diff --git a/nautobot_chatops/models.py b/nautobot_chatops/models.py
index 5bf667ab..7e8fb1dc 100644
--- a/nautobot_chatops/models.py
+++ b/nautobot_chatops/models.py
@@ -9,6 +9,26 @@
 
 from .choices import AccessGrantTypeChoices, CommandStatusChoices, CommandTokenPlatformChoices
 
+import re
+
+
+class QuerySetRegexMatch(models.QuerySet):
+    """Customized QuerySet to match string agains regexes stored in database.
+
+    Return a list of matched records.
+    """
+
+    def match_re(self, value):
+        records = self.all()
+
+        results = []
+        for row in records:
+            if row.subcommand == "*":  # skip as it is not a valid regex expression and would raise exception
+                continue
+            if re.match(row.subcommand, value):
+                results.append(row.subcommand)
+        return results
+
 
 class CommandLog(BaseModel):
     """Record of a single fully-executed Nautobot command.
@@ -68,6 +88,7 @@ class AccessGrant(BaseModel, ChangeLoggedModel):
         max_length=64,
         help_text="Enter <tt>*</tt> to grant access to all subcommands of the given command",
     )
+    regexMatch = QuerySetRegexMatch.as_manager()
 
     grant_type = models.CharField(max_length=32, choices=AccessGrantTypeChoices)
 
diff --git a/nautobot_chatops/tests/test_utils.py b/nautobot_chatops/tests/test_utils.py
index f9c10cd8..903e98ed 100644
--- a/nautobot_chatops/tests/test_utils.py
+++ b/nautobot_chatops/tests/test_utils.py
@@ -203,6 +203,29 @@ def setup_db(self):
             name="user3",
             value="3333",
         )
+
+        AccessGrant.objects.create(
+            command="x",
+            subcommand="get-.*",
+            grant_type=AccessGrantTypeChoices.TYPE_ORGANIZATION,
+            name="org3",
+            value="33",
+        )
+        AccessGrant.objects.create(
+            command="x",
+            subcommand="get-.*",
+            grant_type=AccessGrantTypeChoices.TYPE_CHANNEL,
+            name="channel3",
+            value="333",
+        )
+        AccessGrant.objects.create(
+            command="x",
+            subcommand="get-.*",
+            grant_type=AccessGrantTypeChoices.TYPE_USER,
+            name="user3",
+            value="3333",
+        )
+
         # And some wildcard access grants:
         AccessGrant.objects.create(
             command="y",
@@ -313,6 +336,42 @@ def test_permitted_subcommand(self, mock_enqueue_task):
             )
             mock_enqueue_task.assert_not_called()
 
+    def test_permitted_subcommand_re(self, mock_enqueue_task):
+        """A per-subcommand access grant applies that subcommands under that command, and no others."""
+        self.setup_db()
+        for cmd, subcmd in [("x", "get-device"), ("x", "get-prefix-status"), ("x", "")]:
+            mock_enqueue_task.reset_mock()
+            check_and_enqueue_command(
+                self.mock_registry,
+                cmd,
+                subcmd,
+                [],
+                {"org_id": "33", "channel_id": "333", "user_id": "3333"},
+                MockDispatcher.reset(),
+            )
+            self.assertIsNone(MockDispatcher.error)
+            mock_enqueue_task.assert_called_once()
+
+    def test_not_permitted_re(self, mock_enqueue_task):
+        """Per-user access grants are checked."""
+        self.setup_db()
+        for cmd, subcmd in [("x", "set-device")]:
+            mock_enqueue_task.reset_mock()
+            check_and_enqueue_command(
+                self.mock_registry,
+                cmd,
+                subcmd,
+                [],
+                {"org_id": "33", "channel_id": "333", "user_id": "3333"},
+                MockDispatcher.reset(),
+            )
+            self.assertEqual(
+                MockDispatcher.error,
+                "Access to this bot and/or command is not permitted in organization 33, "
+                "ask your Nautobot administrator to define an appropriate Access Grant",
+            )
+            mock_enqueue_task.assert_not_called()
+
     def test_not_permitted_user(self, mock_enqueue_task):
         """Per-user access grants are checked."""
         self.setup_db()
diff --git a/nautobot_chatops/utils.py b/nautobot_chatops/utils.py
index c1e99e39..f2723501 100644
--- a/nautobot_chatops/utils.py
+++ b/nautobot_chatops/utils.py
@@ -147,7 +147,10 @@ def check_and_enqueue_command(
     else:
         # Actual subcommand  - permit only if this particular subcommand (or all commands/subcommands) are permitted
         access_grants = AccessGrant.objects.filter(
-            Q(command="*") | Q(command=command, subcommand="*") | Q(command=command, subcommand=subcommand),
+            Q(command="*")
+            | Q(command=command, subcommand="*")
+            | Q(command=command, subcommand=subcommand)
+            | Q(command=command, subcommand__in=AccessGrant.regexMatch.match_re(subcommand))
         )
 
     org_grants = access_grants.filter(grant_type=AccessGrantTypeChoices.TYPE_ORGANIZATION)