diff --git a/test/common/quic/test-client.mjs b/test/common/quic/test-client.mjs
index 1e450e99ed673f..5e837ef5a3af30 100644
--- a/test/common/quic/test-client.mjs
+++ b/test/common/quic/test-client.mjs
@@ -33,8 +33,8 @@ export default class QuicTestClient {
     const args = [
       address,
       port,
-      uri ?? '',
     ];
+    if (uri !== undefined) args.push(uri);
     this.#runningProcess = spawn(this.#pathToClient, args, options);
     this.#runningProcess.on('error', (err) => {
       this.#runningProcess = undefined;
diff --git a/test/sequential/test-quic-client-handshake-with-test-server.mjs b/test/sequential/test-quic-client-handshake-with-test-server.mjs
new file mode 100644
index 00000000000000..3a484c1f0a7a16
--- /dev/null
+++ b/test/sequential/test-quic-client-handshake-with-test-server.mjs
@@ -0,0 +1,60 @@
+// Flags: --experimental-quic
+import { hasQuic, isAIX, isWindows, skip, getPort } from '../common/index.mjs';
+import { partialDeepStrictEqual } from 'node:assert';
+import { setTimeout } from 'node:timers/promises';
+
+if (!hasQuic) {
+  skip('QUIC support is not enabled');
+}
+if (isAIX) {
+  // AIX does not support some of the networking features used in the ngtcp2
+  // example server and client.
+  skip('QUIC third-party tests are disabled on AIX');
+}
+if (isWindows) {
+  // Windows does not support the [Li/U]nix specific headers and system calls
+  // required by the ngtcp2 example server/client.
+  skip('QUIC third-party tests are disabled on Windows');
+}
+
+// Test that our QUIC client can successfully handshake with the ngtcp2
+// test server (not our implementation).
+
+const { default: QuicTestServer } = await import('../common/quic/test-server.mjs');
+const { connect } = await import('node:quic');
+const fixtures = await import('../common/fixtures.mjs');
+const kPort = getPort();
+
+const server = new QuicTestServer();
+const fixturesPath = fixtures.path();
+
+// If this completes without throwing, the test passes.
+await server.help({ stdio: 'ignore' });
+
+server.run('localhost', kPort,
+           `${fixturesPath}/keys/agent1-key.pem`,
+           `${fixturesPath}/keys/agent1-cert.pem`,
+           { stdio: 'ignore' });
+
+const client = await connect({
+  host: 'localhost',
+  port: kPort
+});
+
+const check = {
+  servername: 'localhost',
+  protocol: 'h3',
+  cipher: 'TLS_AES_128_GCM_SHA256',
+  cipherVersion: 'TLSv1.3',
+};
+
+// If the handshake completes without throwing the opened promise
+// will be resolved with the basic handshake info.
+const info = await client.opened;
+
+partialDeepStrictEqual(info, check);
+
+client.close();
+
+await setTimeout(100);
+server.stop();
diff --git a/test/sequential/test-quic-server-handshake-with-test-client.mjs b/test/sequential/test-quic-server-handshake-with-test-client.mjs
new file mode 100644
index 00000000000000..c3e1eb49676ad1
--- /dev/null
+++ b/test/sequential/test-quic-server-handshake-with-test-client.mjs
@@ -0,0 +1,63 @@
+// Flags: --experimental-quic
+import { hasQuic, isAIX, isWindows, skip } from '../common/index.mjs';
+import { partialDeepStrictEqual, ok } from 'node:assert';
+import { setTimeout } from 'node:timers/promises';
+
+if (!hasQuic) {
+  skip('QUIC support is not enabled');
+}
+if (isAIX) {
+  // AIX does not support some of the networking features used in the ngtcp2
+  // example server and client.
+  skip('QUIC third-party tests are disabled on AIX');
+}
+if (isWindows) {
+  // Windows does not support the [Li/U]nix specific headers and system calls
+  // required by the ngtcp2 example server/client.
+  skip('QUIC third-party tests are disabled on Windows');
+}
+
+// Import after the hasQuic check
+const { default: QuicTestClient } = await import('../common/quic/test-client.mjs');
+const { listen } = await import('node:quic');
+const { readKey } = await import('../common/fixtures.mjs');
+const { createPrivateKey } = await import('node:crypto');
+
+const keys = createPrivateKey(readKey('agent1-key.pem'));
+const certs = readKey('agent1-cert.pem');
+
+const check = {
+  // The SNI value
+  servername: 'localhost',
+  // The selected ALPN protocol
+  protocol: 'h3',
+  // The negotiated cipher suite
+  cipher: 'TLS_AES_128_GCM_SHA256',
+  cipherVersion: 'TLSv1.3',
+};
+
+const serverOpened = Promise.withResolvers();
+
+const server = await listen(async (session) => {
+  // Wrapping in a mustCall is not necessary here since if this
+  // function is not called the test will time out and fail.
+  const info = await session.opened;
+  partialDeepStrictEqual(info, check);
+  serverOpened.resolve();
+  session.destroy();
+}, { keys, certs });
+
+// The server must have an address to connect to after listen resolves.
+const address = server.address;
+ok(address !== undefined);
+
+const client = new QuicTestClient();
+client.run(address.address, address.port, undefined, {
+  stdio: 'ignore',
+});
+
+await serverOpened.promise;
+
+await setTimeout(100);
+client.stop();
+await server.close();
diff --git a/test/parallel/test-quic-test-client.mjs b/test/sequential/test-quic-test-client.mjs
similarity index 69%
rename from test/parallel/test-quic-test-client.mjs
rename to test/sequential/test-quic-test-client.mjs
index 921001e84ddc10..ada7037e91ce34 100644
--- a/test/parallel/test-quic-test-client.mjs
+++ b/test/sequential/test-quic-test-client.mjs
@@ -1,6 +1,5 @@
 // Flags: --experimental-quic
-import { hasQuic, isAIX, isWindows, skip } from '../common/index.mjs';
-import { rejects } from 'node:assert';
+import { hasQuic, isAIX, isWindows, skip, getPort } from '../common/index.mjs';
 
 if (!hasQuic) {
   skip('QUIC support is not enabled');
@@ -27,6 +26,4 @@ setTimeout(() => {
   client.stop();
 }, 100);
 
-// We expect this to fail since there's no server running.
-await rejects(client.run('localhost', '12345', undefined, { stdio: 'ignore' }),
-              { message: /Process exited with code 1 and signal null/ });
+await client.run('localhost', getPort(), undefined, { stdio: 'ignore' });
diff --git a/test/parallel/test-quic-test-server.mjs b/test/sequential/test-quic-test-server.mjs
similarity index 89%
rename from test/parallel/test-quic-test-server.mjs
rename to test/sequential/test-quic-test-server.mjs
index 0951984b2a708a..4fb56789b14201 100644
--- a/test/parallel/test-quic-test-server.mjs
+++ b/test/sequential/test-quic-test-server.mjs
@@ -1,5 +1,5 @@
 // Flags: --experimental-quic
-import { hasQuic, isAIX, isWindows, skip } from '../common/index.mjs';
+import { hasQuic, isAIX, isWindows, skip, getPort } from '../common/index.mjs';
 
 if (!hasQuic) {
   skip('QUIC support is not enabled');
@@ -28,7 +28,7 @@ setTimeout(() => {
   server.stop();
 }, 100);
 
-await server.run('localhost', '12345',
+await server.run('localhost', getPort(),
                  `${fixturesPath}/keys/agent1-key.pem`,
                  `${fixturesPath}/keys/agent1-cert.pem`,
                  { stdio: 'inherit' });