diff --git a/subsys/net/l2/openthread/openthread.c b/subsys/net/l2/openthread/openthread.c
index 61fe1d5c3bc3..f3553e138742 100644
--- a/subsys/net/l2/openthread/openthread.c
+++ b/subsys/net/l2/openthread/openthread.c
@@ -329,7 +329,11 @@ static void ot_joiner_start_handler(otError error, void *context)
 	switch (error) {
 	case OT_ERROR_NONE:
 		NET_INFO("Join success");
-		otThreadSetEnabled(ot_context->instance, true);
+		error = otThreadSetEnabled(ot_context->instance, true);
+		if (error != OT_ERROR_NONE) {
+			NET_ERR("Failed to start the OpenThread network [%d]", error);
+		}
+
 		break;
 	default:
 		NET_ERR("Join failed [%d]", error);
@@ -430,7 +434,11 @@ int openthread_start(struct openthread_context *ot_context)
 		goto exit;
 	}
 
-	otIp6SetEnabled(ot_context->instance, true);
+	error = otIp6SetEnabled(ot_context->instance, true);
+	if (error != OT_ERROR_NONE) {
+		NET_ERR("Failed to set %s [%d]", "IPv6 support", error);
+		goto exit;
+	}
 
 	/* Sleepy End Device specific configuration. */
 	if (IS_ENABLED(CONFIG_OPENTHREAD_MTD_SED)) {
@@ -441,8 +449,17 @@ int openthread_start(struct openthread_context *ot_context)
 		 */
 		ot_mode.mRxOnWhenIdle = false;
 
-		otThreadSetLinkMode(ot_context->instance, ot_mode);
-		otLinkSetPollPeriod(ot_context->instance, OT_POLL_PERIOD);
+		error = otThreadSetLinkMode(ot_context->instance, ot_mode);
+		if (error != OT_ERROR_NONE) {
+			NET_ERR("Failed to set %s [%d]", "link mode", error);
+			goto exit;
+		}
+
+		error = otLinkSetPollPeriod(ot_context->instance, OT_POLL_PERIOD);
+		if (error != OT_ERROR_NONE) {
+			NET_ERR("Failed to set %s [%d]", "poll period", error);
+			goto exit;
+		}
 	}
 
 	/* Configure Child Supervision and MLE Child timeouts. */
@@ -477,16 +494,39 @@ int openthread_start(struct openthread_context *ot_context)
 		otExtendedPanId xpanid;
 		otNetworkKey    networkKey;
 
-		otThreadSetNetworkName(ot_instance, OT_NETWORK_NAME);
-		otLinkSetChannel(ot_instance, OT_CHANNEL);
-		otLinkSetPanId(ot_instance, OT_PANID);
+		error = otThreadSetNetworkName(ot_instance, OT_NETWORK_NAME);
+		if (error != OT_ERROR_NONE) {
+			NET_ERR("Failed to set %s [%d]", "network name", error);
+			goto exit;
+		}
+
+		error = otLinkSetChannel(ot_instance, OT_CHANNEL);
+		if (error != OT_ERROR_NONE) {
+			NET_ERR("Failed to set %s [%d]", "channel", error);
+			goto exit;
+		}
+
+		error = otLinkSetPanId(ot_instance, OT_PANID);
+		if (error != OT_ERROR_NONE) {
+			NET_ERR("Failed to set %s [%d]", "PAN ID", error);
+			goto exit;
+		}
+
 		net_bytes_from_str(xpanid.m8, 8, (char *)OT_XPANID);
-		otThreadSetExtendedPanId(ot_instance, &xpanid);
+		error = otThreadSetExtendedPanId(ot_instance, &xpanid);
+		if (error != OT_ERROR_NONE) {
+			NET_ERR("Failed to set %s [%d]", "ext PAN ID", error);
+			goto exit;
+		}
 
 		if (strlen(OT_NETWORKKEY)) {
 			net_bytes_from_str(networkKey.m8, OT_NETWORK_KEY_SIZE,
 					   (char *)OT_NETWORKKEY);
-			otThreadSetNetworkKey(ot_instance, &networkKey);
+			error = otThreadSetNetworkKey(ot_instance, &networkKey);
+			if (error != OT_ERROR_NONE) {
+				NET_ERR("Failed to set %s [%d]", "network key", error);
+				goto exit;
+			}
 		}
 	}
 
@@ -533,7 +573,7 @@ static int openthread_init(struct net_if *iface)
 		.name = "openthread",
 		.no_yield = true,
 	};
-	otError err;
+	otError err = OT_ERROR_NONE;
 
 	NET_DBG("openthread_init");
 
@@ -556,7 +596,11 @@ static int openthread_init(struct net_if *iface)
 	}
 
 	if (IS_ENABLED(CONFIG_OPENTHREAD_COPROCESSOR)) {
-		otPlatUartEnable();
+		err = otPlatUartEnable();
+		if (err != OT_ERROR_NONE) {
+			NET_ERR("Failed to enable UART: [%d]", err);
+		}
+
 		otNcpHdlcInit(ot_context->instance, ncp_hdlc_send);
 	} else {
 		otIp6SetReceiveFilterEnabled(ot_context->instance, true);
@@ -604,7 +648,7 @@ static int openthread_init(struct net_if *iface)
 
 	(void)k_work_submit_to_queue(&ot_context->work_q, &ot_context->api_work);
 
-	return 0;
+	return (err == OT_ERROR_NONE) ? 0 : -EIO;
 }
 
 void ieee802154_init(struct net_if *iface)