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Large-scale Evidence Generation and Evaluation for Heterogeneity of Treatment Effect for Type 2 Diabetes Mellitus Drugs (LEGEND-T2DM)

Analytics use case(s): Population-Level Estimation
Study type: Clinical Application
Tags: -
Study lead: Hsin Yi Chen, George Hripcsak
Study lead forums tag: --
Study start date: 1 May 2025
Study end date: -
Protocol: HTML document
Publications: -
Results explorer: -

Requirements

A database in Common Data Model version 5 in one of these platforms: SQL Server, Oracle, PostgreSQL, IBM Netezza, Apache Impala, Amazon RedShift, Google BigQuery, or Microsoft APS.
R version 4.0.5
On Windows: RTools
Java
100 GB of free disk space

How to run

Follow these instructions for setting up your R environment, including RTools and Java.
Open your study package in RStudio. Use the following code to install all the dependencies:
```
install.packages("renv")
renv::activate()
renv::restore()
```
Once all dependencies are installed, you can execute the analysis by modifying and using the code provided in StrategusCodeToRun.R.
Heterogeneity analysis code and code to produce characterization tables are located in extras/Characterization Tables and extras/HTE Code

License

The LegendT2dm package is licensed under Apache License 2.0

Development

LegendT2dmArpah was developed in ATLAS and R Studio.

Development status

Study complete.