diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 30249c98..804b55f7 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -84,6 +84,7 @@ jobs:
             permissions_custom,
             symlinks,
             acme_hooks,
+            networks_segregation
           ]
         setup: [2containers, 3containers]
         acme-ca: [pebble]
diff --git a/app/letsencrypt_service_data.tmpl b/app/letsencrypt_service_data.tmpl
index b7077ff2..b6c107a4 100644
--- a/app/letsencrypt_service_data.tmpl
+++ b/app/letsencrypt_service_data.tmpl
@@ -1,7 +1,21 @@
+{{ $CurrentContainer := where $ "ID" .Docker.CurrentContainerID | first }}
+
+{{ $activeContainers := whereExist $ "Env.LETSENCRYPT_HOST" }}
+{{ if trim (default "" $CurrentContainer.Env.NETWORK_SCOPE) }}
+    {{ $filteredContainers := list }}
+    {{ range $activeContainers }}
+        {{ if gt (where .Networks "Name" (trim $CurrentContainer.Env.NETWORK_SCOPE) | len) 0 }}
+            {{ $filteredContainers = append $filteredContainers . }}
+        {{ end }}
+    {{ end }}
+    {{ $activeContainers = $filteredContainers }}
+{{ end }}
+
 LETSENCRYPT_CONTAINERS=(
-    {{ range $hosts, $containers := groupBy $ "Env.LETSENCRYPT_HOST" }}
+    {{ range $hosts, $containers := groupBy $activeContainers "Env.LETSENCRYPT_HOST" }}
         {{ if trim $hosts }}
             {{ range $container := $containers }}
+                {{ $cid := printf "%.12s" $container.ID }}
                 {{ if parseBool (coalesce $container.Env.LETSENCRYPT_SINGLE_DOMAIN_CERTS "false") }}
                     {{/* Explicit per-domain splitting of the certificate */}}
                     {{ range $host := split $hosts "," }}
@@ -17,7 +31,7 @@ LETSENCRYPT_CONTAINERS=(
     {{ end }}
 )
 
-{{ range $hosts, $containers := groupBy $ "Env.LETSENCRYPT_HOST" }}
+{{ range $hosts, $containers := groupBy $activeContainers "Env.LETSENCRYPT_HOST" }}
     {{ $hosts := trimSuffix "," $hosts }}
     {{ range $container := $containers }}
         {{/* Trim spaces and set empty values on per-container environment variables */}}
diff --git a/docs/Let's-Encrypt-and-ACME.md b/docs/Let's-Encrypt-and-ACME.md
index 8633a69b..0d2031d6 100644
--- a/docs/Let's-Encrypt-and-ACME.md
+++ b/docs/Let's-Encrypt-and-ACME.md
@@ -101,3 +101,13 @@ Reusing private keys can help if you intend to use [HPKP](https://developer.mozi
     1. The container will use the special purpose `staging` configuration directory.
     1. The directory URI is forced to The Let's Encrypt v2 staging one (`ACME_CA_URI` is ignored)
     2. The account email address is forced empty (`DEFAULT_EMAIL` and `LETSENCRYPT_EMAIL` are ignored)
+
+#### Running multiple **nginx-proxy** and **acme-companion** containers on a same Docker machine
+
+The `NETWORK_SCOPE` variable must be set in order to run multiple **acme-companion** containers on a same Docker machine. The value should be a name of network, that 
+connects **nginx-proxy** with the proxied containers.
+
+When a server has multiple IP addresses, you might run multiple **nginx-proxy** + **acme-companion** instances on it, each for a different set of proxied
+containers. By default, **acme-companion** discovers all running containers and tries to generate SSL certificates for them, meaning multiple **acme-companion** 
+instances will try to generate the same set of certificates. In order to limit **acme-companion** discovery scope to a smaller set of containers, set the
+`NETWORK_SCOPE` environment variable.
\ No newline at end of file
diff --git a/test/config.sh b/test/config.sh
index bb370407..c0b0e2e7 100755
--- a/test/config.sh
+++ b/test/config.sh
@@ -17,6 +17,7 @@ globalTests+=(
 	permissions_custom
 	symlinks
 	acme_hooks
+	networks_segregation
 )
 
 # The ocsp_must_staple test does not work with Pebble
diff --git a/test/tests/networks_segregation/expected-std-out.txt b/test/tests/networks_segregation/expected-std-out.txt
new file mode 100644
index 00000000..94f95564
--- /dev/null
+++ b/test/tests/networks_segregation/expected-std-out.txt
@@ -0,0 +1,8 @@
+Started test web server for le1.wtf in the network 0
+Started test web server for le2.wtf in the network 1
+Started test web server for le3.wtf in the network 2
+le1.wtf is in the primary network, cert should be generated
+le2.wtf is not in the primary network, cert should not be generated
+Domain le2.wtf was not included in the service_data.
+le3.wtf is not in the primary network, cert should not be generated
+Domain le3.wtf was not included in the service_data.
diff --git a/test/tests/networks_segregation/run.sh b/test/tests/networks_segregation/run.sh
new file mode 100755
index 00000000..b4d68f4b
--- /dev/null
+++ b/test/tests/networks_segregation/run.sh
@@ -0,0 +1,83 @@
+#!/bin/bash
+
+## Test for Network segregation.
+
+case $ACME_CA in
+  pebble)
+    test_net='acme_net'
+
+  ;;
+  boulder)
+    test_net='boulder_bluenet'
+  ;;
+  *)
+    echo "$0 $ACME_CA: invalid option."
+    exit 1
+esac
+
+if [[ -z $GITHUB_ACTIONS ]]; then
+  le_container_name="$(basename "${0%/*}")_$(date "+%Y-%m-%d_%H.%M.%S")"
+else
+  le_container_name="$(basename "${0%/*}")"
+fi
+
+run_le_container ${1:?} "$le_container_name" "--env NETWORK_SCOPE=$test_net"
+
+# Create the $domains array from comma separated domains in TEST_DOMAINS.
+IFS=',' read -r -a domains <<< "$TEST_DOMAINS"
+
+# Cleanup function with EXIT trap
+function cleanup {
+  # Remove any remaining Nginx container(s) silently.
+  for domain in "${domains[@]}"; do
+    docker rm --force "$domain" > /dev/null 2>&1
+  done
+  # Cleanup the files created by this run of the test to avoid foiling following test(s).
+  docker exec "$le_container_name" /app/cleanup_test_artifacts
+  # Remove the LE container, as it it network-scoped and may affect following test(s).
+  docker rm --force "$le_container_name" > /dev/null
+  # Drop temp network
+  docker network rm "le_test_other_net1" > /dev/null
+  docker network rm "le_test_other_net2" > /dev/null
+}
+trap cleanup EXIT
+
+docker network create "le_test_other_net1" > /dev/null
+docker network create "le_test_other_net2" > /dev/null
+
+networks_map=("$test_net" le_test_other_net1 le_test_other_net2)
+
+# Run a separate nginx container for each domain in the $domains array.
+# Start all the containers in a row so that docker-gen debounce timers fire only once.
+i=0
+for domain in "${domains[@]}"; do
+  docker run --rm -d \
+    --name "$domain" \
+    -e "VIRTUAL_HOST=${domain}" \
+    -e "LETSENCRYPT_HOST=${domain}" \
+    --network "${networks_map[i]}" \
+    nginx:alpine > /dev/null && echo "Started test web server for $domain in the network ${i}"
+
+  i=$(( $i + 1 ))
+done
+
+i=0
+for domain in "${domains[@]}"; do
+  if [ "${networks_map[i]}" != "$test_net" ]; then
+     echo "$domain is not in the primary network, cert should not be generated";
+
+     service_data="$(docker exec "$le_container_name" cat /app/letsencrypt_service_data)"
+     if grep -q "$domain" <<< "$service_data"; then
+       echo "Domain $domain is on data list, but MUST not!"
+     else
+       echo "Domain $domain was not included in the service_data."
+     fi
+  else
+      echo "$domain is in the primary network, cert should be generated";
+      wait_for_symlink "$domain" "$le_container_name"
+  fi
+  # Stop the Nginx container silently.
+  docker stop "$domain" > /dev/null
+  i=$(( $i + 1 ))
+done
+