diff --git a/Directory.Packages.props b/Directory.Packages.props
index 8746f3b26e5..9e5649067f1 100644
--- a/Directory.Packages.props
+++ b/Directory.Packages.props
@@ -6,25 +6,46 @@
   </PropertyGroup>
 
   <!--
-      This section covers packages that are directly referenced by the NuGet packages published from this repository.
-      Any security vulnerability in these packages or their downstream dependencies will be considered as a security
-      vulnerability in the NuGet packages that are published from this repository.
+      For modern .NET runtimes, match the major version of packages to the major version of the runtime.
+      This is to ensure that the NuGet packages that users deploy match the support lifetimes of the .NET version they are using (i.e. LTS vs STS).
+      See https://github.com/open-telemetry/opentelemetry-dotnet/issues/5973 for more details.
   -->
   <ItemGroup>
-    <!--
-        Typically, for the Microsoft.Extensions.* packages relating to DI Abstractions, Hosting Abstractions, and Logging,
-        the latest stable version should be used because:
-        1) Each major version bump will have some new API capabilities (e.g.For Logging, .NET 6 introduced compile-time logging
-          source generation, .NET 8 introduced automatic event id generation).
-        2) Each minor version bump is normally security hotfixes or critical bug fixes.
-        3) Since version 3.1.0, the .NET runtime team is holding a high bar for backward compatibility on
-          these packages even during major version bumps, so compatibility is not a concern here.
-    -->
+    <!-- Default to latest versions for all TFMs -->
     <PackageVersion Include="Microsoft.Extensions.DependencyInjection.Abstractions" Version="[9.0.0,)" />
     <PackageVersion Include="Microsoft.Extensions.Diagnostics.Abstractions" Version="[9.0.0,)" />
     <PackageVersion Include="Microsoft.Extensions.Hosting.Abstractions" Version="[9.0.0,)" />
     <PackageVersion Include="Microsoft.Extensions.Logging.Configuration" Version="[9.0.0,)" />
+  </ItemGroup>
+  <!-- Version overrides for specific netX.0 TFMs -->
+  <ItemGroup Condition="'$(TargetFramework)' == 'net8.0'">
+    <PackageVersion Update="Microsoft.Extensions.DependencyInjection.Abstractions" Version="[8.0.0,)" />
+    <PackageVersion Update="Microsoft.Extensions.Diagnostics.Abstractions" Version="[8.0.0,)" />
+    <PackageVersion Update="Microsoft.Extensions.Hosting.Abstractions" Version="[8.0.0,)" />
+    <PackageVersion Update="Microsoft.Extensions.Logging.Configuration" Version="[8.0.0,)" />
+  </ItemGroup>
+  <ItemGroup Condition="'$(TargetFramework)' == 'net9.0'">
+    <PackageVersion Update="Microsoft.Extensions.DependencyInjection.Abstractions" Version="[9.0.0,)" />
+    <PackageVersion Update="Microsoft.Extensions.Diagnostics.Abstractions" Version="[9.0.0,)" />
+    <PackageVersion Update="Microsoft.Extensions.Hosting.Abstractions" Version="[9.0.0,)" />
+    <PackageVersion Update="Microsoft.Extensions.Logging.Configuration" Version="[9.0.0,)" />
+  </ItemGroup>
+
+  <!--
+      System.Diagnostics.DiagnosticSource is exempted from the requirement to match the major version of
+      the runtime so that new APIs and/or semantic conventions are available to all versions of .NET.
+      See https://github.com/open-telemetry/opentelemetry-dotnet/issues/5973 for more details.
+  -->
+  <ItemGroup>
+    <PackageVersion Include="System.Diagnostics.DiagnosticSource" Version="[9.0.0,)" />
+  </ItemGroup>
 
+  <!--
+      This section covers packages that are directly referenced by the NuGet packages published from this repository.
+      Any security vulnerability in these packages or their downstream dependencies will be considered as a security
+      vulnerability in the NuGet packages that are published from this repository.
+  -->
+  <ItemGroup>
     <!--
         OTel packages always point to latest stable release.
     -->
@@ -35,17 +56,6 @@
     <PackageVersion Include="OpenTelemetry.Extensions.Hosting" Version="[$(OTelLatestStableVer),2.0)" />
     <PackageVersion Include="OpenTelemetry.Extensions.Propagators" Version="[$(OTelLatestStableVer),2.0)" />
     <PackageVersion Include="OpenTracing" Version="[0.12.1,0.13)" />
-
-    <!--
-        Typically, the latest stable version of System.Diagnostics.DiagnosticSource should be used here because:
-        1) Each major version bump will likely have some new OpenTelemetry capabilities (e.g. .NET 6 introduced Meter
-          API, .NET 7 added UpDownCounter, .NET 8 added Meter/Instrument level attributes support, .NET 9 added
-          Advice/Hint API, etc.).
-        2) Each minor version bump is normally security hotfixes or critical bug fixes.
-        3) The .NET runtime team provides extra backward compatibility guarantee to System.Diagnostics.DiagnosticSource
-          even during major version bumps, so compatibility is not a concern here.
-    -->
-    <PackageVersion Include="System.Diagnostics.DiagnosticSource" Version="[9.0.0,)" />
   </ItemGroup>
 
   <ItemGroup>
diff --git a/src/OpenTelemetry.Api.ProviderBuilderExtensions/CHANGELOG.md b/src/OpenTelemetry.Api.ProviderBuilderExtensions/CHANGELOG.md
index ac8e53bdce9..d63d1feab2e 100644
--- a/src/OpenTelemetry.Api.ProviderBuilderExtensions/CHANGELOG.md
+++ b/src/OpenTelemetry.Api.ProviderBuilderExtensions/CHANGELOG.md
@@ -7,6 +7,10 @@ Notes](../../RELEASENOTES.md).
 
 ## Unreleased
 
+* **Breaking Change** When targeting `net8.0`, the package now depends on version
+  `8.0.0` of the `Microsoft.Extensions.DependencyInjection.Abstractions` NuGet package.
+  ([#6327](https://github.com/open-telemetry/opentelemetry-dotnet/pull/6327))
+
 ## 1.13.1
 
 Released 2025-Oct-09
diff --git a/src/OpenTelemetry.Exporter.Console/CHANGELOG.md b/src/OpenTelemetry.Exporter.Console/CHANGELOG.md
index e510ee49dbf..3e6d6315e3f 100644
--- a/src/OpenTelemetry.Exporter.Console/CHANGELOG.md
+++ b/src/OpenTelemetry.Exporter.Console/CHANGELOG.md
@@ -6,6 +6,12 @@ Notes](../../RELEASENOTES.md).
 
 ## Unreleased
 
+* **Breaking Change** When targeting `net8.0`, the package now depends on version
+  `8.0.0` of the `Microsoft.Extensions.DependencyInjection.Abstractions`,
+  `Microsoft.Extensions.Diagnostics.Abstractions` and
+  `Microsoft.Extensions.Logging.Configuration` NuGet packages.
+  ([#6327](https://github.com/open-telemetry/opentelemetry-dotnet/pull/6327))
+
 ## 1.13.1
 
 Released 2025-Oct-09
diff --git a/src/OpenTelemetry.Exporter.InMemory/CHANGELOG.md b/src/OpenTelemetry.Exporter.InMemory/CHANGELOG.md
index 7fe915f230c..af949b0f061 100644
--- a/src/OpenTelemetry.Exporter.InMemory/CHANGELOG.md
+++ b/src/OpenTelemetry.Exporter.InMemory/CHANGELOG.md
@@ -6,6 +6,12 @@ Notes](../../RELEASENOTES.md).
 
 ## Unreleased
 
+* **Breaking Change** When targeting `net8.0`, the package now depends on version
+  `8.0.0` of the `Microsoft.Extensions.DependencyInjection.Abstractions`,
+  `Microsoft.Extensions.Diagnostics.Abstractions` and
+  `Microsoft.Extensions.Logging.Configuration` NuGet packages.
+  ([#6327](https://github.com/open-telemetry/opentelemetry-dotnet/pull/6327))
+
 ## 1.13.1
 
 Released 2025-Oct-09
diff --git a/src/OpenTelemetry.Exporter.OpenTelemetryProtocol/OpenTelemetry.Exporter.OpenTelemetryProtocol.csproj b/src/OpenTelemetry.Exporter.OpenTelemetryProtocol/OpenTelemetry.Exporter.OpenTelemetryProtocol.csproj
index 8470c6df958..ac94f6c5826 100644
--- a/src/OpenTelemetry.Exporter.OpenTelemetryProtocol/OpenTelemetry.Exporter.OpenTelemetryProtocol.csproj
+++ b/src/OpenTelemetry.Exporter.OpenTelemetryProtocol/OpenTelemetry.Exporter.OpenTelemetryProtocol.csproj
@@ -19,6 +19,11 @@
     <AllowUnsafeBlocks Condition="'$(TargetFramework)' == 'netstandard2.0' OR '$(TargetFramework)' == '$(NetFrameworkMinimumSupportedVersion)'">true</AllowUnsafeBlocks>
   </PropertyGroup>
 
+  <!-- This package is explicitly upgraded for .NET 8 to fix native AoT compatibility issues -->
+  <ItemGroup>
+    <PackageReference Include="Microsoft.Extensions.Configuration.Binder" VersionOverride="8.0.2" Condition="'$(TargetFramework)' == 'net8.0'" />
+  </ItemGroup>
+
   <ItemGroup>
     <ProjectReference Include="$(RepoRoot)\src\OpenTelemetry\OpenTelemetry.csproj" />
   </ItemGroup>
diff --git a/src/OpenTelemetry.Exporter.Prometheus.AspNetCore/CHANGELOG.md b/src/OpenTelemetry.Exporter.Prometheus.AspNetCore/CHANGELOG.md
index ffe7af474dc..9e4445d53d3 100644
--- a/src/OpenTelemetry.Exporter.Prometheus.AspNetCore/CHANGELOG.md
+++ b/src/OpenTelemetry.Exporter.Prometheus.AspNetCore/CHANGELOG.md
@@ -7,6 +7,12 @@ Notes](../../RELEASENOTES.md).
 
 ## Unreleased
 
+* **Breaking Change** When targeting `net8.0`, the package now depends on version
+  `8.0.0` of the `Microsoft.Extensions.DependencyInjection.Abstractions`,
+  `Microsoft.Extensions.Diagnostics.Abstractions` and
+  `Microsoft.Extensions.Logging.Configuration` NuGet packages.
+  ([#6327](https://github.com/open-telemetry/opentelemetry-dotnet/pull/6327))
+
 ## 1.13.0-beta.1
 
 Released 2025-Oct-01
diff --git a/src/OpenTelemetry.Exporter.Prometheus.HttpListener/CHANGELOG.md b/src/OpenTelemetry.Exporter.Prometheus.HttpListener/CHANGELOG.md
index 04c569e2b9a..bd9f791be04 100644
--- a/src/OpenTelemetry.Exporter.Prometheus.HttpListener/CHANGELOG.md
+++ b/src/OpenTelemetry.Exporter.Prometheus.HttpListener/CHANGELOG.md
@@ -7,6 +7,12 @@ Notes](../../RELEASENOTES.md).
 
 ## Unreleased
 
+* **Breaking Change** When targeting `net8.0`, the package now depends on version
+  `8.0.0` of the `Microsoft.Extensions.DependencyInjection.Abstractions`,
+  `Microsoft.Extensions.Diagnostics.Abstractions` and
+  `Microsoft.Extensions.Logging.Configuration` NuGet packages.
+  ([#6327](https://github.com/open-telemetry/opentelemetry-dotnet/pull/6327))
+
 ## 1.13.0-beta.1
 
 Released 2025-Oct-01
diff --git a/src/OpenTelemetry.Exporter.Zipkin/CHANGELOG.md b/src/OpenTelemetry.Exporter.Zipkin/CHANGELOG.md
index c7714c8edf7..835d3136a80 100644
--- a/src/OpenTelemetry.Exporter.Zipkin/CHANGELOG.md
+++ b/src/OpenTelemetry.Exporter.Zipkin/CHANGELOG.md
@@ -6,6 +6,12 @@ Notes](../../RELEASENOTES.md).
 
 ## Unreleased
 
+* **Breaking Change** When targeting `net8.0`, the package now depends on version
+  `8.0.0` of the `Microsoft.Extensions.DependencyInjection.Abstractions`,
+  `Microsoft.Extensions.Diagnostics.Abstractions` and
+  `Microsoft.Extensions.Logging.Configuration` NuGet packages.
+  ([#6327](https://github.com/open-telemetry/opentelemetry-dotnet/pull/6327))
+
 ## 1.13.1
 
 Released 2025-Oct-09
diff --git a/src/OpenTelemetry.Extensions.Hosting/CHANGELOG.md b/src/OpenTelemetry.Extensions.Hosting/CHANGELOG.md
index b20ac39a042..36278a05bba 100644
--- a/src/OpenTelemetry.Extensions.Hosting/CHANGELOG.md
+++ b/src/OpenTelemetry.Extensions.Hosting/CHANGELOG.md
@@ -6,6 +6,13 @@ Notes](../../RELEASENOTES.md).
 
 ## Unreleased
 
+* **Breaking Change** When targeting `net8.0`, the package now depends on version
+  `8.0.0` of the `Microsoft.Extensions.DependencyInjection.Abstractions`,
+  `Microsoft.Extensions.Diagnostics.Abstractions`,
+  `Microsoft.Extensions.Hosting.Abstractions` and
+  `Microsoft.Extensions.Logging.Configuration` NuGet packages.
+  ([#6327](https://github.com/open-telemetry/opentelemetry-dotnet/pull/6327))
+
 ## 1.13.1
 
 Released 2025-Oct-09
diff --git a/src/OpenTelemetry/CHANGELOG.md b/src/OpenTelemetry/CHANGELOG.md
index 783762ab10d..a605afa0592 100644
--- a/src/OpenTelemetry/CHANGELOG.md
+++ b/src/OpenTelemetry/CHANGELOG.md
@@ -6,6 +6,12 @@ Notes](../../RELEASENOTES.md).
 
 ## Unreleased
 
+* **Breaking Change** When targeting `net8.0`, the package now depends on version
+  `8.0.0` of the `Microsoft.Extensions.DependencyInjection.Abstractions`,
+  `Microsoft.Extensions.Diagnostics.Abstractions` and
+  `Microsoft.Extensions.Logging.Configuration` NuGet packages.
+  ([#6327](https://github.com/open-telemetry/opentelemetry-dotnet/pull/6327))
+
 ## 1.13.1
 
 Released 2025-Oct-09
diff --git a/test/OpenTelemetry.Instrumentation.W3cTraceContext.Tests/OpenTelemetry.Instrumentation.W3cTraceContext.Tests.csproj b/test/OpenTelemetry.Instrumentation.W3cTraceContext.Tests/OpenTelemetry.Instrumentation.W3cTraceContext.Tests.csproj
index 300d53feacb..e7c04435cd0 100644
--- a/test/OpenTelemetry.Instrumentation.W3cTraceContext.Tests/OpenTelemetry.Instrumentation.W3cTraceContext.Tests.csproj
+++ b/test/OpenTelemetry.Instrumentation.W3cTraceContext.Tests/OpenTelemetry.Instrumentation.W3cTraceContext.Tests.csproj
@@ -6,6 +6,7 @@
   </PropertyGroup>
 
   <ItemGroup>
+    <PackageReference Include="Microsoft.Extensions.DependencyInjection.Abstractions" VersionOverride="9.0.9" />
     <PackageReference Include="OpenTelemetry.Instrumentation.AspNetCore" />
   </ItemGroup>