diff --git a/examples/multiple-metric-readers-README.md b/examples/multiple-metric-readers-README.md
new file mode 100644
index 00000000000..afe9580ac7f
--- /dev/null
+++ b/examples/multiple-metric-readers-README.md
@@ -0,0 +1,74 @@
+# Multiple Metric Readers Example
+
+This example demonstrates how to use the new `metricReaders` (plural) option in the NodeSDK configuration to register multiple metric readers simultaneously.
+
+## Features
+
+- **Multiple Metric Readers**: Configure multiple metric readers in a single SDK instance
+- **Console Export**: Metrics are exported to the console for easy debugging
+- **Prometheus Export**: Metrics are also exported to a Prometheus endpoint
+- **Auto-instrumentation**: Automatic instrumentation of Node.js applications
+
+## Usage
+
+### Running the Example
+
+```bash
+node multiple-metric-readers.js
+```
+
+### What Happens
+
+1. The SDK is configured with two metric readers:
+   - A `ConsoleMetricExporter` that prints metrics to the console
+   - A `PrometheusExporter` that exposes metrics on `http://localhost:9464/metrics`
+
+2. A counter metric is created and incremented every second
+
+3. Metrics are automatically exported to both destinations
+
+### API Changes
+
+This example demonstrates the new API that supports multiple metric readers:
+
+```javascript
+// OLD (deprecated) - single metric reader
+const sdk = new opentelemetry.NodeSDK({
+  metricReader: singleMetricReader, // deprecated
+});
+
+// NEW - multiple metric readers
+const sdk = new opentelemetry.NodeSDK({
+  metricReaders: [consoleMetricReader, prometheusMetricReader], // new
+});
+```
+
+### Benefits
+
+- **Flexibility**: Export metrics to multiple destinations simultaneously
+- **Debugging**: Console export for development and debugging
+- **Production**: Prometheus export for production monitoring
+- **Backward Compatibility**: The old `metricReader` option still works but shows a deprecation warning
+
+### Checking the Results
+
+1. **Console Output**: Watch the console for metric exports every second
+2. **Prometheus Endpoint**: Visit `http://localhost:9464/metrics` to see the Prometheus-formatted metrics
+
+## Migration Guide
+
+If you're currently using the single `metricReader` option, you can migrate to the new `metricReaders` option:
+
+```javascript
+// Before
+const sdk = new opentelemetry.NodeSDK({
+  metricReader: myMetricReader,
+});
+
+// After
+const sdk = new opentelemetry.NodeSDK({
+  metricReaders: [myMetricReader],
+});
+```
+
+The old `metricReader` option will continue to work but will show a deprecation warning. It's recommended to migrate to the new `metricReaders` option for future compatibility. 
\ No newline at end of file
diff --git a/examples/multiple-metric-readers.js b/examples/multiple-metric-readers.js
new file mode 100644
index 00000000000..5b52bc4b4cf
--- /dev/null
+++ b/examples/multiple-metric-readers.js
@@ -0,0 +1,78 @@
+/*
+ * Copyright The OpenTelemetry Authors
+ *
+ * Licensed under the Apache License, Version 2.0 (the "License");
+ * you may not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ *      https://www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an "AS IS" BASIS,
+ * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+'use strict';
+
+const process = require('process');
+const opentelemetry = require('@opentelemetry/sdk-node');
+const { getNodeAutoInstrumentations } = require('@opentelemetry/auto-instrumentations-node');
+const { ConsoleSpanExporter } = require('@opentelemetry/sdk-trace-base');
+const { resourceFromAttributes } = require('@opentelemetry/resources');
+const { ATTR_SERVICE_NAME } = require('@opentelemetry/semantic-conventions');
+const { 
+  ConsoleMetricExporter, 
+  PeriodicExportingMetricReader 
+} = require('@opentelemetry/sdk-metrics');
+const { PrometheusExporter } = require('@opentelemetry/exporter-prometheus');
+
+// Create multiple metric readers
+const consoleMetricReader = new PeriodicExportingMetricReader({
+  exporter: new ConsoleMetricExporter(),
+  exportIntervalMillis: 1000,
+  exportTimeoutMillis: 500,
+});
+
+const prometheusMetricReader = new PrometheusExporter({
+  port: 9464,
+  endpoint: '/metrics',
+});
+
+// Configure the SDK with multiple metric readers
+const sdk = new opentelemetry.NodeSDK({
+  resource: resourceFromAttributes({
+    [ATTR_SERVICE_NAME]: 'multiple-metric-readers-example',
+  }),
+  traceExporter: new ConsoleSpanExporter(),
+  // Use the new metricReaders option (plural) instead of the deprecated metricReader (singular)
+  metricReaders: [consoleMetricReader, prometheusMetricReader],
+  instrumentations: [getNodeAutoInstrumentations()]
+});
+
+// Initialize the SDK and register with the OpenTelemetry API
+sdk.start();
+
+// Create a meter and some metrics
+const meter = opentelemetry.metrics.getMeter('example-meter');
+const counter = meter.createCounter('example_counter', {
+  description: 'An example counter',
+});
+
+// Increment the counter every second
+setInterval(() => {
+  counter.add(1, { 'example.label': 'value' });
+  console.log('Counter incremented');
+}, 1000);
+
+// Gracefully shut down the SDK on process exit
+process.on('SIGTERM', () => {
+  sdk.shutdown()
+    .then(() => console.log('Tracing terminated'))
+    .catch((error) => console.log('Error terminating tracing', error))
+    .finally(() => process.exit(0));
+});
+
+console.log('Multiple metric readers example started');
+console.log('Metrics will be exported to console and Prometheus endpoint at http://localhost:9464/metrics'); 
\ No newline at end of file
diff --git a/experimental/CHANGELOG.md b/experimental/CHANGELOG.md
index 56a9316c7e6..b680b2050d9 100644
--- a/experimental/CHANGELOG.md
+++ b/experimental/CHANGELOG.md
@@ -10,6 +10,18 @@ For notes on migrating to 2.x / 0.200.x see [the upgrade guide](doc/upgrade-to-2
 
 ### :rocket: Features
 
+* feat(sdk-node): Add support for multiple metric readers via the new `metricReaders` option in NodeSDK configuration. Users can now register multiple metric readers (e.g., Console, Prometheus) directly through the NodeSDK constructor. The old `metricReader` (singular) option is now deprecated and will show a warning if used, but remains supported for backward compatibility. Comprehensive tests and documentation have been added. [#5760](https://github.com/open-telemetry/opentelemetry-js/issues/5760)
+  * **Migration:**
+    - Before:
+      ```js
+      const sdk = new NodeSDK({ metricReader: myMetricReader });
+      ```
+    - After:
+      ```js
+      const sdk = new NodeSDK({ metricReaders: [myMetricReader] });
+      ```
+  * Users should migrate to the new `metricReaders` array option for future compatibility. The old option will continue to work but is deprecated.
+
 ### :bug: Bug Fixes
 
 ### :books: Documentation
@@ -123,7 +135,7 @@ For notes on migrating to 2.x / 0.200.x see [the upgrade guide](doc/upgrade-to-2
 
 ### :house: (Internal)
 
-* chore(instrumentation-grpc): remove unused findIndex() function [#5372](https://github.com/open-telemetry/opentelemetry-js/pull/5372) @cjihrig
+* refactor(instrumentation-grpc): remove unused findIndex() function [#5372](https://github.com/open-telemetry/opentelemetry-js/pull/5372) @cjihrig
 * refactor(otlp-exporter-base): remove unnecessary isNaN() checks [#5374](https://github.com/open-telemetry/opentelemetry-js/pull/5374) @cjihrig
 * refactor(exporter-prometheus): remove unnecessary isNaN() check [#5377](https://github.com/open-telemetry/opentelemetry-js/pull/5377) @cjihrig
 * refactor(sdk-node): move code to auto-instantiate propagators into utils [#5355](https://github.com/open-telemetry/opentelemetry-js/pull/5355) @pichlermarc
diff --git a/experimental/packages/opentelemetry-sdk-node/src/sdk.ts b/experimental/packages/opentelemetry-sdk-node/src/sdk.ts
index e653b55dc15..8ff8e2d6c20 100644
--- a/experimental/packages/opentelemetry-sdk-node/src/sdk.ts
+++ b/experimental/packages/opentelemetry-sdk-node/src/sdk.ts
@@ -85,9 +85,9 @@ import {
 
 export type MeterProviderConfig = {
   /**
-   * Reference to the MetricReader instance by the NodeSDK
+   * Reference to the MetricReader instances by the NodeSDK
    */
-  reader?: IMetricReader;
+  readers?: IMetricReader[];
   /**
    * List of {@link ViewOptions}s that should be passed to the MeterProvider
    */
@@ -312,10 +312,20 @@ export class NodeSDK {
       this.configureLoggerProviderFromEnv();
     }
 
-    if (configuration.metricReader || configuration.views) {
+    if (
+      configuration.metricReaders ||
+      configuration.metricReader ||
+      configuration.views
+    ) {
       const meterProviderConfig: MeterProviderConfig = {};
-      if (configuration.metricReader) {
-        meterProviderConfig.reader = configuration.metricReader;
+
+      if (configuration.metricReaders) {
+        meterProviderConfig.readers = configuration.metricReaders;
+      } else if (configuration.metricReader) {
+        meterProviderConfig.readers = [configuration.metricReader];
+        diag.warn(
+          "The 'metricReader' option is deprecated. Please use 'metricReaders' instead."
+        );
       }
 
       if (configuration.views) {
@@ -395,8 +405,8 @@ export class NodeSDK {
       configureMetricProviderFromEnv();
     if (this._meterProviderConfig || metricReadersFromEnv.length > 0) {
       const readers: IMetricReader[] = [];
-      if (this._meterProviderConfig?.reader) {
-        readers.push(this._meterProviderConfig.reader);
+      if (this._meterProviderConfig?.readers) {
+        readers.push(...this._meterProviderConfig.readers);
       }
 
       if (readers.length === 0) {
diff --git a/experimental/packages/opentelemetry-sdk-node/src/types.ts b/experimental/packages/opentelemetry-sdk-node/src/types.ts
index ff400de8f21..48b363a18f9 100644
--- a/experimental/packages/opentelemetry-sdk-node/src/types.ts
+++ b/experimental/packages/opentelemetry-sdk-node/src/types.ts
@@ -35,7 +35,9 @@ export interface NodeSDKConfiguration {
   /** @deprecated use logRecordProcessors instead*/
   logRecordProcessor: LogRecordProcessor;
   logRecordProcessors?: LogRecordProcessor[];
+  /** @deprecated use metricReaders instead*/
   metricReader: IMetricReader;
+  metricReaders?: IMetricReader[];
   views: ViewOptions[];
   instrumentations: (Instrumentation | Instrumentation[])[];
   resource: Resource;
diff --git a/experimental/packages/opentelemetry-sdk-node/test/sdk.test.ts b/experimental/packages/opentelemetry-sdk-node/test/sdk.test.ts
index 8884d4b7455..11fba7f5159 100644
--- a/experimental/packages/opentelemetry-sdk-node/test/sdk.test.ts
+++ b/experimental/packages/opentelemetry-sdk-node/test/sdk.test.ts
@@ -322,6 +322,123 @@ describe('Node SDK', () => {
       delete env.OTEL_TRACES_EXPORTER;
     });
 
+    it('should register a meter provider if multiple readers are provided', async () => {
+      // need to set OTEL_TRACES_EXPORTER to none since default value is otlp
+      // which sets up an exporter and affects the context manager
+      env.OTEL_TRACES_EXPORTER = 'none';
+      const consoleExporter = new ConsoleMetricExporter();
+      const inMemoryExporter = new InMemoryMetricExporter(
+        AggregationTemporality.CUMULATIVE
+      );
+      const metricReader1 = new PeriodicExportingMetricReader({
+        exporter: consoleExporter,
+        exportIntervalMillis: 100,
+        exportTimeoutMillis: 100,
+      });
+      const metricReader2 = new PeriodicExportingMetricReader({
+        exporter: inMemoryExporter,
+        exportIntervalMillis: 100,
+        exportTimeoutMillis: 100,
+      });
+
+      const sdk = new NodeSDK({
+        metricReaders: [metricReader1, metricReader2],
+        autoDetectResources: false,
+      });
+
+      sdk.start();
+
+      assert.strictEqual(
+        context['_getContextManager'](),
+        ctxManager,
+        'context manager should not change'
+      );
+      assert.strictEqual(
+        propagation['_getGlobalPropagator'](),
+        propagator,
+        'propagator should not change'
+      );
+      assert.strictEqual(
+        (trace.getTracerProvider() as ProxyTracerProvider).getDelegate(),
+        delegate,
+        'tracer provider should not have changed'
+      );
+
+      const meterProvider = metrics.getMeterProvider() as MeterProvider;
+      assert.ok(meterProvider instanceof MeterProvider);
+
+      // Verify that both metric readers are registered
+      const sharedState = (meterProvider as any)['_sharedState'];
+      assert.strictEqual(sharedState.metricCollectors.length, 2);
+
+      await sdk.shutdown();
+      delete env.OTEL_TRACES_EXPORTER;
+    });
+
+    it('should show deprecation warning when using metricReader option', async () => {
+      // need to set OTEL_TRACES_EXPORTER to none since default value is otlp
+      // which sets up an exporter and affects the context manager
+      env.OTEL_TRACES_EXPORTER = 'none';
+      const exporter = new ConsoleMetricExporter();
+      const metricReader = new PeriodicExportingMetricReader({
+        exporter: exporter,
+        exportIntervalMillis: 100,
+        exportTimeoutMillis: 100,
+      });
+
+      const warnSpy = Sinon.spy(diag, 'warn');
+
+      const sdk = new NodeSDK({
+        metricReader: metricReader,
+        autoDetectResources: false,
+      });
+
+      sdk.start();
+
+      // Verify deprecation warning was shown
+      sinon.assert.calledWith(
+        warnSpy,
+        "The 'metricReader' option is deprecated. Please use 'metricReaders' instead."
+      );
+
+      assert.ok(metrics.getMeterProvider() instanceof MeterProvider);
+
+      await sdk.shutdown();
+      delete env.OTEL_TRACES_EXPORTER;
+    });
+
+    it('should not show deprecation warning when using metricReaders option', async () => {
+      // need to set OTEL_TRACES_EXPORTER to none since default value is otlp
+      // which sets up an exporter and affects the context manager
+      env.OTEL_TRACES_EXPORTER = 'none';
+      const exporter = new ConsoleMetricExporter();
+      const metricReader = new PeriodicExportingMetricReader({
+        exporter: exporter,
+        exportIntervalMillis: 100,
+        exportTimeoutMillis: 100,
+      });
+
+      const warnSpy = Sinon.spy(diag, 'warn');
+
+      const sdk = new NodeSDK({
+        metricReaders: [metricReader],
+        autoDetectResources: false,
+      });
+
+      sdk.start();
+
+      // Verify no metricReader deprecation warning was shown
+      sinon.assert.neverCalledWith(
+        warnSpy,
+        "The 'metricReader' option is deprecated. Please use 'metricReaders' instead."
+      );
+
+      assert.ok(metrics.getMeterProvider() instanceof MeterProvider);
+
+      await sdk.shutdown();
+      delete env.OTEL_TRACES_EXPORTER;
+    });
+
     it('should register a logger provider if a log record processor is provided', async () => {
       env.OTEL_TRACES_EXPORTER = 'none';
       const logRecordExporter = new InMemoryLogRecordExporter();
diff --git a/test-backward-compatibility.js b/test-backward-compatibility.js
new file mode 100644
index 00000000000..c18cca1b3fb
--- /dev/null
+++ b/test-backward-compatibility.js
@@ -0,0 +1,43 @@
+'use strict';
+
+const opentelemetry = require('@opentelemetry/sdk-node');
+const { metrics } = require('@opentelemetry/api');
+const { ConsoleSpanExporter } = require('@opentelemetry/sdk-trace-base');
+const { resourceFromAttributes } = require('@opentelemetry/resources');
+const { ATTR_SERVICE_NAME } = require('@opentelemetry/semantic-conventions');
+const { 
+  ConsoleMetricExporter, 
+  PeriodicExportingMetricReader 
+} = require('@opentelemetry/sdk-metrics');
+
+// Test backward compatibility with the old metricReader option
+const oldMetricReader = new PeriodicExportingMetricReader({
+  exporter: new ConsoleMetricExporter(),
+  exportIntervalMillis: 1000,
+  exportTimeoutMillis: 500,
+});
+
+const sdk = new opentelemetry.NodeSDK({
+  resource: resourceFromAttributes({
+    [ATTR_SERVICE_NAME]: 'backward-compatibility-test',
+  }),
+  traceExporter: new ConsoleSpanExporter(),
+  // This should still work but show a deprecation warning
+  metricReader: oldMetricReader,
+});
+
+console.log('Testing backward compatibility with metricReader option...');
+sdk.start();
+
+// Create a simple metric to verify it works
+const meter = metrics.getMeter('test-meter');
+const counter = meter.createCounter('test_counter');
+counter.add(1);
+
+console.log('Backward compatibility test completed successfully!');
+console.log('You should see a deprecation warning above.');
+
+sdk.shutdown().then(() => {
+  console.log('Test completed.');
+  process.exit(0);
+}); 
\ No newline at end of file