diff --git a/instrumentation/lettuce/lettuce-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v4_0/LettuceAsyncCommandsInstrumentation.java b/instrumentation/lettuce/lettuce-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v4_0/LettuceAsyncCommandsInstrumentation.java
index a16468a35cd5..37d9850d2a57 100644
--- a/instrumentation/lettuce/lettuce-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v4_0/LettuceAsyncCommandsInstrumentation.java
+++ b/instrumentation/lettuce/lettuce-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v4_0/LettuceAsyncCommandsInstrumentation.java
@@ -63,6 +63,10 @@ public void end(
     public static AdviceScope onEnter(@Advice.Argument(0) RedisCommand<?, ?, ?> command) {
 
       Context parentContext = currentContext();
+      if (!instrumenter().shouldStart(parentContext, command)) {
+        return null;
+      }
+
       Context context = instrumenter().start(parentContext, command);
       // remember the context that called dispatch, it is used in LettuceAsyncCommandInstrumentation
       context = context.with(LettuceSingletons.COMMAND_CONTEXT_KEY, parentContext);
@@ -72,10 +76,12 @@ public static AdviceScope onEnter(@Advice.Argument(0) RedisCommand<?, ?, ?> comm
     @Advice.OnMethodExit(onThrowable = Throwable.class, suppress = Throwable.class)
     public static void onExit(
         @Advice.Argument(0) RedisCommand<?, ?, ?> command,
-        @Advice.Thrown Throwable throwable,
-        @Advice.Return AsyncCommand<?, ?, ?> asyncCommand,
-        @Advice.Enter AdviceScope adviceScope) {
-      adviceScope.end(throwable, command, asyncCommand);
+        @Advice.Thrown @Nullable Throwable throwable,
+        @Advice.Return @Nullable AsyncCommand<?, ?, ?> asyncCommand,
+        @Advice.Enter @Nullable AdviceScope adviceScope) {
+      if (adviceScope != null) {
+        adviceScope.end(throwable, command, asyncCommand);
+      }
     }
   }
 }
diff --git a/instrumentation/lettuce/lettuce-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v4_0/LettuceConnectInstrumentation.java b/instrumentation/lettuce/lettuce-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v4_0/LettuceConnectInstrumentation.java
index aa1d094f946d..62851588ed98 100644
--- a/instrumentation/lettuce/lettuce-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v4_0/LettuceConnectInstrumentation.java
+++ b/instrumentation/lettuce/lettuce-4.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v4_0/LettuceConnectInstrumentation.java
@@ -54,7 +54,12 @@ public void end(Throwable throwable, RedisURI redisUri) {
 
     @Advice.OnMethodEnter(suppress = Throwable.class)
     public static AdviceScope onEnter(@Advice.Argument(1) RedisURI redisUri) {
-      Context context = connectInstrumenter().start(currentContext(), redisUri);
+      Context parentContext = currentContext();
+      if (!connectInstrumenter().shouldStart(parentContext, redisUri)) {
+        return null;
+      }
+
+      Context context = connectInstrumenter().start(parentContext, redisUri);
       return new AdviceScope(context, context.makeCurrent());
     }
 
@@ -62,8 +67,10 @@ public static AdviceScope onEnter(@Advice.Argument(1) RedisURI redisUri) {
     public static void onExit(
         @Advice.Argument(1) RedisURI redisUri,
         @Advice.Thrown @Nullable Throwable throwable,
-        @Advice.Enter AdviceScope adviceScope) {
-      adviceScope.end(throwable, redisUri);
+        @Advice.Enter @Nullable AdviceScope adviceScope) {
+      if (adviceScope != null) {
+        adviceScope.end(throwable, redisUri);
+      }
     }
   }
 }
diff --git a/instrumentation/lettuce/lettuce-5.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v5_0/LettuceAsyncCommandsInstrumentation.java b/instrumentation/lettuce/lettuce-5.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v5_0/LettuceAsyncCommandsInstrumentation.java
index 3b395f5f89ee..9c1f62655a4d 100644
--- a/instrumentation/lettuce/lettuce-5.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v5_0/LettuceAsyncCommandsInstrumentation.java
+++ b/instrumentation/lettuce/lettuce-5.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v5_0/LettuceAsyncCommandsInstrumentation.java
@@ -75,6 +75,10 @@ public void end(
     public static AdviceScope onEnter(@Advice.Argument(0) RedisCommand<?, ?, ?> command) {
 
       Context parentContext = currentContext();
+      if (!instrumenter().shouldStart(parentContext, command)) {
+        return null;
+      }
+
       Context context = instrumenter().start(parentContext, command);
       // remember the context that called dispatch, it is used in LettuceAsyncCommandInstrumentation
       context = context.with(LettuceSingletons.COMMAND_CONTEXT_KEY, parentContext);
@@ -85,10 +89,12 @@ public static AdviceScope onEnter(@Advice.Argument(0) RedisCommand<?, ?, ?> comm
     public static void stopSpan(
         @Advice.Argument(0) RedisCommand<?, ?, ?> command,
         @Advice.Thrown @Nullable Throwable throwable,
-        @Advice.Return AsyncCommand<?, ?, ?> asyncCommand,
-        @Advice.Enter AdviceScope adviceScope) {
+        @Advice.Return @Nullable AsyncCommand<?, ?, ?> asyncCommand,
+        @Advice.Enter @Nullable AdviceScope adviceScope) {
 
-      adviceScope.end(throwable, command, asyncCommand);
+      if (adviceScope != null) {
+        adviceScope.end(throwable, command, asyncCommand);
+      }
     }
   }
 }
diff --git a/instrumentation/lettuce/lettuce-5.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v5_0/LettuceClientInstrumentation.java b/instrumentation/lettuce/lettuce-5.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v5_0/LettuceClientInstrumentation.java
index c8d697023f22..54eabdc94212 100644
--- a/instrumentation/lettuce/lettuce-5.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v5_0/LettuceClientInstrumentation.java
+++ b/instrumentation/lettuce/lettuce-5.0/javaagent/src/main/java/io/opentelemetry/javaagent/instrumentation/lettuce/v5_0/LettuceClientInstrumentation.java
@@ -72,7 +72,12 @@ public void end(
 
     @Advice.OnMethodEnter(suppress = Throwable.class)
     public static AdviceScope onEnter(@Advice.Argument(1) RedisURI redisUri) {
-      Context context = connectInstrumenter().start(currentContext(), redisUri);
+      Context parentContext = currentContext();
+      if (!connectInstrumenter().shouldStart(parentContext, redisUri)) {
+        return null;
+      }
+
+      Context context = connectInstrumenter().start(parentContext, redisUri);
       return new AdviceScope(context, context.makeCurrent());
     }
 
@@ -80,9 +85,11 @@ public static AdviceScope onEnter(@Advice.Argument(1) RedisURI redisUri) {
     public static void stopSpan(
         @Advice.Argument(1) RedisURI redisUri,
         @Advice.Thrown @Nullable Throwable throwable,
-        @Advice.Return ConnectionFuture<?> connectionFuture,
-        @Advice.Enter AdviceScope adviceScope) {
-      adviceScope.end(throwable, redisUri, connectionFuture);
+        @Advice.Return @Nullable ConnectionFuture<?> connectionFuture,
+        @Advice.Enter @Nullable AdviceScope adviceScope) {
+      if (adviceScope != null) {
+        adviceScope.end(throwable, redisUri, connectionFuture);
+      }
     }
   }
 }