diff --git a/.evergreen/config.yml b/.evergreen/config.yml
index 6490b069f..6aa2020ca 100644
--- a/.evergreen/config.yml
+++ b/.evergreen/config.yml
@@ -31,13 +31,12 @@ functions:
     - command: subprocess.exec
       params:
         binary: bash
-        env:
-          MONGODB_VERSION: "5.0"
-          TOPOLOGY: server
-          AUTH: "noauth"
-          SSL: "nossl"
+        add_expansions_to_env: true
         args:
           - ${DRIVERS_TOOLS}/.evergreen/run-orchestration.sh
+    - command: expansions.update
+      params:
+        file: mo-expansion.yml
 
   "run unit tests":
     - command: subprocess.exec
@@ -45,7 +44,7 @@ functions:
       params:
         binary: bash
         working_dir: "src"
-        include_expansions_in_env: ["DRIVERS_TOOLS"]
+        include_expansions_in_env: ["DRIVERS_TOOLS", "MONGODB_URI"]
         args:
           - ./.evergreen/run-tests.sh
 
@@ -64,13 +63,51 @@ post:
   - func: teardown
 
 tasks:
-- name: run-tests
-  commands:
-    - func: "run unit tests"
+  - name: run-tests
+    commands:
+      - func: "run unit tests"
 
 buildvariants:
-- name: tests
-  display_name: Run Tests
-  run_on: rhel87-small
-  tasks:
-  - name: run-tests
+  - name: tests-5-noauth-nossl
+    display_name: Run Tests 5.0 NoAuth NoSSL
+    run_on: rhel87-small
+    expansions:
+      MONGODB_VERSION: "5.0"
+      TOPOLOGY: server
+      AUTH: "noauth"
+      SSL: "nossl"
+    tasks:
+      - name: run-tests
+
+  - name: tests-5-auth-ssl
+    display_name: Run Tests 5.0 Auth SSL
+    run_on: rhel87-small
+    expansions:
+      MONGODB_VERSION: "5.0"
+      TOPOLOGY: server
+      AUTH: "auth"
+      SSL: "ssl"
+    tasks:
+      - name: run-tests
+
+  - name: tests-8-noauth-nossl
+    display_name: Run Tests 8.0 NoAuth NoSSL
+    run_on: rhel87-small
+    expansions:
+      MONGODB_VERSION: "8.0"
+      TOPOLOGY: server
+      AUTH: "noauth"
+      SSL: "nossl"
+    tasks:
+      - name: run-tests
+
+  - name: tests-8-auth-ssl
+    display_name: Run Tests 8.0 Auth SSL
+    run_on: rhel87-small
+    expansions:
+      MONGODB_VERSION: "8.0"
+      TOPOLOGY: server
+      AUTH: "auth"
+      SSL: "ssl"
+    tasks:
+      - name: run-tests
diff --git a/.github/workflows/mongodb_settings.py b/.github/workflows/mongodb_settings.py
index dc543a1e9..f33d458ac 100644
--- a/.github/workflows/mongodb_settings.py
+++ b/.github/workflows/mongodb_settings.py
@@ -1,13 +1,29 @@
-DATABASES = {
-    "default": {
-        "ENGINE": "django_mongodb_backend",
-        "NAME": "djangotests",
-    },
-    "other": {
-        "ENGINE": "django_mongodb_backend",
-        "NAME": "djangotests-other",
-    },
-}
+import os
+
+from django_mongodb_backend import parse_uri
+
+if mongodb_uri := os.getenv("MONGODB_URI"):
+    db_settings = parse_uri(mongodb_uri)
+
+    # Workaround for https://github.com/mongodb-labs/mongo-orchestration/issues/268
+    if db_settings["USER"] and db_settings["PASSWORD"]:
+        db_settings["OPTIONS"].update({"tls": True, "tlsAllowInvalidCertificates": True})
+    DATABASES = {
+        "default": {**db_settings, "NAME": "djangotests"},
+        "other": {**db_settings, "NAME": "djangotests-other"},
+    }
+else:
+    DATABASES = {
+        "default": {
+            "ENGINE": "django_mongodb_backend",
+            "NAME": "djangotests",
+        },
+        "other": {
+            "ENGINE": "django_mongodb_backend",
+            "NAME": "djangotests-other",
+        },
+    }
+
 DEFAULT_AUTO_FIELD = "django_mongodb_backend.fields.ObjectIdAutoField"
 PASSWORD_HASHERS = ("django.contrib.auth.hashers.MD5PasswordHasher",)
 SECRET_KEY = "django_tests_secret_key"