diff --git a/experimental/packages/opentelemetry-exporter-prometheus/src/PrometheusExporter.ts b/experimental/packages/opentelemetry-exporter-prometheus/src/PrometheusExporter.ts
index c7cd9e77287..77e285225c7 100644
--- a/experimental/packages/opentelemetry-exporter-prometheus/src/PrometheusExporter.ts
+++ b/experimental/packages/opentelemetry-exporter-prometheus/src/PrometheusExporter.ts
@@ -84,9 +84,12 @@ export class PrometheusExporter extends MetricReader {
       typeof config.appendTimestamp === 'boolean'
         ? config.appendTimestamp
         : PrometheusExporter.DEFAULT_OPTIONS.appendTimestamp;
+    const _resourceConstantLabelsFromEnv = process.env.OTEL_EXPORTER_PROMETHEUS_RESOURCE_CONSTANT_LABELS;
     const _withResourceConstantLabels =
       config.withResourceConstantLabels ||
-      PrometheusExporter.DEFAULT_OPTIONS.withResourceConstantLabels;
+      (_resourceConstantLabelsFromEnv
+        ? new RegExp(_resourceConstantLabelsFromEnv)
+        : PrometheusExporter.DEFAULT_OPTIONS.withResourceConstantLabels);
     const _withoutTargetInfo =
       config.withoutTargetInfo ||
       PrometheusExporter.DEFAULT_OPTIONS.withoutTargetInfo;
diff --git a/experimental/packages/opentelemetry-exporter-prometheus/test/PrometheusExporter.test.ts b/experimental/packages/opentelemetry-exporter-prometheus/test/PrometheusExporter.test.ts
index 421e0403481..fb01e98915c 100644
--- a/experimental/packages/opentelemetry-exporter-prometheus/test/PrometheusExporter.test.ts
+++ b/experimental/packages/opentelemetry-exporter-prometheus/test/PrometheusExporter.test.ts
@@ -50,6 +50,7 @@ describe('PrometheusExporter', () => {
     sinon.restore();
     delete process.env.OTEL_EXPORTER_PROMETHEUS_HOST;
     delete process.env.OTEL_EXPORTER_PROMETHEUS_PORT;
+    delete process.env.OTEL_EXPORTER_PROMETHEUS_RESOURCE_CONSTANT_LABELS;
   });
 
   describe('constructor', () => {
@@ -90,6 +91,12 @@ describe('PrometheusExporter', () => {
       const exporter = new PrometheusExporter({ preventServerStart: true });
       assert.ok(exporter['_server'].listening === false);
     });
+
+    it('should config resource constant labels by env', () => {
+      process.env.OTEL_EXPORTER_PROMETHEUS_RESOURCE_CONSTANT_LABELS = 'test';
+      const exporter = new PrometheusExporter({ preventServerStart: true });
+      assert.ok(exporter['_serializer']['_withResourceConstantLabels']);
+    });
   });
 
   describe('server', () => {