diff --git a/pymongo/pyopenssl_context.py b/pymongo/pyopenssl_context.py
index 50d8680a74..a320e94929 100644
--- a/pymongo/pyopenssl_context.py
+++ b/pymongo/pyopenssl_context.py
@@ -125,7 +125,8 @@ def _call(self, call: Callable[..., _T], *args: Any, **kwargs: Any) -> _T:
             try:
                 return call(*args, **kwargs)
             except BLOCKING_IO_ERRORS as exc:
-                if is_async:
+                # Do not retry if the connection is in non-blocking mode.
+                if is_async or timeout == 0:
                     raise exc
                 # Check for closed socket.
                 if self.fileno() == -1: