diff --git a/drivers/mspi/mspi_sqspi.c b/drivers/mspi/mspi_sqspi.c
index 3f0932603dad..d9465051ffb4 100644
--- a/drivers/mspi/mspi_sqspi.c
+++ b/drivers/mspi/mspi_sqspi.c
@@ -17,8 +17,9 @@
 #include <softperipheral_regif.h>
 #include <nrfx_qspi2.h>
 #if defined(CONFIG_SOC_SERIES_NRF54LX)
-#include <hal/nrf_spu.h>
+#include <hal/nrf_memconf.h>
 #include <hal/nrf_oscillators.h>
+#include <hal/nrf_spu.h>
 #endif
 #if defined(CONFIG_SOC_NRF54H20_GPD)
 #include <nrf/gpd.h>
@@ -288,6 +289,8 @@ static int process_packet(const struct device *dev,
 {
 	const struct mspi_sqspi_config *dev_config = dev->config;
 	nrfx_qspi2_xfer_t qspi2_xfer = {
+		/* Use TX direction when there is no data to transfer. */
+		.dir = NRFX_QSPI2_XFER_DIR_TX,
 		.cmd = packet->cmd,
 		.address = packet->address,
 		.data_length = packet->num_bytes,
@@ -437,6 +440,10 @@ static int dev_pm_action_cb(const struct device *dev,
 		}
 #endif
 		nrfx_qspi2_activate(&dev_config->qspi2);
+#if defined(CONFIG_SOC_SERIES_NRF54LX)
+		nrf_memconf_ramblock_ret_enable_set(NRF_MEMCONF,
+			1, MEMCONF_POWER_RET_MEM0_Pos, false);
+#endif
 
 		dev_data->suspended = false;
 
@@ -464,6 +471,10 @@ static int dev_pm_action_cb(const struct device *dev,
 			return -EBUSY;
 		}
 
+#if defined(CONFIG_SOC_SERIES_NRF54LX)
+		nrf_memconf_ramblock_ret_enable_set(NRF_MEMCONF,
+			1, MEMCONF_POWER_RET_MEM0_Pos, true);
+#endif
 		nrfx_qspi2_deactivate(&dev_config->qspi2);
 
 		k_sem_give(&dev_data->ctx_lock);
@@ -506,10 +517,12 @@ static int dev_init(const struct device *dev)
 #if defined(CONFIG_SOC_SERIES_NRF54LX)
 	nrf_oscillators_pll_freq_set(NRF_OSCILLATORS,
 				     NRF_OSCILLATORS_PLL_FREQ_128M);
+#if !defined(CONFIG_TRUSTED_EXECUTION_NONSECURE)
 	nrf_spu_periph_perm_secattr_set(NRF_SPU00,
 		nrf_address_slave_get(DT_REG_ADDR(DT_NODELABEL(cpuflpr_vpr))),
 		true);
 #endif
+#endif /* defined(CONFIG_SOC_SERIES_NRF54LX) */
 
 	IRQ_CONNECT(DT_IRQN(VPR_NODE), DT_IRQ(VPR_NODE, priority),
 		    nrfx_isr, nrfx_qspi2_irq_handler, 0);