diff --git a/.github/workflows/test-python.yml b/.github/workflows/test-python.yml
index 40a497480c..0ed23b9d83 100644
--- a/.github/workflows/test-python.yml
+++ b/.github/workflows/test-python.yml
@@ -14,6 +14,9 @@ defaults:
   run:
     shell: bash -eux {0}
 
+permissions:
+  contents: read
+
 jobs:
 
   static:
@@ -163,6 +166,36 @@ jobs:
         run: |
           just typing
 
+  integration_tests:
+    runs-on: ubuntu-latest
+    name: Integration Tests
+    steps:
+      - uses: actions/checkout@v5
+        with:
+          persist-credentials: false
+      - name: Install uv
+        uses: astral-sh/setup-uv@557e51de59eb14aaaba2ed9621916900a91d50c6 # v5
+        with:
+          enable-cache: true
+          python-version: "3.10"
+      - name: Install just
+        run: uv tool install rust-just
+      - name: Install dependencies
+        run: |
+          just install
+      - id: setup-mongodb
+        uses: mongodb-labs/drivers-evergreen-tools@master
+      - name: Run tests
+        run:  |
+          just integration-tests
+      - id: setup-mongodb-ssl
+        uses: mongodb-labs/drivers-evergreen-tools@master
+        with:
+          ssl: true
+      - name: Run tests
+        run: |
+          just integration-tests
+
   make_sdist:
     runs-on: ubuntu-latest
     name: "Make an sdist"
diff --git a/CONTRIBUTING.md b/CONTRIBUTING.md
index c4f7b55817..a8881db9cb 100644
--- a/CONTRIBUTING.md
+++ b/CONTRIBUTING.md
@@ -411,6 +411,14 @@ a use the ticket number as the "reason" parameter to the decorator, e.g. `@flaky
 When running tests locally (not in CI), the `flaky` decorator will be disabled unless `ENABLE_FLAKY` is set.
 To disable the `flaky` decorator in CI, you can use `evergreen patch --param DISABLE_FLAKY=1`.
 
+## Integration Tests
+
+The `integration_tests` directory has a set of scripts that verify the usage of PyMongo with downstream packages or frameworks.  See the [README](./integration_tests/README.md) for more information.
+
+To run the tests, use `just integration_tests`.
+
+The tests should be able to run with and without SSL enabled.
+
 ## Specification Tests
 
 The MongoDB [specifications repository](https://github.com/mongodb/specifications)
diff --git a/integration_tests/README.md b/integration_tests/README.md
new file mode 100644
index 0000000000..fb64a9066f
--- /dev/null
+++ b/integration_tests/README.md
@@ -0,0 +1,42 @@
+# Integration Tests
+
+A set of tests that verify the usage of PyMongo with downstream packages or frameworks.
+
+Each test uses [PEP 723 inline metadata](https://packaging.python.org/en/latest/specifications/inline-script-metadata/) and can be run using `pipx` or `uv`.
+
+The `run.sh` convenience script can be used to run all of the files using `uv`.
+
+Here is an example header for the script with the inline dependencies:
+
+```python
+# /// script
+# dependencies = [
+#   "uvloop>=0.18"
+# ]
+# requires-python = ">=3.10"
+# ///
+```
+
+Here is an example of using the test helper function to create a configured client for the test:
+
+
+```python
+import asyncio
+import sys
+from pathlib import Path
+
+# Use pymongo from parent directory.
+root = Path(__file__).parent.parent
+sys.path.insert(0, str(root))
+
+from test.asynchronous import async_simple_test_client  # noqa: E402
+
+
+async def main():
+    async with async_simple_test_client() as client:
+        result = await client.admin.command("ping")
+        assert result["ok"]
+
+
+asyncio.run(main())
+```
diff --git a/integration_tests/run.sh b/integration_tests/run.sh
new file mode 100755
index 0000000000..051e2b8a75
--- /dev/null
+++ b/integration_tests/run.sh
@@ -0,0 +1,11 @@
+#!/bin/bash
+# Run all of the integration test files using `uv run`.
+set -eu
+
+for file in integration_tests/test_*.py ; do
+    echo "-----------------"
+    echo "Running $file..."
+    uv run $file
+    echo "Running $file...done."
+    echo "-----------------"
+done
diff --git a/integration_tests/test_uv_loop.py b/integration_tests/test_uv_loop.py
new file mode 100644
index 0000000000..88a3ad73ab
--- /dev/null
+++ b/integration_tests/test_uv_loop.py
@@ -0,0 +1,27 @@
+# /// script
+# dependencies = [
+#   "uvloop>=0.18"
+# ]
+# requires-python = ">=3.10"
+# ///
+from __future__ import annotations
+
+import sys
+from pathlib import Path
+
+import uvloop
+
+# Use pymongo from parent directory.
+root = Path(__file__).parent.parent
+sys.path.insert(0, str(root))
+
+from test.asynchronous import async_simple_test_client  # noqa: E402
+
+
+async def main():
+    async with async_simple_test_client() as client:
+        result = await client.admin.command("ping")
+        assert result["ok"]
+
+
+uvloop.run(main())
diff --git a/justfile b/justfile
index 9b6cce62c9..f235346160 100644
--- a/justfile
+++ b/justfile
@@ -72,6 +72,10 @@ setup-tests *args="":
 teardown-tests:
     bash .evergreen/scripts/teardown-tests.sh
 
+[group('test')]
+integration-tests:
+    bash integration_tests/run.sh
+
 [group('server')]
 run-server *args="":
     bash .evergreen/scripts/run-server.sh {{args}}
diff --git a/test/__init__.py b/test/__init__.py
index f3b66c20a9..1ee2c283d6 100644
--- a/test/__init__.py
+++ b/test/__init__.py
@@ -1227,6 +1227,13 @@ def teardown():
     print_running_clients()
 
 
+@contextmanager
+def simple_test_client():
+    client_context.init()
+    yield client_context.client
+    client_context.client.close()
+
+
 def test_cases(suite):
     """Iterator over all TestCases within a TestSuite."""
     for suite_or_case in suite._tests:
diff --git a/test/asynchronous/__init__.py b/test/asynchronous/__init__.py
index 7a6a23ed27..78d0576add 100644
--- a/test/asynchronous/__init__.py
+++ b/test/asynchronous/__init__.py
@@ -1243,6 +1243,13 @@ async def async_teardown():
     print_running_clients()
 
 
+@asynccontextmanager
+async def async_simple_test_client():
+    await async_client_context.init()
+    yield async_client_context.client
+    await async_client_context.client.close()
+
+
 def test_cases(suite):
     """Iterator over all TestCases within a TestSuite."""
     for suite_or_case in suite._tests:
diff --git a/tools/synchro.py b/tools/synchro.py
index a4190529c4..e3d4835502 100644
--- a/tools/synchro.py
+++ b/tools/synchro.py
@@ -131,6 +131,7 @@
     "async_create_barrier": "create_barrier",
     "async_barrier_wait": "barrier_wait",
     "async_joinall": "joinall",
+    "async_simple_test_client": "simple_test_client",
     "_async_create_connection": "_create_connection",
     "pymongo.asynchronous.srv_resolver._SrvResolver.get_hosts": "pymongo.synchronous.srv_resolver._SrvResolver.get_hosts",
     "dns.asyncresolver.resolve": "dns.resolver.resolve",