diff --git a/boards/nordic/nrf54l15dk/Kconfig b/boards/nordic/nrf54l15dk/Kconfig
index 29168aeb17e..bf64dd32293 100644
--- a/boards/nordic/nrf54l15dk/Kconfig
+++ b/boards/nordic/nrf54l15dk/Kconfig
@@ -3,7 +3,7 @@
 
 # nRF54L15 DK board configuration
 
-if BOARD_NRF54L15DK_NRF54L15_CPUAPP_NS
+if BOARD_NRF54L15DK_NRF54L15_CPUAPP_NS || BOARD_NRF54L15DK_NRF54L10_CPUAPP_NS
 
 DT_NRF_MPC := $(dt_nodelabel_path,nrf_mpc)
 
@@ -27,4 +27,4 @@ config NRF_TRUSTZONE_RAM_REGION_SIZE
 	  This abstraction allows us to configure TrustZone without depending
 	  on peripheral specific symbols.
 
-endif # BOARD_NRF54L15DK_NRF54L15_CPUAPP_NS
+endif # BOARD_NRF54L15DK_NRF54L15_CPUAPP_NS || BOARD_NRF54L15DK_NRF54L10_CPUAPP_NS
diff --git a/boards/nordic/nrf54l15dk/Kconfig.defconfig b/boards/nordic/nrf54l15dk/Kconfig.defconfig
index 5835146bc57..b7b15587c58 100644
--- a/boards/nordic/nrf54l15dk/Kconfig.defconfig
+++ b/boards/nordic/nrf54l15dk/Kconfig.defconfig
@@ -15,7 +15,7 @@ config ROM_START_OFFSET
 endif # BOARD_NRF54L15DK_NRF54L05_CPUAPP || BOARD_NRF54L15DK_NRF54L10_CPUAPP || \
 	# BOARD_NRF54L15DK_NRF54L15_CPUAPP
 
-if BOARD_NRF54L15DK_NRF54L15_CPUAPP_NS
+if BOARD_NRF54L15DK_NRF54L15_CPUAPP_NS || BOARD_NRF54L15DK_NRF54L10_CPUAPP_NS
 
 config BT_CTLR
 	default BT
@@ -31,4 +31,4 @@ config FLASH_LOAD_SIZE
 config BUILD_WITH_TFM
 	default y
 
-endif # BOARD_NRF54L15DK_NRF54L15_CPUAPP_NS
+endif # BOARD_NRF54L15DK_NRF54L15_CPUAPP_NS || BOARD_NRF54L15DK_NRF54L10_CPUAPP_NS
diff --git a/boards/nordic/nrf54l15dk/Kconfig.nrf54l15dk b/boards/nordic/nrf54l15dk/Kconfig.nrf54l15dk
index 57b90e2c516..c7ae2fff596 100644
--- a/boards/nordic/nrf54l15dk/Kconfig.nrf54l15dk
+++ b/boards/nordic/nrf54l15dk/Kconfig.nrf54l15dk
@@ -3,7 +3,7 @@
 
 config BOARD_NRF54L15DK
 	select SOC_NRF54L05_CPUAPP if BOARD_NRF54L15DK_NRF54L05_CPUAPP
-	select SOC_NRF54L10_CPUAPP if BOARD_NRF54L15DK_NRF54L10_CPUAPP
+	select SOC_NRF54L10_CPUAPP if BOARD_NRF54L15DK_NRF54L10_CPUAPP || BOARD_NRF54L15DK_NRF54L10_CPUAPP_NS
 	select SOC_NRF54L15_CPUAPP if BOARD_NRF54L15DK_NRF54L15_CPUAPP || BOARD_NRF54L15DK_NRF54L15_CPUAPP_NS
 	select SOC_NRF54L15_CPUFLPR if BOARD_NRF54L15DK_NRF54L15_CPUFLPR || \
 					    BOARD_NRF54L15DK_NRF54L15_CPUFLPR_XIP
diff --git a/boards/nordic/nrf54l15dk/board.cmake b/boards/nordic/nrf54l15dk/board.cmake
index 08f5afb160d..d47b437d14a 100644
--- a/boards/nordic/nrf54l15dk/board.cmake
+++ b/boards/nordic/nrf54l15dk/board.cmake
@@ -8,7 +8,7 @@ elseif(CONFIG_SOC_NRF54L05_CPUFLPR OR CONFIG_SOC_NRF54L10_CPUFLPR OR CONFIG_SOC_
   board_runner_args(jlink "--device=RISC-V" "--speed=4000" "-if SW" "--tool-opt=-jlinkscriptfile ${JLINKSCRIPTFILE}")
 endif()
 
-if(CONFIG_BOARD_NRF54L15DK_NRF54L15_CPUAPP_NS)
+if(CONFIG_BOARD_NRF54L15DK_NRF54L15_CPUAPP_NS OR CONFIG_BOARD_NRF54L15DK_NRF54L10_CPUAPP_NS)
   set(TFM_PUBLIC_KEY_FORMAT "full")
 endif()
 
diff --git a/boards/nordic/nrf54l15dk/board.yml b/boards/nordic/nrf54l15dk/board.yml
index f4214f09d28..8d97ef356a9 100644
--- a/boards/nordic/nrf54l15dk/board.yml
+++ b/boards/nordic/nrf54l15dk/board.yml
@@ -3,11 +3,51 @@ board:
   full_name: nRF54L15 DK
   vendor: nordic
   socs:
-  - name: nrf54l05
-  - name: nrf54l10
-  - name: nrf54l15
-    variants:
-    - name: xip
-      cpucluster: cpuflpr
-    - name: ns
-      cpucluster: cpuapp
+    - name: nrf54l05
+    - name: nrf54l10
+      variants:
+        - name: ns
+          cpucluster: cpuapp
+    - name: nrf54l15
+      variants:
+        - name: xip
+          cpucluster: cpuflpr
+        - name: ns
+          cpucluster: cpuapp
+runners:
+  run_once:
+    '--recover':
+      - runners:
+          - nrfjprog
+          - nrfutil
+        run: first
+        groups:
+          - boards:
+              - nrf54l15dk/nrf54l15/cpuapp
+              - nrf54l15dk/nrf54l15/cpuapp/ns
+              - nrf54l15dk/nrf54l15/cpuflpr
+              - nrf54l15dk/nrf54l15/cpuflpr/xip
+    '--erase':
+      - runners:
+          - nrfjprog
+          - jlink
+          - nrfutil
+        run: first
+        groups:
+          - boards:
+              - nrf54l15dk/nrf54l15/cpuapp
+              - nrf54l15dk/nrf54l15/cpuapp/ns
+              - nrf54l15dk/nrf54l15/cpuflpr
+              - nrf54l15dk/nrf54l15/cpuflpr/xip
+    '--reset':
+      - runners:
+          - nrfjprog
+          - jlink
+          - nrfutil
+        run: last
+        groups:
+          - boards:
+              - nrf54l15dk/nrf54l15/cpuapp
+              - nrf54l15dk/nrf54l15/cpuapp/ns
+              - nrf54l15dk/nrf54l15/cpuflpr
+              - nrf54l15dk/nrf54l15/cpuflpr/xip
diff --git a/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l10_cpuapp_ns.dts b/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l10_cpuapp_ns.dts
new file mode 100644
index 00000000000..f1aa851ed2d
--- /dev/null
+++ b/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l10_cpuapp_ns.dts
@@ -0,0 +1,107 @@
+/*
+ * Copyright (c) 2025 Nordic Semiconductor ASA
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ */
+
+/dts-v1/;
+
+#define USE_NON_SECURE_ADDRESS_MAP 1
+
+#include <nordic/nrf54l10_cpuapp.dtsi>
+#include "nrf54l_05_10_15_cpuapp_common.dtsi"
+
+/ {
+	compatible = "nordic,nrf54l15dk_nrf54l10-cpuapp";
+	model = "Nordic nRF54L15 DK nRF54L10 Application MCU";
+
+	chosen {
+		zephyr,code-partition = &slot0_ns_partition;
+		zephyr,sram = &sram0_ns;
+		zephyr,entropy = &psa_rng;
+	};
+
+	/delete-node/ rng;
+
+	psa_rng: psa-rng {
+		status = "okay";
+	};
+};
+
+/ {
+	/*
+	 * Default SRAM planning when building for nRF54L10 with ARM TrustZone-M support.
+	 * - Lowest 96 kB SRAM allocated to Secure image (sram0_s).
+	 * - Upper 96 kB SRAM allocated to Non-Secure image (sram0_ns).
+	 *
+	 * nRF54L10 has 192 kB of volatile memory (SRAM) but the last 42kB are reserved for
+	 * the FLPR MCU.
+	 * This static layout needs to be the same with the upstream TF-M layout in the
+	 * header flash_layout.h of the relevant platform. Any updates in the layout
+	 * needs to happen both in the flash_layout.h and in this file at the same time.
+	 */
+	reserved-memory {
+		#address-cells = <1>;
+		#size-cells = <1>;
+		ranges;
+
+		sram0_s: image_s@20000000 {
+			/* Secure image memory */
+			reg = <0x20000000 DT_SIZE_K(72)>;
+		};
+
+		sram0_ns: image_ns@20012000 {
+			/* Non-Secure image memory */
+			reg = <0x20012000 DT_SIZE_K(72)>;
+		};
+	};
+};
+
+&cpuapp_rram {
+	partitions {
+		compatible = "fixed-partitions";
+		#address-cells = <1>;
+		#size-cells = <1>;
+		/* nRF54L10 has 1022 kB of non volatile memory (RRAM) but the
+		 * last 62kB are reserved for the FLPR MCU.
+		 *
+		 * This static layout needs to be the same with the upstream TF-M layout in the
+		 * header flash_layout.h of the relevant platform. Any updates in the layout
+		 * needs to happen both in the flash_layout.h and in this file at the same time.
+		 */
+		slot0_partition: partition@0 {
+			label = "image-0";
+			reg = <0x0000000 DT_SIZE_K(384)>;
+		};
+
+		tfm_ps_partition: partition@60000 {
+			label = "tfm-ps";
+			reg = <0x00060000 DT_SIZE_K(16)>;
+		};
+
+		tfm_its_partition: partition@64000 {
+			label = "tfm-its";
+			reg = <0x00064000 DT_SIZE_K(16)>;
+		};
+
+		tfm_otp_partition: partition@68000 {
+			label = "tfm-otp";
+			reg = <0x00068000 DT_SIZE_K(8)>;
+		};
+
+		slot0_ns_partition: partition@6A000 {
+			label = "image-0-nonsecure";
+			reg = <0x0006A000 DT_SIZE_K(504)>;
+		};
+
+		storage_partition: partition@E8000 {
+			label = "storage";
+			reg = <0x000E8000 DT_SIZE_K(32)>;
+		};
+	};
+};
+
+&uart30 {
+	/* Disable so that TF-M can use this UART */
+	status = "disabled";
+};
diff --git a/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l10_cpuapp_ns.yaml b/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l10_cpuapp_ns.yaml
new file mode 100644
index 00000000000..c771aca2e38
--- /dev/null
+++ b/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l10_cpuapp_ns.yaml
@@ -0,0 +1,21 @@
+# Copyright (c) 2025 Nordic Semiconductor ASA
+# SPDX-License-Identifier: Apache-2.0
+
+identifier: nrf54l15dk/nrf54l10/cpuapp/ns
+name: nRF54l15-DK-nRF54l10-Application-Non-Secure
+type: mcu
+arch: arm
+toolchain:
+  - gnuarmemb
+  - zephyr
+ram: 192
+flash: 1022
+supported:
+  - adc
+  - gpio
+  - i2c
+  - spi
+  - counter
+  - watchdog
+  - adc
+  - i2s
diff --git a/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l10_cpuapp_ns_defconfig b/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l10_cpuapp_ns_defconfig
new file mode 100644
index 00000000000..1d759be671c
--- /dev/null
+++ b/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l10_cpuapp_ns_defconfig
@@ -0,0 +1,36 @@
+# Copyright (c) 2025 Nordic Semiconductor ASA
+# SPDX-License-Identifier: Apache-2.0
+
+CONFIG_ARM_MPU=y
+CONFIG_HW_STACK_PROTECTION=y
+CONFIG_NULL_POINTER_EXCEPTION_DETECTION_NONE=y
+CONFIG_ARM_TRUSTZONE_M=y
+
+# This Board implies building Non-Secure firmware
+CONFIG_TRUSTED_EXECUTION_NONSECURE=y
+
+# Don't enable the cache in the non-secure image as it is a
+# secure-only peripheral on 54l
+CONFIG_CACHE_MANAGEMENT=n
+CONFIG_EXTERNAL_CACHE=n
+
+CONFIG_UART_CONSOLE=y
+CONFIG_CONSOLE=y
+CONFIG_SERIAL=y
+CONFIG_GPIO=y
+
+# Start SYSCOUNTER on driver init
+CONFIG_NRF_GRTC_START_SYSCOUNTER=y
+
+# Disable TFM BL2 since it is not supported
+CONFIG_TFM_BL2=n
+
+# Support for silence logging is not supported at the moment
+# Tracked by: NCSDK-31930
+CONFIG_TFM_LOG_LEVEL_SILENCE=n
+
+# The oscillators are configured as secure and cannot be configured
+# from the non secure application directly. This needs to be set
+# otherwise nrfx will try to configure them, resulting in a bus
+# fault.
+CONFIG_SOC_NRF54LX_SKIP_CLOCK_CONFIG=y
diff --git a/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l15_cpuapp_ns.yaml b/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l15_cpuapp_ns.yaml
index 6798de376fd..43bd7c8f244 100644
--- a/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l15_cpuapp_ns.yaml
+++ b/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l15_cpuapp_ns.yaml
@@ -1,5 +1,5 @@
 # Copyright (c) 2025 Nordic Semiconductor ASA
-# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+# SPDX-License-Identifier: Apache-2.0
 
 identifier: nrf54l15dk/nrf54l15/cpuapp/ns
 name: nRF54l15-DK-nRF54l15-Application-Non-Secure
diff --git a/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l15_cpuapp_ns_defconfig b/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l15_cpuapp_ns_defconfig
index bcd99e01dc9..1d759be671c 100644
--- a/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l15_cpuapp_ns_defconfig
+++ b/boards/nordic/nrf54l15dk/nrf54l15dk_nrf54l15_cpuapp_ns_defconfig
@@ -1,5 +1,5 @@
 # Copyright (c) 2025 Nordic Semiconductor ASA
-# SPDX-License-Identifier: LicenseRef-Nordic-5-Clause
+# SPDX-License-Identifier: Apache-2.0
 
 CONFIG_ARM_MPU=y
 CONFIG_HW_STACK_PROTECTION=y
diff --git a/modules/trusted-firmware-m/Kconfig.tfm b/modules/trusted-firmware-m/Kconfig.tfm
index c8f8b656e28..644a78279a2 100644
--- a/modules/trusted-firmware-m/Kconfig.tfm
+++ b/modules/trusted-firmware-m/Kconfig.tfm
@@ -26,6 +26,7 @@ config TFM_BOARD
 	default "${ZEPHYR_BASE}/modules/trusted-firmware-m/nordic/nrf9120" if SOC_NRF9120
 	default "${ZEPHYR_BASE}/modules/trusted-firmware-m/nordic/nrf5340_cpuapp" if SOC_NRF5340_CPUAPP
 	default "${ZEPHYR_BASE}/modules/trusted-firmware-m/nordic/nrf54l15_cpuapp" if SOC_NRF54L15_CPUAPP
+	default "${ZEPHYR_BASE}/modules/trusted-firmware-m/nordic/nrf54l10_cpuapp" if SOC_NRF54L10_CPUAPP
 	help
 	  The board name used for building TFM. Building with TFM requires that
 	  TFM has been ported to the given board/SoC.
diff --git a/modules/trusted-firmware-m/nordic/nrf54l10_cpuapp/CMakeLists.txt b/modules/trusted-firmware-m/nordic/nrf54l10_cpuapp/CMakeLists.txt
new file mode 100644
index 00000000000..c1bdb28c52c
--- /dev/null
+++ b/modules/trusted-firmware-m/nordic/nrf54l10_cpuapp/CMakeLists.txt
@@ -0,0 +1,23 @@
+#
+# Copyright (c) 2025, Nordic Semiconductor ASA.
+#
+# SPDX-License-Identifier: Apache-2.0
+#
+
+set(NRF_BOARD_SELECTED True)
+
+add_subdirectory(${Trusted\ Firmware\ M_SOURCE_DIR}/platform/ext/target/nordic_nrf/common/nrf54l10 nrf54l10)
+
+add_subdirectory(.. common)
+
+install(FILES       ${CMAKE_CURRENT_LIST_DIR}/ns/cpuarch_ns.cmake
+        DESTINATION ${INSTALL_PLATFORM_NS_DIR}
+        RENAME      cpuarch.cmake)
+
+install(FILES       config.cmake
+        DESTINATION ${INSTALL_PLATFORM_NS_DIR})
+
+install(DIRECTORY   ${Trusted\ Firmware\ M_SOURCE_DIR}/platform/ext/target/nordic_nrf/nrf54l15dk_nrf54l10_cpuapp/tests
+
+        DESTINATION ${INSTALL_PLATFORM_NS_DIR}
+)
diff --git a/modules/trusted-firmware-m/nordic/nrf54l10_cpuapp/config.cmake b/modules/trusted-firmware-m/nordic/nrf54l10_cpuapp/config.cmake
new file mode 100644
index 00000000000..275295a164d
--- /dev/null
+++ b/modules/trusted-firmware-m/nordic/nrf54l10_cpuapp/config.cmake
@@ -0,0 +1,9 @@
+#
+# Copyright (c) 2025, Nordic Semiconductor ASA.
+#
+# SPDX-License-Identifier: Apache-2.0
+#
+
+set(NRF_SOC_VARIANT nrf54l10 CACHE STRING "nRF SoC Variant")
+
+include(${PLATFORM_PATH}/common/nrf54l10/config.cmake)
diff --git a/modules/trusted-firmware-m/nordic/nrf54l10_cpuapp/cpuarch.cmake b/modules/trusted-firmware-m/nordic/nrf54l10_cpuapp/cpuarch.cmake
new file mode 100644
index 00000000000..e6b6c70674e
--- /dev/null
+++ b/modules/trusted-firmware-m/nordic/nrf54l10_cpuapp/cpuarch.cmake
@@ -0,0 +1,9 @@
+#
+# Copyright (c) 2025, Nordic Semiconductor ASA.
+#
+# SPDX-License-Identifier: Apache-2.0
+#
+
+set(PLATFORM_PATH platform/ext/target/nordic_nrf)
+
+include(${PLATFORM_PATH}/common/nrf54l10/cpuarch.cmake)
diff --git a/modules/trusted-firmware-m/nordic/nrf54l10_cpuapp/ns/cpuarch_ns.cmake b/modules/trusted-firmware-m/nordic/nrf54l10_cpuapp/ns/cpuarch_ns.cmake
new file mode 100644
index 00000000000..c45f535be70
--- /dev/null
+++ b/modules/trusted-firmware-m/nordic/nrf54l10_cpuapp/ns/cpuarch_ns.cmake
@@ -0,0 +1,10 @@
+#
+# Copyright (c) 2025, Nordic Semiconductor ASA.
+#
+# SPDX-License-Identifier: Apache-2.0
+#
+
+set(PLATFORM_DIR  ${CMAKE_CURRENT_LIST_DIR})
+set(PLATFORM_PATH ${CMAKE_CURRENT_LIST_DIR})
+
+include(${CMAKE_CURRENT_LIST_DIR}/common/nrf54l10/cpuarch.cmake)
diff --git a/samples/tfm_integration/config_build/sample.yaml b/samples/tfm_integration/config_build/sample.yaml
index f57da72a379..3c46c148f7b 100644
--- a/samples/tfm_integration/config_build/sample.yaml
+++ b/samples/tfm_integration/config_build/sample.yaml
@@ -9,6 +9,7 @@ common:
     - nrf5340dk/nrf5340/cpuapp/ns
     - nrf9160dk/nrf9160/ns
     - nrf54l15dk/nrf54l15/cpuapp/ns
+    - nrf54l15dk/nrf54l10/cpuapp/ns
     - bl5340_dvk/nrf5340/cpuapp/ns
   integration_platforms:
     - nrf5340dk/nrf5340/cpuapp/ns
diff --git a/samples/tfm_integration/tfm_ipc/sample.yaml b/samples/tfm_integration/tfm_ipc/sample.yaml
index fb0acbdd988..390efa24fb7 100644
--- a/samples/tfm_integration/tfm_ipc/sample.yaml
+++ b/samples/tfm_integration/tfm_ipc/sample.yaml
@@ -34,6 +34,7 @@ tests:
     platform_allow:
       - mps2/an521/cpu0/ns
       - nrf54l15dk/nrf54l15/cpuapp/ns
+      - nrf54l15dk/nrf54l10/cpuapp/ns
     extra_configs:
       - CONFIG_TFM_BL2=n
     harness: console