diff --git a/instrumentation/dalli/lib/opentelemetry/instrumentation/dalli/instrumentation.rb b/instrumentation/dalli/lib/opentelemetry/instrumentation/dalli/instrumentation.rb
index 190933eade..70a4c7bb7b 100644
--- a/instrumentation/dalli/lib/opentelemetry/instrumentation/dalli/instrumentation.rb
+++ b/instrumentation/dalli/lib/opentelemetry/instrumentation/dalli/instrumentation.rb
@@ -33,7 +33,7 @@ def add_patches
           if Gem::Version.new(::Dalli::VERSION) < Gem::Version.new('3.0.0')
             ::Dalli::Server.prepend(Patches::Server)
           else
-            ::Dalli::Protocol::Binary.prepend(Patches::Server)
+            ::Dalli::Protocol::Binary.prepend(Patches::Server) if defined?(::Dalli::Protocol::Binary)
             ::Dalli::Protocol::Meta.prepend(Patches::Server) if defined?(::Dalli::Protocol::Meta)
           end
         end