@@ -176,6 +176,27 @@ This feature has several intended use-cases:
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See also the ``--level `` flag, which can be used to control which derivatives are
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generated.
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+ Head motion correction
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+ ----------------------
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+ *PETPrep * can correct for head motion in the PET data.
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+ The head motion is estimated using a frame-based robust registration approach to an unbiased mean
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+ volume implemented in FreeSurfer's mri_robust_register (Reuter et al., 2010), combined with
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+ preprocessing steps using tools from FSL (Jenkinson et al., 2012). Specifically, for the estimation
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+ of head motion, each frame is initially smoothed with a Gaussian filter (full-width half-maximum [FWHM] of 10 mm, --hmc-fwhm 10),
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+ followed by thresholding at 20% of the intensity range to reduce noise and improve registration
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+ accuracy (removing stripe artefacts from filtered back projection reconstructions).
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+ Per default, the motion is estimated selectively of frames acquired after 120 seconds post-injection of the tracer (--hmc-start-time 120),
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+ as frames before this often contain low count statistics. Frames preceding 120 seconds were corrected
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+ using identical transformations as derived for the first frame after 120 seconds. The robust
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+ registration (mri_robust_register) algorithm utilized settings optimized for PET data: intensity
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+ scaling was enabled, automated sensitivity detection was activated, and the Frobenius norm threshold
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+ for convergence was set at 0.0001, ensuring precise and consistent alignment across frames.
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+
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+ To edit the motion correction parameters and run the workflow, use
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+
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+ $ petprep /data/bids_root /out participant --hmc-fwhm 8 --hmc-start-time 60
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+
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Segmentation
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----------------
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*PETPrep * can segment the brain into different brain regions and extract time activity curves from these regions.
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