diff --git a/CHANGELOG.md b/CHANGELOG.md
index 977f4eea8f..5e20cc8a0b 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -10,12 +10,16 @@ and this project adheres to [Semantic Versioning](https://semver.org/spec/v2.0.0
 - `opentelemetry-instrumentation-fastapi` Add autoinstrumentation mechanism tests.
   ([#2860](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2860))
 
+### Breaking changes
+
+- Deprecation of pkg_resource in favor of importlib.metadata
+  ([#2181](https://github.com/open-telemetry/opentelemetry-python-contrib/issues/2181))
+
 ## Version 1.27.0/0.48b0 ()
 
 ### Added
 
-- `opentelemetry-instrumentation-kafka-python` Instrument temporary fork, kafka-python-ng
-  inside kafka-python's instrumentation
+- `opentelemetry-instrumentation-kafka-python` Instrument temporary fork, kafka-python-ng inside kafka-python's instrumentation
   ([#2537](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2537))
 - `opentelemetry-instrumentation-asgi`, `opentelemetry-instrumentation-fastapi` Add ability to disable internal HTTP send and receive spans
   ([#2802](https://github.com/open-telemetry/opentelemetry-python-contrib/pull/2802))
diff --git a/exporter/opentelemetry-exporter-prometheus-remote-write/test-requirements.txt b/exporter/opentelemetry-exporter-prometheus-remote-write/test-requirements.txt
index 5836dc9764..f6d259c40b 100644
--- a/exporter/opentelemetry-exporter-prometheus-remote-write/test-requirements.txt
+++ b/exporter/opentelemetry-exporter-prometheus-remote-write/test-requirements.txt
@@ -6,7 +6,6 @@ cramjam==2.1.0; platform_python_implementation == "PyPy"
 cramjam==2.8.1; platform_python_implementation != "PyPy"
 Deprecated==1.2.14
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/exporter/opentelemetry-exporter-richconsole/test-requirements.txt b/exporter/opentelemetry-exporter-richconsole/test-requirements.txt
index 0ef562821f..ccd7be9a1e 100644
--- a/exporter/opentelemetry-exporter-richconsole/test-requirements.txt
+++ b/exporter/opentelemetry-exporter-richconsole/test-requirements.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 Deprecated==1.2.14
 flaky==3.7.0
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 markdown-it-py==3.0.0
 mdurl==0.1.2
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-0.txt
index de853e16c9..ea86a1bc30 100644
--- a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-0.txt
@@ -3,7 +3,6 @@ aiormq==6.2.3
 asgiref==3.8.1
 Deprecated==1.2.14
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 multidict==6.0.5
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-1.txt
index dbfb89fe82..b99878d2c1 100644
--- a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-1.txt
@@ -3,7 +3,6 @@ aiormq==6.6.4
 asgiref==3.8.1
 Deprecated==1.2.14
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 multidict==6.0.5
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt
index 6a95bd69f0..1216b7313f 100644
--- a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-2.txt
@@ -3,7 +3,6 @@ aiormq==6.7.1
 asgiref==3.8.1
 Deprecated==1.2.14
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 multidict==6.0.5
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-3.txt b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-3.txt
index 82e742a1f4..d16e8f62cb 100644
--- a/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-3.txt
+++ b/instrumentation/opentelemetry-instrumentation-aio-pika/test-requirements-3.txt
@@ -3,7 +3,6 @@ aiormq==6.8.0
 asgiref==3.8.1
 Deprecated==1.2.14
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 multidict==6.0.5
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt
index dee4736133..34a7ca4e92 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-client/test-requirements.txt
@@ -11,7 +11,6 @@ Flask==3.0.2
 frozenlist==1.4.1
 http_server_mock==1.7
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 itsdangerous==2.1.2
 Jinja2==3.1.4
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-client/tests/test_aiohttp_client_integration.py b/instrumentation/opentelemetry-instrumentation-aiohttp-client/tests/test_aiohttp_client_integration.py
index 8474bd436f..9ebb180de1 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-client/tests/test_aiohttp_client_integration.py
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-client/tests/test_aiohttp_client_integration.py
@@ -24,7 +24,6 @@
 import aiohttp.test_utils
 import yarl
 from http_server_mock import HttpServerMock
-from pkg_resources import iter_entry_points
 
 from opentelemetry import trace as trace_api
 from opentelemetry.instrumentation import aiohttp_client
@@ -47,6 +46,7 @@
 from opentelemetry.semconv.trace import SpanAttributes
 from opentelemetry.test.test_base import TestBase
 from opentelemetry.trace import Span, StatusCode
+from opentelemetry.util._importlib_metadata import entry_points
 
 
 def run_with_test_server(
@@ -886,9 +886,9 @@ def response_hook(
 
 class TestLoadingAioHttpInstrumentor(unittest.TestCase):
     def test_loading_instrumentor(self):
-        entry_points = iter_entry_points(
-            "opentelemetry_instrumentor", "aiohttp-client"
+        (entry_point,) = entry_points(
+            group="opentelemetry_instrumentor", name="aiohttp-client"
         )
 
-        instrumentor = next(entry_points).load()()
+        instrumentor = entry_point.load()()
         self.assertIsInstance(instrumentor, AioHttpClientInstrumentor)
diff --git a/instrumentation/opentelemetry-instrumentation-aiohttp-server/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-aiohttp-server/test-requirements.txt
index e6dff52db9..594172be6a 100644
--- a/instrumentation/opentelemetry-instrumentation-aiohttp-server/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-aiohttp-server/test-requirements.txt
@@ -5,7 +5,6 @@ async-timeout==4.0.3
 Deprecated==1.2.14
 frozenlist==1.4.1
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 multidict==6.0.5
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-aiopg/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-aiopg/test-requirements.txt
index 1443104081..4e9d96ebc1 100644
--- a/instrumentation/opentelemetry-instrumentation-aiopg/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-aiopg/test-requirements.txt
@@ -2,7 +2,6 @@ aiopg==1.4.0
 asgiref==3.8.1
 async-timeout==4.0.3
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-asgi/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-asgi/test-requirements.txt
index 18a11500e1..3b1c52d94f 100644
--- a/instrumentation/opentelemetry-instrumentation-asgi/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-asgi/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt
index 7f20d1497c..427ded20cc 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-asyncio/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-asyncpg/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-asyncpg/test-requirements.txt
index 60cef50a7a..83f5b10c17 100644
--- a/instrumentation/opentelemetry-instrumentation-asyncpg/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-asyncpg/test-requirements.txt
@@ -2,7 +2,6 @@ asgiref==3.8.1
 async-timeout==4.0.3
 asyncpg==0.29.0
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-aws-lambda/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-aws-lambda/test-requirements.txt
index 8d9fe19483..bf065b1451 100644
--- a/instrumentation/opentelemetry-instrumentation-aws-lambda/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-aws-lambda/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-boto/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-boto/test-requirements.txt
index fe6467d1c4..c00886c599 100644
--- a/instrumentation/opentelemetry-instrumentation-boto/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-boto/test-requirements.txt
@@ -9,7 +9,6 @@ cryptography==42.0.5
 Deprecated==1.2.14
 docker==7.0.0
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 Jinja2==3.1.4
 jmespath==1.0.1
diff --git a/instrumentation/opentelemetry-instrumentation-boto3sqs/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-boto3sqs/test-requirements.txt
index d8a9c38315..c3c6aa5a5b 100644
--- a/instrumentation/opentelemetry-instrumentation-boto3sqs/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-boto3sqs/test-requirements.txt
@@ -2,7 +2,6 @@ asgiref==3.8.1
 boto3==1.34.44
 botocore==1.34.44
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 jmespath==1.0.1
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt
index a89fdf2e30..042fc98187 100644
--- a/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-botocore/test-requirements.txt
@@ -9,7 +9,6 @@ cryptography==42.0.5
 Deprecated==1.2.14
 docker==7.0.0
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 Jinja2==3.1.4
 jmespath==1.0.1
diff --git a/instrumentation/opentelemetry-instrumentation-cassandra/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-cassandra/test-requirements.txt
index 189b2f65d0..cac6c911b0 100644
--- a/instrumentation/opentelemetry-instrumentation-cassandra/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-cassandra/test-requirements.txt
@@ -3,7 +3,6 @@ cassandra-driver==3.29.0
 click==8.1.7
 Deprecated==1.2.14
 geomet==0.2.1.post1
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-celery/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-celery/test-requirements-0.txt
index fcf838fc32..9fc159dae9 100644
--- a/instrumentation/opentelemetry-instrumentation-celery/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-celery/test-requirements-0.txt
@@ -8,7 +8,6 @@ click-didyoumean==0.3.0
 click-plugins==1.1.1
 click-repl==0.3.0
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 kombu==5.3.5
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-celery/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-celery/test-requirements-1.txt
index 76b2f03d12..afa6644218 100644
--- a/instrumentation/opentelemetry-instrumentation-celery/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-celery/test-requirements-1.txt
@@ -7,7 +7,6 @@ click-didyoumean==0.3.0
 click-plugins==1.1.1
 click-repl==0.3.0
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 kombu==5.3.5
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-confluent-kafka/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-confluent-kafka/test-requirements.txt
index f78f498620..2ec70ea453 100644
--- a/instrumentation/opentelemetry-instrumentation-confluent-kafka/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-confluent-kafka/test-requirements.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 confluent-kafka==2.4.0
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-dbapi/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-dbapi/test-requirements.txt
index f76b488d90..49ee702dcf 100644
--- a/instrumentation/opentelemetry-instrumentation-dbapi/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-dbapi/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-django/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-django/test-requirements-0.txt
index 9d7ee964fe..c7759b21be 100644
--- a/instrumentation/opentelemetry-instrumentation-django/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-django/test-requirements-0.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 Deprecated==1.2.14
 Django==2.2.28
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-django/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-django/test-requirements-1.txt
index 9c21d2dfd4..d2ecb426d3 100644
--- a/instrumentation/opentelemetry-instrumentation-django/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-django/test-requirements-1.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 Deprecated==1.2.14
 Django==3.2.25
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt
index d3a55aae34..fefaa9b7ae 100644
--- a/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt
+++ b/instrumentation/opentelemetry-instrumentation-django/test-requirements-2.txt
@@ -2,7 +2,6 @@ asgiref==3.8.1
 backports.zoneinfo==0.2.1
 Deprecated==1.2.14
 Django==4.2.15
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt b/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt
index 89923379d3..f859e643fc 100644
--- a/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt
+++ b/instrumentation/opentelemetry-instrumentation-django/test-requirements-3.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 Deprecated==1.2.14
 Django==4.2.15
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt
index 55eabe1ef5..be9acbee2a 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-0.txt
@@ -2,7 +2,6 @@ asgiref==3.8.1
 Deprecated==1.2.14
 elasticsearch==6.8.2
 elasticsearch-dsl==6.4.0
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt
index 2fab7287ad..1569483d69 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-1.txt
@@ -2,7 +2,6 @@ asgiref==3.8.1
 Deprecated==1.2.14
 elasticsearch==7.17.9
 elasticsearch-dsl==7.4.1
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt
index 5f2ccd41ac..bec43c9d6c 100644
--- a/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt
+++ b/instrumentation/opentelemetry-instrumentation-elasticsearch/test-requirements-2.txt
@@ -3,7 +3,6 @@ Deprecated==1.2.14
 elasticsearch==8.13.1
 elasticsearch-dsl==8.13.1
 elastic-transport==8.13.0
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-0.txt
index 6967c57b6d..6a8d7e1c01 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-0.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 Deprecated==1.2.14
 falcon==1.4.1
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-1.txt
index e535925b14..0a63d9015c 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-1.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 Deprecated==1.2.14
 falcon==2.0.0
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-2.txt
index 30d21e2773..afd3e5c4f0 100644
--- a/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-2.txt
+++ b/instrumentation/opentelemetry-instrumentation-falcon/test-requirements-2.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 Deprecated==1.2.14
 falcon==3.1.1
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
index 927e68f94e..51879c8177 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/test-requirements.txt
@@ -10,7 +10,6 @@ h11==0.14.0
 httpcore==1.0.4
 httpx==0.27.0
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py b/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py
index b8a6ef010e..7596c13cd3 100644
--- a/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py
+++ b/instrumentation/opentelemetry-instrumentation-fastapi/tests/test_fastapi_instrumentation.py
@@ -16,13 +16,12 @@
 
 import unittest
 from timeit import default_timer
-from unittest.mock import Mock, patch
+from unittest.mock import patch
 
 import fastapi
 from fastapi.middleware.httpsredirect import HTTPSRedirectMiddleware
 from fastapi.responses import JSONResponse
 from fastapi.testclient import TestClient
-from pkg_resources import DistributionNotFound, iter_entry_points
 
 import opentelemetry.instrumentation.fastapi as otel_fastapi
 from opentelemetry import trace
@@ -35,9 +34,6 @@
     _server_duration_attrs_old,
 )
 from opentelemetry.instrumentation.asgi import OpenTelemetryMiddleware
-from opentelemetry.instrumentation.auto_instrumentation._load import (
-    _load_instrumentors,
-)
 from opentelemetry.sdk.metrics.export import (
     HistogramDataPoint,
     NumberDataPoint,
@@ -55,6 +51,10 @@
 from opentelemetry.semconv.trace import SpanAttributes
 from opentelemetry.test.globals_test import reset_trace_globals
 from opentelemetry.test.test_base import TestBase
+from opentelemetry.util._importlib_metadata import (
+    PackageNotFoundError,
+    entry_points,
+)
 from opentelemetry.util.http import (
     OTEL_INSTRUMENTATION_HTTP_CAPTURE_HEADERS_SANITIZE_FIELDS,
     OTEL_INSTRUMENTATION_HTTP_CAPTURE_HEADERS_SERVER_REQUEST,
@@ -1028,16 +1028,24 @@ def client_response_hook(send_span, scope, message):
             )
 
 
-def get_distribution_with_fastapi(*args, **kwargs):
-    dist = args[0]
-    if dist == "fastapi~=0.58":
-        # Value does not matter. Only whether an exception is thrown
-        return None
-    raise DistributionNotFound()
+def mock_version_with_fastapi(*args, **kwargs):
+    req_name = args[0]
+    if req_name == "fastapi":
+        # TODO: Value now matters
+        return "0.58"
+    raise PackageNotFoundError()
+
+
+def mock_version_with_old_fastapi(*args, **kwargs):
+    req_name = args[0]
+    if req_name == "fastapi":
+        # TODO: Value now matters
+        return "0.57"
+    raise PackageNotFoundError()
 
 
-def get_distribution_without_fastapi(*args, **kwargs):
-    raise DistributionNotFound()
+def mock_version_without_fastapi(*args, **kwargs):
+    raise PackageNotFoundError()
 
 
 class TestAutoInstrumentation(TestBaseAutoFastAPI):
@@ -1048,42 +1056,42 @@ class TestAutoInstrumentation(TestBaseAutoFastAPI):
     """
 
     def test_entry_point_exists(self):
-        eps = iter_entry_points("opentelemetry_instrumentor")
-        ep = next(eps)
-        self.assertEqual(ep.dist.key, "opentelemetry-instrumentation-fastapi")
-        self.assertEqual(
-            ep.module_name, "opentelemetry.instrumentation.fastapi"
-        )
-        self.assertEqual(ep.attrs, ("FastAPIInstrumentor",))
+        (ep,) = entry_points(group="opentelemetry_instrumentor")
         self.assertEqual(ep.name, "fastapi")
-        self.assertIsNone(next(eps, None))
 
-    @patch("opentelemetry.instrumentation.dependencies.get_distribution")
-    def test_instruments_with_fastapi_installed(self, mock_get_distribution):
-        mock_get_distribution.side_effect = get_distribution_with_fastapi
+    @patch("opentelemetry.instrumentation.dependencies.version")
+    def test_instruments_with_fastapi_installed(self, mock_version):
+        mock_version.side_effect = mock_version_with_fastapi
         mock_distro = Mock()
         _load_instrumentors(mock_distro)
-        mock_get_distribution.assert_called_once_with("fastapi~=0.58")
+        mock_version.assert_called_once_with("fastapi")
         self.assertEqual(len(mock_distro.load_instrumentor.call_args_list), 1)
-        args = mock_distro.load_instrumentor.call_args.args
-        ep = args[0]
-        self.assertEqual(ep.dist.key, "opentelemetry-instrumentation-fastapi")
-        self.assertEqual(
-            ep.module_name, "opentelemetry.instrumentation.fastapi"
-        )
-        self.assertEqual(ep.attrs, ("FastAPIInstrumentor",))
+        (ep,) = mock_distro.load_instrumentor.call_args.args
         self.assertEqual(ep.name, "fastapi")
 
-    @patch("opentelemetry.instrumentation.dependencies.get_distribution")
+    @patch("opentelemetry.instrumentation.dependencies.version")
+    def test_instruments_with_old_fastapi_installed(self, mock_version):
+        mock_version.side_effect = mock_version_with_old_fastapi
+        mock_distro = Mock()
+        _load_instrumentors(mock_distro)
+        mock_version.assert_called_once_with("fastapi")
+        with self.assertRaises(PackageNotFoundError):
+            mock_version("fastapi")
+        self.assertEqual(len(mock_distro.load_instrumentor.call_args_list), 0)
+        mock_distro.load_instrumentor.assert_not_called()
+
+    @patch("opentelemetry.instrumentation.dependencies.version")
     def test_instruments_without_fastapi_installed(
-        self, mock_get_distribution
+        self, mock_version
     ):
-        mock_get_distribution.side_effect = get_distribution_without_fastapi
+        mock_version.side_effect = mock_version_without_fastapi
         mock_distro = Mock()
         _load_instrumentors(mock_distro)
-        mock_get_distribution.assert_called_once_with("fastapi~=0.58")
-        with self.assertRaises(DistributionNotFound):
-            mock_get_distribution("fastapi~=0.58")
+        mock_version.assert_called_once_with("fastapi")
+        try:
+            mock_version("fastapi")
+        except PackageNotFoundError:
+            self.fail("FastAPI not found.")
         self.assertEqual(len(mock_distro.load_instrumentor.call_args_list), 0)
         mock_distro.load_instrumentor.assert_not_called()
 
diff --git a/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml b/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
index 0e74ca331f..8d02775824 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
+++ b/instrumentation/opentelemetry-instrumentation-flask/pyproject.toml
@@ -31,7 +31,6 @@ dependencies = [
   "opentelemetry-semantic-conventions == 0.49b0.dev",
   "opentelemetry-util-http == 0.49b0.dev",
   "packaging >= 21.0",
-  "importlib-metadata >= 4.0",
 ]
 
 [project.optional-dependencies]
diff --git a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
index 192e044655..761fa3660f 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-flask/src/opentelemetry/instrumentation/flask/__init__.py
@@ -245,7 +245,6 @@ def response_hook(span: Span, status: str, response_headers: List):
 from typing import Collection
 
 import flask
-import importlib_metadata as metadata
 from packaging import version as package_version
 
 import opentelemetry.instrumentation.wsgi as otel_wsgi
@@ -272,6 +271,7 @@ def response_hook(span: Span, status: str, response_headers: List):
     HTTP_SERVER_REQUEST_DURATION,
 )
 from opentelemetry.semconv.trace import SpanAttributes
+from opentelemetry.util._importlib_metadata import version
 from opentelemetry.util.http import (
     get_excluded_urls,
     parse_excluded_urls,
@@ -288,7 +288,7 @@ def response_hook(span: Span, status: str, response_headers: List):
 
 _excluded_urls_from_env = get_excluded_urls("FLASK")
 
-flask_version = metadata.version("flask")
+flask_version = version("flask")
 
 if package_version.parse(flask_version) >= package_version.parse("2.2.0"):
 
diff --git a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-0.txt
index 0bd176848d..96549a0c09 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-0.txt
@@ -2,7 +2,6 @@ asgiref==3.8.1
 click==8.1.7
 Deprecated==1.2.14
 Flask==2.1.3
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 itsdangerous==2.1.2
 Jinja2==3.1.4
diff --git a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-1.txt
index d73ab497b5..9cdfbc502f 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-1.txt
@@ -2,7 +2,6 @@ asgiref==3.8.1
 click==8.1.7
 Deprecated==1.2.14
 Flask==2.2.0
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 itsdangerous==2.1.2
 Jinja2==3.1.4
diff --git a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt
index 299a347d66..3599dcf933 100644
--- a/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt
+++ b/instrumentation/opentelemetry-instrumentation-flask/test-requirements-2.txt
@@ -3,7 +3,6 @@ blinker==1.7.0
 click==8.1.7
 Deprecated==1.2.14
 Flask==3.0.2
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 itsdangerous==2.1.2
 Jinja2==3.1.4
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-0.txt
index 83ec6e8e70..f93fe1b766 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-0.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 Deprecated==1.2.14
 grpcio==1.62.0
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-1.txt
index d77d67148a..0f2bfa3ec9 100644
--- a/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-grpc/test-requirements-1.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 Deprecated==1.2.14
 grpcio==1.63.0
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt
index 28b475a3a4..eae40429be 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-0.txt
@@ -7,7 +7,6 @@ h11==0.12.0
 httpcore==0.13.7
 httpx==0.18.2
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt
index 42c032a546..0f6d136354 100644
--- a/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-httpx/test-requirements-1.txt
@@ -7,7 +7,6 @@ h11==0.14.0
 httpcore==1.0.4
 httpx==0.27.0
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-jinja2/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-jinja2/test-requirements.txt
index 59eabe6997..b4b4d71c02 100644
--- a/instrumentation/opentelemetry-instrumentation-jinja2/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-jinja2/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 Jinja2==3.1.4
 MarkupSafe==2.0.1
diff --git a/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements-ng.txt b/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements-ng.txt
index 05e169a7e3..83cef19c4f 100644
--- a/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements-ng.txt
+++ b/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements-ng.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 kafka-python-ng==2.2.2
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements.txt
index 6582cf875b..4ed0e3df67 100644
--- a/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-kafka-python/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 kafka-python==2.0.2
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-logging/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-logging/test-requirements.txt
index c0d2f044c8..13f9a9c403 100644
--- a/instrumentation/opentelemetry-instrumentation-logging/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-logging/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-0.txt
index bf93434850..04eea4f3c6 100644
--- a/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-0.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 mysql-connector-python==8.3.0
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-1.txt
index 1a58c16a05..0ca8efb64c 100644
--- a/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-mysql/test-requirements-1.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 mysql-connector-python==9.0.0
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt
index 8c3ed72f35..41c6ae91a4 100644
--- a/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-mysqlclient/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 mysqlclient==2.2.4
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-pika/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-pika/test-requirements-0.txt
index e06bc0b395..f23aa4ed80 100644
--- a/instrumentation/opentelemetry-instrumentation-pika/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-pika/test-requirements-0.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pika==0.13.1
diff --git a/instrumentation/opentelemetry-instrumentation-pika/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-pika/test-requirements-1.txt
index 8928f655c8..433d9ede22 100644
--- a/instrumentation/opentelemetry-instrumentation-pika/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-pika/test-requirements-1.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pika==1.3.2
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-0.txt
index 42bbac77d9..6ad7e1a1a8 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-0.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 backports.zoneinfo==0.2.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-1.txt
index 1f7fb59f2d..d00955e8fa 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-psycopg/test-requirements-1.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-psycopg2/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-psycopg2/test-requirements.txt
index aa98fa93d0..f759a60462 100644
--- a/instrumentation/opentelemetry-instrumentation-psycopg2/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-psycopg2/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-0.txt
index 2c6e0e2749..9454be134a 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-0.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-1.txt
index 36db8d4416..4ae3f6b579 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-1.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-2.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-2.txt
index 3e0359f731..e3c04ff25e 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-2.txt
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-2.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-3.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-3.txt
index 916c9c9c3a..46139219c9 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-3.txt
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-3.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-4.txt b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-4.txt
index e90a138ff8..22fc8bfdba 100644
--- a/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-4.txt
+++ b/instrumentation/opentelemetry-instrumentation-pymemcache/test-requirements-4.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-pymongo/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-pymongo/test-requirements.txt
index 6c8de553b6..d0adc0e1fb 100644
--- a/instrumentation/opentelemetry-instrumentation-pymongo/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-pymongo/test-requirements.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 Deprecated==1.2.14
 dnspython==2.6.1
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-pymysql/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-pymysql/test-requirements.txt
index 7ad69f2b81..e7ce34d6a7 100644
--- a/instrumentation/opentelemetry-instrumentation-pymysql/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-pymysql/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
index 6f33f33449..6b9ac40ed2 100644
--- a/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-pyramid/test-requirements.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 Deprecated==1.2.14
 hupper==1.12.1
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 PasteDeploy==3.1.0
diff --git a/instrumentation/opentelemetry-instrumentation-redis/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-redis/test-requirements.txt
index 7b8d8459b7..d84a7fe146 100644
--- a/instrumentation/opentelemetry-instrumentation-redis/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-redis/test-requirements.txt
@@ -2,7 +2,6 @@ asgiref==3.8.1
 async-timeout==4.0.3
 Deprecated==1.2.14
 fakeredis==2.23.3
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-remoulade/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-remoulade/test-requirements.txt
index b850e46f9f..bf1e781366 100644
--- a/instrumentation/opentelemetry-instrumentation-remoulade/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-remoulade/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-requests/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-requests/test-requirements.txt
index 9f40c6d5b2..1c5ac00479 100644
--- a/instrumentation/opentelemetry-instrumentation-requests/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-requests/test-requirements.txt
@@ -4,7 +4,6 @@ charset-normalizer==3.3.2
 Deprecated==1.2.14
 httpretty==1.1.4
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-0.txt
index 45992bc2e1..df091600dc 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-0.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 cffi==1.15.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-1.txt
index eb1ee371b7..ca24cf0eef 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-sqlalchemy/test-requirements-1.txt
@@ -2,7 +2,6 @@ aiosqlite==0.20.0
 asgiref==3.8.1
 Deprecated==1.2.14
 greenlet==3.0.3
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-sqlite3/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-sqlite3/test-requirements.txt
index e260861814..8ff4a4130d 100644
--- a/instrumentation/opentelemetry-instrumentation-sqlite3/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-sqlite3/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-starlette/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-starlette/test-requirements.txt
index d81a15a40c..d565d2e0cc 100644
--- a/instrumentation/opentelemetry-instrumentation-starlette/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-starlette/test-requirements.txt
@@ -8,7 +8,6 @@ h11==0.14.0
 httpcore==1.0.4
 httpx==0.27.0
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-system-metrics/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-system-metrics/test-requirements.txt
index 76f2f2a4e7..da067b793d 100644
--- a/instrumentation/opentelemetry-instrumentation-system-metrics/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-system-metrics/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-threading/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-threading/test-requirements.txt
index 2d13857e9e..f65e0e1b58 100644
--- a/instrumentation/opentelemetry-instrumentation-threading/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-threading/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
index 236c45f87b..b6bd4f93fa 100644
--- a/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-tornado/test-requirements.txt
@@ -7,7 +7,6 @@ Deprecated==1.2.14
 Flask==3.0.2
 http_server_mock==1.7
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 itsdangerous==2.1.2
 Jinja2==3.1.4
diff --git a/instrumentation/opentelemetry-instrumentation-tortoiseorm/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-tortoiseorm/test-requirements.txt
index 31b044a2f3..ec54c45665 100644
--- a/instrumentation/opentelemetry-instrumentation-tortoiseorm/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-tortoiseorm/test-requirements.txt
@@ -2,7 +2,6 @@ aiosqlite==0.17.0
 annotated-types==0.6.0
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 iso8601==1.1.0
 packaging==24.0
diff --git a/instrumentation/opentelemetry-instrumentation-urllib/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-urllib/test-requirements.txt
index 06bc8322dc..fd112c99af 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-urllib/test-requirements.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 Deprecated==1.2.14
 httpretty==1.1.4
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-0.txt b/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-0.txt
index e7392b0c31..594b9a023f 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-0.txt
+++ b/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-0.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 Deprecated==1.2.14
 httpretty==1.1.4
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-1.txt b/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-1.txt
index 21cb3acbe6..da90160ab9 100644
--- a/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-1.txt
+++ b/instrumentation/opentelemetry-instrumentation-urllib3/test-requirements-1.txt
@@ -1,7 +1,6 @@
 asgiref==3.8.1
 Deprecated==1.2.14
 httpretty==1.1.4
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/test-requirements.txt b/instrumentation/opentelemetry-instrumentation-wsgi/test-requirements.txt
index d63bd5a637..49d1204bc2 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/test-requirements.txt
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/instrumentation/opentelemetry-instrumentation-wsgi/tests/__init__.py b/instrumentation/opentelemetry-instrumentation-wsgi/tests/__init__.py
index 8a3124243a..e69de29bb2 100644
--- a/instrumentation/opentelemetry-instrumentation-wsgi/tests/__init__.py
+++ b/instrumentation/opentelemetry-instrumentation-wsgi/tests/__init__.py
@@ -1,23 +0,0 @@
-# Copyright The OpenTelemetry Authors
-#
-# Licensed under the Apache License, Version 2.0 (the "License");
-# you may not use this file except in compliance with the License.
-# You may obtain a copy of the License at
-#
-#     http://www.apache.org/licenses/LICENSE-2.0
-#
-# Unless required by applicable law or agreed to in writing, software
-# distributed under the License is distributed on an "AS IS" BASIS,
-# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
-# See the License for the specific language governing permissions and
-# limitations under the License.
-import pkg_resources
-
-# IMPORTANT: Only the wsgi module needs this because it is always the first
-# package that uses the `{rootdir}/*/tests/` path and gets installed by
-# `eachdist.py` and according to `eachdist.ini`.
-
-# Naming the tests module as a namespace package ensures that
-# relative imports will resolve properly for subsequent test packages,
-# as it enables searching for a composite of multiple test modules.
-pkg_resources.declare_namespace(__name__)
diff --git a/opentelemetry-distro/test-requirements.txt b/opentelemetry-distro/test-requirements.txt
index 050054c39b..d66fdcf0a4 100644
--- a/opentelemetry-distro/test-requirements.txt
+++ b/opentelemetry-distro/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/opentelemetry-distro/tests/test_distro.py b/opentelemetry-distro/tests/test_distro.py
index ea7b9f08c8..9cd89eb039 100644
--- a/opentelemetry-distro/tests/test_distro.py
+++ b/opentelemetry-distro/tests/test_distro.py
@@ -16,21 +16,23 @@
 import os
 from unittest import TestCase, mock
 
-from pkg_resources import DistributionNotFound, require
-
 from opentelemetry.distro import OpenTelemetryDistro
 from opentelemetry.environment_variables import (
     OTEL_METRICS_EXPORTER,
     OTEL_TRACES_EXPORTER,
 )
 from opentelemetry.sdk.environment_variables import OTEL_EXPORTER_OTLP_PROTOCOL
+from opentelemetry.util._importlib_metadata import (
+    PackageNotFoundError,
+    version,
+)
 
 
 class TestDistribution(TestCase):
     def test_package_available(self):
         try:
-            require(["opentelemetry-distro"])
-        except DistributionNotFound:
+            version("opentelemetry-distro")
+        except PackageNotFoundError:
             self.fail("opentelemetry-distro not installed")
 
     @mock.patch.dict("os.environ", {}, clear=True)
diff --git a/opentelemetry-instrumentation/pyproject.toml b/opentelemetry-instrumentation/pyproject.toml
index edaf400419..9d9dfe91a8 100644
--- a/opentelemetry-instrumentation/pyproject.toml
+++ b/opentelemetry-instrumentation/pyproject.toml
@@ -26,8 +26,8 @@ classifiers = [
 ]
 dependencies = [
   "opentelemetry-api ~= 1.4",
-  "setuptools >= 16.0",
   "wrapt >= 1.0.0, < 2.0.0",
+  "packaging >= 18.0",
 ]
 
 [project.scripts]
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/__init__.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/__init__.py
index a09334432d..963b3a6956 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/__init__.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/__init__.py
@@ -19,9 +19,8 @@
 from re import sub
 from shutil import which
 
-from pkg_resources import iter_entry_points
-
 from opentelemetry.instrumentation.version import __version__
+from opentelemetry.util._importlib_metadata import entry_points
 
 _logger = getLogger(__name__)
 
@@ -48,8 +47,8 @@ def run() -> None:
 
     argument_otel_environment_variable = {}
 
-    for entry_point in iter_entry_points(
-        "opentelemetry_environment_variables"
+    for entry_point in entry_points(
+        group="opentelemetry_environment_variables"
     ):
         environment_variable_module = entry_point.load()
 
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/_load.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/_load.py
index 27b57da3ef..7154238bb7 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/_load.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/auto_instrumentation/_load.py
@@ -12,11 +12,10 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
+from functools import cached_property
 from logging import getLogger
 from os import environ
 
-from pkg_resources import iter_entry_points
-
 from opentelemetry.instrumentation.dependencies import (
     get_dist_dependency_conflicts,
 )
@@ -27,13 +26,39 @@
     OTEL_PYTHON_DISTRO,
 )
 from opentelemetry.instrumentation.version import __version__
+from opentelemetry.util._importlib_metadata import (
+    EntryPoint,
+    distributions,
+    entry_points,
+)
 
 _logger = getLogger(__name__)
 
 
+class _EntryPointDistFinder:
+    @cached_property
+    def _mapping(self):
+        return {
+            self._key_for(ep): dist
+            for dist in distributions()
+            for ep in dist.entry_points
+        }
+
+    def dist_for(self, entry_point: EntryPoint):
+        dist = getattr(entry_point, "dist", None)
+        if dist:
+            return dist
+
+        return self._mapping.get(self._key_for(entry_point))
+
+    @staticmethod
+    def _key_for(entry_point: EntryPoint):
+        return f"{entry_point.group}:{entry_point.name}:{entry_point.value}"
+
+
 def _load_distro() -> BaseDistro:
     distro_name = environ.get(OTEL_PYTHON_DISTRO, None)
-    for entry_point in iter_entry_points("opentelemetry_distro"):
+    for entry_point in entry_points(group="opentelemetry_distro"):
         try:
             # If no distro is specified, use first to come up.
             if distro_name is None or distro_name == entry_point.name:
@@ -58,15 +83,16 @@ def _load_distro() -> BaseDistro:
 
 def _load_instrumentors(distro):
     package_to_exclude = environ.get(OTEL_PYTHON_DISABLED_INSTRUMENTATIONS, [])
+    entry_point_finder = _EntryPointDistFinder()
     if isinstance(package_to_exclude, str):
         package_to_exclude = package_to_exclude.split(",")
         # to handle users entering "requests , flask" or "requests, flask" with spaces
         package_to_exclude = [x.strip() for x in package_to_exclude]
 
-    for entry_point in iter_entry_points("opentelemetry_pre_instrument"):
+    for entry_point in entry_points(group="opentelemetry_pre_instrument"):
         entry_point.load()()
 
-    for entry_point in iter_entry_points("opentelemetry_instrumentor"):
+    for entry_point in entry_points(group="opentelemetry_instrumentor"):
         if entry_point.name in package_to_exclude:
             _logger.debug(
                 "Instrumentation skipped for library %s", entry_point.name
@@ -74,7 +100,8 @@ def _load_instrumentors(distro):
             continue
 
         try:
-            conflict = get_dist_dependency_conflicts(entry_point.dist)
+            entry_point_dist = entry_point_finder.dist_for(entry_point)
+            conflict = get_dist_dependency_conflicts(entry_point_dist)
             if conflict:
                 _logger.debug(
                     "Skipping instrumentation %s: %s",
@@ -90,14 +117,14 @@ def _load_instrumentors(distro):
             _logger.exception("Instrumenting of %s failed", entry_point.name)
             raise exc
 
-    for entry_point in iter_entry_points("opentelemetry_post_instrument"):
+    for entry_point in entry_points(group="opentelemetry_post_instrument"):
         entry_point.load()()
 
 
 def _load_configurators():
     configurator_name = environ.get(OTEL_PYTHON_CONFIGURATOR, None)
     configured = None
-    for entry_point in iter_entry_points("opentelemetry_configurator"):
+    for entry_point in entry_points(group="opentelemetry_configurator"):
         if configured is not None:
             _logger.warning(
                 "Configuration of %s not loaded, %s already loaded",
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py
index 1cc28abca4..02926ea5c4 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/bootstrap.py
@@ -23,13 +23,17 @@
     check_call,
 )
 
-import pkg_resources
+from packaging.requirements import Requirement
 
 from opentelemetry.instrumentation.bootstrap_gen import (
     default_instrumentations,
     libraries,
 )
 from opentelemetry.instrumentation.version import __version__
+from opentelemetry.util._importlib_metadata import (
+    PackageNotFoundError,
+    version,
+)
 
 logger = logging.getLogger(__name__)
 
@@ -91,18 +95,19 @@ def _pip_check():
 
 
 def _is_installed(req):
-    if req in sys.modules:
-        return True
+    req = Requirement(req)
 
     try:
-        pkg_resources.get_distribution(req)
-    except pkg_resources.DistributionNotFound:
+        dist_version = version(req.name)
+    except PackageNotFoundError:
         return False
-    except pkg_resources.VersionConflict as exc:
+
+    if not req.specifier.filter(dist_version):
         logger.warning(
-            "instrumentation for package %s is available but version %s is installed. Skipping.",
-            exc.req,
-            exc.dist.as_requirement(),  # pylint: disable=no-member
+            "instrumentation for package %s is available"
+            " but version %s is installed. Skipping.",
+            req,
+            dist_version,
         )
         return False
     return True
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/dependencies.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/dependencies.py
index 2da0a3d18b..7ebc88d647 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/dependencies.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/dependencies.py
@@ -1,12 +1,26 @@
+# Copyright The OpenTelemetry Authors
+#
+# Licensed under the Apache License, Version 2.0 (the "License");
+# you may not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+#     http://www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an "AS IS" BASIS,
+# WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+
 from logging import getLogger
-from typing import Collection, Optional
+from typing import Collection, Optional, Union
+
+from packaging.requirements import InvalidRequirement, Requirement
 
-from pkg_resources import (
+from opentelemetry.util._importlib_metadata import (
     Distribution,
-    DistributionNotFound,
-    RequirementParseError,
-    VersionConflict,
-    get_distribution,
+    PackageNotFoundError,
+    version,
 )
 
 logger = getLogger(__name__)
@@ -27,36 +41,43 @@ def __str__(self):
 def get_dist_dependency_conflicts(
     dist: Distribution,
 ) -> Optional[DependencyConflict]:
-    main_deps = dist.requires()
     instrumentation_deps = []
-    for dep in dist.requires(("instruments",)):
-        if dep not in main_deps:
-            # we set marker to none so string representation of the dependency looks like
-            #    requests ~= 1.0
-            # instead of
-            #    requests ~= 1.0; extra = "instruments"
-            # which does not work with `get_distribution()`
-            dep.marker = None
-            instrumentation_deps.append(str(dep))
+    extra = "extra"
+    instruments = "instruments"
+    instruments_marker = {extra: instruments}
+    for dep in dist.requires:
+        if extra not in dep or instruments not in dep:
+            continue
+
+        req = Requirement(dep)
+        if req.marker.evaluate(instruments_marker):
+            instrumentation_deps.append(req)
 
     return get_dependency_conflicts(instrumentation_deps)
 
 
 def get_dependency_conflicts(
-    deps: Collection[str],
+    deps: Collection[Union[str, Requirement]],
 ) -> Optional[DependencyConflict]:
     for dep in deps:
+        if isinstance(dep, Requirement):
+            req = dep
+        else:
+            try:
+                req = Requirement(dep)
+            except InvalidRequirement as exc:
+                logger.warning(
+                    'error parsing dependency, reporting as a conflict: "%s" - %s',
+                    dep,
+                    exc,
+                )
+                return DependencyConflict(dep)
+
         try:
-            get_distribution(dep)
-        except VersionConflict as exc:
-            return DependencyConflict(dep, exc.dist)
-        except DistributionNotFound:
-            return DependencyConflict(dep)
-        except RequirementParseError as exc:
-            logger.warning(
-                'error parsing dependency, reporting as a conflict: "%s" - %s',
-                dep,
-                exc,
-            )
+            dist_version = version(req.name)
+        except PackageNotFoundError:
             return DependencyConflict(dep)
+
+        if not req.specifier.contains(dist_version):
+            return DependencyConflict(dep, f"{req.name} {dist_version}")
     return None
diff --git a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/distro.py b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/distro.py
index 93646bbb2f..1bc847f988 100644
--- a/opentelemetry-instrumentation/src/opentelemetry/instrumentation/distro.py
+++ b/opentelemetry-instrumentation/src/opentelemetry/instrumentation/distro.py
@@ -20,9 +20,8 @@
 from abc import ABC, abstractmethod
 from logging import getLogger
 
-from pkg_resources import EntryPoint
-
 from opentelemetry.instrumentation.instrumentor import BaseInstrumentor
+from opentelemetry.util._importlib_metadata import EntryPoint
 
 _LOG = getLogger(__name__)
 
diff --git a/opentelemetry-instrumentation/test-requirements.txt b/opentelemetry-instrumentation/test-requirements.txt
index 31f1ef76ab..f5ad4c861b 100644
--- a/opentelemetry-instrumentation/test-requirements.txt
+++ b/opentelemetry-instrumentation/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/opentelemetry-instrumentation/tests/auto_instrumentation/test_load.py b/opentelemetry-instrumentation/tests/auto_instrumentation/test_load.py
index 5fc59b542d..5e6efb46b1 100644
--- a/opentelemetry-instrumentation/tests/auto_instrumentation/test_load.py
+++ b/opentelemetry-instrumentation/tests/auto_instrumentation/test_load.py
@@ -30,7 +30,7 @@ class TestLoad(TestCase):
         "os.environ", {OTEL_PYTHON_CONFIGURATOR: "custom_configurator2"}
     )
     @patch(
-        "opentelemetry.instrumentation.auto_instrumentation._load.iter_entry_points"
+        "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
     )
     def test_load_configurators(
         self, iter_mock
@@ -61,7 +61,7 @@ def test_load_configurators(
         "os.environ", {OTEL_PYTHON_CONFIGURATOR: "custom_configurator2"}
     )
     @patch(
-        "opentelemetry.instrumentation.auto_instrumentation._load.iter_entry_points"
+        "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
     )
     def test_load_configurators_no_ep(
         self, iter_mock
@@ -74,7 +74,7 @@ def test_load_configurators_no_ep(
         "os.environ", {OTEL_PYTHON_CONFIGURATOR: "custom_configurator2"}
     )
     @patch(
-        "opentelemetry.instrumentation.auto_instrumentation._load.iter_entry_points"
+        "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
     )
     def test_load_configurators_error(self, iter_mock):
         # Add multiple entry points but only specify the 2nd in the environment variable.
@@ -101,7 +101,7 @@ def test_load_configurators_error(self, iter_mock):
         "opentelemetry.instrumentation.auto_instrumentation._load.isinstance"
     )
     @patch(
-        "opentelemetry.instrumentation.auto_instrumentation._load.iter_entry_points"
+        "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
     )
     def test_load_distro(self, iter_mock, isinstance_mock):
         # Add multiple entry points but only specify the 2nd in the environment variable.
@@ -134,7 +134,7 @@ def test_load_distro(self, iter_mock, isinstance_mock):
         "opentelemetry.instrumentation.auto_instrumentation._load.DefaultDistro"
     )
     @patch(
-        "opentelemetry.instrumentation.auto_instrumentation._load.iter_entry_points"
+        "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
     )
     def test_load_distro_not_distro(
         self, iter_mock, default_distro_mock, isinstance_mock
@@ -166,7 +166,7 @@ def test_load_distro_not_distro(
         "opentelemetry.instrumentation.auto_instrumentation._load.DefaultDistro"
     )
     @patch(
-        "opentelemetry.instrumentation.auto_instrumentation._load.iter_entry_points"
+        "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
     )
     def test_load_distro_no_ep(self, iter_mock, default_distro_mock):
         iter_mock.return_value = ()
@@ -181,7 +181,7 @@ def test_load_distro_no_ep(self, iter_mock, default_distro_mock):
         "opentelemetry.instrumentation.auto_instrumentation._load.isinstance"
     )
     @patch(
-        "opentelemetry.instrumentation.auto_instrumentation._load.iter_entry_points"
+        "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
     )
     def test_load_distro_error(self, iter_mock, isinstance_mock):
         ep_mock1 = Mock()
@@ -211,7 +211,7 @@ def test_load_distro_error(self, iter_mock, isinstance_mock):
         "opentelemetry.instrumentation.auto_instrumentation._load.get_dist_dependency_conflicts"
     )
     @patch(
-        "opentelemetry.instrumentation.auto_instrumentation._load.iter_entry_points"
+        "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
     )
     def test_load_instrumentors(self, iter_mock, dep_mock):
         # Mock opentelemetry_pre_instrument entry points
@@ -285,7 +285,7 @@ def test_load_instrumentors(self, iter_mock, dep_mock):
         "opentelemetry.instrumentation.auto_instrumentation._load.get_dist_dependency_conflicts"
     )
     @patch(
-        "opentelemetry.instrumentation.auto_instrumentation._load.iter_entry_points"
+        "opentelemetry.instrumentation.auto_instrumentation._load.entry_points"
     )
     def test_load_instrumentors_dep_conflict(
         self, iter_mock, dep_mock
diff --git a/opentelemetry-instrumentation/tests/test_dependencies.py b/opentelemetry-instrumentation/tests/test_dependencies.py
index 04bcf476ea..bdee0f6f01 100644
--- a/opentelemetry-instrumentation/tests/test_dependencies.py
+++ b/opentelemetry-instrumentation/tests/test_dependencies.py
@@ -14,8 +14,8 @@
 
 # pylint: disable=protected-access
 
-import pkg_resources
 import pytest
+from packaging.requirements import Requirement
 
 from opentelemetry.instrumentation.dependencies import (
     DependencyConflict,
@@ -23,15 +23,30 @@
     get_dist_dependency_conflicts,
 )
 from opentelemetry.test.test_base import TestBase
+from opentelemetry.util._importlib_metadata import Distribution
 
 
 class TestDependencyConflicts(TestBase):
     def test_get_dependency_conflicts_empty(self):
         self.assertIsNone(get_dependency_conflicts([]))
 
+    def test_get_dependency_conflicts_no_conflict_requirement(self):
+        req = Requirement("pytest")
+        self.assertIsNone(get_dependency_conflicts([req]))
+
     def test_get_dependency_conflicts_no_conflict(self):
         self.assertIsNone(get_dependency_conflicts(["pytest"]))
 
+    def test_get_dependency_conflicts_not_installed_requirement(self):
+        req = Requirement("this-package-does-not-exist")
+        conflict = get_dependency_conflicts([req])
+        self.assertTrue(conflict is not None)
+        self.assertTrue(isinstance(conflict, DependencyConflict))
+        self.assertEqual(
+            str(conflict),
+            'DependencyConflict: requested: "this-package-does-not-exist" but found: "None"',
+        )
+
     def test_get_dependency_conflicts_not_installed(self):
         conflict = get_dependency_conflicts(["this-package-does-not-exist"])
         self.assertTrue(conflict is not None)
@@ -51,24 +66,23 @@ def test_get_dependency_conflicts_mismatched_version(self):
         )
 
     def test_get_dist_dependency_conflicts(self):
-        def mock_requires(extras=()):
-            if "instruments" in extras:
-                return [
-                    pkg_resources.Requirement(
-                        'test-pkg ~= 1.0; extra == "instruments"'
-                    )
-                ]
-            return []
+        class MockDistribution(Distribution):
+            def locate_file(self, path):
+                pass
 
-        dist = pkg_resources.Distribution(
-            project_name="test-instrumentation", version="1.0"
-        )
-        dist.requires = mock_requires
+            def read_text(self, filename):
+                pass
+
+            @property
+            def requires(self):
+                return ['test-pkg ~= 1.0; extra == "instruments"']
+
+        dist = MockDistribution()
 
         conflict = get_dist_dependency_conflicts(dist)
         self.assertTrue(conflict is not None)
         self.assertTrue(isinstance(conflict, DependencyConflict))
         self.assertEqual(
             str(conflict),
-            'DependencyConflict: requested: "test-pkg~=1.0" but found: "None"',
+            'DependencyConflict: requested: "test-pkg~=1.0; extra == "instruments"" but found: "None"',
         )
diff --git a/opentelemetry-instrumentation/tests/test_distro.py b/opentelemetry-instrumentation/tests/test_distro.py
index 399b3f8a65..03a95614df 100644
--- a/opentelemetry-instrumentation/tests/test_distro.py
+++ b/opentelemetry-instrumentation/tests/test_distro.py
@@ -15,10 +15,9 @@
 
 from unittest import TestCase
 
-from pkg_resources import EntryPoint
-
 from opentelemetry.instrumentation.distro import BaseDistro
 from opentelemetry.instrumentation.instrumentor import BaseInstrumentor
+from opentelemetry.util._importlib_metadata import EntryPoint
 
 
 class MockInstrumetor(BaseInstrumentor):
@@ -33,11 +32,13 @@ def _uninstrument(self, **kwargs):
 
 
 class MockEntryPoint(EntryPoint):
-    def __init__(self, obj):  # pylint: disable=super-init-not-called
-        self._obj = obj
+    def __init__(
+        self, name, value, group
+    ):  # pylint: disable=super-init-not-called
+        pass
 
     def load(self, *args, **kwargs):  # pylint: disable=signature-differs
-        return self._obj
+        return MockInstrumetor
 
 
 class MockDistro(BaseDistro):
@@ -51,7 +52,11 @@ def test_load_instrumentor(self):
         distro = MockDistro()
 
         instrumentor = MockInstrumetor()
-        entry_point = MockEntryPoint(MockInstrumetor)
+        entry_point = MockEntryPoint(
+            "MockInstrumetor",
+            value="opentelemetry",
+            group="opentelemetry_distro",
+        )
 
         self.assertFalse(instrumentor._is_instrumented_by_opentelemetry)
         distro.load_instrumentor(entry_point)
diff --git a/propagator/opentelemetry-propagator-aws-xray/test-requirements.txt b/propagator/opentelemetry-propagator-aws-xray/test-requirements.txt
index 4587d87629..4694c327d8 100644
--- a/propagator/opentelemetry-propagator-aws-xray/test-requirements.txt
+++ b/propagator/opentelemetry-propagator-aws-xray/test-requirements.txt
@@ -3,7 +3,6 @@ certifi==2024.7.4
 charset-normalizer==3.3.2
 Deprecated==1.2.14
 idna==3.7
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/propagator/opentelemetry-propagator-ot-trace/test-requirements.txt b/propagator/opentelemetry-propagator-ot-trace/test-requirements.txt
index b556c4f0cc..f53a5f4acb 100644
--- a/propagator/opentelemetry-propagator-ot-trace/test-requirements.txt
+++ b/propagator/opentelemetry-propagator-ot-trace/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/resource/opentelemetry-resource-detector-azure/test-requirements.txt b/resource/opentelemetry-resource-detector-azure/test-requirements.txt
index 2b29359fbb..6170ab27fc 100644
--- a/resource/opentelemetry-resource-detector-azure/test-requirements.txt
+++ b/resource/opentelemetry-resource-detector-azure/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/resource/opentelemetry-resource-detector-container/test-requirements.txt b/resource/opentelemetry-resource-detector-container/test-requirements.txt
index f7b5b71fcf..1cce681413 100644
--- a/resource/opentelemetry-resource-detector-container/test-requirements.txt
+++ b/resource/opentelemetry-resource-detector-container/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/sdk-extension/opentelemetry-sdk-extension-aws/test-requirements.txt b/sdk-extension/opentelemetry-sdk-extension-aws/test-requirements.txt
index 1fa968a8b3..2103b20ce9 100644
--- a/sdk-extension/opentelemetry-sdk-extension-aws/test-requirements.txt
+++ b/sdk-extension/opentelemetry-sdk-extension-aws/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
diff --git a/tox.ini b/tox.ini
index 600929a6ec..4e651412c1 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1217,7 +1217,6 @@ deps =
   greenlet==3.0.3
   grpcio==1.62.1
   idna==2.10
-  importlib-metadata==6.11.0
   iniconfig==2.0.0
   jsonschema==3.2.0
   kombu==5.3.5
diff --git a/util/opentelemetry-util-http/test-requirements.txt b/util/opentelemetry-util-http/test-requirements.txt
index 1769daa094..ef05dc3a71 100644
--- a/util/opentelemetry-util-http/test-requirements.txt
+++ b/util/opentelemetry-util-http/test-requirements.txt
@@ -1,6 +1,5 @@
 asgiref==3.8.1
 Deprecated==1.2.14
-importlib-metadata==6.11.0
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0