diff --git a/CHANGELOG.md b/CHANGELOG.md
index 0062af4..3aafaf0 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -21,6 +21,7 @@ Initial release of nf-core/seqinspector, created with the [nf-core](https://nf-c
 - [#53](https://github.com/nf-core/seqinspector/pull/53) Add FastQ-Screen database multiplexing and limit scope of nf-test in CI.
 - [#96](https://github.com/nf-core/seqinspector/pull/96) Added missing citations to citation tool
 - [#103](https://github.com/nf-core/seqinspector/pull/103) Configure full-tests
+- [#110](https://github.com/nf-core/seqinspector/pull/110) Update input schema to accept either tar file or directory as rundir, and fastq messages and patterns.
 
 ### `Fixed`
 
diff --git a/assets/schema_input.json b/assets/schema_input.json
index 97ec617..c879c73 100644
--- a/assets/schema_input.json
+++ b/assets/schema_input.json
@@ -17,21 +17,31 @@
                 "type": "string",
                 "format": "file-path",
                 "exists": true,
-                "pattern": "^\\S+\\.f(ast)?q\\.gz$",
-                "errorMessage": "FastQ file for reads 1 must be provided, cannot contain spaces and must have extension '.fq.gz' or '.fastq.gz'"
+                "pattern": "\\.f(ast)?q\\.gz$",
+                "errorMessage": "FastQ files for read 1 must be provided and must have extension '.fq.gz' or '.fastq.gz'"
             },
             "fastq_2": {
                 "type": "string",
                 "format": "file-path",
                 "exists": true,
-                "pattern": "^\\S+\\.f(ast)?q\\.gz$",
-                "errorMessage": "FastQ file for reads 2 cannot contain spaces and must have extension '.fq.gz' or '.fastq.gz'"
+                "pattern": "\\.f(ast)?q\\.gz$",
+                "errorMessage": "FastQ files for read 2 are optional and must have extension '.fq.gz' or '.fastq.gz' if provided"
             },
             "rundir": {
-                "type": "string",
-                "format": "path",
-                "exists": true,
-                "errorMessage": "Run directory must be a path",
+                "oneOf": [
+                    {
+                        "type": "string",
+                        "format": "file-path",
+                        "exists": true,
+                        "pattern": "\\.tar\\.gz$"
+                    },
+                    {
+                        "type": "string",
+                        "format": "directory-path",
+                        "exists": true
+                    }
+                ],
+                "errorMessage": "Run directory must be a path or tar directory",
                 "meta": ["rundir"]
             },
             "tags": {