diff --git a/CMakeLists.txt b/CMakeLists.txt
index aa5535e553a4..009c01ae03f2 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -35,3 +35,9 @@ add_subdirectory(subsys)
 add_subdirectory(modules)
 add_subdirectory(drivers)
 add_subdirectory(tests)
+
+# TEMPHACK: Add a source file generated by cmake/sysbuild/periphconf_migrate.cmake
+if(CONFIG_NRF_HALTIUM_GENERATE_UICR)
+  file(TOUCH ${PROJECT_BINARY_DIR}/periphconf_migrated.c)
+  zephyr_sources(${PROJECT_BINARY_DIR}/periphconf_migrated.c)
+endif()
diff --git a/CODEOWNERS b/CODEOWNERS
index 321bfd1f7d02..2b64b137cfe9 100644
--- a/CODEOWNERS
+++ b/CODEOWNERS
@@ -537,6 +537,7 @@
 /samples/sensor/bme68x_iaq/               @nrfconnect/ncs-cia
 /samples/nrf5340/empty_app_core/          @nrfconnect/ncs-si-muffin
 /samples/nrf5340/extxip_smp_svr/          @nrfconnect/ncs-pluto
+/samples/nrf54h20/empty_app_core/         @nrfconnect/ncs-aurora
 /samples/nrf_compress/                    @nordicjm
 /samples/nrf_profiler/                    @nrfconnect/ncs-si-bluebagel
 /samples/nrf_rpc/protocols_serialization/ @nrfconnect/ncs-protocols-serialization
diff --git a/applications/machine_learning/configuration/nrf54h20dk_nrf54h20_cpuapp/app.overlay b/applications/machine_learning/configuration/nrf54h20dk_nrf54h20_cpuapp/app.overlay
index 7fd4fbdecb47..378ded27433c 100644
--- a/applications/machine_learning/configuration/nrf54h20dk_nrf54h20_cpuapp/app.overlay
+++ b/applications/machine_learning/configuration/nrf54h20dk_nrf54h20_cpuapp/app.overlay
@@ -40,6 +40,16 @@
 			label = "Green LED 3";
 		};
 	};
+
+	reserved-memory {
+		cpuppr_code_data: memory@2fc00000 {
+			reg = <0x2fc00000 0xf200>;
+		};
+
+		ram3x_agg_area0: memory@2fc0f200 {
+			reg = <0x2fc0f200 0x600>;
+		};
+	};
 };
 
 &cpuppr_vevif {
@@ -50,49 +60,21 @@ ipc1: &cpuapp_cpuppr_ipc {
 	status = "okay";
 };
 
-/* Expand APP slot partition and remove DFU partition. */
-/delete-node/ &cpuapp_rx_partitions;
-/delete-node/ &cpuapp_rw_partitions;
+/delete-node/ &cpuapp_slot0_partition;
+/delete-node/ &cpurad_slot0_partition;
 
-&cpuppr_ram3x_region {
-	cpuppr_code_data: memory@0 {
-		reg = <0x0 0xf200>;
-	};
+&mram1x {
+	partitions {
+		slot0_partition: cpuapp_slot0_partition: partition@30000 {
+			reg = <0x30000 0x82000>;
+		};
 
-	ram3x_agg_area0: memory@f200{
-		reg = <0xf200 0x600>;
+		cpurad_slot0_partition: partition@b2000 {
+			reg = <0xb2000 0x32000>;
+		};
 	};
 };
 
-&mram1x {
-       cpuapp_rx_partitions: cpuapp-rx-partitions {
-	       compatible = "nordic,owned-partitions", "fixed-partitions";
-	       status = "okay";
-	       nordic,access = <NRF_OWNER_ID_APPLICATION NRF_PERM_RXS>;
-	       #address-cells = <1>;
-	       #size-cells = <1>;
-
-	       cpuapp_slot0_partition: partition@a6000 {
-		       reg = <0xa6000 DT_SIZE_K(512)>;
-	       };
-
-	       cpuppr_code_partition: partition@126000 {
-		       reg = <0x126000 DT_SIZE_K(64)>;
-	       };
-       };
-
-       cpuapp_rw_partitions: cpuapp-rw-partitions {
-	       compatible = "nordic,owned-partitions", "fixed-partitions";
-	       status = "okay";
-	       nordic,access = <NRF_OWNER_ID_APPLICATION NRF_PERM_RW>;
-	       #address-cells = < 0x1 >;
-	       #size-cells = < 0x1 >;
-
-	       storage_partition: partition@136000 {
-		       reg = < 0x136000 DT_SIZE_K(24) >;
-	       };
-       };
-};
 
 /* Remove DTS nodes associated with the cpuflpr target as they refer to the
  * cpuflpr_code_partition label from the cpuapp_rx_partitions node. The label has
diff --git a/applications/machine_learning/remote/boards/nrf54h20dk_nrf54h20_cpuppr.overlay b/applications/machine_learning/remote/boards/nrf54h20dk_nrf54h20_cpuppr.overlay
index 14f0f531a2e2..904ab02e6d70 100644
--- a/applications/machine_learning/remote/boards/nrf54h20dk_nrf54h20_cpuppr.overlay
+++ b/applications/machine_learning/remote/boards/nrf54h20dk_nrf54h20_cpuppr.overlay
@@ -14,54 +14,33 @@
 		memory-region = <&ram3x_agg_area0>;
 		status = "okay";
 	};
-};
 
-/* Expand APP slot partition and remove DFU partition. */
-/delete-node/ &cpuapp_rx_partitions;
-/delete-node/ &cpuapp_rw_partitions;
 
-/*
- * Place aggregator buffers in PPR memory region.
- */
-&cpuppr_ram3x_region {
-	cpuppr_code_data: memory@0 {
-		reg = <0x0 0xf200>;
-	};
+	reserved-memory {
+		cpuppr_code_data: memory@2fc00000 {
+			reg = <0x2fc00000 0xf200>;
+		};
 
-	ram3x_agg_area0: memory@f200{
-		reg = <0xf200 0x600>;
+		ram3x_agg_area0: memory@2fc0f200 {
+			reg = <0x2fc0f200 0x600>;
+		};
 	};
 };
 
+/delete-node/ &cpuapp_slot0_partition;
+/delete-node/ &cpurad_slot0_partition;
+
 /* This duplicates the Application core configuration to build PPR image under valid address. */
 &mram1x {
-       cpuapp_rx_partitions: cpuapp-rx-partitions {
-	       compatible = "nordic,owned-partitions", "fixed-partitions";
-	       status = "okay";
-	       nordic,access = <NRF_OWNER_ID_APPLICATION NRF_PERM_RXS>;
-	       #address-cells = <1>;
-	       #size-cells = <1>;
-
-	       cpuapp_slot0_partition: partition@a6000 {
-		       reg = <0xa6000 DT_SIZE_K(512)>;
-	       };
-
-	       cpuppr_code_partition: partition@126000 {
-		       reg = <0x126000 DT_SIZE_K(64)>;
-	       };
-       };
-
-       cpuapp_rw_partitions: cpuapp-rw-partitions {
-	       compatible = "nordic,owned-partitions", "fixed-partitions";
-	       status = "okay";
-	       nordic,access = <NRF_OWNER_ID_APPLICATION NRF_PERM_RW>;
-	       #address-cells = < 0x1 >;
-	       #size-cells = < 0x1 >;
-
-	       storage_partition: partition@136000 {
-		       reg = < 0x136000 DT_SIZE_K(24) >;
-	       };
-       };
+	partitions {
+		cpuapp_slot0_partition: slot0_partition: partition@30000 {
+			reg = <0x30000 0x82000>;
+		};
+
+		cpurad_slot0_partition: partition@b2000 {
+			reg = <0xb2000 0x32000>;
+		};
+	};
 };
 
 ipc1: &cpuapp_cpuppr_ipc {
diff --git a/applications/machine_learning/sysbuild/ipc_radio/boards/nrf54h20dk_nrf54h20_cpurad.overlay b/applications/machine_learning/sysbuild/ipc_radio/boards/nrf54h20dk_nrf54h20_cpurad.overlay
index fedab1ff4a5f..eced374a0660 100644
--- a/applications/machine_learning/sysbuild/ipc_radio/boards/nrf54h20dk_nrf54h20_cpurad.overlay
+++ b/applications/machine_learning/sysbuild/ipc_radio/boards/nrf54h20dk_nrf54h20_cpurad.overlay
@@ -18,37 +18,3 @@
 &cpurad_dma_region {
 	status = "disabled";
 };
-
-/* Expand APP slot partition and remove DFU partition. */
-/delete-node/ &cpuapp_rx_partitions;
-/delete-node/ &cpuapp_rw_partitions;
-
-&mram1x {
-	cpuapp_rx_partitions: cpuapp-rx-partitions {
-		compatible = "nordic,owned-partitions", "fixed-partitions";
-		status = "disabled";
-		nordic,access = <NRF_OWNER_ID_APPLICATION NRF_PERM_RXS>;
-		#address-cells = <1>;
-		#size-cells = <1>;
-
-		cpuapp_slot0_partition: partition@a6000 {
-			reg = <0xa6000 DT_SIZE_K(512)>;
-		};
-
-		cpuppr_code_partition: partition@126000 {
-			reg = <0x126000 DT_SIZE_K(64)>;
-		};
-	};
-
-	cpuapp_rw_partitions: cpuapp-rw-partitions {
-		compatible = "nordic,owned-partitions", "fixed-partitions";
-		status = "disabled";
-		nordic,access = <NRF_OWNER_ID_APPLICATION NRF_PERM_RW>;
-		#address-cells = < 0x1 >;
-		#size-cells = < 0x1 >;
-
-		storage_partition: partition@136000 {
-			reg = < 0x136000 DT_SIZE_K(24) >;
-		};
-	};
-};
diff --git a/boards/shields/coverage_support/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/boards/shields/coverage_support/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
index a69335671a90..510aaa8067b9 100644
--- a/boards/shields/coverage_support/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ b/boards/shields/coverage_support/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
@@ -4,26 +4,6 @@
  * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
  */
 
-/* Delete current app definition to redefine belowe */
-/delete-node/ &cpuapp_slot0_partition;
-
-/* Extend by 160 KB, taken from rad */
-&cpuapp_rx_partitions {
-	cpuapp_slot0_partition: partition@6C000 {
-		reg = <0x6C000 DT_SIZE_K(480)>;
-	};
-};
-
-/* Shrink by 160 KB */
-&cpurad_slot0_partition {
-	reg = <0x54000 DT_SIZE_K(96)>;
-};
-
 &uart136 {
 	hw-flow-control;
 };
-
-/* To disable SDFW_SERVICES to save RAM */
-&cpusec_cpuapp_ipc {
-	status = "disabled";
-};
diff --git a/cmake/sysbuild/periphconf_migrate.cmake b/cmake/sysbuild/periphconf_migrate.cmake
new file mode 100644
index 000000000000..9eda9bcf5309
--- /dev/null
+++ b/cmake/sysbuild/periphconf_migrate.cmake
@@ -0,0 +1,66 @@
+# Copyright (c) 2025 Nordic Semiconductor ASA
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+
+# This file includes extra sysbuild POST_CMAKE logic to assist with
+# autogenerating an IronSide SE compatible UICR.
+#
+# It is enabled when SB_CONFIG_NRF_PERIPHCONF_MIGRATE=y is set and
+# one of the sysbuild images has CONFIG_NRF_HALTIUM_GENERATE_UICR=y.
+# It uses nrf-regtool to produce an extra source file for that image
+# (periphconf_migrated.c) based on multiple image devicetrees.
+#
+# NOTE: This is a temporary solution for NCS. The planned solution
+# for upstream Zephyr will not require nrf-regtool.
+
+set(ironside_uicr_images "")
+set(ironside_uicr_main_image)
+foreach(image ${POST_CMAKE_IMAGES})
+  sysbuild_get(${image}_54h20_app IMAGE ${image} VAR CONFIG_SOC_NRF54H20_CPUAPP KCONFIG)
+  sysbuild_get(${image}_54h20_rad IMAGE ${image} VAR CONFIG_SOC_NRF54H20_CPURAD KCONFIG)
+  if(${image}_54h20_app OR ${image}_54h20_rad)
+    list(APPEND ironside_uicr_images ${image})
+    if(NOT DEFINED ironside_uicr_main_image)
+      sysbuild_get(image_generates_uicr IMAGE ${image} VAR CONFIG_NRF_HALTIUM_GENERATE_UICR KCONFIG)
+      if(image_generates_uicr)
+        set(ironside_uicr_main_image ${image})
+      endif()
+    endif()
+  endif()
+endforeach()
+if(DEFINED ironside_uicr_main_image)
+  find_program(NRF_REGTOOL nrf-regtool REQUIRED)
+  set(nrf_regtool_cmd
+    COMMAND
+    ${CMAKE_COMMAND} -E env PYTHONPATH=${ZEPHYR_BASE}/scripts/dts/python-devicetree/src
+    ${NRF_REGTOOL}
+  )
+  ExternalProject_Get_Property(${ironside_uicr_main_image} BINARY_DIR)
+  set(nrf_regtool_migrate_cmd
+    ${nrf_regtool_cmd}
+    uicr-migrate
+    --edt-pickle-file ${BINARY_DIR}/zephyr/edt.pickle
+    --output-periphconf-file ${BINARY_DIR}/zephyr/periphconf_migrated.c
+  )
+  foreach(image ${ironside_uicr_images})
+    ExternalProject_Get_Property(${image} BINARY_DIR)
+    sysbuild_get(image_soc IMAGE ${image} VAR CONFIG_SOC KCONFIG)
+    set(image_uicr_hex ${PROJECT_BINARY_DIR}/uicr_${image}.hex)
+    message(STATUS "Running nrf-regtool uicr-compile for ${image}")
+    execute_process(
+      ${nrf_regtool_cmd}
+      uicr-compile
+      --edt-pickle-file ${BINARY_DIR}/zephyr/edt.pickle
+      --product-name ${image_soc}
+      --output-file ${image_uicr_hex}
+      WORKING_DIRECTORY ${APPLICATION_SOURCE_DIR}
+      COMMAND_ERROR_IS_FATAL ANY
+    )
+    list(APPEND nrf_regtool_migrate_cmd --uicr-hex-file ${image_uicr_hex})
+  endforeach()
+  message(STATUS "Running nrf-regtool uicr-migrate for ${ironside_uicr_main_image}")
+  execute_process(
+    ${nrf_regtool_migrate_cmd}
+    WORKING_DIRECTORY ${APPLICATION_SOURCE_DIR}
+    COMMAND_ERROR_IS_FATAL ANY
+  )
+endif()
diff --git a/cmake/sysbuild/suit_provisioning.cmake b/cmake/sysbuild/suit_provisioning.cmake
index c42fe71240ec..6bd6a55a5779 100644
--- a/cmake/sysbuild/suit_provisioning.cmake
+++ b/cmake/sysbuild/suit_provisioning.cmake
@@ -227,10 +227,9 @@ function (generate_mpi_area area)
   message(INFO " Generate merged MPI for ${area} (${output})")
 endfunction()
 
-if((DEFINED SB_CONFIG_SOC_SERIES_NRF54HX) OR
-    (DEFINED SB_CONFIG_SOC_SERIES_NRF92X))
+if(DEFINED SB_CONFIG_SOC_SERIES_NRF92X)
   configure_storage_address_cache()
-endif() # SB_CONFIG_SOC_SERIES_NRF54HX OR SB_CONFIG_SOC_SERIES_NRF92X
+endif() # SB_CONFIG_SOC_SERIES_NRF92X
 
 if(DEFINED SB_CONFIG_SUIT_MPI_GENERATE)
   include(${CMAKE_CURRENT_LIST_DIR}/suit_provisioning_${SB_CONFIG_SOC}.cmake)
diff --git a/doc/nrf/drivers/mspi_sqspi.rst b/doc/nrf/drivers/mspi_sqspi.rst
index 82c6278cbce4..027ba78bddc8 100644
--- a/doc/nrf/drivers/mspi_sqspi.rst
+++ b/doc/nrf/drivers/mspi_sqspi.rst
@@ -69,10 +69,6 @@ See the following configuration example for the nRF54L15 SoC:
 
 	/ {
 		reserved-memory {
-			#address-cells = <1>;
-			#size-cells = <1>;
-			ranges;
-
 			softperiph_ram: memory@2003c000 {
 				reg = <0x2003c000 0x4000>;
 				ranges = <0 0x2003c000 0x4000>;
@@ -145,31 +141,35 @@ The following example configuration for the nRF54H20 SoC sets up the necessary p
 	/delete-node/ &cpuflpr_cpuapp_ipc_shm;
 	/delete-node/ &cpuapp_cpuflpr_ipc;
 
-	&ram21_region {
-		status = "okay";
-
-		softperiph_ram: memory@0 {
-			reg = <0 0x4000>;
-			ranges;
+	/ {
+		reserved-memory {
 			#address-cells = <1>;
 			#size-cells = <1>;
+			ranges;
 
-			sqspi: sqspi@3e00 {
-				compatible = "nordic,nrf-sqspi";
+			softperiph_ram: memory@2f890000 {
+				reg = <0x2f890000 0x4000>;
+				ranges;
 				#address-cells = <1>;
-				#size-cells = <0>;
-				reg = <0x3e00 0x200>;
-				zephyr,pm-device-runtime-auto;
-				memory-regions = <&sqspi_buffers>;
+				#size-cells = <1>;
+
+				dut: sqspi: sqspi@3e00 {
+					compatible = "nordic,nrf-sqspi";
+					#address-cells = <1>;
+					#size-cells = <0>;
+					reg = <0x3e00 0x200>;
+					zephyr,pm-device-runtime-auto;
+					memory-regions = <&sqspi_buffers>;
+				};
 			};
-		};
 
-		sqspi_buffers: memory@4000 {
-			compatible = "zephyr,memory-region";
-			reg = <0x4000 0x4000>;
-			#memory-region-cells = <0>;
-			zephyr,memory-region = "SQSPI_BUFFERS";
-			zephyr,memory-attr = <DT_MEM_CACHEABLE>;
+			sqspi_buffers: memory@2f894000 {
+				compatible = "zephyr,memory-region";
+				reg = <0x2f894000 0x4000>;
+				#memory-region-cells = <0>;
+				zephyr,memory-region = "SQSPI_BUFFERS";
+				zephyr,memory-attr = <DT_MEM_CACHEABLE>;
+			};
 		};
 	};
 
diff --git a/lib/fprotect/Kconfig b/lib/fprotect/Kconfig
index 220c570c93ea..69eb4859f83e 100644
--- a/lib/fprotect/Kconfig
+++ b/lib/fprotect/Kconfig
@@ -50,6 +50,7 @@ menuconfig FPROTECT
 	bool "Enable FPROTECT"
 	depends on SOC_FAMILY_NORDIC_NRF
 	depends on !(SOC_SERIES_NRF54LX && IS_SECURE_BOOTLOADER)
+	depends on !SOC_SERIES_NRF54HX
 	default y if MCUBOOT && (!SOC_SERIES_NRF54LX || (SOC_SERIES_NRF54LX && MCUBOOT_MCUBOOT_IMAGE_NUMBER = -1))
 	#enabled for nRF54L SoC's when MCUboot is the only one bootloader
 	select NRFX_RRAMC if SOC_SERIES_NRF54LX
diff --git a/samples/benchmarks/coremark/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/benchmarks/coremark/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
index f1f688bb29f7..1e9de644c4f9 100644
--- a/samples/benchmarks/coremark/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ b/samples/benchmarks/coremark/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
@@ -40,10 +40,6 @@
 	status = "okay";
 };
 
-&cpuppr_ram3x_region {
-	status = "okay";
-};
-
 /* DTS nodes required for the STM standalone logging, imported from the nordic-log-stm snippet. */
 &tbm {
 	status = "okay";
diff --git a/samples/bluetooth/central_and_peripheral_hr/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/central_and_peripheral_hr/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/central_and_peripheral_hr/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/central_hids/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/central_hids/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/central_hids/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/central_hr_coded/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/central_hr_coded/boards/nrf54h20dk_nrf54h20_cpuapp.conf
index 680413f53d81..da0648f98253 100644
--- a/samples/bluetooth/central_hr_coded/boards/nrf54h20dk_nrf54h20_cpuapp.conf
+++ b/samples/bluetooth/central_hr_coded/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -7,3 +7,5 @@
 # Application core does not have BLE controller. Disable controller related options.
 CONFIG_BT_CTLR_ADV_EXT=n
 CONFIG_BT_CTLR_PHY_CODED=n
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/central_uart/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/central_uart/boards/nrf54h20dk_nrf54h20_cpuapp.conf
index fb5a71c62404..f33f5c19a38a 100644
--- a/samples/bluetooth/central_uart/boards/nrf54h20dk_nrf54h20_cpuapp.conf
+++ b/samples/bluetooth/central_uart/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -10,3 +10,5 @@ CONFIG_NRFX_UARTE0=n
 # Don't get entropy from HCI on nRF54H20 devices
 CONFIG_BT_HOST_CRYPTO_PRNG=y
 CONFIG_ENTROPY_BT_HCI=n
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/channel_sounding_ras_initiator/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/channel_sounding_ras_initiator/boards/nrf54h20dk_nrf54h20_cpuapp.conf
index b7182995c84d..e2257827a19d 100644
--- a/samples/bluetooth/channel_sounding_ras_initiator/boards/nrf54h20dk_nrf54h20_cpuapp.conf
+++ b/samples/bluetooth/channel_sounding_ras_initiator/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -12,3 +12,5 @@ CONFIG_PSA_SSF_CRYPTO_CLIENT=y
 CONFIG_SSF_PSA_CRYPTO_SERVICE_ENABLED=y
 CONFIG_MBEDTLS_PSA_CRYPTO_C=y
 CONFIG_NRF_SECURITY=y
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/channel_sounding_ras_initiator/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/bluetooth/channel_sounding_ras_initiator/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
index 17952e023ccf..507f74dee3b9 100644
--- a/samples/bluetooth/channel_sounding_ras_initiator/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ b/samples/bluetooth/channel_sounding_ras_initiator/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
@@ -4,25 +4,6 @@
  * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
  */
 
-/delete-node/ &cpuapp_slot0_partition;
-/delete-node/ &cpurad_slot0_partition;
-
-/* Allocate extra MRAM as 256K is not enough NVM for multiantenna CS.
- * The extra memory is taken from cpuapp below.
- */
-&cpurad_rx_partitions {
-	cpurad_slot0_partition: partition@54000 {
-		reg = <0x00054000 DT_SIZE_K(316)>;
-	};
-};
-
-/* Reduce cpuapp by 60K (default 320 - 60) */
-&cpuapp_rx_partitions {
-	cpuapp_slot0_partition: partition@a3000 {
-		reg = <0xa3000 DT_SIZE_K(260)>;
-	};
-};
-
 // Enable PSA RNG
 / {
 	chosen {
diff --git a/samples/bluetooth/channel_sounding_ras_initiator/sysbuild/hci_ipc/boards/nrf54h20dk_nrf54h20_cpurad.overlay b/samples/bluetooth/channel_sounding_ras_initiator/sysbuild/hci_ipc/boards/nrf54h20dk_nrf54h20_cpurad.overlay
index ed23a52f6b11..0cd7b8aff403 100644
--- a/samples/bluetooth/channel_sounding_ras_initiator/sysbuild/hci_ipc/boards/nrf54h20dk_nrf54h20_cpurad.overlay
+++ b/samples/bluetooth/channel_sounding_ras_initiator/sysbuild/hci_ipc/boards/nrf54h20dk_nrf54h20_cpurad.overlay
@@ -4,25 +4,6 @@
  * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
  */
 
-/delete-node/ &cpuapp_slot0_partition;
-/delete-node/ &cpurad_slot0_partition;
-
-/* Allocate extra MRAM as 256K is not enough NVM for multiantenna CS.
- * The extra memory is taken from cpuapp below.
- */
-&cpurad_rx_partitions {
-	cpurad_slot0_partition: partition@54000 {
-		reg = <0x00054000 DT_SIZE_K(316)>;
-	};
-};
-
-/* Reduce cpuapp by 60K (default 320 - 60) */
-&cpuapp_rx_partitions {
-	cpuapp_slot0_partition: partition@a3000 {
-		reg = <0xa3000 DT_SIZE_K(260)>;
-	};
-};
-
 / {
 	cs_antenna_switch: cs-antenna-config {
 		status = "okay";
diff --git a/samples/bluetooth/channel_sounding_ras_reflector/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/channel_sounding_ras_reflector/boards/nrf54h20dk_nrf54h20_cpuapp.conf
index b7182995c84d..e2257827a19d 100644
--- a/samples/bluetooth/channel_sounding_ras_reflector/boards/nrf54h20dk_nrf54h20_cpuapp.conf
+++ b/samples/bluetooth/channel_sounding_ras_reflector/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -12,3 +12,5 @@ CONFIG_PSA_SSF_CRYPTO_CLIENT=y
 CONFIG_SSF_PSA_CRYPTO_SERVICE_ENABLED=y
 CONFIG_MBEDTLS_PSA_CRYPTO_C=y
 CONFIG_NRF_SECURITY=y
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/channel_sounding_ras_reflector/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/bluetooth/channel_sounding_ras_reflector/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
index 17952e023ccf..507f74dee3b9 100644
--- a/samples/bluetooth/channel_sounding_ras_reflector/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ b/samples/bluetooth/channel_sounding_ras_reflector/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
@@ -4,25 +4,6 @@
  * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
  */
 
-/delete-node/ &cpuapp_slot0_partition;
-/delete-node/ &cpurad_slot0_partition;
-
-/* Allocate extra MRAM as 256K is not enough NVM for multiantenna CS.
- * The extra memory is taken from cpuapp below.
- */
-&cpurad_rx_partitions {
-	cpurad_slot0_partition: partition@54000 {
-		reg = <0x00054000 DT_SIZE_K(316)>;
-	};
-};
-
-/* Reduce cpuapp by 60K (default 320 - 60) */
-&cpuapp_rx_partitions {
-	cpuapp_slot0_partition: partition@a3000 {
-		reg = <0xa3000 DT_SIZE_K(260)>;
-	};
-};
-
 // Enable PSA RNG
 / {
 	chosen {
diff --git a/samples/bluetooth/channel_sounding_ras_reflector/sysbuild/hci_ipc/boards/nrf54h20dk_nrf54h20_cpurad.overlay b/samples/bluetooth/channel_sounding_ras_reflector/sysbuild/hci_ipc/boards/nrf54h20dk_nrf54h20_cpurad.overlay
index ed23a52f6b11..0cd7b8aff403 100644
--- a/samples/bluetooth/channel_sounding_ras_reflector/sysbuild/hci_ipc/boards/nrf54h20dk_nrf54h20_cpurad.overlay
+++ b/samples/bluetooth/channel_sounding_ras_reflector/sysbuild/hci_ipc/boards/nrf54h20dk_nrf54h20_cpurad.overlay
@@ -4,25 +4,6 @@
  * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
  */
 
-/delete-node/ &cpuapp_slot0_partition;
-/delete-node/ &cpurad_slot0_partition;
-
-/* Allocate extra MRAM as 256K is not enough NVM for multiantenna CS.
- * The extra memory is taken from cpuapp below.
- */
-&cpurad_rx_partitions {
-	cpurad_slot0_partition: partition@54000 {
-		reg = <0x00054000 DT_SIZE_K(316)>;
-	};
-};
-
-/* Reduce cpuapp by 60K (default 320 - 60) */
-&cpuapp_rx_partitions {
-	cpuapp_slot0_partition: partition@a3000 {
-		reg = <0xa3000 DT_SIZE_K(260)>;
-	};
-};
-
 / {
 	cs_antenna_switch: cs-antenna-config {
 		status = "okay";
diff --git a/samples/bluetooth/conn_time_sync/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/conn_time_sync/boards/nrf54h20dk_nrf54h20_cpuapp.conf
index 7524a2983194..a672468b02bf 100644
--- a/samples/bluetooth/conn_time_sync/boards/nrf54h20dk_nrf54h20_cpuapp.conf
+++ b/samples/bluetooth/conn_time_sync/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -12,3 +12,5 @@ CONFIG_PSA_SSF_CRYPTO_CLIENT=y
 CONFIG_SSF_PSA_CRYPTO_SERVICE_ENABLED=y
 CONFIG_MBEDTLS_PSA_CRYPTO_C=y
 CONFIG_NRF_SECURITY=y
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/fast_pair/input_device/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/fast_pair/input_device/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/fast_pair/input_device/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/fast_pair/input_device/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/bluetooth/fast_pair/input_device/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
index e048e4492899..5c691bc35bd9 100644
--- a/samples/bluetooth/fast_pair/input_device/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ b/samples/bluetooth/fast_pair/input_device/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
@@ -4,27 +4,12 @@
  * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
  */
 
+/* Define the Fast Pair partition. */
 &mram1x {
-	/delete-node/ cpuapp-rw-partitions;
-
-	cpuapp_rw_partitions: cpuapp-rw-partitions {
-		compatible = "nordic,owned-partitions", "fixed-partitions";
-		status = "okay";
-		nordic,access = <NRF_OWNER_ID_APPLICATION NRF_PERM_RWS>;
-		#address-cells = <1>;
-		#size-cells = <1>;
-
-		dfu_partition: partition@100000 {
-			reg = <0x100000 DT_SIZE_K(908)>;
-		};
-
+	partitions {
 		/* Align the partition size to 4096 B to avoid gaps. */
-		bt_fast_pair_partition: partition@1e3000 {
-			reg = <0x1e3000 DT_SIZE_K(4)>;
-		};
-
-		storage_partition: partition@1e4000 {
-			reg = <0x1e4000 DT_SIZE_K(20)>;
+		bt_fast_pair_partition: partition@1b0000 {
+			reg = <0x1b0000 DT_SIZE_K(4)>;
 		};
 	};
 };
diff --git a/samples/bluetooth/fast_pair/locator_tag/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/fast_pair/locator_tag/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/fast_pair/locator_tag/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/fast_pair/locator_tag/configuration/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/bluetooth/fast_pair/locator_tag/configuration/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
index e20e38641864..935b365b139d 100644
--- a/samples/bluetooth/fast_pair/locator_tag/configuration/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ b/samples/bluetooth/fast_pair/locator_tag/configuration/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
@@ -4,31 +4,12 @@
  * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
  */
 
-/* Decrease the storage partition size by 0x1000 bytes and move it 0x1000 bytes forward
- * in the address space to create a place for the Fast Pair partition. Define the Fast
- * Pair partition in the provided memory gap.
- */
+/* Define the Fast Pair partition. */
 &mram1x {
-	/delete-node/ cpuapp-rw-partitions;
-
-	cpuapp_rw_partitions: cpuapp-rw-partitions {
-		compatible = "nordic,owned-partitions", "fixed-partitions";
-		status = "okay";
-		nordic,access = <NRF_OWNER_ID_APPLICATION NRF_PERM_RWS>;
-		#address-cells = <1>;
-		#size-cells = <1>;
-
-		dfu_partition: partition@100000 {
-			reg = <0x100000 DT_SIZE_K(908)>;
-		};
-
+	partitions {
 		/* Align the partition size to 4096 B to avoid gaps. */
-		bt_fast_pair_partition: partition@1e3000 {
-			reg = <0x1e3000 DT_SIZE_K(4)>;
-		};
-
-		storage_partition: partition@1e4000 {
-			reg = <0x1e4000 DT_SIZE_K(20)>;
+		bt_fast_pair_partition: partition@1b0000 {
+			reg = <0x1b0000 DT_SIZE_K(4)>;
 		};
 	};
 };
diff --git a/samples/bluetooth/iso_combined_bis_and_cis/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/iso_combined_bis_and_cis/boards/nrf54h20dk_nrf54h20_cpuapp.conf
index e4af07f6818a..2fcbea5c63bf 100644
--- a/samples/bluetooth/iso_combined_bis_and_cis/boards/nrf54h20dk_nrf54h20_cpuapp.conf
+++ b/samples/bluetooth/iso_combined_bis_and_cis/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -10,3 +10,5 @@ CONFIG_PSA_SSF_CRYPTO_CLIENT=y
 CONFIG_SSF_PSA_CRYPTO_SERVICE_ENABLED=y
 CONFIG_MBEDTLS_PSA_CRYPTO_C=y
 CONFIG_NRF_SECURITY=y
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/iso_time_sync/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/iso_time_sync/boards/nrf54h20dk_nrf54h20_cpuapp.conf
index 7524a2983194..a672468b02bf 100644
--- a/samples/bluetooth/iso_time_sync/boards/nrf54h20dk_nrf54h20_cpuapp.conf
+++ b/samples/bluetooth/iso_time_sync/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -12,3 +12,5 @@ CONFIG_PSA_SSF_CRYPTO_CLIENT=y
 CONFIG_SSF_PSA_CRYPTO_SERVICE_ENABLED=y
 CONFIG_MBEDTLS_PSA_CRYPTO_C=y
 CONFIG_NRF_SECURITY=y
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/llpm/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/llpm/boards/nrf54h20dk_nrf54h20_cpuapp.conf
index 17e055ab3b0d..d090d44f4b9f 100644
--- a/samples/bluetooth/llpm/boards/nrf54h20dk_nrf54h20_cpuapp.conf
+++ b/samples/bluetooth/llpm/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -19,3 +19,5 @@ CONFIG_MBEDTLS_PSA_CRYPTO_C=y
 CONFIG_NRF_SECURITY=y
 # More receive buffers are needed, possibly due to broken flow control in the HCI over IPC implementation.
 CONFIG_BT_BUF_EVT_RX_COUNT=22
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/multiple_adv_sets/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/multiple_adv_sets/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/multiple_adv_sets/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/peripheral_ams_client/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/peripheral_ams_client/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/peripheral_ams_client/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/peripheral_bms/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/peripheral_bms/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/peripheral_bms/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/peripheral_cgms/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/peripheral_cgms/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/peripheral_cgms/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/peripheral_cts_client/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/peripheral_cts_client/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/peripheral_cts_client/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/peripheral_hids_keyboard/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/peripheral_hids_keyboard/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/peripheral_hids_keyboard/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/peripheral_hids_mouse/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/peripheral_hids_mouse/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/peripheral_hids_mouse/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/peripheral_hr_coded/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/peripheral_hr_coded/boards/nrf54h20dk_nrf54h20_cpuapp.conf
index 404775ebf004..798212e6d8cd 100644
--- a/samples/bluetooth/peripheral_hr_coded/boards/nrf54h20dk_nrf54h20_cpuapp.conf
+++ b/samples/bluetooth/peripheral_hr_coded/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -7,3 +7,5 @@
 # Application core does not have BLE controller. Disable controller related options.
 CONFIG_BT_CTLR_PHY_CODED=n
 CONFIG_BT_CTLR_ADV_EXT=n
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/peripheral_lbs/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/peripheral_lbs/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/peripheral_lbs/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/peripheral_nfc_pairing/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/peripheral_nfc_pairing/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/peripheral_nfc_pairing/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/peripheral_rscs/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/peripheral_rscs/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/peripheral_rscs/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/peripheral_status/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/peripheral_status/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/peripheral_status/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/peripheral_uart/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/peripheral_uart/boards/nrf54h20dk_nrf54h20_cpuapp.conf
index ec5f8e3fbb40..e0b1b25fda81 100644
--- a/samples/bluetooth/peripheral_uart/boards/nrf54h20dk_nrf54h20_cpuapp.conf
+++ b/samples/bluetooth/peripheral_uart/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -10,3 +10,5 @@ CONFIG_NRFX_UARTE0=n
 # Don't get entropy from HCI on nRF54H20 devices
 CONFIG_BT_HOST_CRYPTO_PRNG=y
 CONFIG_ENTROPY_BT_HCI=n
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/peripheral_uart/boards/nrf54h20dk_nrf54h20_cpurad.overlay b/samples/bluetooth/peripheral_uart/boards/nrf54h20dk_nrf54h20_cpurad.overlay
index e48075792d7d..8827d25090b4 100644
--- a/samples/bluetooth/peripheral_uart/boards/nrf54h20dk_nrf54h20_cpurad.overlay
+++ b/samples/bluetooth/peripheral_uart/boards/nrf54h20dk_nrf54h20_cpurad.overlay
@@ -92,51 +92,19 @@
 	owned-channels = <4 5 6 7>;
 };
 
-/* Change to memory map to make room for read write partition for settings
- * module and increase the radio core program memory size.
+/* Add a read write partition for the settings module.
  *
  * @note In case of running firmware on the application core, the same memory map
  * change must be applied to the application core DTS.
  */
-/delete-node/ &dfu_partition;
-/delete-node/ &storage_partition;
-/delete-node/ &cpuapp_slot0_partition;
-
-&cpuapp_rw_partitions {
-	dfu_partition: partition@100000 {
-		reg = < 0x100000 DT_SIZE_K(884) >;
-	};
-
-	storage_partition: partition@1dd000 {
-		reg = < 0x1dd000 DT_SIZE_K(24) >;
-	};
-};
-
-&cpurad_rx_partitions {
-	cpurad_slot0_partition: partition@54000 {
-		reg = <0x54000 DT_SIZE_K(320)>;
-	};
-};
-
-&cpuapp_rx_partitions {
-	cpuapp_slot0_partition: partition@a4000 {
-		reg = <0xa4000 DT_SIZE_K(256)>;
-	};
-};
-
 &mram1x {
-	cpurad_rw_partitions: cpurad-rw-partitions {
-		compatible = "nordic,owned-partitions", "fixed-partitions";
-		nordic,access = <NRF_OWNER_ID_RADIOCORE NRF_PERM_RWS>;
-		#address-cells = <1>;
-		#size-cells = <1>;
-
+	partitions {
+		/* Note: the location here has been kept the same as before the introduction of
+		 * IronSide on nrf54h20, which has brought with it an updated memory map.
+		 * It will likely need to be updated as the MRAM memory map is not yet final.
+		 */
 		cpurad_storage_partition: partition@1e3000 {
 			reg = <0x1e3000 DT_SIZE_K(24)>;
 		};
 	};
 };
-
-&cpurad_rw_partitions {
-	status = "okay";
-};
diff --git a/samples/bluetooth/shell_bt_nus/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/shell_bt_nus/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/samples/bluetooth/shell_bt_nus/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/subrating/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/subrating/boards/nrf54h20dk_nrf54h20_cpuapp.conf
index e4af07f6818a..2fcbea5c63bf 100644
--- a/samples/bluetooth/subrating/boards/nrf54h20dk_nrf54h20_cpuapp.conf
+++ b/samples/bluetooth/subrating/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -10,3 +10,5 @@ CONFIG_PSA_SSF_CRYPTO_CLIENT=y
 CONFIG_SSF_PSA_CRYPTO_SERVICE_ENABLED=y
 CONFIG_MBEDTLS_PSA_CRYPTO_C=y
 CONFIG_NRF_SECURITY=y
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/bluetooth/throughput/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/samples/bluetooth/throughput/boards/nrf54h20dk_nrf54h20_cpuapp.conf
index 2ea17b6d5f6b..176c09559601 100644
--- a/samples/bluetooth/throughput/boards/nrf54h20dk_nrf54h20_cpuapp.conf
+++ b/samples/bluetooth/throughput/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -6,3 +6,5 @@
 
 # For better shell and logger coexistence.
 CONFIG_NCS_SAMPLES_DEFAULTS=n
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/samples/caf_sensor_manager/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/caf_sensor_manager/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
index 61921a874c2b..0cc9607a6679 100644
--- a/samples/caf_sensor_manager/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ b/samples/caf_sensor_manager/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
@@ -24,6 +24,16 @@
 		buf_data_length = <240>;
 		sample_size = <3>;
 	};
+
+	reserved-memory {
+		cpuppr_code_data: memory@2fc00000 {
+			reg = <0x2fc00000 0xf200>;
+		};
+
+		ram3x_agg_area0: memory@2fc0f200 {
+			reg = <0x2fc0f200 0x600>;
+		};
+	};
 };
 
 /* Enabled nodes required by IPC
@@ -42,16 +52,6 @@ ipc0: &cpuapp_cpuppr_ipc {
 	status = "okay";
 };
 
-&cpuppr_ram3x_region {
-	cpuppr_code_data: memory@0 {
-		reg = <0x0 0xf200>;
-	};
-
-	ram3x_agg_area0: memory@f200 {
-		reg = <0xf200 0x600>;
-	};
-};
-
 /* UART and RAM3 instance used by PPR should be enabled at build time
  * using nordic-ppr snippet.
  */
diff --git a/samples/caf_sensor_manager/remote/boards/nrf54h20dk_nrf54h20_cpuppr.overlay b/samples/caf_sensor_manager/remote/boards/nrf54h20dk_nrf54h20_cpuppr.overlay
index a3a77d6a9b6d..49e9b91ce4d9 100644
--- a/samples/caf_sensor_manager/remote/boards/nrf54h20dk_nrf54h20_cpuppr.overlay
+++ b/samples/caf_sensor_manager/remote/boards/nrf54h20dk_nrf54h20_cpuppr.overlay
@@ -18,16 +18,16 @@
 		sample_size = <3>;
 		memory-region = <&ram3x_agg_area0>;
 	};
-};
 
-/* Place aggregator buffers in PPR memory region. */
-&cpuppr_ram3x_region {
-	cpuppr_code_data: memory@0 {
-		reg = <0x0 0xf200>;
-	};
+	reserved-memory {
+		/* Place aggregator buffers in PPR memory region. */
+		cpuppr_code_data: memory@2fc00000 {
+			reg = <0x2fc00000 0xf200>;
+		};
 
-	ram3x_agg_area0: memory@f200 {
-		reg = <0xf200 0x600>;
+		ram3x_agg_area0: memory@2fc0f200 {
+			reg = <0x2fc0f200 0x600>;
+		};
 	};
 };
 
diff --git a/samples/crypto/aes_cbc/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/aes_cbc/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/aes_cbc/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/aes_ccm/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/aes_ccm/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/aes_ccm/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/aes_ctr/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/aes_ctr/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/aes_ctr/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/aes_gcm/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/aes_gcm/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/aes_gcm/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/aes_gcm/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay b/samples/crypto/aes_gcm/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/aes_gcm/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/aes_gcm/sample.yaml b/samples/crypto/aes_gcm/sample.yaml
index 84d2408bb247..335d236328db 100644
--- a/samples/crypto/aes_gcm/sample.yaml
+++ b/samples/crypto/aes_gcm/sample.yaml
@@ -98,7 +98,6 @@ tests:
       - ci_samples_crypto
     platform_allow:
       - nrf54h20dk/nrf54h20/cpuapp
-      - nrf54h20dk/nrf54h20/cpuapp/iron
     harness: console
     harness_config:
       type: multi_line
diff --git a/samples/crypto/chachapoly/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/chachapoly/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/chachapoly/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/ecdh/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/ecdh/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/ecdh/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/ecdh/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay b/samples/crypto/ecdh/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/ecdh/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/ecdh/sample.yaml b/samples/crypto/ecdh/sample.yaml
index a3abfda3c7f0..d4ca11c8621a 100644
--- a/samples/crypto/ecdh/sample.yaml
+++ b/samples/crypto/ecdh/sample.yaml
@@ -78,7 +78,6 @@ tests:
       - ci_samples_crypto
     platform_allow:
       - nrf54h20dk/nrf54h20/cpuapp
-      - nrf54h20dk/nrf54h20/cpuapp/iron
     harness: console
     harness_config:
       type: multi_line
diff --git a/samples/crypto/ecdsa/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/ecdsa/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/ecdsa/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/ecdsa/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay b/samples/crypto/ecdsa/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/ecdsa/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/ecdsa/sample.yaml b/samples/crypto/ecdsa/sample.yaml
index fbd300394e59..9485576c54fc 100644
--- a/samples/crypto/ecdsa/sample.yaml
+++ b/samples/crypto/ecdsa/sample.yaml
@@ -94,7 +94,6 @@ tests:
       - ci_samples_crypto
     platform_allow:
       - nrf54h20dk/nrf54h20/cpuapp
-      - nrf54h20dk/nrf54h20/cpuapp/iron
     harness: console
     harness_config:
       type: multi_line
diff --git a/samples/crypto/ecjpake/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/ecjpake/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/ecjpake/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/eddsa/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/eddsa/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/eddsa/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/hkdf/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/hkdf/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/hkdf/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/hmac/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/hmac/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/hmac/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/pbkdf2/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/pbkdf2/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/pbkdf2/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/psa_tls/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/psa_tls/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
index 9cb0cb663d96..f068a120f05c 100644
--- a/samples/crypto/psa_tls/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ b/samples/crypto/psa_tls/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
@@ -4,22 +4,6 @@
  * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
  */
 
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
-
 / {
 	eth-rtt {
 		compatible = "segger,eth-rtt";
diff --git a/samples/crypto/psa_tls/boards/nrf54h20dk_nrf54h20_cpurad.overlay b/samples/crypto/psa_tls/boards/nrf54h20dk_nrf54h20_cpurad.overlay
index 34a30857a5a8..d64a1b9c718e 100644
--- a/samples/crypto/psa_tls/boards/nrf54h20dk_nrf54h20_cpurad.overlay
+++ b/samples/crypto/psa_tls/boards/nrf54h20dk_nrf54h20_cpurad.overlay
@@ -13,21 +13,6 @@
 	};
 };
 
-&cpusec_cpurad_ipc {
-	status = "okay";
-};
-
-&cpurad_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpurad_bellboard {
-	status = "okay";
-};
 
 &uart136 {
 	status = "okay";
diff --git a/samples/crypto/rng/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/rng/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/rng/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/rng/boards/nrf54h20dk_nrf54h20_cpuapp_iron.conf b/samples/crypto/rng/boards/nrf54h20dk_nrf54h20_cpuapp_iron.conf
deleted file mode 100644
index d172f58efb93..000000000000
--- a/samples/crypto/rng/boards/nrf54h20dk_nrf54h20_cpuapp_iron.conf
+++ /dev/null
@@ -1,16 +0,0 @@
-#
-# Copyright (c) 2024 Nordic Semiconductor
-#
-# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
-#
-
-# Disable Oberon PSA crypto drivers
-CONFIG_PSA_CRYPTO_DRIVER_OBERON=n
-
-# Enable PSA crypto from SSF client
-CONFIG_PSA_SSF_CRYPTO_CLIENT=y
-CONFIG_SSF_PSA_CRYPTO_SERVICE_ENABLED=y
-
-# Mbedtls configuration
-CONFIG_MBEDTLS_ENABLE_HEAP=y
-CONFIG_MBEDTLS_HEAP_SIZE=8192
diff --git a/samples/crypto/rng/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay b/samples/crypto/rng/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/rng/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/rng/sample.yaml b/samples/crypto/rng/sample.yaml
index 72efed8f7038..67a499371b2b 100644
--- a/samples/crypto/rng/sample.yaml
+++ b/samples/crypto/rng/sample.yaml
@@ -76,7 +76,6 @@ tests:
       - ci_samples_crypto
     platform_allow:
       - nrf54h20dk/nrf54h20/cpuapp
-      - nrf54h20dk/nrf54h20/cpuapp/iron
     harness: console
     harness_config:
       type: multi_line
diff --git a/samples/crypto/sha256/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/sha256/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/sha256/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/sha256/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay b/samples/crypto/sha256/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/sha256/boards/nrf54h20dk_nrf54h20_cpuapp_iron.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/crypto/sha256/sample.yaml b/samples/crypto/sha256/sample.yaml
index 1110385f413c..28562f8a45e2 100644
--- a/samples/crypto/sha256/sample.yaml
+++ b/samples/crypto/sha256/sample.yaml
@@ -129,7 +129,6 @@ tests:
       - ci_samples_crypto
     platform_allow:
       - nrf54h20dk/nrf54h20/cpuapp
-      - nrf54h20dk/nrf54h20/cpuapp/iron
     harness: console
     harness_config:
       type: multi_line
diff --git a/samples/crypto/spake2p/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/samples/crypto/spake2p/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
deleted file mode 100644
index 1ca688cf9792..000000000000
--- a/samples/crypto/spake2p/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ /dev/null
@@ -1,21 +0,0 @@
-/*
- * Copyright (c) 2024 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpusec_cpuapp_ipc {
-	status = "okay";
-};
-
-&cpuapp_ram0x_region {
-	status = "okay";
-};
-
-&cpusec_bellboard {
-	status = "okay";
-};
-
-&cpuapp_bellboard {
-	status = "okay";
-};
diff --git a/samples/ipc/ipc_service/sample.yaml b/samples/ipc/ipc_service/sample.yaml
index ea19c3920d74..208226ae02d3 100644
--- a/samples/ipc/ipc_service/sample.yaml
+++ b/samples/ipc/ipc_service/sample.yaml
@@ -98,6 +98,8 @@ tests:
       - nrf54h20dk/nrf54h20/cpuapp
     integration_platforms:
       - nrf54h20dk/nrf54h20/cpuapp
+    extra_args:
+      - ipc_service_CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
     timeout: 20
   sample.ipc.ipc_service.nrf54h20dk_cpuapp_cpuppr_icmsg:
     platform_allow:
diff --git a/samples/nrf54h20/empty_app_core/CMakeLists.txt b/samples/nrf54h20/empty_app_core/CMakeLists.txt
new file mode 100644
index 000000000000..0af68e58be14
--- /dev/null
+++ b/samples/nrf54h20/empty_app_core/CMakeLists.txt
@@ -0,0 +1,11 @@
+# Copyright (c) 2025 Nordic Semiconductor
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+
+cmake_minimum_required(VERSION 3.20.0)
+
+find_package(Zephyr REQUIRED HINTS $ENV{ZEPHYR_BASE})
+project(empty_app_core)
+
+# NORDIC SDK APP START
+target_sources(app PRIVATE src/main.c)
+# NORDIC SDK APP END
diff --git a/samples/nrf54h20/empty_app_core/app.overlay b/samples/nrf54h20/empty_app_core/app.overlay
new file mode 100644
index 000000000000..005d7f2bbc4b
--- /dev/null
+++ b/samples/nrf54h20/empty_app_core/app.overlay
@@ -0,0 +1,75 @@
+/*
+ * Copyright (c) 2025 Nordic Semiconductor ASA
+ * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+ */
+
+/* Disable some of the default nRF54H20 DK configuration.
+ *
+ * Ideally, doing this shouldn't be needed, but it prevents unused resources
+ * from being included in the autogenerated UICR.PERIPHCONF.
+ */
+
+/ {
+	/delete-node/ aliases;
+	/delete-node/ buttons;
+	/delete-node/ leds;
+	/delete-node/ pwmleds;
+
+	chosen {
+		/delete-property/ zephyr,serial;
+	};
+
+	aliases {
+		/* Required by NRFS_LOCAL_DOMAIN */
+		ipc-to-cpusys = &cpuapp_cpusys_ipc;
+	};
+};
+
+&usbhs {
+	status = "disabled";
+};
+
+&exmif {
+	status = "disabled";
+};
+
+&canpll {
+	status = "disabled";
+};
+
+&can120 {
+	status = "disabled";
+};
+
+&gpiote130 {
+	status = "disabled";
+	/delete-property/ owned-channels;
+};
+
+&gpio0 {
+	status = "disabled";
+};
+
+&gpio6 {
+	status = "disabled";
+};
+
+&gpio9 {
+	status = "disabled";
+};
+
+&adc {
+	status = "disabled";
+};
+
+&nfct {
+	status = "disabled";
+};
+
+&pwm130 {
+	status = "disabled";
+};
+
+&uart136 {
+	status = "disabled";
+};
diff --git a/samples/nrf54h20/empty_app_core/prj.conf b/samples/nrf54h20/empty_app_core/prj.conf
new file mode 100644
index 000000000000..b8fa037b4bac
--- /dev/null
+++ b/samples/nrf54h20/empty_app_core/prj.conf
@@ -0,0 +1,27 @@
+# Copyright (c) 2025 Nordic Semiconductor
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+
+# Start radiocore and suspend app core
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
+CONFIG_PM=y
+
+# Minimal configuration
+CONFIG_SIZE_OPTIMIZATIONS=y
+CONFIG_LTO=y
+CONFIG_ISR_TABLES_LOCAL_DECLARATION=y
+CONFIG_NUM_PREEMPT_PRIORITIES=0
+CONFIG_THREAD_STACK_INFO=n
+CONFIG_KERNEL_MEM_POOL=n
+CONFIG_COMMON_LIBC_MALLOC=n
+CONFIG_ARM_MPU=n
+CONFIG_BUILTIN_STACK_GUARD=n
+CONFIG_GPIO=n
+CONFIG_PINCTRL=n
+CONFIG_SERIAL=n
+CONFIG_CONSOLE=n
+CONFIG_EARLY_CONSOLE=n
+CONFIG_STDOUT_CONSOLE=n
+CONFIG_UART_CONSOLE=n
+CONFIG_BOOT_BANNER=n
+CONFIG_NCS_BOOT_BANNER=n
+CONFIG_PRINTK=n
diff --git a/samples/nrf54h20/empty_app_core/sample.yaml b/samples/nrf54h20/empty_app_core/sample.yaml
new file mode 100644
index 000000000000..55b7471e1b5a
--- /dev/null
+++ b/samples/nrf54h20/empty_app_core/sample.yaml
@@ -0,0 +1,12 @@
+sample:
+  description: Minimal sample used to boot radiocore
+  name: Empty firmware for application core (nRF54H20)
+tests:
+  sample.nrf54h20.empty_app_core.build:
+    build_only: true
+    integration_platforms:
+      - nrf54h20dk/nrf54h20/cpuapp
+    platform_allow:
+      - nrf54h20dk/nrf54h20/cpuapp
+    tags:
+      - ci_build
diff --git a/samples/nrf54h20/empty_app_core/src/main.c b/samples/nrf54h20/empty_app_core/src/main.c
new file mode 100644
index 000000000000..f34aa3dfd712
--- /dev/null
+++ b/samples/nrf54h20/empty_app_core/src/main.c
@@ -0,0 +1,9 @@
+/*
+ * Copyright (c) 2025 Nordic Semiconductor ASA
+ * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+ */
+
+int main(void)
+{
+	return 0;
+}
diff --git a/samples/peripheral/radio_test/boards/nrf54h20dk_nrf54h20_cpurad.overlay b/samples/peripheral/radio_test/boards/nrf54h20dk_nrf54h20_cpurad.overlay
index e0d2f91776f5..237b118608f3 100644
--- a/samples/peripheral/radio_test/boards/nrf54h20dk_nrf54h20_cpurad.overlay
+++ b/samples/peripheral/radio_test/boards/nrf54h20dk_nrf54h20_cpurad.overlay
@@ -22,7 +22,6 @@
 /* Take Application's DMA region, which is larger and unused. */
 cpurad_dma_region_alt: &cpuapp_dma_region {
 	status = "okay";
-	nordic,access = <NRF_OWNER_ID_RADIOCORE NRF_PERM_RW>;
 };
 
 &uart136 {
diff --git a/scripts/quarantine.yaml b/scripts/quarantine.yaml
index 33db29bd703c..15009e7fac32 100644
--- a/scripts/quarantine.yaml
+++ b/scripts/quarantine.yaml
@@ -55,6 +55,8 @@
     - suit.integration.*
     - suit-processor.integration.*
     - suit.unit.*
+    - dfu.dfu_target.suit.*
+    - drivers.flash.flash_ipuc
   platforms:
     - nrf54h20dk@0.9.0/nrf54h20/cpuapp
     - nrf52840dk/nrf52840
@@ -67,3 +69,34 @@
   platforms:
     - nrf54l15dk/nrf54l15/cpuapp
   comment: "https://nordicsemi.atlassian.net/browse/NRFX-7878"
+
+- scenarios:
+    - sample.find_my.*
+    - test.find_my.*
+  platforms:
+    - nrf54h20dk@0.9.0/nrf54h20/cpuapp
+  comment: "Needs alignment to work with IronSide SE"
+
+- scenarios:
+    - application.jwt.*
+  platforms:
+    - nrf54h20dk@0.9.0/nrf54h20/cpuapp
+  comment: "Needs OTP service to be implemented in IronSide SE"
+
+- scenarios:
+    - sample.bluetooth.fast_pair.*
+  platforms:
+    - nrf54h20dk@0.9.0/nrf54h20/cpuapp
+  comment: "Needs alignment to work with IronSide SE"
+
+- scenarios:
+    - applications.nrf_desktop.*
+  platforms:
+    - nrf54h20dk@0.9.0/nrf54h20/cpuapp
+  comment: "Needs alignment to work with MCUBoot"
+
+- scenarios:
+    - drivers.counter.basic_api
+  platforms:
+    - nrf54h20dk@0.9.0/nrf54h20/cpuapp
+  comment: "https://nordicsemi.atlassian.net/browse/NCSDK-34187"
diff --git a/snippets/nordic-bt-rpc/boards/nrf54h20dk_nrf54h20-mem-map-move.dtsi b/snippets/nordic-bt-rpc/boards/nrf54h20dk_nrf54h20-mem-map-move.dtsi
index 039c68efb9bb..f987c2428401 100644
--- a/snippets/nordic-bt-rpc/boards/nrf54h20dk_nrf54h20-mem-map-move.dtsi
+++ b/snippets/nordic-bt-rpc/boards/nrf54h20dk_nrf54h20-mem-map-move.dtsi
@@ -2,27 +2,13 @@
  * Copyright (c) 2024 Nordic Semiconductor
  * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
  */
-/delete-node/ &dfu_partition;
-/delete-node/ &storage_partition;
-
-&cpuapp_rw_partitions {
-	dfu_partition: partition@100000 {
-		reg = < 0x100000 DT_SIZE_K(884) >;
-	};
-
-	storage_partition: partition@1dd000 {
-		reg = < 0x1dd000 DT_SIZE_K(24) >;
-	};
-};
 
 &mram1x {
-	cpurad_rw_partitions: cpurad-rw-partitions {
-		compatible = "nordic,owned-partitions", "fixed-partitions";
-		status = "disabled";
-		nordic,access = <NRF_OWNER_ID_RADIOCORE NRF_PERM_RWS>;
-		#address-cells = <1>;
-		#size-cells = <1>;
-
+	partitions {
+		/* Note: the location here has been kept the same as before the introduction of
+		 * IronSide on nrf54h20, which has brought with it an updated memory map.
+		 * It will likely need to be updated as the MRAM memory map is not yet final.
+		 */
 		cpurad_storage_partition: partition@1e3000 {
 			reg = <0x1e3000 DT_SIZE_K(24)>;
 		};
diff --git a/snippets/nordic-bt-rpc/boards/nrf54h20dk_nrf54h20_cpurad.overlay b/snippets/nordic-bt-rpc/boards/nrf54h20dk_nrf54h20_cpurad.overlay
index aada0a89dd32..78d0758adab4 100644
--- a/snippets/nordic-bt-rpc/boards/nrf54h20dk_nrf54h20_cpurad.overlay
+++ b/snippets/nordic-bt-rpc/boards/nrf54h20dk_nrf54h20_cpurad.overlay
@@ -8,10 +8,6 @@
  */
 #include "nrf54h20dk_nrf54h20-mem-map-move.dtsi"
 
-&cpurad_rw_partitions {
-	status = "okay";
-};
-
 / {
 	chosen {
 		zephyr,settings_partition = &cpurad_storage_partition;
diff --git a/snippets/nrf70-wifi/nrf54h20_cpuapp.overlay b/snippets/nrf70-wifi/nrf54h20_cpuapp.overlay
index b5a9e2c59275..d102db5d25de 100644
--- a/snippets/nrf70-wifi/nrf54h20_cpuapp.overlay
+++ b/snippets/nrf70-wifi/nrf54h20_cpuapp.overlay
@@ -4,39 +4,26 @@
  * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
  */
 
+/delete-node/ &cpuapp_boot_partition;
 /delete-node/ &cpuapp_slot0_partition;
+/delete-node/ &cpurad_slot0_partition;
 /delete-node/ &cpuppr_code_partition;
 /delete-node/ &cpuflpr_code_partition;
+/delete-node/ &cpuapp_slot1_partition;
+/delete-node/ &cpurad_slot1_partition;
 
-&cpuapp_rx_partitions {
-	cpuapp_slot0_partition: partition@a6000 {
-		reg = <0xa6000 DT_SIZE_K(1140)>;
-	};
-
-	cpuppr_code_partition: partition@1c3000 {
-		reg = <0x1c3000 DT_SIZE_K(64)>;
-	};
+&mram1x {
+	partitions {
+		slot0_partition: cpuapp_slot0_partition: partition@30000 {
+			reg = <0x30000 DT_SIZE_K(1140)>;
+		};
 
-	cpuflpr_code_partition: partition@1d3000 {
-		reg = <0x1d3000 DT_SIZE_K(48)>;
-	};
-};
-
-/delete-node/ &dfu_partition;
-/delete-node/ &storage_partition;
-
-&cpuapp_rw_partitions {
-	storage_partition: partition@1df000 {
-		reg = < 0x1df000 DT_SIZE_K(24) >;
-	};
-};
+		cpuppr_code_partition: partition@121000 {
+			reg = <0x121000 DT_SIZE_K(64)>;
+		};
 
-/delete-node/ &cpurad_ram0x_region;
-&cpuapp_ram0x_region {
-	status = "okay";
-	reg = <0x2f010000 DT_SIZE_K(436)>;
-	ranges = <0x0 0x2f010000 0x6e000>;
-	cpuapp_data: memory@1000 {
-		reg = <0x1000 DT_SIZE_K(432)>;
+		cpuflpr_code_partition: partition@131000 {
+			reg = <0x131000 DT_SIZE_K(48)>;
+		};
 	};
 };
diff --git a/subsys/bluetooth/rpc/common/bt_rpc_common.c b/subsys/bluetooth/rpc/common/bt_rpc_common.c
index d99d09e0193f..6ba972da08e5 100644
--- a/subsys/bluetooth/rpc/common/bt_rpc_common.c
+++ b/subsys/bluetooth/rpc/common/bt_rpc_common.c
@@ -54,7 +54,7 @@ static int serialization_init(void)
 	return 0;
 }
 
-SYS_INIT(serialization_init, POST_KERNEL, CONFIG_APPLICATION_INIT_PRIORITY);
+SYS_INIT(serialization_init, APPLICATION, CONFIG_APPLICATION_INIT_PRIORITY);
 #endif /* CONFIG_BT_RPC_INITIALIZE_NRF_RPC */
 
 enum {
diff --git a/subsys/nrf_security/src/ssf_secdom/Kconfig b/subsys/nrf_security/src/ssf_secdom/Kconfig
index bfbbf2fc9b61..1321b139b77d 100644
--- a/subsys/nrf_security/src/ssf_secdom/Kconfig
+++ b/subsys/nrf_security/src/ssf_secdom/Kconfig
@@ -8,7 +8,7 @@ config PSA_SSF_CRYPTO_CLIENT
 	bool
 	prompt "PSA crypto provided through SSF"
 	default y
-	depends on (SSF_CLIENT && SSF_PSA_CRYPTO_SERVICE_ENABLED) || SOC_NRF54H20_IRON
+	depends on (SSF_CLIENT && SSF_PSA_CRYPTO_SERVICE_ENABLED) || SOC_NRF54H20
 	select NRF_IRONSIDE_CALL if !SSF_CLIENT
 
 if PSA_SSF_CRYPTO_CLIENT
diff --git a/subsys/sdfw_services/Kconfig b/subsys/sdfw_services/Kconfig
index ecba5fa274d5..bef4c22ecd62 100644
--- a/subsys/sdfw_services/Kconfig
+++ b/subsys/sdfw_services/Kconfig
@@ -7,10 +7,9 @@
 rsource "services/Kconfig"
 
 config SSF_CLIENT
-	bool
 	def_bool $(dt_nodelabel_enabled_with_compat,cpusec_cpuapp_ipc,$(DT_COMPAT_ZEPHYR_IPC_ICMSG)) \
 	      || $(dt_nodelabel_enabled_with_compat,cpusec_cpurad_ipc,$(DT_COMPAT_ZEPHYR_IPC_ICMSG))
-	depends on !SOC_NRF54H20_IRON
+	depends on SOC_SERIES_NRF92X
 
 config SDFW_SERVICES_ENABLED
 	bool
@@ -26,14 +25,14 @@ menu "SDFW Service Framework"
 
 config SSF_CLIENT_DOMAIN_ID
 	int
-	default 2 if SOC_NRF54H20_CPUAPP || SOC_NRF9280_CPUAPP
-	default 3 if SOC_NRF54H20_CPURAD || SOC_NRF9280_CPURAD
+	default 2 if SOC_NRF9280_CPUAPP
+	default 3 if SOC_NRF9280_CPURAD
 	default 0
 
 config SSF_CLIENT_NRF_RPC_GROUP_NAME
 	string
-	default "app" if SOC_NRF54H20_CPUAPP || SOC_NRF9280_CPUAPP
-	default "rad" if SOC_NRF54H20_CPURAD || SOC_NRF9280_CPURAD
+	default "app" if SOC_NRF9280_CPUAPP
+	default "rad" if SOC_NRF9280_CPURAD
 	default ""
 
 config SSF_CLIENT_SYS_INIT
diff --git a/subsys/suit/Kconfig b/subsys/suit/Kconfig
index 2ab614d876c8..947002d9b5b0 100644
--- a/subsys/suit/Kconfig
+++ b/subsys/suit/Kconfig
@@ -6,7 +6,7 @@
 
 menuconfig SUIT
 	bool "Enable SUIT modules"
-	depends on !SOC_NRF54H20_IRON
+	depends on !SOC_NRF54H20
 
 if SUIT
 
diff --git a/sysbuild/CMakeLists.txt b/sysbuild/CMakeLists.txt
index f84b0b529010..37291ad542da 100644
--- a/sysbuild/CMakeLists.txt
+++ b/sysbuild/CMakeLists.txt
@@ -752,10 +752,8 @@ function(${SYSBUILD_CURRENT_MODULE_NAME}_post_cmake)
   endif()
 
   include_packaging()
-  if(NOT SB_CONFIG_SOC_NRF54H20_IRON)
-    include_suit_provisioning()
-    include_suit()
-  endif()
+  include_suit_provisioning()
+  include_suit()
 
   if(SB_CONFIG_SECURE_BOOT OR SB_CONFIG_MCUBOOT_HARDWARE_DOWNGRADE_PREVENTION)
     include_provision_hex()
@@ -880,6 +878,10 @@ function(${SYSBUILD_CURRENT_MODULE_NAME}_post_cmake)
       set_property(DIRECTORY APPEND PROPERTY CMAKE_CONFIGURE_DEPENDS ${BINARY_DIR}/zephyr/.config)
     endif()
   endif()
+
+  if(SB_CONFIG_NRF_PERIPHCONF_MIGRATE)
+    include(${ZEPHYR_NRF_MODULE_DIR}/cmake/sysbuild/periphconf_migrate.cmake)
+  endif()
 endfunction(${SYSBUILD_CURRENT_MODULE_NAME}_post_cmake)
 
 # Enable use of partition manager with sysbuild.
diff --git a/sysbuild/Kconfig.appcore b/sysbuild/Kconfig.appcore
index d42a2be348dc..742adcc1123e 100644
--- a/sysbuild/Kconfig.appcore
+++ b/sysbuild/Kconfig.appcore
@@ -67,8 +67,9 @@ config APPCORE_IMAGE_NAME
 
 config APPCORE_IMAGE_PATH
 	string
-	default "${ZEPHYR_NRF_MODULE_DIR}/samples/nrf5340/empty_app_core" if APPCORE_EMPTY
-	default "${ZEPHYR_NRF_MODULE_DIR}/samples/nrf5340/remote_shell" if APPCORE_REMOTE_SHELL
+	default "${ZEPHYR_NRF_MODULE_DIR}/samples/nrf5340/empty_app_core" if APPCORE_EMPTY && SOC_SERIES_NRF53X
+	default "${ZEPHYR_NRF_MODULE_DIR}/samples/nrf5340/remote_shell" if APPCORE_REMOTE_SHELL && SOC_SERIES_NRF53X
+	default "${ZEPHYR_NRF_MODULE_DIR}/samples/nrf54h20/empty_app_core" if APPCORE_EMPTY && SOC_NRF54H20
 	help
 	  Source directory of appcore image.
 
diff --git a/sysbuild/Kconfig.periphconf b/sysbuild/Kconfig.periphconf
new file mode 100644
index 000000000000..812165863d1b
--- /dev/null
+++ b/sysbuild/Kconfig.periphconf
@@ -0,0 +1,11 @@
+# Copyright (c) 2025 Nordic Semiconductor
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+
+config NRF_PERIPHCONF_MIGRATE
+	bool "Generate periphconf_migrated.c"
+	default y
+	depends on SOC_SERIES_NRF54HX
+	help
+	  Enable autogenerating UICR.PERIPHCONF tables for multi-image builds,
+	  to migrate an existing project for running with IronSide SE.
+	  You can disable this if you have your own UICR.PERIPHCONF file.
diff --git a/sysbuild/Kconfig.suit b/sysbuild/Kconfig.suit
index 01e6c85d541d..a56dd5ea7d06 100644
--- a/sysbuild/Kconfig.suit
+++ b/sysbuild/Kconfig.suit
@@ -8,7 +8,6 @@ menu "SUIT"
 
 menuconfig SUIT_ENVELOPE
 	bool "Create SUIT envelope"
-	default y if SOC_SERIES_NRF54HX
 	help
 	  Enable DFU SUIT envelope creation
 
diff --git a/sysbuild/Kconfig.suit_provisioning b/sysbuild/Kconfig.suit_provisioning
index bc351201863e..a1fede46d1af 100644
--- a/sysbuild/Kconfig.suit_provisioning
+++ b/sysbuild/Kconfig.suit_provisioning
@@ -8,8 +8,7 @@ menu "SUIT provisioning"
 
 config SUIT_MPI_GENERATE
 	bool "Generate SUIT Manifest Provisioning Information binary"
-	default y if SOC_SERIES_NRF54HX || SOC_SERIES_NRF92X
-	depends on !SOC_NRF54H20_IRON
+	default y if SOC_SERIES_NRF92X
 
 if SUIT_MPI_GENERATE
 
diff --git a/sysbuild/Kconfig.sysbuild b/sysbuild/Kconfig.sysbuild
index fca45ace5d98..77377ec5bed7 100644
--- a/sysbuild/Kconfig.sysbuild
+++ b/sysbuild/Kconfig.sysbuild
@@ -86,3 +86,4 @@ rsource "Kconfig.approtect"
 rsource "Kconfig.lwm2m_carrier"
 rsource "Kconfig.cracen"
 rsource "Kconfig.tfm"
+rsource "Kconfig.periphconf"
diff --git a/tests/benchmarks/current_consumption/beacon_vs_vddh/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/benchmarks/current_consumption/beacon_vs_vddh/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/tests/benchmarks/current_consumption/beacon_vs_vddh/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/benchmarks/current_consumption/uart_console/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/benchmarks/current_consumption/uart_console/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/tests/benchmarks/current_consumption/uart_console/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/benchmarks/current_consumption/uarte_suspend/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/benchmarks/current_consumption/uarte_suspend/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/tests/benchmarks/current_consumption/uarte_suspend/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/benchmarks/multicore/idle/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/tests/benchmarks/multicore/idle/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
index d508cc299c22..174c23ab5150 100644
--- a/tests/benchmarks/multicore/idle/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ b/tests/benchmarks/multicore/idle/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
@@ -4,16 +4,6 @@
  * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
  */
 
-&cpurad_ram0x_region {
-	reg = <0x2f010000 0x1000>;
-	ranges = <0x0 0x2f010000 0x1000>;
-};
-
-&cpuapp_ram0x_region {
-	reg = <0x2f011000 0x41000>;
-	ranges = <0x0 0x2f011000 0x41000>;
-};
-
 &cpuapp_data {
-	reg = <0x1000 0x40000>;
+	reg = <0x2f000000 0x40000>;
 };
diff --git a/tests/benchmarks/multicore/idle/boards/nrf54h20dk_nrf54h20_cpuapp_ram_high_usage.overlay b/tests/benchmarks/multicore/idle/boards/nrf54h20dk_nrf54h20_cpuapp_ram_high_usage.overlay
index be011f498789..24abdc9b7ce4 100644
--- a/tests/benchmarks/multicore/idle/boards/nrf54h20dk_nrf54h20_cpuapp_ram_high_usage.overlay
+++ b/tests/benchmarks/multicore/idle/boards/nrf54h20dk_nrf54h20_cpuapp_ram_high_usage.overlay
@@ -4,24 +4,19 @@
  * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
  */
 
-&cpurad_ram0x_region {
-	reg = <0x2f010000 0x1000>;
-	ranges = <0x0 0x2f010000 0x1000>;
-};
-
-&cpuapp_ram0x_region {
-	reg = <0x2f011000 0x91000>;
-	ranges = <0x0 0x2f011000 0x91000>;
-};
-
+/* Note: updated as part of move to IronSide where the default size of this has increased.
+ * At the time of writing the size used here is actually lower than the default.
+ * Global RAM retention is now also not based on memory regions in UICR, but must be configured in
+ * PERIPHCONF. So this likely needs further updates.
+ */
 &cpuapp_data {
-    reg = <0x1000 0x90000>;
+	reg = <0x2f000000 0x90000>;
 };
 
 &can120 {
-    status = "disabled";
+	status = "disabled";
 };
 
 &usbhs {
-    status = "disabled";
+	status = "disabled";
 };
diff --git a/tests/benchmarks/multicore/idle/boards/nrf54h20dk_nrf54h20_cpuapp_ram_low_usage.overlay b/tests/benchmarks/multicore/idle/boards/nrf54h20dk_nrf54h20_cpuapp_ram_low_usage.overlay
index 25a11e8e1653..fb022de2b229 100644
--- a/tests/benchmarks/multicore/idle/boards/nrf54h20dk_nrf54h20_cpuapp_ram_low_usage.overlay
+++ b/tests/benchmarks/multicore/idle/boards/nrf54h20dk_nrf54h20_cpuapp_ram_low_usage.overlay
@@ -4,24 +4,14 @@
  * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
  */
 
-&cpurad_ram0x_region {
-	reg = <0x2f010000 0x1000>;
-	ranges = <0x0 0x2f010000 0x1000>;
-};
-
-&cpuapp_ram0x_region {
-	reg = <0x2f011000 0x21000>;
-	ranges = <0x0 0x2f011000 0x21000>;
-};
-
 &cpuapp_data {
-    reg = <0x1000 0x20000>;
+	reg = <0x2f000000 0x20000>;
 };
 
 &can120 {
-    status = "disabled";
+	status = "disabled";
 };
 
 &usbhs {
-    status = "disabled";
+	status = "disabled";
 };
diff --git a/tests/benchmarks/multicore/idle/remote/boards/nrf54h20dk_nrf54h20_cpurad.overlay b/tests/benchmarks/multicore/idle/remote/boards/nrf54h20dk_nrf54h20_cpurad.overlay
deleted file mode 100644
index 9b09be677faa..000000000000
--- a/tests/benchmarks/multicore/idle/remote/boards/nrf54h20dk_nrf54h20_cpurad.overlay
+++ /dev/null
@@ -1,15 +0,0 @@
-/*
- * Copyright (c) 2025 Nordic Semiconductor ASA
- *
- * SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
- */
-
-&cpurad_ram0x_region {
-	reg = <0x2f010000 0x1000>;
-	ranges = <0x0 0x2f010000 0x1000>;
-};
-
-&cpuapp_ram0x_region {
-	reg = <0x2f011000 0x41000>;
-	ranges = <0x0 0x2f011000 0x41000>;
-};
diff --git a/tests/benchmarks/multicore/idle/testcase.yaml b/tests/benchmarks/multicore/idle/testcase.yaml
index 35fea3b77ae4..9f3fdc5e7fa6 100644
--- a/tests/benchmarks/multicore/idle/testcase.yaml
+++ b/tests/benchmarks/multicore/idle/testcase.yaml
@@ -59,6 +59,7 @@ tests:
     integration_platforms:
       - nrf54h20dk/nrf54h20/cpuapp
     extra_args:
+      - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
       - SB_CONF_FILE=sysbuild/nrf54h20dk_nrf54h20_cpurad.conf
       - CONFIG_FIRST_SLEEP_OFFSET=y
 
@@ -68,6 +69,7 @@ tests:
     integration_platforms:
       - nrf54h20dk/nrf54h20/cpuapp
     extra_args:
+      - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
       - SB_CONF_FILE=sysbuild/nrf54h20dk_nrf54h20_cpurad.conf
       - CONFIG_FIRST_SLEEP_OFFSET=y
     harness: pytest
@@ -85,6 +87,7 @@ tests:
       - nrf54h20dk/nrf54h20/cpuapp
     extra_args:
       - SB_CONF_FILE=sysbuild/nrf54h20dk_nrf54h20_cpurad.conf
+      - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
       - CONFIG_FIRST_SLEEP_OFFSET=y
       - CONFIG_PM=y
       - CONFIG_PM_S2RAM=y
@@ -116,6 +119,7 @@ tests:
       - nrf54h20dk/nrf54h20/cpuapp
     extra_args:
       - SB_CONF_FILE=sysbuild/nrf54h20dk_nrf54h20_cpurad.conf
+      - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
       - CONFIG_FIRST_SLEEP_OFFSET=y
       - CONFIG_PM=y
       - CONFIG_PM_S2RAM=y
@@ -148,6 +152,7 @@ tests:
       - nrf54h20dk/nrf54h20/cpuapp
     extra_args:
       - SB_CONF_FILE=sysbuild/nrf54h20dk_nrf54h20_cpurad.conf
+      - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
       - CONFIG_FIRST_SLEEP_OFFSET=y
       - CONFIG_PM=y
       - CONFIG_PM_S2RAM=y
@@ -180,6 +185,7 @@ tests:
       - nrf54h20dk/nrf54h20/cpuapp
     extra_args:
       - SB_CONF_FILE=sysbuild/nrf54h20dk_nrf54h20_cpurad.conf
+      - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
       - CONFIG_FIRST_SLEEP_OFFSET=y
       - CONFIG_PM=y
       - CONFIG_PM_S2RAM=y
@@ -211,6 +217,7 @@ tests:
       - nrf54h20dk/nrf54h20/cpuapp
     extra_args:
       - SB_CONF_FILE=sysbuild/nrf54h20dk_nrf54h20_cpurad.conf
+      - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
       - CONFIG_FIRST_SLEEP_OFFSET=y
       - CONFIG_PM=y
       - CONFIG_PM_S2RAM=y
@@ -243,6 +250,7 @@ tests:
       - nrf54h20dk/nrf54h20/cpuapp
     extra_args:
       - SB_CONF_FILE=sysbuild/nrf54h20dk_nrf54h20_cpurad.conf
+      - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
       - CONFIG_FIRST_SLEEP_OFFSET=y
       - CONFIG_PM=y
       - CONFIG_PM_S2RAM=y
diff --git a/tests/benchmarks/multicore/idle_adc/testcase.yaml b/tests/benchmarks/multicore/idle_adc/testcase.yaml
index 3ee2a73ce606..5a17efb6baa0 100644
--- a/tests/benchmarks/multicore/idle_adc/testcase.yaml
+++ b/tests/benchmarks/multicore/idle_adc/testcase.yaml
@@ -1,6 +1,8 @@
 common:
   sysbuild: true
   depends_on: adc
+  extra_args:
+    - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
 
 tests:
   benchmarks.multicore.idle_adc.nrf54h20dk_cpuapp_cpurad.s2ram:
diff --git a/tests/benchmarks/multicore/idle_comp/testcase.yaml b/tests/benchmarks/multicore/idle_comp/testcase.yaml
index 643b2437a103..49a14b67ee1d 100644
--- a/tests/benchmarks/multicore/idle_comp/testcase.yaml
+++ b/tests/benchmarks/multicore/idle_comp/testcase.yaml
@@ -1,5 +1,7 @@
 common:
   sysbuild: true
+  extra_args:
+    - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
 
 tests:
   benchmarks.multicore.idle_comp.nrf54h20dk_cpuapp_cpurad.s2ram:
diff --git a/tests/benchmarks/multicore/idle_counter/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/benchmarks/multicore/idle_counter/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/tests/benchmarks/multicore/idle_counter/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/benchmarks/multicore/idle_exmif/testcase.yaml b/tests/benchmarks/multicore/idle_exmif/testcase.yaml
index 7f7131e971ed..cba68052bc03 100644
--- a/tests/benchmarks/multicore/idle_exmif/testcase.yaml
+++ b/tests/benchmarks/multicore/idle_exmif/testcase.yaml
@@ -1,6 +1,8 @@
 common:
   sysbuild: true
   depends_on: spi
+  extra_args:
+    - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
 
 tests:
   benchmarks.multicore.idle_exmif.nrf54h20dk_cpuapp_cpurad:
diff --git a/tests/benchmarks/multicore/idle_gpio/testcase.yaml b/tests/benchmarks/multicore/idle_gpio/testcase.yaml
index 64f2c4cd4797..f503da5ad7d7 100644
--- a/tests/benchmarks/multicore/idle_gpio/testcase.yaml
+++ b/tests/benchmarks/multicore/idle_gpio/testcase.yaml
@@ -9,6 +9,8 @@ common:
     regex:
       - "Multicore idle_gpio test on"
       - "Multicore idle_gpio test iteration 0"
+  extra_args:
+    - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
 
 tests:
   benchmarks.multicore.idle_gpio.nrf54h20dk_cpuapp_cpurad.s2ram:
diff --git a/tests/benchmarks/multicore/idle_hpu_temp_meas/testcase.yaml b/tests/benchmarks/multicore/idle_hpu_temp_meas/testcase.yaml
index 6cac985663f9..c7d2b16699dd 100644
--- a/tests/benchmarks/multicore/idle_hpu_temp_meas/testcase.yaml
+++ b/tests/benchmarks/multicore/idle_hpu_temp_meas/testcase.yaml
@@ -5,6 +5,9 @@ common:
     - ci_tests_benchmarks_multicore
     - hpu
     - ppk_power_measure
+  extra_args:
+    - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
+
 tests:
   benchmarks.multicore.idle_hpu_temp_meas:
     harness: pytest
diff --git a/tests/benchmarks/multicore/idle_ipc/testcase.yaml b/tests/benchmarks/multicore/idle_ipc/testcase.yaml
index 483b7548c77a..ac0ea69aec83 100644
--- a/tests/benchmarks/multicore/idle_ipc/testcase.yaml
+++ b/tests/benchmarks/multicore/idle_ipc/testcase.yaml
@@ -1,5 +1,7 @@
 common:
   sysbuild: true
+  extra_args:
+    - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
 
 tests:
   benchmarks.multicore.idle_ipc.nrf54h20dk_cpuapp_cpurad.s2ram:
diff --git a/tests/benchmarks/multicore/idle_outside_of_main/testcase.yaml b/tests/benchmarks/multicore/idle_outside_of_main/testcase.yaml
index 98ca099fcecf..12973b8aa94c 100644
--- a/tests/benchmarks/multicore/idle_outside_of_main/testcase.yaml
+++ b/tests/benchmarks/multicore/idle_outside_of_main/testcase.yaml
@@ -4,6 +4,9 @@ common:
     - ci_build
     - ci_tests_benchmarks_multicore
     - ppk_power_measure
+  extra_args:
+    - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
+
 tests:
   benchmarks.multicore.idle_outside_of_main.nrf54h20dk_cpuapp_cpurad.s2ram:
     harness: pytest
diff --git a/tests/benchmarks/multicore/idle_ppr/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/tests/benchmarks/multicore/idle_ppr/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
index 9c842508b5aa..c0a31e2d2ec5 100644
--- a/tests/benchmarks/multicore/idle_ppr/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ b/tests/benchmarks/multicore/idle_ppr/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
@@ -8,11 +8,6 @@
 	status = "okay";
 };
 
-&cpuppr_ram3x_region {
-	status = "okay";
-};
-
-
 / {
 	aliases {
 		/delete-property/ led1;
diff --git a/tests/benchmarks/multicore/idle_pwm_led/testcase.yaml b/tests/benchmarks/multicore/idle_pwm_led/testcase.yaml
index 2cfe054bc724..b3e290a3c3fd 100644
--- a/tests/benchmarks/multicore/idle_pwm_led/testcase.yaml
+++ b/tests/benchmarks/multicore/idle_pwm_led/testcase.yaml
@@ -7,6 +7,8 @@ common:
     - nrf54h20dk/nrf54h20/cpuapp
   integration_platforms:
     - nrf54h20dk/nrf54h20/cpuapp
+  extra_args:
+    - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
 
 tests:
   benchmarks.multicore.idle_pwm_led.nrf54h20dk_cpuapp_cpurad.no_sleep:
diff --git a/tests/benchmarks/multicore/idle_pwm_loopback/testcase.yaml b/tests/benchmarks/multicore/idle_pwm_loopback/testcase.yaml
index 9175b0fa7552..056eedc301f8 100644
--- a/tests/benchmarks/multicore/idle_pwm_loopback/testcase.yaml
+++ b/tests/benchmarks/multicore/idle_pwm_loopback/testcase.yaml
@@ -7,6 +7,8 @@ common:
     - nrf54h20dk/nrf54h20/cpuapp
   integration_platforms:
     - nrf54h20dk/nrf54h20/cpuapp
+  extra_args:
+    - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
 
 tests:
   benchmarks.multicore.idle_pwm_loopback.nrf54h20dk_cpuapp_cpurad.no_sleep:
diff --git a/tests/benchmarks/multicore/idle_stm/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/tests/benchmarks/multicore/idle_stm/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
index 016db6a8b76f..a28617970dc1 100644
--- a/tests/benchmarks/multicore/idle_stm/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ b/tests/benchmarks/multicore/idle_stm/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
@@ -8,10 +8,6 @@
 	status = "okay";
 };
 
-&cpuppr_ram3x_region {
-	status = "okay";
-};
-
 &uart136 {
 	zephyr,pm-device-runtime-auto;
 };
diff --git a/tests/benchmarks/multicore/idle_stm/testcase.yaml b/tests/benchmarks/multicore/idle_stm/testcase.yaml
index be43dc582d84..09bb29eafc69 100644
--- a/tests/benchmarks/multicore/idle_stm/testcase.yaml
+++ b/tests/benchmarks/multicore/idle_stm/testcase.yaml
@@ -9,6 +9,8 @@ common:
     - nrf54h20dk/nrf54h20/cpuapp
   integration_platforms:
     - nrf54h20dk/nrf54h20/cpuapp
+  extra_args:
+    - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
 
 tests:
   benchmarks.multicore.idle_stm.nrf54h20dk_cpuapp_cpurad_cpuppr.no_sleep:
diff --git a/tests/benchmarks/multicore/idle_twim/testcase.yaml b/tests/benchmarks/multicore/idle_twim/testcase.yaml
index 646e8b43df56..2eca1a6d4f97 100644
--- a/tests/benchmarks/multicore/idle_twim/testcase.yaml
+++ b/tests/benchmarks/multicore/idle_twim/testcase.yaml
@@ -1,6 +1,8 @@
 common:
   sysbuild: true
   depends_on: i2c
+  extra_args:
+    - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
 
 tests:
   benchmarks.multicore.idle_twim.nrf54h20dk_cpuapp_cpurad.s2ram:
diff --git a/tests/benchmarks/multicore/idle_uarte/testcase.yaml b/tests/benchmarks/multicore/idle_uarte/testcase.yaml
index f34a4dce2930..767d0d057182 100644
--- a/tests/benchmarks/multicore/idle_uarte/testcase.yaml
+++ b/tests/benchmarks/multicore/idle_uarte/testcase.yaml
@@ -1,6 +1,8 @@
 common:
   sysbuild: true
   depends_on: gpio
+  extra_args:
+    - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
 
 tests:
   benchmarks.multicore.idle_uarte.nrf54h20dk_cpuapp_cpurad.s2ram:
diff --git a/tests/benchmarks/multicore/idle_wdt/testcase.yaml b/tests/benchmarks/multicore/idle_wdt/testcase.yaml
index c8a5c11b0e8f..771f4d2d3d7b 100644
--- a/tests/benchmarks/multicore/idle_wdt/testcase.yaml
+++ b/tests/benchmarks/multicore/idle_wdt/testcase.yaml
@@ -7,6 +7,8 @@ common:
     - nrf54h20dk/nrf54h20/cpuapp
   integration_platforms:
     - nrf54h20dk/nrf54h20/cpuapp
+  extra_args:
+    - CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
 
 tests:
   benchmarks.multicore.idle_wdt.nrf54h20dk_cpuapp_cpurad.no_sleep:
diff --git a/tests/benchmarks/power_consumption/adc_async/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/benchmarks/power_consumption/adc_async/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/tests/benchmarks/power_consumption/adc_async/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/benchmarks/power_consumption/flash/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/benchmarks/power_consumption/flash/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..a6fa5758d9ae
--- /dev/null
+++ b/tests/benchmarks/power_consumption/flash/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1 @@
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/benchmarks/power_consumption/lpcomp/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/benchmarks/power_consumption/lpcomp/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/tests/benchmarks/power_consumption/lpcomp/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/benchmarks/power_consumption/spi/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/benchmarks/power_consumption/spi/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/tests/benchmarks/power_consumption/spi/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/benchmarks/power_consumption/timer_waiting/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/benchmarks/power_consumption/timer_waiting/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/tests/benchmarks/power_consumption/timer_waiting/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/benchmarks/power_consumption/uart_async/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/benchmarks/power_consumption/uart_async/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/tests/benchmarks/power_consumption/uart_async/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/benchmarks/power_consumption/uart_polling/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/benchmarks/power_consumption/uart_polling/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/tests/benchmarks/power_consumption/uart_polling/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/drivers/audio/pdm_loopback/boards/nrf54h20dk_nrf54h20_cpuapp.overlay b/tests/drivers/audio/pdm_loopback/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
index c537da3a96d0..8be30faa6856 100644
--- a/tests/drivers/audio/pdm_loopback/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
+++ b/tests/drivers/audio/pdm_loopback/boards/nrf54h20dk_nrf54h20_cpuapp.overlay
@@ -44,13 +44,13 @@ pdm_dev: &pdm0 {
 };
 
 &dppic130 {
-	owned-channels = <0>;
-	source-channels = <0>;
+	owned-channels = <1>;
+	source-channels = <1>;
 	status = "okay";
 };
 
 &dppic133 {
-	owned-channels = <0>;
-	sink-channels = <0>;
+	owned-channels = <1>;
+	sink-channels = <1>;
 	status = "okay";
 };
diff --git a/tests/drivers/audio/pdm_loopback/boards/nrf54h20dk_nrf54h20_cpuapp_audiopll_44k1.overlay b/tests/drivers/audio/pdm_loopback/boards/nrf54h20dk_nrf54h20_cpuapp_audiopll_44k1.overlay
index ef17ec364865..78dedcec140d 100644
--- a/tests/drivers/audio/pdm_loopback/boards/nrf54h20dk_nrf54h20_cpuapp_audiopll_44k1.overlay
+++ b/tests/drivers/audio/pdm_loopback/boards/nrf54h20dk_nrf54h20_cpuapp_audiopll_44k1.overlay
@@ -49,13 +49,13 @@ pdm_dev: &pdm0 {
 };
 
 &dppic130 {
-	owned-channels = <0>;
-	source-channels = <0>;
+	owned-channels = <1>;
+	source-channels = <1>;
 	status = "okay";
 };
 
 &dppic133 {
-	owned-channels = <0>;
-	sink-channels = <0>;
+	owned-channels = <1>;
+	sink-channels = <1>;
 	status = "okay";
 };
diff --git a/tests/drivers/audio/pdm_loopback/boards/nrf54h20dk_nrf54h20_cpuapp_audiopll_48k.overlay b/tests/drivers/audio/pdm_loopback/boards/nrf54h20dk_nrf54h20_cpuapp_audiopll_48k.overlay
index 574e68417771..1297c1e384a8 100644
--- a/tests/drivers/audio/pdm_loopback/boards/nrf54h20dk_nrf54h20_cpuapp_audiopll_48k.overlay
+++ b/tests/drivers/audio/pdm_loopback/boards/nrf54h20dk_nrf54h20_cpuapp_audiopll_48k.overlay
@@ -49,13 +49,13 @@ pdm_dev: &pdm0 {
 };
 
 &dppic130 {
-	owned-channels = <0>;
-	source-channels = <0>;
+	owned-channels = <1>;
+	source-channels = <1>;
 	status = "okay";
 };
 
 &dppic133 {
-	owned-channels = <0>;
-	sink-channels = <0>;
+	owned-channels = <1>;
+	sink-channels = <1>;
 	status = "okay";
 };
diff --git a/tests/drivers/mspi/mspi_with_spis/boards/nrf54h20dk_nrf54h20_cpuapp_sqspi.overlay b/tests/drivers/mspi/mspi_with_spis/boards/nrf54h20dk_nrf54h20_cpuapp_sqspi.overlay
index 0391de2aa1aa..e4e2fd973cd9 100644
--- a/tests/drivers/mspi/mspi_with_spis/boards/nrf54h20dk_nrf54h20_cpuapp_sqspi.overlay
+++ b/tests/drivers/mspi/mspi_with_spis/boards/nrf54h20dk_nrf54h20_cpuapp_sqspi.overlay
@@ -128,31 +128,31 @@
 /delete-node/ &cpuflpr_cpuapp_ipc_shm;
 /delete-node/ &cpuapp_cpuflpr_ipc;
 
-&ram21_region {
-	status = "okay";
-
-	softperiph_ram: memory@0 {
-		reg = <0 0x4000>;
-		ranges;
-		#address-cells = <1>;
-		#size-cells = <1>;
-
-		dut: sqspi: sqspi@3e00 {
-			compatible = "nordic,nrf-sqspi";
+/ {
+	reserved-memory {
+		softperiph_ram: memory@2f890000 {
+			reg = <0x2f890000 0x4000>;
+			ranges;
 			#address-cells = <1>;
-			#size-cells = <0>;
-			reg = <0x3e00 0x200>;
-			zephyr,pm-device-runtime-auto;
-			memory-regions = <&sqspi_buffers>;
+			#size-cells = <1>;
+
+			dut: sqspi: sqspi@3e00 {
+				compatible = "nordic,nrf-sqspi";
+				#address-cells = <1>;
+				#size-cells = <0>;
+				reg = <0x3e00 0x200>;
+				zephyr,pm-device-runtime-auto;
+				memory-regions = <&sqspi_buffers>;
+			};
 		};
-	};
 
-	sqspi_buffers: memory@4000 {
-		compatible = "zephyr,memory-region";
-		reg = <0x4000 0x4000>;
-		#memory-region-cells = <0>;
-		zephyr,memory-region = "SQSPI_BUFFERS";
-		zephyr,memory-attr = <DT_MEM_CACHEABLE>;
+		sqspi_buffers: memory@2f894000 {
+			compatible = "zephyr,memory-region";
+			reg = <0x2f894000 0x4000>;
+			#memory-region-cells = <0>;
+			zephyr,memory-region = "SQSPI_BUFFERS";
+			zephyr,memory-attr = <DT_MEM_CACHEABLE>;
+		};
 	};
 };
 
diff --git a/tests/drivers/sensor/multicore_temp/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/drivers/sensor/multicore_temp/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/tests/drivers/sensor/multicore_temp/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/drivers/sensor/multicore_temp/remote/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/drivers/sensor/multicore_temp/remote/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..a6fa5758d9ae
--- /dev/null
+++ b/tests/drivers/sensor/multicore_temp/remote/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1 @@
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/drivers/sensor/multicore_temp/sysbuild/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/drivers/sensor/multicore_temp/sysbuild/nrf54h20dk_nrf54h20_cpuapp.conf
index 896239e180ef..07f0afc22190 100644
--- a/tests/drivers/sensor/multicore_temp/sysbuild/nrf54h20dk_nrf54h20_cpuapp.conf
+++ b/tests/drivers/sensor/multicore_temp/sysbuild/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -1 +1,2 @@
 SB_CONFIG_REMOTE_BOARD="nrf54h20dk/nrf54h20/cpuapp"
+SB_CONFIG_APPCORE_NONE=y
diff --git a/tests/subsys/bluetooth/fast_pair/crypto/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/subsys/bluetooth/fast_pair/crypto/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/tests/subsys/bluetooth/fast_pair/crypto/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/subsys/bluetooth/fast_pair/storage/account_key_storage/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/subsys/bluetooth/fast_pair/storage/account_key_storage/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/tests/subsys/bluetooth/fast_pair/storage/account_key_storage/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/tests/subsys/bluetooth/fast_pair/storage/factory_reset/boards/nrf54h20dk_nrf54h20_cpuapp.conf b/tests/subsys/bluetooth/fast_pair/storage/factory_reset/boards/nrf54h20dk_nrf54h20_cpuapp.conf
new file mode 100644
index 000000000000..cc10b7737d12
--- /dev/null
+++ b/tests/subsys/bluetooth/fast_pair/storage/factory_reset/boards/nrf54h20dk_nrf54h20_cpuapp.conf
@@ -0,0 +1,7 @@
+#
+# Copyright (c) 2025 Nordic Semiconductor ASA
+#
+# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+#
+
+CONFIG_SOC_NRF54H20_CPURAD_ENABLE=y
diff --git a/west.yml b/west.yml
index 12eb1747ff5c..f844e8f7cbd3 100644
--- a/west.yml
+++ b/west.yml
@@ -65,7 +65,7 @@ manifest:
     # https://developer.nordicsemi.com/nRF_Connect_SDK/doc/latest/zephyr/guides/modules.html
     - name: zephyr
       repo-path: sdk-zephyr
-      revision: d7b901d0c1951441440037c9fc7e022c065cea96
+      revision: 2ea472de16fa9ac3e75587f8aabaa4909d9619bc
       import:
         # In addition to the zephyr repository itself, NCS also
         # imports the contents of zephyr/west.yml at the above