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# vpop-demo
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The model mechanistically accounts for the influence of key mediators relevant to COVID-19 pathophysiology including, interactions between viral dynamics, the major host immune response mediators, and alveolar tissue damage and regeneration.
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This code re-simulates example 1 from the Duffull and Gulati commentary in CPT:PSP:
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https://ascpt.onlinelibrary.wiley.com/doi/10.1002/psp4.12559
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Along with an example analysis of a Vpop workflow coupled with it.
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## Prerequisites
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MATLAB
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This code was written in MATLAB 2020b
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## Setup
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Add all files in this repository to the MATLAB working directory.
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## Contents
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The repository should contain the following required files:
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1. run_demo.m -> *main program script*
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2. mh_generate_pps.m --> driver function for M-H algorithm
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3. sim_clin_data.m --> simulate the model of Gulati and Duffull and choose a simulated set of data to match
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4. sim_clin_data_for_mh.m --> simulate the model of Gulati and Duffull
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4. sim_clin_data_for_mh.m --> simulate the model of Duffull and Gulati
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## Authors
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Theodore Rieger*, Richard Allen*, CJ Musante

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