Futher work

We're very interested in maintaining, contributing to, and managing an open source solution for NGS of the MHC. Current and future efforts are aimed at further optimization and validation of the workflow.

Validate

. With other gene families (including KIR and ABO/Rh)
. With data from other sequencing platforms
. With multiple target capture methods

Optimize

. Assembly methods (the most critical step)
. Interpretation and nomenclature assignment to allow genetic matching that can scale to higher resolution typing of the MHC as well as other gene families that are important for immunohistocompatibility (see below)
. Predominant data model -- move away from format-specific I/O between algorithmic components and batch processing toward unified, distributed storage-compute platforms such as ADAM