diff --git a/package-lock.json b/package-lock.json
index d2bd0e9f95..bca73f58ae 100644
--- a/package-lock.json
+++ b/package-lock.json
@@ -4703,13 +4703,23 @@
       "dev": true
     },
     "node_modules/@fastify/express": {
-      "version": "3.0.0",
-      "resolved": "https://registry.npmjs.org/@fastify/express/-/express-3.0.0.tgz",
-      "integrity": "sha512-Ug6aulXCUiHgMyrHVYQqnQbGdsAV0aTad6nZxbOr6w3QjKn1mdQS3Kyzvc+I0xMjZ9yIyMUWHSooHgZ0l7nOng==",
+      "version": "4.0.2",
+      "resolved": "https://registry.npmjs.org/@fastify/express/-/express-4.0.2.tgz",
+      "integrity": "sha512-lzu9MLdjlsK4Q2RiqEAwTgwQPrWQVP0kmbgAi/w9rIUqtnacjKvj3EHVTR6PIvXDs6Ut1jnTHiGbuNxHTsZwHQ==",
       "dev": true,
+      "funding": [
+        {
+          "type": "github",
+          "url": "https://github.com/sponsors/fastify"
+        },
+        {
+          "type": "opencollective",
+          "url": "https://opencollective.com/fastify"
+        }
+      ],
       "dependencies": {
-        "express": "^4.17.1",
-        "fastify-plugin": "^4.0.0"
+        "express": "^4.18.3",
+        "fastify-plugin": "^5.0.0"
       }
     },
     "node_modules/@fastify/express/node_modules/accepts": {
@@ -16476,9 +16486,9 @@
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     },
     "node_modules/fastify-plugin": {
-      "version": "4.5.1",
-      "resolved": "https://registry.npmjs.org/fastify-plugin/-/fastify-plugin-4.5.1.tgz",
-      "integrity": "sha512-stRHYGeuqpEZTL1Ef0Ovr2ltazUT9g844X5z/zEBFLG8RYlpDiOCIG+ATvYEp+/zmc7sN29mcIMp8gvYplYPIQ==",
+      "version": "5.0.1",
+      "resolved": "https://registry.npmjs.org/fastify-plugin/-/fastify-plugin-5.0.1.tgz",
+      "integrity": "sha512-HCxs+YnRaWzCl+cWRYFnHmeRFyR5GVnJTAaCJQiYzQSDwK9MgJdyAsuL3nh0EWRCYMgQ5MeziymvmAhUHYHDUQ==",
       "dev": true
     },
     "node_modules/fastify/node_modules/buffer": {
@@ -32016,7 +32026,7 @@
         "@opentelemetry/semantic-conventions": "^1.27.0"
       },
       "devDependencies": {
-        "@fastify/express": "^3.0.0",
+        "@fastify/express": "^4.0.0",
         "@opentelemetry/api": "^1.3.0",
         "@opentelemetry/context-async-hooks": "^2.0.0",
         "@opentelemetry/contrib-test-utils": "^0.49.0",
@@ -37941,13 +37951,13 @@
       "dev": true
     },
     "@fastify/express": {
-      "version": "3.0.0",
-      "resolved": "https://registry.npmjs.org/@fastify/express/-/express-3.0.0.tgz",
-      "integrity": "sha512-Ug6aulXCUiHgMyrHVYQqnQbGdsAV0aTad6nZxbOr6w3QjKn1mdQS3Kyzvc+I0xMjZ9yIyMUWHSooHgZ0l7nOng==",
+      "version": "4.0.2",
+      "resolved": "https://registry.npmjs.org/@fastify/express/-/express-4.0.2.tgz",
+      "integrity": "sha512-lzu9MLdjlsK4Q2RiqEAwTgwQPrWQVP0kmbgAi/w9rIUqtnacjKvj3EHVTR6PIvXDs6Ut1jnTHiGbuNxHTsZwHQ==",
       "dev": true,
       "requires": {
-        "express": "^4.17.1",
-        "fastify-plugin": "^4.0.0"
+        "express": "^4.18.3",
+        "fastify-plugin": "^5.0.0"
       },
       "dependencies": {
         "accepts": {
@@ -40526,7 +40536,7 @@
     "@opentelemetry/instrumentation-fastify": {
       "version": "file:packages/instrumentation-fastify",
       "requires": {
-        "@fastify/express": "^3.0.0",
+        "@fastify/express": "^4.0.0",
         "@opentelemetry/api": "^1.3.0",
         "@opentelemetry/context-async-hooks": "^2.0.0",
         "@opentelemetry/contrib-test-utils": "^0.49.0",
@@ -48829,9 +48839,9 @@
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     "fastify-plugin": {
-      "version": "4.5.1",
-      "resolved": "https://registry.npmjs.org/fastify-plugin/-/fastify-plugin-4.5.1.tgz",
-      "integrity": "sha512-stRHYGeuqpEZTL1Ef0Ovr2ltazUT9g844X5z/zEBFLG8RYlpDiOCIG+ATvYEp+/zmc7sN29mcIMp8gvYplYPIQ==",
+      "version": "5.0.1",
+      "resolved": "https://registry.npmjs.org/fastify-plugin/-/fastify-plugin-5.0.1.tgz",
+      "integrity": "sha512-HCxs+YnRaWzCl+cWRYFnHmeRFyR5GVnJTAaCJQiYzQSDwK9MgJdyAsuL3nh0EWRCYMgQ5MeziymvmAhUHYHDUQ==",
       "dev": true
     },
     "fastq": {
diff --git a/packages/instrumentation-fastify/package.json b/packages/instrumentation-fastify/package.json
index ab320beaf4..d42842e2f8 100644
--- a/packages/instrumentation-fastify/package.json
+++ b/packages/instrumentation-fastify/package.json
@@ -47,7 +47,7 @@
     "@opentelemetry/api": "^1.3.0"
   },
   "devDependencies": {
-    "@fastify/express": "^3.0.0",
+    "@fastify/express": "^4.0.0",
     "@opentelemetry/api": "^1.3.0",
     "@opentelemetry/context-async-hooks": "^2.0.0",
     "@opentelemetry/contrib-test-utils": "^0.49.0",