In some of our DAAC notebooks, we include the following Boto3 snippet to check if the notebook is being executed inside us-west-2, and throws a ValueError (with emojis) if you are not, preventing the notebook from being fully executed:

if (boto3.client('s3').meta.region_name == 'us-west-2'):
    display(Markdown('### us-west-2 Region Check: ✅'))
else:
    display(Markdown('### us-west-2 Region Check: ❌'))
    raise ValueError('Your notebook is not running inside the AWS us-west-2 region, and will not be able to directly access NASA Earthdata S3 buckets')

It may be useful to include a method that the user can call to check if they are in us-west-2 for direct S3 access and will throw an error like this, possibly using an fsspec transitive dependency, or the existing authorization checks.