diff --git a/instrumentation/spring/spring-boot-autoconfigure/src/main/java/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/kafka/KafkaInstrumentationAutoConfiguration.java b/instrumentation/spring/spring-boot-autoconfigure/src/main/java/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/kafka/KafkaInstrumentationAutoConfiguration.java
index 80734c2f2c64..44f845e25ff1 100644
--- a/instrumentation/spring/spring-boot-autoconfigure/src/main/java/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/kafka/KafkaInstrumentationAutoConfiguration.java
+++ b/instrumentation/spring/spring-boot-autoconfigure/src/main/java/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/kafka/KafkaInstrumentationAutoConfiguration.java
@@ -24,7 +24,11 @@
  * any time.
  */
 @ConditionalOnEnabledInstrumentation(module = "kafka")
-@ConditionalOnClass({KafkaTemplate.class, ConcurrentKafkaListenerContainerFactory.class})
+@ConditionalOnClass({
+  KafkaTemplate.class,
+  ConcurrentKafkaListenerContainerFactory.class,
+  DefaultKafkaProducerFactoryCustomizer.class
+})
 @Configuration
 public class KafkaInstrumentationAutoConfiguration {
 
diff --git a/instrumentation/spring/spring-boot-autoconfigure/src/main/java/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/mongo/MongoClientInstrumentationAutoConfiguration.java b/instrumentation/spring/spring-boot-autoconfigure/src/main/java/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/mongo/MongoClientInstrumentationAutoConfiguration.java
index 1fbfdbfb0178..39a56a8b07c4 100644
--- a/instrumentation/spring/spring-boot-autoconfigure/src/main/java/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/mongo/MongoClientInstrumentationAutoConfiguration.java
+++ b/instrumentation/spring/spring-boot-autoconfigure/src/main/java/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/mongo/MongoClientInstrumentationAutoConfiguration.java
@@ -22,7 +22,7 @@
  * any time.
  */
 @ConditionalOnBean(OpenTelemetry.class)
-@ConditionalOnClass(MongoClientSettings.class)
+@ConditionalOnClass({MongoClientSettings.class, MongoClientSettingsBuilderCustomizer.class})
 @ConditionalOnEnabledInstrumentation(module = "mongo")
 @Configuration
 public class MongoClientInstrumentationAutoConfiguration {
diff --git a/instrumentation/spring/spring-boot-autoconfigure/src/main/java/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/web/SpringWebInstrumentationAutoConfiguration.java b/instrumentation/spring/spring-boot-autoconfigure/src/main/java/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/web/SpringWebInstrumentationAutoConfiguration.java
index b3e4aa31f3d5..21a18ec8db2b 100644
--- a/instrumentation/spring/spring-boot-autoconfigure/src/main/java/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/web/SpringWebInstrumentationAutoConfiguration.java
+++ b/instrumentation/spring/spring-boot-autoconfigure/src/main/java/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/web/SpringWebInstrumentationAutoConfiguration.java
@@ -24,7 +24,7 @@
  * at any time.
  */
 @ConditionalOnEnabledInstrumentation(module = "spring-web")
-@ConditionalOnClass(RestTemplate.class)
+@ConditionalOnClass({RestTemplate.class, RestTemplateCustomizer.class})
 @Configuration
 public class SpringWebInstrumentationAutoConfiguration {
 
diff --git a/instrumentation/spring/spring-boot-autoconfigure/src/main/javaSpring3/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/web/RestClientInstrumentationAutoConfiguration.java b/instrumentation/spring/spring-boot-autoconfigure/src/main/javaSpring3/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/web/RestClientInstrumentationAutoConfiguration.java
index d5cc3af7b0d9..a0fad74b0a35 100644
--- a/instrumentation/spring/spring-boot-autoconfigure/src/main/javaSpring3/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/web/RestClientInstrumentationAutoConfiguration.java
+++ b/instrumentation/spring/spring-boot-autoconfigure/src/main/javaSpring3/io/opentelemetry/instrumentation/spring/autoconfigure/internal/instrumentation/web/RestClientInstrumentationAutoConfiguration.java
@@ -26,7 +26,7 @@
  * at any time.
  */
 @ConditionalOnEnabledInstrumentation(module = "spring-web")
-@ConditionalOnClass(RestClient.class)
+@ConditionalOnClass({RestClient.class, RestClientCustomizer.class})
 @AutoConfiguration(after = RestClientAutoConfiguration.class)
 @Configuration
 public class RestClientInstrumentationAutoConfiguration {