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@@ -8,8 +8,7 @@ Swiss army knife of **HLA** Nomenclature
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### `py-ard` is ARD reduction for HLA in Python
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HLA genes regulate cell surface proteins that present cellular antigens to the immune system.
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The exons of HLA that encode peptide binding groove of Antigen Recognition Domain (ARD) are the most polymorphic region of HLA and are important for [HLA matching](https://bethematch.org/patients-and-families/before-transplant/find-a-donor/hla-matching/). The version 3 of HLA [Nomenclature](https://www.theatlantic.com/magazine/archive/2023/04/clint-smith-nomenclature-poem/673097/) was defined by [The WHO Nomenclature Committee](https://hla.alleles.org/nomenclature/committee.html) in 2010 specifying how HLA Alleles are named and grouped. The history of allele typing methods has played a major role in determining resolution and ambiguity of reported HLA. `py-ard` is aware of these various resolutions and grouping and is able to translate from one representation to another based on alleles published quarterly by [IPD/IMGT-HLA](https://github.com/ANHIG/IMGTHLA/).
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HLA genes express cell surface proteins that are important for immune regulation. The exons of HLA that encode peptide binding groove of Antigen Recognition Domain (ARD) are the most polymorphic region of HLA and are important for [HLA matching](https://bethematch.org/patients-and-families/before-transplant/find-a-donor/hla-matching/). The history of allele typing methods has played a major role in determining resolution and ambiguity of reported HLA. Although HLA [Nomenclature](https://www.theatlantic.com/magazine/archive/2023/04/clint-smith-nomenclature-poem/673097/) has not always conformed to the same standard, it is now defined by [The WHO Nomenclature Committee](https://hla.alleles.org/nomenclature/committee.html). `py-ard` is aware of the variation in historical resolutions and grouping and is able to translate from one representation to another based on alleles published quarterly by [IPD/IMGT-HLA](https://github.com/ANHIG/IMGTHLA/).
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