diff --git a/common.gypi b/common.gypi
index a5588d43e3401f..33e39334594b7f 100644
--- a/common.gypi
+++ b/common.gypi
@@ -38,7 +38,7 @@
 
     # Reset this number to 0 on major V8 upgrades.
     # Increment by one for each non-official patch applied to deps/v8.
-    'v8_embedder_string': '-node.21',
+    'v8_embedder_string': '-node.22',
 
     ##### V8 defaults for Node.js #####
 
diff --git a/deps/v8/src/flags/flags.cc b/deps/v8/src/flags/flags.cc
index 92f43e4c937c67..0cdea771822f59 100644
--- a/deps/v8/src/flags/flags.cc
+++ b/deps/v8/src/flags/flags.cc
@@ -473,6 +473,15 @@ uint32_t ComputeFlagListHash() {
     if (flag.PointsTo(&v8_flags.random_seed)) continue;
     if (flag.PointsTo(&v8_flags.predictable)) continue;
 
+    // These flags are not relevant for code caching and are often set by
+    // embedders to tune memory usage.
+    if (flag.PointsTo(&v8_flags.max_old_space_size) ||
+        flag.PointsTo(&v8_flags.min_semi_space_size) ||
+        flag.PointsTo(&v8_flags.max_semi_space_size) ||
+        flag.PointsTo(&v8_flags.max_heap_size)) {
+      continue;
+    }
+
     // The following flags are implied by --predictable (some negated).
     if (flag.PointsTo(&v8_flags.concurrent_sparkplug) ||
         flag.PointsTo(&v8_flags.concurrent_recompilation) ||