-12T16:51:55.194Z"
              }
            }
          ]
        },
        {
          "name": "industry_stakeholders",
          "type": "directory",
          "path": "community/industry_stakeholders",
          "children": [
            {
              "name": "README.md",
              "type": "file",
              "path": "community/industry_stakeholders/README.md",
              "children": [],
              "metadata": {
                "description": "A directory for industry stakeholders including pharmaceutical companies, insurance companies, biotech firms, and medical device manufacturers contributing to the project.",
                "emoji": "👥",
                "title": "Industry Stakeholders Directory",
                "tags": "fda-community, stakeholders, pharmaceuticals, biotech, medical-devices, insurance, decentralized-fda",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T16:51:58.855Z",
                "dateCreated": "2025-02-12T16:51:58.855Z"
              }
            }
          ]
        },
        {
          "name": "open-source-projects",
          "type": "directory",
          "path": "community/open-source-projects",
          "children": [
            {
              "name": "open-source-projects.md",
              "type": "file",
              "path": "community/open-source-projects/open-source-projects.md",
              "children": [],
              "metadata": {
                "description": "A list of open-source projects aimed at accelerating clinical discovery relevant to the dFDA's mission.",
                "emoji": "💻",
                "title": "Open Source Projects for Clinical Discovery",
                "tags": "open-source, clinical-discovery, projects",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T16:52:01.808Z",
                "dateCreated": "2025-02-12T16:52:01.808Z"
              }
            }
          ]
        },
        {
          "name": "opencures.md",
          "type": "file",
          "path": "community/opencures.md",
          "children": [],
          "metadata": {
            "description": "OpenCures is a platform that accelerates intervention development by empowering individuals with advanced personal health management tools and connecting them to research through data ownership, biobanking, and trial management services.",
            "emoji": "🩸",
            "title": "OpenCures",
            "tags": "health-data, biobanking, clinical-trials, personal-health-management, research",
            "published": true,
            "editor": "markdown",
            "date": "2022-08-26T20:24:32.745Z",
            "dateCreated": "2022-07-27T21:22:28.927Z"
          }
        },
        {
          "name": "partners",
          "type": "directory",
          "path": "community/partners",
          "children": [
            {
              "name": "README.md",
              "type": "file",
              "path": "community/partners/README.md",
              "children": [],
              "metadata": {
                "description": "A directory for partners involved in the project, providing a space for organizations to introduce themselves, share their roles, and facilitate collaboration.",
                "emoji": "🤝",
                "title": "Partners Directory",
                "tags": "partners, collaboration, community-directory",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T16:52:04.915Z",
                "dateCreated": "2025-02-12T16:52:04.915Z"
              }
            },
            {
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                "description": "An Act to revolutionize healthcare through AI and data analysis, focusing on personalized health optimization, accelerated clinical discovery, and global health equity.",
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                "description": "An autonomous FDAi agent's role in collecting symptom data, analyzing food and drug effects, optimizing diet and supplements, and exploring clinical trials.",
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                "description": "Exploration of automating clinical research and its potential cost savings with automated data collection methods.",
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                "description": "A petition advocating for the creation of the FDAi system to revolutionize healthcare using AI.",
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                "description": "Exploration of the potential benefits of personal FDAi agents in addressing health issues caused by untested chemicals and poor diets.",
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                "description": "Discussion between a patient and the FDAi agent about health concerns linked to dietary factors.",
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                "date": "2025-02-09T16:35:09.090Z",
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          "path": "features/global-health-unifier-agent.md",
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            "description": "A global health agent that accelerates medical progress through the Disease Eradication Act by coordinating decentralized clinical trials and automating research validation.",
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            "description": "The Human File System Protocol SDK is a suite of interoperable software libraries, meticulously designed to facilitate the creation of user-access controlled digital twins on the blockchain.",
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            "title": "Human File System",
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            "date": "2025-02-12T16:53:09.454Z",
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          "metadata": {
            "description": "Gamification to Incentivize Healthy Behaviour",
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            "title": "Life Force Score",
            "tags": "digital-twins, nft, metaverse, health-data, gaming",
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            "description": "A platform for creating health data collection and analysis applications without coding skills.",
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          "metadata": {
            "description": "Web and mobile push notifications with action buttons for recording treatments and symptoms without opening the app, available on Android, iOS, and desktop browsers.",
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            "description": "A plugin for conducting observational studies, which are used to collect data and identify relationships between variables without intervention.",
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            "description": "Optimitron is an AI agent within PersonalFDA nodes that uses causal inference to analyze health factors and provide personalized recommendations.",
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          "metadata": {
            "description": "Proposal for replacing traditional nutrition labels with outcome labels to better inform consumers about health impacts",
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            "title": "🏷 Outcome Labels Plugin",
            "tags": "nutrition, health-outcomes, food-labels, public-health",
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            "date": "2022-08-28T15:12:30.345Z",
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          "metadata": {
            "description": "Introduction to Outcome Labels, a new approach to food and product labeling focusing on health outcomes and symptoms rather than micronutrients.",
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            "tags": "health, nutrition, food-labels, chronic-disease, innovation",
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            "date": "2025-02-12T16:53:22.107Z",
            "dateCreated": "2025-02-12T16:53:22.107Z"
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          "name": "personal-fda-nodes.md",
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          "path": "features/personal-fda-nodes.md",
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          "metadata": {
            "description": "PersonalFDA Nodes are applications that run on personal devices to store and analyze health data using a Digital Twin Safe and an AI agent called Optimitron.",
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            "title": "PersonalFDA Nodes",
            "tags": "personal-health, data-analysis, AI-agent, Digital-Twin-Safe, Optimitron",
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          "path": "features/predictor-search-engine.md",
          "children": [],
          "metadata": {
            "description": "A search engine plugin that uses aggregated user data to identify factors influencing health, offering personalized effectiveness rates of treatments.",
            "emoji": "🔍",
            "title": "Predictor Search Engine Plugin",
            "tags": "health, wellness, search-engine, personalized-medicine, data-aggregation",
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            "editor": "markdown",
            "date": "2025-02-12T16:53:28.700Z",
            "dateCreated": "2025-02-12T16:53:28.700Z"
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        },
        {
          "name": "root-cause-analysis-plugin.md",
          "type": "file",
          "path": "features/root-cause-analysis-plugin.md",
          "children": [],
          "metadata": {
            "description": "Reports are intended to help you and your physician to gain insight into the root causes and effective solutions to help you minimize your symptoms.",
            "emoji": " 自动生成的报告 📊",
            "title": "🥕 Root Cause Analysis Plugin",
            "tags": "root-cause-analysis, health, symptoms, CuroBot",
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            "date": "2022-08-28T15:10:37.898Z",
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        {
          "name": "root-cause-analysis-reports.md",
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          "path": "features/root-cause-analysis-reports.md",
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          "metadata": {
            "description": "Analysis of the failures in current clinical research systems leading to high costs and lack of data on non-patentable factors affecting chronic conditions",
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            "description": "A review agent responsible for analyzing study plausibility, validating data quality, and conducting temporality analysis in research studies.",
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    },
    {
      "name": "interventions",
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          "path": "interventions/focused-ultrasound.md",
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            "date": "2023-10-02T01:47:34.315Z",
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        },
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        "description": "A proposal for a decentralized autonomous FDA (dFDA) aiming to reduce clinical trial costs, provide personalized treatment recommendations, and ensure comprehensive transparency in drug evaluation.",
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          "metadata": {
            "description": "Overcoming Cognitive Bias Against Acts of Commission",
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            "date": "2022-07-28T03:57:38.074Z",
            "dateCreated": "2022-07-22T19:03:21.545Z"
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          "path": "problems/clinical-research-is-expensive.md",
          "children": [],
          "metadata": {
            "title": "Clinical Research is Expensive",
            "description": "It costs $1.6 billion to bring a drug to market (including failed attempts) and trials currently cost over $36k per participant.",
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            "featuredImage": "https://static.crowdsourcingcures.org/dfda/assets/cost-of-clinical-trials.png"
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          "path": "problems/clinical-research-is-slow.md",
          "children": [],
          "metadata": {
            "title": "Clinical Research is Slow",
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        },
        {
          "name": "clinical-research-is-too-expensive.md",
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          "children": [],
          "metadata": {
            "description": "It costs $2.6 billion to bring a drug to market (including failed attempts).",
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            "title": "💰 Clinical Research is Too Expensive",
            "tags": "clinical-research, costs, drug-development, phase-iii-trials",
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            "date": "2022-07-28T03:58:50.155Z",
            "dateCreated": "2022-07-22T19:03:26.235Z"
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          "type": "file",
          "path": "problems/conflicts-of-interest.md",
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          "metadata": {
            "description": "When billions of dollars in losses or gains are riding on the results of a study, this will almost inevitably influence the results.",
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            "editor": "markdown",
            "date": "2022-07-29T01:56:32.735Z",
            "dateCreated": "2022-07-22T19:03:31.052Z"
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            "title": "Deaths Due to US Regulatory Drug Lag",
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          "metadata": {
            "title": "90% of Willing Patients Do Not Participate in Clinical Trials",
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        {
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          "metadata": {
            "description": "A comparative analysis between countries suggests that delays in new interventions cost anywhere from 21,000 to 120, 000 US lives per decade.",
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            "editor": "markdown",
            "date": "2022-07-29T02:11:03.058Z",
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        },
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          "type": "file",
          "path": "problems/fda-decisions-not-based-on-cost-benefit-analysis.md",
          "children": [],
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            "title": "Lack of Logical Reasoning Based on Quantitative Cost-Benefit Analysis in FDA Decisions",
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          "metadata": {
            "description": "In the case of rare diseases, increasing the cost of treatment development to over a billion makes it impossible to recover your investment from a small number of patients.",
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            "editor": "markdown",
            "date": "2022-08-18T07:59:09.359Z",
            "dateCreated": "2022-07-22T19:03:45.469Z"
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          "metadata": {
            "description": "The 1962 efficacy amendment made drugs more expensive by granting longer monopolies.",
            "emoji": "🤖",
            "title": "🎩 Excessive Patent Monopolies",
            "tags": "content, tokens, efficiency",
            "published": true,
            "editor": "markdown",
            "date": "2022-07-29T01:55:49.553Z",
            "dateCreated": "2022-07-22T19:03:40.532Z"
          }
        },
        {
          "name": "negative-results-are-never-published.md",
          "type": "file",
          "path": "problems/negative-results-are-never-published.md",
          "children": [],
          "metadata": {
            "title": "Negative Results are Never Published",
            "description": "We waste billions of dollars repeating failed drug trials because companies only publish the positive results.",
            "emoji": "🙈"
          }
        },
        {
          "name": "no-comparative-effectiveness-rankings.md",
          "type": "file",
          "path": "problems/no-comparative-effectiveness-rankings.md",
          "children": [],
          "metadata": {
            "title": "No Treatment Effectiveness Rankings",
            "description": "Shockingly, the existing system does not give us a ranked list of the most safe and effective treatments for a given condition.",
            "emoji": "📊"
          }
        },
        {
          "name": "no-data-on-unpatentable-molecules.md",
          "type": "file",
          "path": "problems/no-data-on-unpatentable-molecules.md",
          "children": [],
          "metadata": {
            "title": "No Data on Unpatentable Treatments",
            "description": "We still know next to nothing about the long-term effects of 99.9% of the 4 pounds of over 7,000 different synthetic or natural chemicals you consume every day.",
            "emoji": "🥫",
            "featuredImage": "https://static.crowdsourcingcures.org/dfda/assets/how-much-we-know (1) (1) (1).png"
          }
        },
        {
          "name": "no-incentive-to-discover-benefits-of-off-patent-treatments.md",
          "type": "file",
          "path": "problems/no-incentive-to-discover-benefits-of-off-patent-treatments.md",
          "children": [],
          "metadata": {
            "description": "If a drug is found to be effective for other diseases after the patent has expired, no one has the financial incentive to get it approved for another disease.",
            "emoji": "🩺",
            "title": "📃 No Incentive to Discover Benefits of Off-Patent Treatments",
            "tags": "orphan-diseases, drug-approval, pharmaceuticals, clinical-trials",
            "published": true,
            "editor": "markdown",
            "date": "2022-08-18T08:00:43.662Z",
            "dateCreated": "2022-07-22T19:03:58.465Z"
          }
        },
        {
          "name": "no-long-term-outcome-data.md",
          "type": "file",
          "path": "problems/no-long-term-outcome-data.md",
          "children": [],
          "metadata": {
            "title": "No Long-Term Outcome Data",
            "description": "Current trials often only last a few months, so we have no idea what the long-term positive or negative effects of a drug are!",
            "emoji": "🗓"
          }
        },
        {
          "name": "people-with-rare-disease-are-severely-punished.md",
          "type": "file",
          "path": "problems/people-with-rare-disease-are-severely-punished.md",
          "children": [],
          "metadata": {
            "title": "People With Rare Disease are Severely Punished",
            "description": "It's impossible to recover a billion dollars of drug development from a small number of patients.",
            "emoji": "🤒"
          }
        },
        {
          "name": "pre-determining-clinical-endpoints-requires-psychic-powers.md",
          "type": "file",
          "path": "problems/pre-determining-clinical-endpoints-requires-psychic-powers.md",
          "children": [],
          "metadata": {
            "title": "Pre-Determining Clinical Endpoints Requires Psychic Powers",
            "description": "Drug Developers to Have Psychic Powers Needed to Pre-Determine Very Specific Clinical Endpoints Before Collecting Data",
            "emoji": "🔮"
          }
        },
        {
          "name": "problems-in-clinical-research.md",
          "type": "file",
          "path": "problems/problems-in-clinical-research.md",
          "children": [],
          "metadata": {
            "title": "Problems in Clinical Research",
            "description": "The existing regulatory framework for drug approval presents several challenges, hindering the efficiency and effectiveness of pharmaceutical research and public health.",
            "published": true,
            "date": "2023-10-26T19:50:44.089Z",
            "tags": "dfda, fda, problems, clinical research",
            "editor": "markdown",
            "dateCreated": "2023-10-26T19:50:44.089Z"
          }
        },
        {
          "name": "slowed-growth-in-life-expectancy.md",
          "type": "file",
          "path": "problems/slowed-growth-in-life-expectancy.md",
          "children": [],
          "metadata": {
            "description": "Following this new 70% reduction in the pace of medical progress, the growth in human lifespan was immediately cut in half to an increase of 2 years per decade.",
            "emoji": "📈",
            "title": "☠ Slowed Growth in Life Expectancy",
            "tags": "life-expectancy, medical-progress, diminishing-returns, regulations",
            "published": true,
            "editor": "markdown",
            "date": "2022-07-31T17:06:24.891Z",
            "dateCreated": "2022-07-22T19:04:12.318Z"
          }
        },
        {
          "name": "statistics",
          "type": "directory",
          "path": "problems/statistics",
          "children": [
            {
              "name": "cost-per-participant.md",
              "type": "file",
              "path": "problems/statistics/cost-per-participant.md",
              "children": [],
              "metadata": {
                "number": "$41k",
                "textFollowingNumber": "cost per participant in traditional clinical trials",
                "title": "Clinical Trials Cost $41,413 Per Trial Participant",
                "description": "The cost per participant in clinical trials is a staggering $41,413",
                "emoji": "👥",
                "featuredImage": "cost-per-participant.jpg",
                "source": "https://clinicalresearch.io/blog/running-a-study/cost-of-clinical-trials-breakdown/"
              }
            },
            {
              "name": "cost-per-treatment.md",
              "type": "file",
              "path": "problems/statistics/cost-per-treatment.md",
              "children": [],
              "metadata": {
                "number": "$1.6 Billion",
                "textFollowingNumber": "cost to develop a new treatment falls on patients",
                "title": "$1.6 Billion Per New Treatment Falls on Patients",
                "description": "The total cost passed to patients for each new medical treatment developed",
                "emoji": "💸",
                "featuredImage": "cost-per-treatment.jpg",
                "source": "https://www.genengnews.com/gen-edge/the-unbearable-cost-of-drug-development-deloitte-report-shows-15-jump-in-rd-to-2-3-billion/"
              }
            },
            {
              "name": "deaths-due-to-drug-lag.md",
              "type": "file",
              "path": "problems/statistics/deaths-due-to-drug-lag.md",
              "children": [],
              "metadata": {
                "number": "120,000 Deaths/Decade",
                "textFollowingNumber": "due to regulatory delays",
                "title": "120,000 US Deaths Per Decade Due to Drug Lag",
                "description": "Delays in FDA drug approvals compared to other countries result in up to 120,000 preventable deaths per decade",
                "emoji": "☠️",
                "featuredImage": "https://static.crowdsourcingcures.org/dfda/assets/us-swiss-life-expectancy-drug-approvals.png"
              }
            },
            {
              "name": "percent-excluded-from-trials.md",
              "type": "file",
              "path": "problems/statistics/percent-excluded-from-trials.md",
              "children": [],
              "metadata": {
                "number": "85%",
                "textFollowingNumber": "of patients are unable to participate in clinical trials",
                "title": "85% of Willing Participants Excluded from Trials",
                "description": "Clinical trials often exclude as much as 85% of patients so they don't tell us if the drug will work for the majority of patients.",
                "emoji": "🚫",
                "featuredImage": "https://static.crowdsourcingcures.org/dfda/assets/wellbutrin-effectiveness-small-sample-size.png"
              }
            },
            {
              "name": "percent-of-diseases-with-fda-approved-treatments.md",
              "type": "file",
              "path": "problems/statistics/percent-of-diseases-with-fda-approved-treatments.md",
              "children": [],
              "metadata": {
                "number": "95%",
                "textFollowingNumber": "of diseases have NO FDA-approved treatments",
                "title": "95% of Diseases Have NO FDA-Approved Treatments",
                "description": "Only 5% of diseases have FDA-approved treatments, leaving millions without effective therapies",
                "emoji": "💊",
                "featuredImage": "fda-treatments.jpg"
              }
            },
            {
              "name": "treatments-tested.md",
              "type": "file",
              "path": "problems/statistics/treatments-tested.md",
              "children": [],
              "metadata": {
                "number": "166 billion",
                "textFollowingNumber": "potential treatments have not been tested",
                "title": "166 billion potential treatments have not been tested",
                "description": "The vast number of potential drug combinations that exist, compared to the limited number that have been tested",
                "emoji": "⚛️",
                "featuredImage": "treatments-tested.jpg"
              }
            },
            {
              "name": "uncured-people.md",
              "type": "file",
              "path": "problems/statistics/uncured-people.md",
              "children": [],
              "metadata": {
                "number": "2 Billion",
                "textFollowingNumber": "people are suffering from uncured diseases",
                "title": "2 Billion People With Uncured Diseases",
                "description": "An estimated two billion people worldwide live with chronic diseases and rare conditions that currently have no cure",
                "emoji": "🌍",
                "featuredImage": "uncured-people.jpg"
              }
            },
            {
              "name": "years-since-last-cure.md",
              "type": "file",
              "path": "problems/statistics/years-since-last-cure.md",
              "children": [],
              "metadata": {
                "number": "44 years",
                "textFollowingNumber": "since we last cured a disease",
                "title": "44 Years Since Last Cure",
                "description": "The medical research community has not discovered a complete cure for any disease since 1980",
                "emoji": "🧫",
                "featuredImage": "years-since-last-cure.jpg"
              }
            }
          ]
        },
        {
          "name": "trials-often-arent-representative-of-real-patients.md",
          "type": "file",
          "path": "problems/trials-often-arent-representative-of-real-patients.md",
          "children": [],
          "metadata": {
            "title": "Trials Often Aren't Representative of Real Patients",
            "description": "Clinical trials often exclude as much as 85% of patients so they don't tell us if the drug will work for the majority of patients.",
            "emoji": "🥸",
            "featuredImage": "https://static.crowdsourcingcures.org/dfda/assets/wellbutrin-effectiveness-small-sample-size.png"
          }
        },
        {
          "name": "unpatentable-treatments.md",
          "type": "file",
          "path": "problems/unpatentable-treatments.md",
          "children": [],
          "metadata": {
            "description": "We still know next to nothing about the long-term effects of 99.9% of the 4 pounds of over 7,000 different synthetic or natural chemicals you consume every day.",
            "emoji": "🥫",
            "title": "No Data on Unpatentable Molecules",
            "tags": "clinical-trials, unpatentable-molecules, off-patent-treatments, orphan-diseases, pharmaceutical-research",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-12T16:55:54.489Z",
            "dateCreated": "2025-02-12T16:55:54.489Z"
          }
        },
        {
          "name": "unrepresentative-participants.md",
          "type": "file",
          "path": "problems/unrepresentative-participants.md",
          "children": [],
          "metadata": {
            "description": "Phase III clinical trials are often designed to exclude a vast majority of the population of interest.",
            "emoji": "👥",
            "title": "Trials Often Aren't Representative of Real Patients",
            "tags": "clinical-trials, external-validity, generalizability, mental-health, eligibility-criteria",
            "published": true,
            "editor": "markdown",
            "date": "2022-07-29T02:10:38.403Z",
            "dateCreated": "2022-07-22T19:04:16.586Z"
          }
        },
        {
          "name": "we-know-nothing.md",
          "type": "file",
          "path": "problems/we-know-nothing.md",
          "children": [],
          "metadata": {
            "title": "We Know Next to Nothing",
            "description": "There are thousands of diseases and trillions of compounds with drug-like properties, but we've only studied 0.000000002% of potential treatments so far.",
            "emoji": "❓",
            "featuredImage": "https://static.crowdsourcingcures.org/dfda/assets/number-of-molecules-with-drug-like-properties.png"
          }
        },
        {
          "name": "we-only-know-the-effects-of-0000000002-of-potential-therapies.md",
          "type": "file",
          "path": "problems/we-only-know-the-effects-of-0000000002-of-potential-therapies.md",
          "children": [],
          "metadata": {
            "description": "There are as many untested compounds with drug-like properties as there are atoms in the solar system (166 billion).",
            "emoji": "🔬",
            "title": "❓ We Only Know The Effects of 0.000000002% of Potential Therapies",
            "tags": "medical-research, diseases, drug-compounds, scientific-method",
            "published": true,
            "editor": "markdown",
            "date": "2022-07-29T02:10:00.109Z",
            "dateCreated": "2022-07-22T19:04:21.179Z"
          }
        }
      ]
    },
    {
      "name": "proposals",
      "type": "directory",
      "path": "proposals",
      "children": [
        {
          "name": "dfda-act.md",
          "type": "file",
          "path": "proposals/dfda-act.md",
          "title": "💡 The Decentralized FDA",
          "children": [
            {
              "path": "economic-models/blueprint-gas.md",
              "title": "Blueprint for a World Without Disease"
            },
            {
              "path": "architecture/blueprint-high-level.md",
              "title": "Framework for a World Without Disease"
            },
            {
              "path": "architecture/blueprint-sitemap.md",
              "title": "Blueprint for a World Without Disease"
            },
            {
              "path": "strategy/blueprint-strategy.md",
              "title": "Strategy for a World Without Disease"
            },
            {
              "path": "strategy/blueprint-summary.md",
              "title": "Creating a World Without Disease"
            },
            {
              "path": "architecture/blueprint.md",
              "title": "Creating a World Without Disease"
            }
          ],
          "metadata": {
            "description": "80Xing medical progress by giving all patients the right to effortlessly participate in global decentralized clinical trials 💊",
            "published": true,
            "date": "2024-07-28T16:52:11.076Z",
            "tags": "overview",
            "editor": "markdown",
            "dateCreated": "2023-11-24T22:24:09.275Z"
          }
        },
        {
          "name": "health-savings-sharing.md",
          "type": "file",
          "path": "proposals/health-savings-sharing.md",
          "children": [],
          "metadata": {
            "description": "A program aiming to reduce healthcare costs by incentivizing cures and preventative therapies for chronic diseases.",
            "emoji": "🌟",
            "title": "50/50 Health Savings Sharing Program",
            "tags": "healthcare, cost-reduction, cures, preventative-therapies, chronic-diseases",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-12T16:56:08.061Z",
            "dateCreated": "2025-02-12T16:56:08.061Z"
          }
        },
        {
          "name": "use-github-for-task-management.md",
          "type": "file",
          "path": "proposals/use-github-for-task-management.md",
          "children": [],
          "metadata": {
            "description": "Explanation of using GitHub issues for task management with benefits like universal searchability, prioritization, expertise filtering, and notifications.",
            "emoji": "📋",
            "title": "use-github-for-task-management",
            "tags": "github, task-management, project-management, crowdsourcing, searchability",
            "published": false,
            "editor": "markdown",
            "date": "2022-08-25T20:09:14.553Z",
            "dateCreated": "2022-07-27T20:33:14.760Z"
          }
        }
      ]
    },
    {
      "name": "reference",
      "type": "directory",
      "path": "reference",
      "children": [
        {
          "name": "12-references.md",
          "type": "file",
          "path": "reference/12-references.md",
          "children": [],
          "metadata": {
            "description": "Compilation of references and resources related to FDA spending, drug approvals, economic data, and regulatory impact",
            "emoji": "📚",
            "title": "FDA References and Data Resources",
            "tags": "fda, spending, drug-approvals, economic-data, regulation",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-12T16:56:25.222Z",
            "dateCreated": "2025-02-12T16:56:25.222Z"
          }
        },
        {
          "name": "Research-and-Development-in-the-Pharmaceutical-Industry.md",
          "type": "file",
          "path": "reference/Research-and-Development-in-the-Pharmaceutical-Industry.md",
          "children": [],
          "metadata": {
            "description": "Analysis of pharmaceutical industry's research and development spending and its outcomes, including the increase in new drug approvals.",
            "emoji": "🔬",
            "title": "Pharmaceutical R&D Spending and Outcomes",
            "tags": "pharmaceuticals, R&D, drug-development, industry-analysis",
            "published": true,
            "editor": "markdown",
            "date": "2025-02-12T20:29:04.546Z",
            "dateCreated": "2025-02-12T20:29:04.546Z"
          }
        },
        {
          "name": "cost-barriers",
          "type": "directory",
          "path": "reference/cost-barriers",
          "children": [
            {
              "name": "21-data-sources.md",
              "type": "file",
              "path": "reference/cost-barriers/21-data-sources.md",
              "children": [],
              "metadata": {
                "description": "Overview of data sources used in constructing an operational model of clinical trial decision-making, including literature, expert interviews, FDA hearings, and Medidata Solutions databases.",
                "emoji": "📚",
                "title": "Data Sources for Clinical Trial Decision-Making Model",
                "tags": "clinical-trials, data-sources, FDA, research-methodology, Medidata-Solutions",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T16:56:28.848Z",
                "dateCreated": "2025-02-12T16:56:28.848Z"
              }
            },
            {
              "name": "211-publically-available-literature.md",
              "type": "file",
              "path": "reference/cost-barriers/211-publically-available-literature.md",
              "children": [],
              "metadata": {
                "description": "Overview of publically available literature used to define components of the pharmaceutical decision-making process model, including sources like MIT and CTTI.",
                "emoji": "📚",
                "title": "Publically Available Literature on Pharmaceutical Decision-Making",
                "tags": "literature-review, pharmaceuticals, decision-making, MIT, CTTI",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T16:56:32.278Z",
                "dateCreated": "2025-02-12T16:56:32.278Z"
              }
            },
            {
              "name": "212-discussions-with-experts-fda-personnel-drug-sponsors-contract-research-organizations-cros-and-academic-clinical-research-centers.md",
              "type": "file",
              "path": "reference/cost-barriers/212-discussions-with-experts-fda-personnel-drug-sponsors-contract-research-organizations-cros-and-academic-clinical-research-centers.md",
              "children": [],
              "metadata": {
                "description": "Details of discussions with experts, FDA personnel, drug sponsors, CROs, and academic research centers to understand the decision process in drug development.",
                "emoji": "👥",
                "title": "Discussions on Drug Development Decision Processes",
                "tags": "drug-development, FDA, CROs, academic-research-centers, industry-experts",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T16:56:35.812Z",
                "dateCreated": "2025-02-12T16:56:35.812Z"
              }
            },
            {
              "name": "213-medidata-solutions-databases.md",
              "type": "file",
              "path": "reference/cost-barriers/213-medidata-solutions-databases.md",
              "children": [],
              "metadata": {
                "description": "Overview of Medidata Solutions databases used for clinical trial cost analysis, including PICAS, CROCAS, and Insights.",
                "emoji": "📊",
                "title": "Medidata Solutions Databases for Clinical Trial Costs",
                "tags": "clinical-trials, costs, databases, Medidata Solutions, PICAS, CROCAS, Insights",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T16:56:39.403Z",
                "dateCreated": "2025-02-12T16:56:39.403Z"
              }
            },
            {
              "name": "22-conceptual-framework.md",
              "type": "file",
              "path": "reference/cost-barriers/22-conceptual-framework.md",
              "children": [],
              "metadata": {
                "description": "Conceptual framework for modeling clinical trial decision-making using a decision tree approach from the perspective of a revenue-maximizing sponsor.",
                "emoji": "📊",
                "title": "Conceptual Framework for Clinical Trial Decision-Making",
                "tags": "clinical-trials, decision-making, modeling, sponsors, risk",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T16:56:42.726Z",
                "dateCreated": "2025-02-12T16:56:42.726Z"
              }
            },
            {
              "name": "23-operational-model.md",
              "type": "file",
              "path": "reference/cost-barriers/23-operational-model.md",
              "children": [],
              "metadata": {
                "description": "An operational model developed in Microsoft Excel for clinical trial cost scenario analysis with a guided user interface in Visual Basic.",
                "emoji": "📊",
                "title": "Operational Model for Clinical Trial Cost Analysis",
                "tags": "clinical-trials, cost-analysis, operational-model, microsoft-excel, visual-basic",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T16:56:46.027Z",
                "dateCreated": "2025-02-12T16:56:46.027Z"
              }
            },
            {
              "name": "24-model-parameters.md",
              "type": "file",
              "path": "reference/cost-barriers/24-model-parameters.md",
              "children": [],
              "metadata": {
                "description": "Details on the parameters required for a clinical trial cost/decision-making model, including phase durations, success probabilities, expected revenues, and discount rates.",
                "emoji": "⚙️",
                "title": "Model Parameters for Clinical Trial Cost Analysis",
                "tags": "clinical-trials, model-parameters, cost-analysis, pharmaceutical-research",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:26:21.923Z",
                "dateCreated": "2025-02-12T20:26:21.923Z"
              }
            },
            {
              "name": "31-costs-by-therapeutic-area.md",
              "type": "file",
              "path": "reference/cost-barriers/31-costs-by-therapeutic-area.md",
              "children": [],
              "metadata": {
                "description": "Analysis of clinical trial costs across different therapeutic areas and phases",
                "emoji": "📊",
                "title": "Clinical Trial Costs by Therapeutic Area",
                "tags": "clinical-trials, costs, therapeutic-areas, phases",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:26:24.787Z",
                "dateCreated": "2025-02-12T20:26:24.787Z"
              }
            },
            {
              "name": "32-costs-by-trial-phase.md",
              "type": "file",
              "path": "reference/cost-barriers/32-costs-by-trial-phase.md",
              "children": [],
              "metadata": {
                "description": "Analysis of clinical trial costs by phase using weighted mean and standard deviation",
                "emoji": "📊",
                "title": "Clinical Trial Costs by Phase",
                "tags": "clinical-trials, cost-analysis, phases, weighted-mean, standard-deviation",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:26:27.757Z",
                "dateCreated": "2025-02-12T20:26:27.757Z"
              }
            },
            {
              "name": "33-costs-by-cost-component.md",
              "type": "file",
              "path": "reference/cost-barriers/33-costs-by-cost-component.md",
              "children": [],
              "metadata": {
                "description": "Detailed breakdown of clinical trial costs by cost component across therapeutic areas and trial phases",
                "emoji": "📊",
                "title": "Clinical Trial Costs by Cost Component",
                "tags": "clinical-trials, cost-analysis, therapeutic-areas, trial-phases",
                "published": true,
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                "date": "2025-02-12T20:26:30.722Z",
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                "date": "2025-02-12T20:26:34.037Z",
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                "title": "High Financial Cost of Clinical Research and Drug Development",
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                "published": true,
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                "date": "2025-02-12T20:26:37.027Z",
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                "title": "Lengthy Timelines in Clinical Trials and Drug Development",
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                "published": true,
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                "date": "2025-02-12T20:26:40.234Z",
                "dateCreated": "2025-02-12T20:26:40.234Z"
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              "children": [],
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                "description": "Analysis of the challenges in recruiting and retaining participants for clinical trials, including factors like study size and competition among drugs.",
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                "title": "Difficulties in Recruiting and Retaining Clinical Trial Participants",
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                "published": true,
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                "date": "2025-02-12T20:26:43.708Z",
                "dateCreated": "2025-02-12T20:26:43.708Z"
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              "metadata": {
                "description": "Analysis of the competition for qualified investigators and clinical trial sites, highlighting the challenges faced by sponsors in securing top researchers.",
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                "published": true,
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                "date": "2025-02-12T20:26:46.891Z",
                "dateCreated": "2025-02-12T20:26:46.891Z"
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            },
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              "children": [],
              "metadata": {
                "description": "Analysis of regulatory and administrative barriers in clinical research, including their origins and impact on the clinical trials process.",
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                "title": "Regulatory and Administrative Barriers in Clinical Research",
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                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:26:50.097Z",
                "dateCreated": "2025-02-12T20:26:50.097Z"
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            },
            {
              "name": "451-regulations-protecting-human-research-subjects-and-their-privacy.md",
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              "path": "reference/cost-barriers/451-regulations-protecting-human-research-subjects-and-their-privacy.md",
              "children": [],
              "metadata": {
                "description": "Analysis of the challenges in ethical review processes for human research, focusing on IRB responsibilities and multisite trial approvals",
                "emoji": "🔍",
                "title": "Regulations Protecting Human Research Subjects and Privacy",
                "tags": "IRB, regulations, human-research, ethics, multisite-trials",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:26:53.574Z",
                "dateCreated": "2025-02-12T20:26:53.574Z"
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            },
            {
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              "path": "reference/cost-barriers/452-safety-reporting-requirements-for-investigational-new-drugs-inds-and-biologics-21-cfr-312.md",
              "children": [],
              "metadata": {
                "description": "Safety reporting requirements for Investigational New Drugs (INDs) and biologics as per 21 CFR 312, including definitions of adverse events.",
                "emoji": "⚠️",
                "title": "Safety Reporting Requirements for INDs and Biologics",
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                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:26:57.327Z",
                "dateCreated": "2025-02-12T20:26:57.328Z"
              }
            },
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              "children": [],
              "metadata": {
                "description": "Overview of the complexities and challenges in complying with regulations for clinical trials across multiple jurisdictions, including federal, state, local, and international requirements.",
                "emoji": "🌍",
                "title": "Regulations for Multi-Jurisdiction Clinical Trials",
                "tags": "clinical-trials, regulations, compliance, international, EU",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:00.722Z",
                "dateCreated": "2025-02-12T20:27:00.722Z"
              }
            },
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              "path": "reference/cost-barriers/454-conservative-regulatory-climate.md",
              "children": [],
              "metadata": {
                "description": "Analysis of the risk-averse regulatory climate at the FDA and its impact on drug development",
                "emoji": "🔒",
                "title": "FDA's Conservative Regulatory Climate",
                "tags": "fda, regulatory-climate, drug-development, risk-benefit-analysis",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:03.699Z",
                "dateCreated": "2025-02-12T20:27:03.699Z"
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            },
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              "path": "reference/cost-barriers/455-lack-of-clear-regulatory-pathways-and-guidance-for-some-therapeutic-areas.md",
              "children": [],
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                "title": "Lack of Clear Regulatory Pathways for Some Therapeutic Areas",
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                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:07.107Z",
                "dateCreated": "2025-02-12T20:27:07.107Z"
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              "children": [],
              "metadata": {
                "description": "Analysis of barriers related to the FDA's review process, including resource constraints and concerns about reviewer authority.",
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                "title": "Barriers in the FDA Review Process",
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                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:10.229Z",
                "dateCreated": "2025-02-12T20:27:10.229Z"
              }
            },
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              "metadata": {
                "description": "Analysis of drug sponsor-imposed barriers in clinical research, focusing on risk aversion and its impact on costs and delays.",
                "emoji": "🚫",
                "title": "Drug Sponsor-imposed Barriers in Clinical Research",
                "tags": "clinical-research, drug-sponsors, risk-aversion, costs, delays",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:13.712Z",
                "dateCreated": "2025-02-12T20:27:13.712Z"
              }
            },
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              "children": [],
              "metadata": {
                "description": "Analysis of administrative inefficiencies in drug companies, focusing on contract negotiation and internal review processes impacting clinical trials.",
                "emoji": "📝",
                "title": "Administrative Inefficiencies in Drug Development",
                "tags": "drug-development, clinical-trials, administrative-processes, contracts, internal-review",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:17.038Z",
                "dateCreated": "2025-02-12T20:27:17.038Z"
              }
            },
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              "name": "462-study-design.md",
              "type": "file",
              "path": "reference/cost-barriers/462-study-design.md",
              "children": [],
              "metadata": {
                "description": "Discussion on enrollment restrictions in clinical trials and their impact on participant recruitment and trial completion rates.",
                "emoji": "👥",
                "title": "Enrollment Restrictions in Clinical Trials",
                "tags": "clinical-trials, enrollment, eligibility-criteria, recruitment",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:20.093Z",
                "dateCreated": "2025-02-12T20:27:20.093Z"
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            },
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              "path": "reference/cost-barriers/463-data-and-site-monitoring.md",
              "children": [],
              "metadata": {
                "description": "Analysis of data and site monitoring costs in clinical trials, focusing on the impact of source data verification practices.",
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                "title": "Data and Site Monitoring Costs in Clinical Trials",
                "tags": "clinical-trials, data-monitoring, costs, source-data-verification, FDA-regulations",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:23.388Z",
                "dateCreated": "2025-02-12T20:27:23.388Z"
              }
            },
            {
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              "type": "file",
              "path": "reference/cost-barriers/464-serious-adverse-events-saes-reporting-for-investigational-new-drugs-and-biologics-inds-21-cfr-312.md",
              "children": [],
              "metadata": {
                "description": "Discussion on the reporting of Serious Adverse Events (SAEs) for Investigational New Drugs and Biologics under 21 CFR 312, including historical context and regulatory changes.",
                "emoji": "⚠️",
                "title": "Serious Adverse Events Reporting for INDs",
                "tags": "adverse-events, regulatory-compliance, drug-development, biologics, INDs",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:27.377Z",
                "dateCreated": "2025-02-12T20:27:27.377Z"
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            },
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              "name": "47-disconnect-between-clinical-research-and-medical-care.md",
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              "path": "reference/cost-barriers/47-disconnect-between-clinical-research-and-medical-care.md",
              "children": [],
              "metadata": {
                "description": "Analysis of the disconnect between clinical research and medical care, highlighting issues such as lack of community physician involvement, shortages of investigators and patients, high costs, and lengthy timelines.",
                "emoji": "🔬",
                "title": "Disconnect Between Clinical Research and Medical Care",
                "tags": "clinical-research, medical-care, physicians, health-systems, barriers",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:31.009Z",
                "dateCreated": "2025-02-12T20:27:31.009Z"
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            },
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              "children": [],
              "metadata": {
                "description": "Discussion of barriers faced by drug sponsors when using academic institutions as clinical trial sites, including bureaucratic processes and lengthy timelines.",
                "emoji": "📚",
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                "tags": "clinical-trials, academic-institutions, bureaucracy, drug-sponsors",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:34.398Z",
                "dateCreated": "2025-02-12T20:27:34.398Z"
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              "path": "reference/cost-barriers/49-barriers-related-to-the-globalization-of-clinical-research.md",
              "children": [],
              "metadata": {
                "description": "Discussion of barriers related to globalization in clinical research, including the shift of trial sites overseas and declining U.S.-based investigations.",
                "emoji": "🌍",
                "title": "Globalization Barriers in Clinical Research",
                "tags": "clinical-research, globalization, FDA-regulated, trial-sites, United-States",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:37.826Z",
                "dateCreated": "2025-02-12T20:27:37.826Z"
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              "path": "reference/cost-barriers/51-use-of-electronic-health-records-ehr.md",
              "children": [],
              "metadata": {
                "description": "Exploration of how Electronic Health Records (EHR) enhance clinical trial recruitment through systems like Clinical Trial Alerts, improving referral and enrollment rates.",
                "emoji": "📋",
                "title": "Use of Electronic Health Records in Clinical Trials",
                "tags": "electronic-health-records, clinical-trials, recruitment, trial-costs",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:41.239Z",
                "dateCreated": "2025-02-12T20:27:41.239Z"
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              "path": "reference/cost-barriers/52-relaxing-trial-enrollment-restrictions.md",
              "children": [],
              "metadata": {
                "description": "Analysis of relaxing trial enrollment restrictions to improve patient recruitment and reduce clinical trial barriers",
                "emoji": "👥",
                "title": "Relaxing Trial Enrollment Restrictions",
                "tags": "clinical-trials, patient-recruitment, enrollment-rates, eligibility-criteria",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:44.286Z",
                "dateCreated": "2025-02-12T20:27:44.286Z"
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              "path": "reference/cost-barriers/53-simplified-clinical-trial-protocols-and-reduced-amendments.md",
              "children": [],
              "metadata": {
                "description": "Strategy to reduce clinical trial costs by simplifying protocols and minimizing avoidable amendments, potentially cutting data collection costs by 22.5%.",
                "emoji": "📋",
                "title": "Simplified Clinical Trial Protocols and Reduced Amendments",
                "tags": "clinical-trials, cost-reduction, protocol-efficiency, data-collection",
                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:47.657Z",
                "dateCreated": "2025-02-12T20:27:47.657Z"
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              "path": "reference/cost-barriers/54-reduced-source-data-verification-sdv.md",
              "children": [],
              "metadata": {
                "description": "Analysis of cost savings from reducing source data verification in clinical trials",
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                "title": "Reduced Source Data Verification in Clinical Trials",
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                "published": true,
                "editor": "markdown",
                "date": "2025-02-12T20:27:50.715Z",
                "dateCreated": "2025-02-12T20:27:50.715Z"
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              "path": "reference/cost-barriers/55-wider-use-of-mobile-technologies-such-as-electronic-data-capture-edc.md",
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                "title": "Wider Use of EDC in Clinical Trials",
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                "published": true,
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                "date": "2025-02-12T20:27:53.757Z",
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                "published": true,
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                "date": "2025-02-12T20:27:57.233Z",
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                "description": "Explanation of Priority Review Vouchers as a policy option to incentivize development of treatments for neglected diseases",
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                "published": true,
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                "published": true,
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                "title": "Barrier Mitigation Strategies in Drug Development",
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                "published": true,
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                "date": "2025-02-12T20:28:07.055Z",
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                    "title": "Barriers to Clinical Trials in the United States",
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                    "description": "Analysis of the high financial costs associated with bringing a new drug to market, ranging from $161 million to $2 billion, and the impact of shifting research focus towards chronic diseases.",
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              "name": "brain-computer-interfaces-for-depression.md",
              "type": "file",
              "path": "wiki/interventions/brain-computer-interfaces-for-depression.md",
              "children": [],
              "metadata": {
                "title": "Brain Computer Interfaces For Depression",
                "description": "Volume knobs for mood",
                "published": true,
                "date": "2023-05-27T23:24:24.846Z",
                "tags": "depression, brain computer interfaces",
                "editor": "markdown",
                "dateCreated": "2023-05-27T23:24:24.846Z"
              }
            }
          ]
        }
      ]
    }
  ]
} as const;

// Type definition for the tree structure
export type TreeNode = {
    name: string;
    type: 'file' | 'directory';
    path: string; // Relative path with forward slashes
    metadata?: Record<string, any>;
    children: TreeNode[];
};