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Merge pull request #1315 from oncokb/data-release-6.2
Data release 6.2
2 parents 1d77456 + 452042c commit 0a13897

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‎screenshot-test/__baseline_snapshots__/Precision Oncology Therapies Page without Login-snap.png‎

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‎scripts/generate-markdown.js‎

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@@ -99,6 +99,17 @@ function fixHtmlString(htmlString) {
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*
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* @throws {Error} If a mutation is found in a row without an associated gene.
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*/
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function isNewlyAddedGenesTrigger(text) {
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const lower = text.toLowerCase();
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if (!lower.includes('new gene')) {
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return false;
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}
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if (lower.includes('new gene page layout')) {
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return false;
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}
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return lower.includes('addition of') || lower.includes('newly added');
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}
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function newlyAddedGenes(md, state) {
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let foundNewlyAddedGenes = false;
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let index = 0;
@@ -107,8 +118,8 @@ function newlyAddedGenes(md, state) {
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const genes = [];
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for (const token of state.tokens) {
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if (
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token.content.toLowerCase().includes('new gene') &&
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!token.content.toLowerCase().includes('new gene page layout')
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token.type === 'inline' &&
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isNewlyAddedGenesTrigger(token.content)
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) {
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foundNewlyAddedGenes = true;
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toRemoveStart = index;

‎src/main/webapp/app/pages/newsPage/NewsPage.tsx‎

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@@ -86,6 +86,7 @@ export default class NewsPage extends React.Component<{
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<CitationText />
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</div>
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<div className="mt-2">
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<NewsList date={'02272026'} />
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<NewsList date={'01292026'} />
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<NewsList date={'12182025'} />
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<NewsList date={'11242025'} />

‎src/main/webapp/app/pages/newsPage/NewsPageContent.tsx‎

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@@ -57,6 +57,7 @@ import NewsContent102025 from './code-generated/NewsContent102025';
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import NewsContent112025 from './code-generated/NewsContent112025';
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import NewsContent122025 from './code-generated/NewsContent122025';
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import NewsContent012026 from './code-generated/NewsContent012026';
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import NewsContent022026 from './code-generated/NewsContent022026';
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export type ChangedAnnotation = {
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content: (ElementType | ElementType[])[][];
@@ -314,6 +315,9 @@ const EVIDENCE_COLUMN_SEPARATOR = '; ';
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// https://stackoverflow.com/questions/41947168/is-it-possible-to-use-keyof-operator-on-literals-instead-of-interfaces
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export const NEWS_BY_DATE: { [date: string]: NewsData } = {
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'02272026': {
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rawComponent: <NewsContent022026 />,
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},
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'01292026': {
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rawComponent: <NewsContent012026 />,
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},

‎src/main/webapp/app/pages/newsPage/code-generated/NewsContent022026.tsx‎

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import React from 'react';
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import { Link } from 'react-router-dom';
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import {
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AlterationPageLink,
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getAlternativeGenePageLinks,
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GenePageLink,
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} from 'app/shared/utils/UrlUtils';
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import { NewlyAddedGenesListItem } from 'app/pages/newsPage/NewlyAddedGenesListItem';
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import { TableOfContents } from 'app/pages/privacyNotice/TableOfContents';
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export default function NewsContent022026() {
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return (
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<>
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<ul>
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<li>
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Update to our{' '}
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<Link to="/oncology-therapies">FDA-Approved Oncology Therapies</Link>{' '}
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page
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</li>
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<li>
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Updates to the functional classification of the following genes:
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<details>
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<summary>View gene classification updates.</summary>
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<div className="table-responsive">
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<table className="table">
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<thead>
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<tr>
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<th>Gene</th>
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<th>Previous Gene Classification</th>
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<th>New Gene Classification</th>
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</tr>
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</thead>
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<tbody>
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<tr>
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<td>{getAlternativeGenePageLinks('KLHL6')}</td>
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<td>Oncogene, Tumor Suppressor</td>
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<td>Tumor Suppressor</td>
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</tr>
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<tr>
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<td>{getAlternativeGenePageLinks('MEF2C')}</td>
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<td>Oncogene, Tumor Suppressor</td>
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<td>Oncogene</td>
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</tr>
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<tr>
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<td>{getAlternativeGenePageLinks('MITF')}</td>
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<td>Oncogene, Tumor Suppressor</td>
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<td>Oncogene</td>
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</tr>
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<tr>
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<td>{getAlternativeGenePageLinks('NSD1')}</td>
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<td>Oncogene, Tumor Suppressor</td>
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<td>Tumor Suppressor</td>
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</tr>
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<tr>
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<td>{getAlternativeGenePageLinks('PRKCB')}</td>
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<td>Oncogene, Tumor Suppressor</td>
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<td>Oncogene</td>
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</tr>
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<tr>
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<td>{getAlternativeGenePageLinks('PTPN1')}</td>
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<td>Oncogene, Tumor Suppressor</td>
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<td>Tumor Suppressor</td>
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</tr>
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<tr>
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<td>{getAlternativeGenePageLinks('SERPINB3')}</td>
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<td>Oncogene, Tumor Suppressor</td>
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<td>
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Insufficient evidence to classify as an Oncogene or Tumor
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Suppressor
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</td>
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</tr>
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<tr>
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<td>{getAlternativeGenePageLinks('SMARCE1')}</td>
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<td>Oncogene, Tumor Suppressor</td>
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<td>
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Insufficient evidence to classify as an Oncogene or Tumor
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Suppressor
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</td>
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</tr>
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<tr>
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<td>{getAlternativeGenePageLinks('SOX9')}</td>
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<td>Oncogene, Tumor Suppressor</td>
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<td>Tumor Suppressor</td>
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</tr>
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<tr>
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<td>{getAlternativeGenePageLinks('ZBTB20')}</td>
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<td>Oncogene, Tumor Suppressor</td>
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<td>Oncogene</td>
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</tr>
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</tbody>
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</table>
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</div>
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</details>
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</li>
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</ul>
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<p>
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<strong>Updated Therapeutic Implications</strong>
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</p>
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<ul>
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<li>
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Removal of therapy(s) associated with a tumor type-specific leveled
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alteration(s) (without changing the alteration's highest level of
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evidence)
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</li>
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</ul>
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<div className="table-responsive">
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<table className="table">
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<thead>
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<tr>
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<th>Level</th>
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<th>Gene</th>
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<th>Mutation</th>
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<th>Cancer Type</th>
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<th>Level-Associated Drug(s) Remaining in OncoKB™</th>
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<th>Drug(s) Removed from OncoKB™</th>
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<th>Evidence</th>
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</tr>
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</thead>
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<tbody>
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<tr>
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<td>R2</td>
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<td>{getAlternativeGenePageLinks('EGFR')}</td>
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<td>
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<AlterationPageLink hugoSymbol="EGFR" alteration="S492R">
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S492R
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</AlterationPageLink>
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</td>
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<td>Colorectal Cancer</td>
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<td>Cetuximab (Level R2)</td>
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<td>Panitumumab (Level R2)</td>
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<td>
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Data does not support EGFR S492R as conferring resistance to
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panitumumab in CRC; PMID:{' '}
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<a href="https://pubmed.ncbi.nlm.nih.gov/22270724/">22270724</a>
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,{' '}
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<a href="https://pubmed.ncbi.nlm.nih.gov/26059438/">26059438</a>
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</td>
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</tr>
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</tbody>
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</table>
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</div>
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<ul>
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<li>
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<NewlyAddedGenesListItem
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genes={[
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'ACACA',
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'ACP3',
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'ACSL4',
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'CARS1',
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'CHUK',
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'D2HGDH',
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'HOXA13',
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'MDH2',
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'MASTL',
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'NFKBIE',
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'TNFRSF9',
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'TOX',
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'XRCC3',
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]}
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></NewlyAddedGenesListItem>
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</li>
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</ul>
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</>
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);
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}

‎src/main/webapp/app/pages/newsPage/markdown/NewsContent022026.md‎

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- Update to our [FDA-Approved Oncology Therapies](https://www.oncokb.org/oncology-therapies) page
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- Updates to the functional classification of the following genes:
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<details>
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<summary>View gene classification updates.</summary>
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| Gene | Previous Gene Classification | New Gene Classification |
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| :------- | :--------------------------- | :------------------------------------------------------------------- |
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| KLHL6 | Oncogene, Tumor Suppressor | Tumor Suppressor |
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| MEF2C | Oncogene, Tumor Suppressor | Oncogene |
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| MITF | Oncogene, Tumor Suppressor | Oncogene |
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| NSD1 | Oncogene, Tumor Suppressor | Tumor Suppressor |
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| PRKCB | Oncogene, Tumor Suppressor | Oncogene |
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| PTPN1 | Oncogene, Tumor Suppressor | Tumor Suppressor |
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| SERPINB3 | Oncogene, Tumor Suppressor | Insufficient evidence to classify as an Oncogene or Tumor Suppressor |
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| SMARCE1 | Oncogene, Tumor Suppressor | Insufficient evidence to classify as an Oncogene or Tumor Suppressor |
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| SOX9 | Oncogene, Tumor Suppressor | Tumor Suppressor |
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| ZBTB20 | Oncogene, Tumor Suppressor | Oncogene |
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</details>
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**Updated Therapeutic Implications**
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- Removal of therapy(s) associated with a tumor type-specific leveled alteration(s) (without changing the alteration's highest level of evidence)
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| Level | Gene | Mutation | Cancer Type | Level-Associated Drug(s) Remaining in OncoKB™ | Drug(s) Removed from OncoKB™ | Evidence |
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| :---- | :--- | :------- | :---------------- | :-------------------------------------------- | :--------------------------- | :-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |
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| R2 | EGFR | S492R | Colorectal Cancer | Cetuximab (Level R2) | Panitumumab (Level R2) | Data does not support EGFR S492R as conferring resistance to panitumumab in CRC; PMID: [22270724](https://pubmed.ncbi.nlm.nih.gov/22270724/), [26059438](https://pubmed.ncbi.nlm.nih.gov/26059438/) |
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- Addition of 13 new genes:
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- ACACA
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- ACP3
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- ACSL4
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- CARS1
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- CHUK
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- D2HGDH
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- HOXA13
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- MDH2
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- MASTL
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- NFKBIE
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- TNFRSF9
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- TOX
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- XRCC3

‎src/main/webapp/app/pages/oncologyTherapiesPage/oncologyTherapiesPage.tsx‎

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@@ -486,7 +486,7 @@ const OncologyTherapiesPage: React.FunctionComponent<{}> = props => {
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'https://www.fda.gov/drugs/resources-information-approved-drugs/oncology-cancer-hematologic-malignancies-approval-notifications'
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}
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>
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Content current as of 12/09/2025
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Content current as of 2/25/2026
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</Linkout>
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</div>
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<div>

‎src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.json‎

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"targetedTx": "Y",
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"pxTx": "Y",
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"ngsTest": "Y"
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},
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{
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"year": "2025",
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"tx": "Trastuzumab deruxtecan + Pertuzumab",
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"biomarker": "HER2+ (ERBB2 Amplification)",
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"agentClass": "Antibody drug conjugate and monocolonal antibody",
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"drugTarget": "HER2 (ERBB2)-directed antibody and topoisomerase inhibitor conjugate + anti-HER2 (ERBB2) antibody",
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"targetedTx": "Y",
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"pxTx": "Y",
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"ngsTest": "Y"
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}
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]

‎src/main/webapp/content/files/oncologyTherapies/fda_approved_oncology_therapies.xlsx‎

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‎src/main/webapp/content/images/oncokb_summary.png‎

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