diff --git a/drivers/adc/adc_nrfx_saadc.c b/drivers/adc/adc_nrfx_saadc.c
index 7d442b482e6..0e39e3bafae 100644
--- a/drivers/adc/adc_nrfx_saadc.c
+++ b/drivers/adc/adc_nrfx_saadc.c
@@ -187,7 +187,6 @@ static int input_assign(nrf_saadc_input_t *pin_p,
 
 	if (channel_cfg->differential) {
 		if (channel_cfg->input_negative > ARRAY_SIZE(saadc_psels) ||
-		    channel_cfg->input_negative < NRF_SAADC_AIN0 ||
 		    (IS_ENABLED(CONFIG_NRF_PLATFORM_HALTIUM) &&
 		     (channel_cfg->input_positive > NRF_SAADC_AIN7) !=
 		     (channel_cfg->input_negative > NRF_SAADC_AIN7))) {
@@ -195,14 +194,17 @@ static int input_assign(nrf_saadc_input_t *pin_p,
 				channel_cfg->input_negative);
 			return -EINVAL;
 		}
-		*pin_n = saadc_psels[channel_cfg->input_negative];
+		*pin_n = channel_cfg->input_negative == NRF_SAADC_GND ?
+			 NRF_SAADC_INPUT_DISABLED :
+			 saadc_psels[channel_cfg->input_negative];
 	} else {
 		*pin_n = NRF_SAADC_INPUT_DISABLED;
 	}
 #else
 	*pin_p = channel_cfg->input_positive;
-	*pin_n = channel_cfg->differential ? channel_cfg->input_negative
-					   : NRF_SAADC_INPUT_DISABLED;
+	*pin_n = (channel_cfg->differential && (channel_cfg->input_negative != NRF_SAADC_GND))
+			 ? channel_cfg->input_negative
+			 : NRF_SAADC_INPUT_DISABLED;
 #endif
 	LOG_DBG("ADC positive input: %d", *pin_p);
 	LOG_DBG("ADC negative input: %d", *pin_n);
@@ -352,8 +354,14 @@ static int adc_nrfx_channel_setup(const struct device *dev,
 	 * after ADC sequence ends.
 	 */
 	if (channel_cfg->differential) {
-		ch_cfg->mode = NRF_SAADC_MODE_DIFFERENTIAL;
-		m_data.single_ended_channels &= ~BIT(channel_cfg->channel_id);
+		if (channel_cfg->input_negative == NRF_SAADC_GND) {
+			ch_cfg->mode = NRF_SAADC_MODE_SINGLE_ENDED;
+			/* Do not mark as single-ended to not correct negative values. */
+			m_data.single_ended_channels &= ~BIT(channel_cfg->channel_id);
+		} else {
+			ch_cfg->mode = NRF_SAADC_MODE_DIFFERENTIAL;
+			m_data.single_ended_channels &= ~BIT(channel_cfg->channel_id);
+		}
 	} else {
 		ch_cfg->mode = NRF_SAADC_MODE_SINGLE_ENDED;
 		m_data.single_ended_channels |= BIT(channel_cfg->channel_id);
diff --git a/include/zephyr/dt-bindings/adc/nrf-saadc.h b/include/zephyr/dt-bindings/adc/nrf-saadc.h
index 4a3deb95cff..e5a86150cd4 100644
--- a/include/zephyr/dt-bindings/adc/nrf-saadc.h
+++ b/include/zephyr/dt-bindings/adc/nrf-saadc.h
@@ -7,6 +7,30 @@
 #ifndef ZEPHYR_INCLUDE_DT_BINDINGS_ADC_NRF_SAADC_H_
 #define ZEPHYR_INCLUDE_DT_BINDINGS_ADC_NRF_SAADC_H_
 
+/**
+ * @brief Short ADC negative input to ground
+ *
+ * @details The nRF SAADC hardware only supports differential readings.
+ * The nRF SAADC SE (single ended) mode is differential with the negative
+ * input shorted to GND (ground). To use the nRF SAADC SE mode, set the
+ * negative input to NRF_SAADC_GND:
+ *
+ * @code{.dts}
+ *   zephyr,input-positive = <NRF_SAADC_AIN3>;
+ *   zephyr,input-negative = <NRF_SAADC_GND>;
+ * @endcode
+ *
+ * The nRF SAADC driver also supports using the nRF SAADC SE mode in
+ * emulated "single-ended" mode, as defined by zephyr. In this mode,
+ * negative readings will be clamped to 0 by software to emulate the
+ * behavior of an ADC in "single-ended" mode, as defined by zephyr. To
+ * do this, only define the positive input:
+ *
+ * @code{.dts}
+ *   zephyr,input-positive = <NRF_SAADC_AIN3>;
+ * @endcode
+ */
+#define NRF_SAADC_GND  0
 #define NRF_SAADC_AIN0 1
 #define NRF_SAADC_AIN1 2
 #define NRF_SAADC_AIN2 3